Diabetes Mellitus Is a Chronic Disease that Can Benefit from Therapy with Induced Pluripotent Stem Cells

8 páginas

Autores:: Arroyave, Felipe
Montaño, Diana
Lizcano, Fernando

Tipo de recurso:

Fecha de publicación:: 2020

Institución:: Universidad de la Sabana

Repositorio:: Repositorio Universidad de la Sabana

Idioma:: eng

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spelling	Arroyave, FelipeMontaño, DianaLizcano, Fernando7/29/2021 14:392021-07-29T19:39:55Z2020-11-18Arroyave, F.; Montaño, D.; Lizcano, F. Diabetes Mellitus Is a Chronic Disease that Can Benefit from Therapy with Induced Pluripotent Stem Cells. Int. J. Mol. Sci. 2020, 21, 8685.1422-0067https://www.mdpi.com/1422-0067/21/22/8685/htmhttp://hdl.handle.net/10818/4803710.3390/ijms212286858 páginasDiabetes mellitus (DM) is one of the main causes of morbidity and mortality, with an increasing incidence worldwide. The impact of DM on public health in developing countries has triggered alarm due to the exaggerated costs of the treatment and monitoring of patients with this disease. Considerable efforts have been made to try to prevent the onset and reduce the complications of DM. However, because insulin-producing pancreatic β-cells progressively deteriorate, many people must receive insulin through subcutaneous injection. Additionally, current therapies do not have consistent results regarding the prevention of chronic complications. Leveraging the approval of real-time continuous glucose monitors and sophisticated algorithms that partially automate insulin infusion pumps has improved glycemic control, decreasing the burden of diabetes management. However, these advances are facing physiologic barriers. New findings in molecular and cellular biology have produced an extraordinary advancement in tissue development for the treatment of DM. Obtaining pancreatic β-cells from somatic cells is a great resource that currently exists for patients with DM. Although this therapeutic option has great prospects for patients, some challenges remain for this therapeutic plan to be used clinically. The purpose of this review is to describe the new techniques in cell biology and regenerative medicine as possible treatments for DM. In particular, this review highlights the origin of induced pluripotent cells (iPSCs) and how they have begun to emerge as a regenerative treatment that may mitigate the pathology of this disease.application/pdfengInternational Journal of Molecular SciencesInt. J. Mol. Sci. 2020, 21, 8685Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaRegenerative medicineiPSCDiabetes mellitusPancreatic β-cellsTranscriptional regulationHistone modificationDiabetes Mellitus Is a Chronic Disease that Can Benefit from Therapy with Induced Pluripotent Stem CellsarticlepublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://intellectum.unisabana.edu.co/bitstream/10818/48037/2/license_rdf4460e5956bc1d1639be9ae6146a50347MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/48037/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD5310818/48037oai:intellectum.unisabana.edu.co:10818/480372022-05-10 05:21:35.421Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.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
dc.title.es_CO.fl_str_mv	Diabetes Mellitus Is a Chronic Disease that Can Benefit from Therapy with Induced Pluripotent Stem Cells
title	Diabetes Mellitus Is a Chronic Disease that Can Benefit from Therapy with Induced Pluripotent Stem Cells
spellingShingle	Diabetes Mellitus Is a Chronic Disease that Can Benefit from Therapy with Induced Pluripotent Stem Cells Regenerative medicine iPSC Diabetes mellitus Pancreatic β-cells Transcriptional regulation Histone modification
title_short	Diabetes Mellitus Is a Chronic Disease that Can Benefit from Therapy with Induced Pluripotent Stem Cells
title_full	Diabetes Mellitus Is a Chronic Disease that Can Benefit from Therapy with Induced Pluripotent Stem Cells
title_fullStr	Diabetes Mellitus Is a Chronic Disease that Can Benefit from Therapy with Induced Pluripotent Stem Cells
title_full_unstemmed	Diabetes Mellitus Is a Chronic Disease that Can Benefit from Therapy with Induced Pluripotent Stem Cells
title_sort	Diabetes Mellitus Is a Chronic Disease that Can Benefit from Therapy with Induced Pluripotent Stem Cells
dc.creator.fl_str_mv	Arroyave, Felipe Montaño, Diana Lizcano, Fernando
dc.contributor.author.none.fl_str_mv	Arroyave, Felipe Montaño, Diana Lizcano, Fernando
dc.subject.other.en.fl_str_mv	Regenerative medicine iPSC Diabetes mellitus Pancreatic β-cells Transcriptional regulation Histone modification
topic	Regenerative medicine iPSC Diabetes mellitus Pancreatic β-cells Transcriptional regulation Histone modification
description	8 páginas
publishDate	2020
dc.date.issued.none.fl_str_mv	2020-11-18
dc.date.available.none.fl_str_mv	2021-07-29T19:39:55Z
dc.date.accessioned.none.fl_str_mv	7/29/2021 14:39
dc.type.en.fl_str_mv	article
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dc.identifier.citation.es_CO.fl_str_mv	Arroyave, F.; Montaño, D.; Lizcano, F. Diabetes Mellitus Is a Chronic Disease that Can Benefit from Therapy with Induced Pluripotent Stem Cells. Int. J. Mol. Sci. 2020, 21, 8685.
dc.identifier.issn.none.fl_str_mv	1422-0067
dc.identifier.other.none.fl_str_mv	https://www.mdpi.com/1422-0067/21/22/8685/htm
dc.identifier.uri.none.fl_str_mv	http://hdl.handle.net/10818/48037
dc.identifier.doi.none.fl_str_mv	10.3390/ijms21228685
identifier_str_mv	Arroyave, F.; Montaño, D.; Lizcano, F. Diabetes Mellitus Is a Chronic Disease that Can Benefit from Therapy with Induced Pluripotent Stem Cells. Int. J. Mol. Sci. 2020, 21, 8685. 1422-0067 10.3390/ijms21228685
url	https://www.mdpi.com/1422-0067/21/22/8685/htm http://hdl.handle.net/10818/48037
dc.language.iso.es_CO.fl_str_mv	eng
language	eng
dc.relation.ispartofseries.none.fl_str_mv	Int. J. Mol. Sci. 2020, 21, 8685
dc.rights.*.fl_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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dc.publisher.es_CO.fl_str_mv	International Journal of Molecular Sciences
dc.source.es_CO.fl_str_mv	Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana
institution	Universidad de la Sabana
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Diabetes Mellitus Is a Chronic Disease that Can Benefit from Therapy with Induced Pluripotent Stem Cells

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