Corticosteroid treatment in critically ill patients with severe influenza pneumonia: a propensity score matching study

13 páginas

Autores:: Alejandro Rodríguez, Gerard Moreno
Reyes Velasco, Luis Felipe
Gomez, Josep
Sole Violan, Jordi
Díaz, Emili
Bodí, María
Trefler, Sandra
Guardiola, Juan
Yébenes, Juan C.
Soriano, Alex
Garnacho Montero, José
Socias, Lorenzo
Valle Ortíz, María del
Correig, Eudald

Tipo de recurso:

Fecha de publicación:: 2018

Institución:: Universidad de la Sabana

Repositorio:: Repositorio Universidad de la Sabana

Idioma:: spa

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dc.title.es_CO.fl_str_mv	Corticosteroid treatment in critically ill patients with severe influenza pneumonia: a propensity score matching study
title	Corticosteroid treatment in critically ill patients with severe influenza pneumonia: a propensity score matching study
spellingShingle	Corticosteroid treatment in critically ill patients with severe influenza pneumonia: a propensity score matching study Influenza Pneumonia Corticosteroids ICU Mortality
title_short	Corticosteroid treatment in critically ill patients with severe influenza pneumonia: a propensity score matching study
title_full	Corticosteroid treatment in critically ill patients with severe influenza pneumonia: a propensity score matching study
title_fullStr	Corticosteroid treatment in critically ill patients with severe influenza pneumonia: a propensity score matching study
title_full_unstemmed	Corticosteroid treatment in critically ill patients with severe influenza pneumonia: a propensity score matching study
title_sort	Corticosteroid treatment in critically ill patients with severe influenza pneumonia: a propensity score matching study
dc.creator.fl_str_mv	Alejandro Rodríguez, Gerard Moreno Reyes Velasco, Luis Felipe Gomez, Josep Sole Violan, Jordi Díaz, Emili Bodí, María Trefler, Sandra Guardiola, Juan Yébenes, Juan C. Soriano, Alex Garnacho Montero, José Socias, Lorenzo Valle Ortíz, María del Correig, Eudald
dc.contributor.author.none.fl_str_mv	Alejandro Rodríguez, Gerard Moreno Reyes Velasco, Luis Felipe Gomez, Josep Sole Violan, Jordi Díaz, Emili Bodí, María Trefler, Sandra Guardiola, Juan Yébenes, Juan C. Soriano, Alex Garnacho Montero, José Socias, Lorenzo Valle Ortíz, María del Correig, Eudald
dc.subject.es_CO.fl_str_mv	Influenza Pneumonia Corticosteroids ICU Mortality
topic	Influenza Pneumonia Corticosteroids ICU Mortality
description	13 páginas
publishDate	2018
dc.date.issued.none.fl_str_mv	2018-09
dc.date.available.none.fl_str_mv	2019-07-26T13:51:38Z
dc.date.accessioned.none.fl_str_mv	7/26/2019 8:51
dc.type.en.fl_str_mv	article
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dc.identifier.citation.es_CO.fl_str_mv	Moreno, G., Rodríguez, A., Reyes, L.F. et al. Intensive Care Med (2018) 44: 1470. https://doi.org/10.1007/s00134-018-5332-4
dc.identifier.issn.none.fl_str_mv	0342-4642
dc.identifier.other.none.fl_str_mv	https://link.springer.com/article/10.1007%2Fs00134-018-5332-4#citeas
dc.identifier.uri.none.fl_str_mv	http://hdl.handle.net/10818/36380
dc.identifier.doi.none.fl_str_mv	10.1007/s0013
identifier_str_mv	Moreno, G., Rodríguez, A., Reyes, L.F. et al. Intensive Care Med (2018) 44: 1470. https://doi.org/10.1007/s00134-018-5332-4 0342-4642 10.1007/s0013
url	https://link.springer.com/article/10.1007%2Fs00134-018-5332-4#citeas http://hdl.handle.net/10818/36380
dc.language.iso.es_CO.fl_str_mv	spa
language	spa
dc.relation.ispartofseries.none.fl_str_mv	Intensive Care Med (2018) 44: 1470
dc.rights.*.fl_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International
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rights_invalid_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2
dc.format.es_CO.fl_str_mv	application/pdf
