Correlation of the Homeostasis Model Assessment Index and Adiponectin, Leptin and Insulin Levels to Body Mass Index-Associated Gene Polymorphisms in Adolescents

8 páginas

Autores:: Martínez Martínez, María D.
Mendieta Zerón, Hugo
Celis Regalado, Luis Gustavo
Layton Tovar, Cristian F.
Torres García, Rocío
Gutiérrez Pliego, Laura E.
Camarillo Romero, Eneida
Garduño García, José D.
Camarillo Romero, María D.

Tipo de recurso:

Fecha de publicación:: 2018

Institución:: Universidad de la Sabana

Repositorio:: Repositorio Universidad de la Sabana

Idioma:: eng

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spelling	Martínez Martínez, María D.Mendieta Zerón, HugoCelis Regalado, Luis GustavoLayton Tovar, Cristian F.Torres García, RocíoGutiérrez Pliego, Laura E.Camarillo Romero, EneidaGarduño García, José D.Camarillo Romero, María D.8/2/2020 10:412020-08-02T15:41:00Z2018-03-13https://journals.squ.edu.om/index.php/squmj/article/view/2848https://journals.squ.edu.om/index.php/squmj/article/view/2848/2512http://hdl.handle.net/10818/4261910.18295/squmj.2018.18.03.0058 páginasObjectives: This study aimed to describe correlations between glucose, insulin and adipokine levels and the homeostasis model assessment (HOMA) index with regards to the presence/absence of fat mass and obesity-associated (FTO) rs9939609 and peroxisome proliferator-activated receptor (PPAR)-y rs1801282 single nucleotide polymorphisms (SNPs) as indicators of body mass index in adolescents. Methods: This cross-sectional study was conducted between September and December 2016 in Toluca, Mexico. A total of 71 students between 14–18 years old were included. Various anthropometric and laboratory measurements were collected, including lipid profile, glucose, insulin and adipokine levels and HOMA index. The degree of association between variables was evaluated with regards to the presence/absence of the SNPs. Results: Leptin levels were significantly higher among female students (P = 0.001), although adiponectin levels did not differ significantly (P = 0.060). There were significant positive correlations between insulin levels and HOMA index with FTO (r = 0.391; P = 0.007 and r = 0.413; P = 0.005, respectively) and PPARγ (r = 0.529; P = 0.007 and r = 0.537; P = 0.007, respectively) SNPs. Leptin showed a significant positive correlation in the presence of PPARγ (r = 0.483; P = 0.007) or in the absence of both SNPs (r = 0.627; P = 0.039). However, adiponectin was significantly negatively correlated in the presence of FTO, either alone (r = −0.333; P = 0.024) or in combination with PPARγ (r = −0.616; P = 0.043). Conclusion: The presence of FTO and/or PPARγ SNPs might be related to a genetic predisposition to metabolic syndrome.application/pdfengSQU Medical JournalSQU Medical Journal, August 2018, Volume 18, Issue 3Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaObesityBody Mass IndexSingle Nucleotide PolymorphismsFat Mass and Obesity Associated ProteinHumanPeroxisome Proliferator-Activated Receptor gammaAdipokinesCorrelation of the Homeostasis Model Assessment Index and Adiponectin, Leptin and Insulin Levels to Body Mass Index-Associated Gene Polymorphisms in AdolescentsarticlepublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/42619/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://intellectum.unisabana.edu.co/bitstream/10818/42619/2/license_rdf4460e5956bc1d1639be9ae6146a50347MD5210818/42619oai:intellectum.unisabana.edu.co:10818/426192022-05-10 05:20:25.322Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.coPGEgcmVsPSJsaWNlbnNlIiBocmVmPSJodHRwOi8vY3JlYXRpdmVjb21tb25zLm9yZy9saWNlbnNlcy9ieS1uYy1uZC8zLjAvIj48aW1nIGFsdD0iTGljZW5jaWEgQ3JlYXRpdmUgQ29tbW9ucyIgc3R5bGU9ImJvcmRlci13aWR0aDowIiBzcmM9Imh0dHA6Ly9pLmNyZWF0aXZlY29tbW9ucy5vcmcvbC9ieS1uYy1uZC8zLjAvODh4MzEucG5nIiAvPjwvYT48YnIgLz5Fc3RlIDxzcGFuIHhtbG5zOmRjdD0iaHR0cDovL3B1cmwub3JnL2RjL3Rlcm1zLyIgaHJlZj0iaHR0cDovL3B1cmwub3JnL2RjL2RjbWl0eXBlL1RleHQiIHJlbD0iZGN0OnR5cGUiPm9icmE8L3NwYW4+IGVzdMOhIGJham8gdW5hIDxhIHJlbD0ibGljZW5zZSIgaHJlZj0iaHR0cDovL2NyZWF0aXZlY29tbW9ucy5vcmcvbGljZW5zZXMvYnktbmMtbmQvMy4wLyI+bGljZW5jaWEgQ3JlYXRpdmUgQ29tbW9ucyBSZWNvbm9jaW1pZW50by1Ob0NvbWVyY2lhbC1TaW5PYnJhRGVyaXZhZGEgMy4wIFVucG9ydGVkPC9hPi4K
