Human ADMC-Derived Adipocyte Thermogenic Capacity Is Regulated by IL-4 Receptor

11 páginas

Autores:: Lizcano Losada, Fernando
Vargas, Diana
Gómez Avilés, Ángela María
Torrado, Astrid

Tipo de recurso:

Fecha de publicación:: 2017

Institución:: Universidad de la Sabana

Repositorio:: Repositorio Universidad de la Sabana

Idioma:: eng

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spelling	Lizcano Losada, FernandoVargas, DianaGómez Avilés, Ángela MaríaTorrado, Astrid6/19/2018 15:262018-06-19T20:26:47Z2017-10-12Lizcano, F., Vargas, D., Gómez, Á. y Torrado, A.(2017).Human ADMC-Derived Adipocyte Thermogenic Capacity Is Regulated by IL-4 Receptor. Stem Cells International, 2017 (2017).https://www.hindawi.com/journals/sci/2017/2767916/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660824/http://hdl.handle.net/10818/3316310.1155/2017/276791611 páginasType two innate immune system is anti-inflammatory and may play an important role as the means whereby “browning” is induced in subcutaneous adipocytes. It was shown that IL-4 may influence the fate of adipose cell precursors by promoting differentiation towards more thermogenic adipocytes in mice. Here, we investigated the influence of IL-4 and IL-4 receptor, a type two immune cytokine pathway, on the metabolic activity and thermogenic potential of human adipocytes differentiated from adipose-derived mesenchymal stem cells (ADMSCs) obtained from subcutaneous samples of healthy women undergoing abdominoplasty. Western blot analysis, qPCR, and biochemical analyses were performed 10 days after ADMSC differentiation into mature adipocytes was induced. IL-4 receptor was expressed in both precursor and differentiated adipocytes, and IL-4 treatment increased phosphorylation Y641 of signal transducer and activator of transcription 6 (STAT6) in both cell types. IL-4 treatment also increased expression of thermogenic proteins PGC-1α, UCP-1, and CITED1. In addition, IL-4 increased the secretion of adiponectin, leptin, and FGF21 and promoted lipolysis in differentiated adipocytes. In conclusion, IL-4 may directly modulate differentiation of human adipocytes towards a beige phenotype acting through IL-4 receptors on both adipose precursors and differentiated human adipocytes, metabolic effect that must be considered in some antiallergic drugs.application/pdfengStem Cells InternationalStem Cells Int. 2017; 2017: 2767916Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaThermogenicADMCIL-4Human ADMC-Derived Adipocyte Thermogenic Capacity Is Regulated by IL-4 ReceptorarticlepublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/33163/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81223https://intellectum.unisabana.edu.co/bitstream/10818/33163/2/license_rdf7c9ab7f006165862d8ce9ac5eac01552MD5210818/33163oai:intellectum.unisabana.edu.co:10818/331632022-05-10 05:17:25.125Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.coPGEgcmVsPSJsaWNlbnNlIiBocmVmPSJodHRwOi8vY3JlYXRpdmVjb21tb25zLm9yZy9saWNlbnNlcy9ieS1uYy1uZC8zLjAvIj48aW1nIGFsdD0iTGljZW5jaWEgQ3JlYXRpdmUgQ29tbW9ucyIgc3R5bGU9ImJvcmRlci13aWR0aDowIiBzcmM9Imh0dHA6Ly9pLmNyZWF0aXZlY29tbW9ucy5vcmcvbC9ieS1uYy1uZC8zLjAvODh4MzEucG5nIiAvPjwvYT48YnIgLz5Fc3RlIDxzcGFuIHhtbG5zOmRjdD0iaHR0cDovL3B1cmwub3JnL2RjL3Rlcm1zLyIgaHJlZj0iaHR0cDovL3B1cmwub3JnL2RjL2RjbWl0eXBlL1RleHQiIHJlbD0iZGN0OnR5cGUiPm9icmE8L3NwYW4+IGVzdMOhIGJham8gdW5hIDxhIHJlbD0ibGljZW5zZSIgaHJlZj0iaHR0cDovL2NyZWF0aXZlY29tbW9ucy5vcmcvbGljZW5zZXMvYnktbmMtbmQvMy4wLyI+bGljZW5jaWEgQ3JlYXRpdmUgQ29tbW9ucyBSZWNvbm9jaW1pZW50by1Ob0NvbWVyY2lhbC1TaW5PYnJhRGVyaXZhZGEgMy4wIFVucG9ydGVkPC9hPi4K