dc.publisher.es_CO.fl_str_mv	Intensive Care Medicine
dc.source.es_CO.fl_str_mv	Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana
institution	Universidad de la Sabana
bitstream.url.fl_str_mv	https://intellectum.unisabana.edu.co/bitstream/10818/36380/2/license_rdf https://intellectum.unisabana.edu.co/bitstream/10818/36380/3/license.txt
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spelling	Alejandro Rodríguez, Gerard MorenoReyes Velasco, Luis FelipeGomez, JosepSole Violan, JordiDíaz, EmiliBodí, MaríaTrefler, SandraGuardiola, JuanYébenes, Juan C.Soriano, AlexGarnacho Montero, JoséSocias, LorenzoValle Ortíz, María delCorreig, Eudald7/26/2019 8:512019-07-26T13:51:38Z2018-09Moreno, G., Rodríguez, A., Reyes, L.F. et al. Intensive Care Med (2018) 44: 1470. https://doi.org/10.1007/s00134-018-5332-40342-4642https://link.springer.com/article/10.1007%2Fs00134-018-5332-4#citeashttp://hdl.handle.net/10818/3638010.1007/s001313 páginasPurpose To determine clinical predictors associated with corticosteroid administration and its association with ICU mortality in critically ill patients with severe influenza pneumonia. Methods Secondary analysis of a prospective cohort study of critically ill patients with confirmed influenza pneumonia admitted to 148 ICUs in Spain between June 2009 and April 2014. Patients who received corticosteroid treatment for causes other than viral pneumonia (e.g., refractory septic shock and asthma or chronic obstructive pulmonary disease [COPD] exacerbation) were excluded. Patients with corticosteroid therapy were compared with those without corticosteroid therapy. We use a propensity score (PS) matching analysis to reduce confounding factors. The primary outcome was ICU mortality. Cox proportional hazards and competing risks analysis was performed to assess the impact of corticosteroids on ICU mortality. Results A total of 1846 patients with primary influenza pneumonia were enrolled. Corticosteroids were administered in 604 (32.7%) patients, with methylprednisolone the most frequently used corticosteroid (578/604 [95.7%]). The median daily dose was equivalent to 80 mg of methylprednisolone (IQR 60–120) for a median duration of 7 days (IQR 5–10). Asthma, COPD, hematological disease, and the need for mechanical ventilation were independently associated with corticosteroid use. Crude ICU mortality was higher in patients who received corticosteroids (27.5%) than in patients who did not receive corticosteroids (18.8%, p < 0.001). After PS matching, corticosteroid use was associated with ICU mortality in the Cox (HR = 1.32 [95% CI 1.08–1.60], p < 0.006) and competing risks analysis (SHR = 1.37 [95% CI 1.12–1.68], p = 0.001). Conclusion Administration of corticosteroids in patients with severe influenza pneumonia is associated with increased ICU mortality, and these agents should not be used as co-adjuvant therapy.application/pdfspaIntensive Care MedicineIntensive Care Med (2018) 44: 1470Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaInfluenzaPneumoniaCorticosteroidsICUMortalityCorticosteroid treatment in critically ill patients with severe influenza pneumonia: a propensity score matching studyarticlepublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://intellectum.unisabana.edu.co/bitstream/10818/36380/2/license_rdf4460e5956bc1d1639be9ae6146a50347MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/36380/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD5310818/36380oai:intellectum.unisabana.edu.co:10818/363802022-05-10 05:18:32.216Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.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

Corticosteroid treatment in critically ill patients with severe influenza pneumonia: a propensity score matching study

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