dc.title.es_CO.fl_str_mv	Correlation of the Homeostasis Model Assessment Index and Adiponectin, Leptin and Insulin Levels to Body Mass Index-Associated Gene Polymorphisms in Adolescents
title	Correlation of the Homeostasis Model Assessment Index and Adiponectin, Leptin and Insulin Levels to Body Mass Index-Associated Gene Polymorphisms in Adolescents
spellingShingle	Correlation of the Homeostasis Model Assessment Index and Adiponectin, Leptin and Insulin Levels to Body Mass Index-Associated Gene Polymorphisms in Adolescents Obesity Body Mass Index Single Nucleotide Polymorphisms Fat Mass and Obesity Associated Protein Human Peroxisome Proliferator-Activated Receptor gamma Adipokines
title_short	Correlation of the Homeostasis Model Assessment Index and Adiponectin, Leptin and Insulin Levels to Body Mass Index-Associated Gene Polymorphisms in Adolescents
title_full	Correlation of the Homeostasis Model Assessment Index and Adiponectin, Leptin and Insulin Levels to Body Mass Index-Associated Gene Polymorphisms in Adolescents
title_fullStr	Correlation of the Homeostasis Model Assessment Index and Adiponectin, Leptin and Insulin Levels to Body Mass Index-Associated Gene Polymorphisms in Adolescents
title_full_unstemmed	Correlation of the Homeostasis Model Assessment Index and Adiponectin, Leptin and Insulin Levels to Body Mass Index-Associated Gene Polymorphisms in Adolescents
title_sort	Correlation of the Homeostasis Model Assessment Index and Adiponectin, Leptin and Insulin Levels to Body Mass Index-Associated Gene Polymorphisms in Adolescents
dc.creator.fl_str_mv	Martínez Martínez, María D. Mendieta Zerón, Hugo Celis Regalado, Luis Gustavo Layton Tovar, Cristian F. Torres García, Rocío Gutiérrez Pliego, Laura E. Camarillo Romero, Eneida Garduño García, José D. Camarillo Romero, María D.
dc.contributor.author.none.fl_str_mv	Martínez Martínez, María D. Mendieta Zerón, Hugo Celis Regalado, Luis Gustavo Layton Tovar, Cristian F. Torres García, Rocío Gutiérrez Pliego, Laura E. Camarillo Romero, Eneida Garduño García, José D. Camarillo Romero, María D.
dc.subject.es_CO.fl_str_mv	Obesity Body Mass Index Single Nucleotide Polymorphisms Fat Mass and Obesity Associated Protein Human Peroxisome Proliferator-Activated Receptor gamma Adipokines
topic	Obesity Body Mass Index Single Nucleotide Polymorphisms Fat Mass and Obesity Associated Protein Human Peroxisome Proliferator-Activated Receptor gamma Adipokines
description	8 páginas
publishDate	2018
dc.date.issued.none.fl_str_mv	2018-03-13
dc.date.available.none.fl_str_mv	2020-08-02T15:41:00Z
dc.date.accessioned.none.fl_str_mv	8/2/2020 10:41
dc.type.en.fl_str_mv	article
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dc.identifier.uri.none.fl_str_mv	http://hdl.handle.net/10818/42619
dc.identifier.doi.none.fl_str_mv	10.18295/squmj.2018.18.03.005
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identifier_str_mv	10.18295/squmj.2018.18.03.005
dc.language.iso.es_CO.fl_str_mv	eng
language	eng
dc.relation.ispartofseries.none.fl_str_mv	SQU Medical Journal, August 2018, Volume 18, Issue 3
dc.rights.*.fl_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.coar.fl_str_mv	http://purl.org/coar/access_right/c_abf2
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dc.publisher.es_CO.fl_str_mv	SQU Medical Journal
dc.source.es_CO.fl_str_mv	Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana
institution	Universidad de la Sabana
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Correlation of the Homeostasis Model Assessment Index and Adiponectin, Leptin and Insulin Levels to Body Mass Index-Associated Gene Polymorphisms in Adolescents

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