Thyroid hormone therapy modulates hypothalamo-pituitary-adrenal axis

6 páginas

Autores:: Lizcano Losada, Fernando
Rodríguez, Javier Salvador

Tipo de recurso:

Fecha de publicación:: 2010

Institución:: Universidad de la Sabana

Repositorio:: Repositorio Universidad de la Sabana

Idioma:: eng

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spelling	Lizcano Losada, FernandoRodríguez, Javier Salvador10/14/2016 10:482016-10-14T15:48:14Z2010-11-30https://www.jstage.jst.go.jp/article/endocrj/58/2/58_K10E-369/_pdfhttp://hdl.handle.net/10818/275266 páginasTo observe the influence of thyroid hormone therapy on hypothalamo-pituitary-adrenal (HPA) axis, a group of 14 athyreotic women due to thyroid cancer treatment were studied before and after thyroid suppression therapy with thyroxine (T4). Changes in plasma adrenocorticotropin (ACTH) and cortisol levels in response to human corticotropin-releasing hormone (hCRH; 100μg, i.v.) were estimated under hypothyroid conditions and after T4 suppression therapy with 2.5μg/kg/day for two months (n=14). A group of seven healthy women was evaluated as a control group. A greater increase in ACTH levels by hCRH was observed in patient group both before and after suppression therapy compared than that of control group. Plasma cortisol levels after hCRH stimulation were also greater in patient group both before and after suppression therapy than that of control group. In conclusion, both hypothyroidism and subclinical hyperthyroidism with suppressive doses of thyroid hormone induced a hypersensitivity of ACTH to hCRH. Considering the role of thyroid hormone on HPA axis, the mechanisms of ACTH hypersensitivity may be different between these two conditions.application/pdfengEndocrine JournalEndocrine Journal 2011, 58 (2), 137-142Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaAdrenocorticotropinhCRHCortisolThyroid hormoneHypothalamo-pituitary-adrenal axisThyroid hormone therapy modulates hypothalamo-pituitary-adrenal axisarticlepublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/27526/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81223https://intellectum.unisabana.edu.co/bitstream/10818/27526/2/license_rdf7c9ab7f006165862d8ce9ac5eac01552MD5210818/27526oai:intellectum.unisabana.edu.co:10818/275262022-05-10 05:17:32.768Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.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
dc.title.es_CO.fl_str_mv	Thyroid hormone therapy modulates hypothalamo-pituitary-adrenal axis
title	Thyroid hormone therapy modulates hypothalamo-pituitary-adrenal axis
spellingShingle	Thyroid hormone therapy modulates hypothalamo-pituitary-adrenal axis Adrenocorticotropin hCRH Cortisol Thyroid hormone Hypothalamo-pituitary-adrenal axis
title_short	Thyroid hormone therapy modulates hypothalamo-pituitary-adrenal axis
title_full	Thyroid hormone therapy modulates hypothalamo-pituitary-adrenal axis
title_fullStr	Thyroid hormone therapy modulates hypothalamo-pituitary-adrenal axis
title_full_unstemmed	Thyroid hormone therapy modulates hypothalamo-pituitary-adrenal axis
title_sort	Thyroid hormone therapy modulates hypothalamo-pituitary-adrenal axis
dc.creator.fl_str_mv	Lizcano Losada, Fernando Rodríguez, Javier Salvador
dc.contributor.author.none.fl_str_mv	Lizcano Losada, Fernando Rodríguez, Javier Salvador
dc.subject.other.en.fl_str_mv	Adrenocorticotropin hCRH Cortisol Thyroid hormone Hypothalamo-pituitary-adrenal axis
topic	Adrenocorticotropin hCRH Cortisol Thyroid hormone Hypothalamo-pituitary-adrenal axis
description	6 páginas
publishDate	2010
dc.date.accessioned.none.fl_str_mv	10/14/2016 10:48
dc.date.issued.none.fl_str_mv	2010-11-30
dc.date.available.none.fl_str_mv	2016-10-14T15:48:14Z
dc.type.en.fl_str_mv	article
dc.type.coarversion.fl_str_mv	http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv	http://purl.org/coar/resource_type/c_6501
dc.type.hasVersion.es_CO.fl_str_mv	publishedVersion
dc.identifier.other.none.fl_str_mv	https://www.jstage.jst.go.jp/article/endocrj/58/2/58_K10E-369/_pdf
dc.identifier.uri.none.fl_str_mv	http://hdl.handle.net/10818/27526
url	https://www.jstage.jst.go.jp/article/endocrj/58/2/58_K10E-369/_pdf http://hdl.handle.net/10818/27526
dc.language.iso.es_CO.fl_str_mv	eng
language	eng
dc.relation.ispartofseries.none.fl_str_mv	Endocrine Journal 2011, 58 (2), 137-142
dc.rights.*.fl_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International
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rights_invalid_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2
dc.format.es_CO.fl_str_mv	application/pdf
dc.publisher.es_CO.fl_str_mv	Endocrine Journal
dc.source.es_CO.fl_str_mv	Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana
institution	Universidad de la Sabana
bitstream.url.fl_str_mv	https://intellectum.unisabana.edu.co/bitstream/10818/27526/3/license.txt https://intellectum.unisabana.edu.co/bitstream/10818/27526/2/license_rdf
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Thyroid hormone therapy modulates hypothalamo-pituitary-adrenal axis

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