dc.title.es_CO.fl_str_mv	Human ADMC-Derived Adipocyte Thermogenic Capacity Is Regulated by IL-4 Receptor
title	Human ADMC-Derived Adipocyte Thermogenic Capacity Is Regulated by IL-4 Receptor
spellingShingle	Human ADMC-Derived Adipocyte Thermogenic Capacity Is Regulated by IL-4 Receptor Thermogenic ADMC IL-4
title_short	Human ADMC-Derived Adipocyte Thermogenic Capacity Is Regulated by IL-4 Receptor
title_full	Human ADMC-Derived Adipocyte Thermogenic Capacity Is Regulated by IL-4 Receptor
title_fullStr	Human ADMC-Derived Adipocyte Thermogenic Capacity Is Regulated by IL-4 Receptor
title_full_unstemmed	Human ADMC-Derived Adipocyte Thermogenic Capacity Is Regulated by IL-4 Receptor
title_sort	Human ADMC-Derived Adipocyte Thermogenic Capacity Is Regulated by IL-4 Receptor
dc.creator.fl_str_mv	Lizcano Losada, Fernando Vargas, Diana Gómez Avilés, Ángela María Torrado, Astrid
dc.contributor.author.none.fl_str_mv	Lizcano Losada, Fernando Vargas, Diana Gómez Avilés, Ángela María Torrado, Astrid
dc.subject.none.fl_str_mv	Thermogenic ADMC IL-4
topic	Thermogenic ADMC IL-4
description	11 páginas
publishDate	2017
dc.date.issued.none.fl_str_mv	2017-10-12
dc.date.available.none.fl_str_mv	2018-06-19T20:26:47Z
dc.date.accessioned.none.fl_str_mv	6/19/2018 15:26
dc.type.en.fl_str_mv	article
dc.type.coarversion.fl_str_mv	http://purl.org/coar/version/c_970fb48d4fbd8a85
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dc.type.hasVersion.es_CO.fl_str_mv	publishedVersion
dc.identifier.citation.es_CO.fl_str_mv	Lizcano, F., Vargas, D., Gómez, Á. y Torrado, A.(2017).Human ADMC-Derived Adipocyte Thermogenic Capacity Is Regulated by IL-4 Receptor. Stem Cells International, 2017 (2017).
dc.identifier.other.none.fl_str_mv	https://www.hindawi.com/journals/sci/2017/2767916/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660824/
dc.identifier.uri.none.fl_str_mv	http://hdl.handle.net/10818/33163
dc.identifier.doi.none.fl_str_mv	10.1155/2017/2767916
identifier_str_mv	Lizcano, F., Vargas, D., Gómez, Á. y Torrado, A.(2017).Human ADMC-Derived Adipocyte Thermogenic Capacity Is Regulated by IL-4 Receptor. Stem Cells International, 2017 (2017). 10.1155/2017/2767916
url	https://www.hindawi.com/journals/sci/2017/2767916/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660824/ http://hdl.handle.net/10818/33163
dc.language.iso.es_CO.fl_str_mv	eng
language	eng
dc.relation.ispartofseries.none.fl_str_mv	Stem Cells Int. 2017; 2017: 2767916
dc.rights.*.fl_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.coar.fl_str_mv	http://purl.org/coar/access_right/c_abf2
dc.rights.uri.*.fl_str_mv	http://creativecommons.org/licenses/by-nc-nd/4.0/
rights_invalid_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2
dc.format.es_CO.fl_str_mv	application/pdf
dc.publisher.es_CO.fl_str_mv	Stem Cells International
dc.source.es_CO.fl_str_mv	Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana
institution	Universidad de la Sabana
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Human ADMC-Derived Adipocyte Thermogenic Capacity Is Regulated by IL-4 Receptor

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