Regulation of adipogenesis by nucelar receptor PPARγ is modulated by the histone demethylase JMJD2C

6 páginas

Autores:: Lizcano Losada, Fernando
Romero, Carolina
Vargas, Diana

Tipo de recurso:

Fecha de publicación:: 2010

Institución:: Universidad de la Sabana

Repositorio:: Repositorio Universidad de la Sabana

Idioma:: eng

id	REPOUSABA2_b993cacd2ce94f0b015fde912b9d46f0
oai_identifier_str	oai:intellectum.unisabana.edu.co:10818/27525
network_acronym_str	REPOUSABA2
network_name_str	Repositorio Universidad de la Sabana
repository_id_str
spelling	Lizcano Losada, FernandoRomero, CarolinaVargas, Diana10/14/2016 10:332016-10-14T15:33:21Z2010-07-291415-4757http://www.scielo.br/pdf/gmb/v34n1/2010-112.pdfhttp://hdl.handle.net/10818/275256 páginasA potential strategy to combat obesity and its associated complications involves modifying gene expression in adipose cells to reduce lipid accumulation. The nuclear receptor Peroxisome Proliferator-activated receptor gamma (PPARγ) is the master regulator of adipose cell differentiation and its functional activation is currently used as a therapeutic approach for Diabetes Mellitus type 2. However, total activation of PPARγ induces undesirable secondary effects that might be set with a partial activation. A group of proteins that produce histone demethylation has been shown to modify the transcriptional activity of nuclear receptors. Here we describe the repressive action of the jumonji domain containing 2C/lysine demethylase 4 C (JMJD2C/KDM4C) on PPARγ transcriptional activation. JMJD2C significantly reduced the rosiglitazone stimulated PPARγ activation. This effect was mainly observed in experiments performed using the Tudor domains that may interact with histone deacetylase class 1 (HDAC) and this interaction probably reduces the mediated activation of PPARγ. Trichostatin A, a HDAC inhibitor, reduces the repressive effect of JMJD2C. When JMJD2C was over-expressed in 3T3-L1 cells, a reduction of differentiation was observed with the Tudor domain. In summary, we herein describe JMJD2C-mediated reduction of PPARgamma transcriptional activation as well as preadipocyte differentiation. This novel action of JMJD2C might have an important role in new therapeutic approaches to treat obesity and its complications.application/pdfengGenetics and Molecular BiologyGenetics and Molecular Biology, 34, 1, 19-24 (2011)Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaPPARγHistonesDemethylationJMJD2CDeacetylationAdipocyteTrichostatin A.Regulation of adipogenesis by nucelar receptor PPARγ is modulated by the histone demethylase JMJD2CarticlepublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81223https://intellectum.unisabana.edu.co/bitstream/10818/27525/2/license_rdf7c9ab7f006165862d8ce9ac5eac01552MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/27525/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD5310818/27525oai:intellectum.unisabana.edu.co:10818/275252022-05-10 05:16:24.729Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.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
dc.title.es_CO.fl_str_mv	Regulation of adipogenesis by nucelar receptor PPARγ is modulated by the histone demethylase JMJD2C
title	Regulation of adipogenesis by nucelar receptor PPARγ is modulated by the histone demethylase JMJD2C
spellingShingle	Regulation of adipogenesis by nucelar receptor PPARγ is modulated by the histone demethylase JMJD2C PPARγ Histones Demethylation JMJD2C Deacetylation Adipocyte Trichostatin A.
title_short	Regulation of adipogenesis by nucelar receptor PPARγ is modulated by the histone demethylase JMJD2C
title_full	Regulation of adipogenesis by nucelar receptor PPARγ is modulated by the histone demethylase JMJD2C
title_fullStr	Regulation of adipogenesis by nucelar receptor PPARγ is modulated by the histone demethylase JMJD2C
title_full_unstemmed	Regulation of adipogenesis by nucelar receptor PPARγ is modulated by the histone demethylase JMJD2C
title_sort	Regulation of adipogenesis by nucelar receptor PPARγ is modulated by the histone demethylase JMJD2C
dc.creator.fl_str_mv	Lizcano Losada, Fernando Romero, Carolina Vargas, Diana
dc.contributor.author.none.fl_str_mv	Lizcano Losada, Fernando Romero, Carolina Vargas, Diana
dc.subject.other.en.fl_str_mv	PPARγ Histones Demethylation JMJD2C Deacetylation Adipocyte Trichostatin A.
topic	PPARγ Histones Demethylation JMJD2C Deacetylation Adipocyte Trichostatin A.
description	6 páginas
publishDate	2010
dc.date.accessioned.none.fl_str_mv	10/14/2016 10:33
dc.date.issued.none.fl_str_mv	2010-07-29
dc.date.available.none.fl_str_mv	2016-10-14T15:33:21Z
dc.type.en.fl_str_mv	article
dc.type.coarversion.fl_str_mv	http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv	http://purl.org/coar/resource_type/c_6501
dc.type.hasVersion.es_CO.fl_str_mv	publishedVersion
dc.identifier.issn.none.fl_str_mv	1415-4757
dc.identifier.other.none.fl_str_mv	http://www.scielo.br/pdf/gmb/v34n1/2010-112.pdf
dc.identifier.uri.none.fl_str_mv	http://hdl.handle.net/10818/27525
identifier_str_mv	1415-4757
url	http://www.scielo.br/pdf/gmb/v34n1/2010-112.pdf http://hdl.handle.net/10818/27525
dc.language.iso.es_CO.fl_str_mv	eng
language	eng
dc.relation.ispartofseries.none.fl_str_mv	Genetics and Molecular Biology, 34, 1, 19-24 (2011)
dc.rights.*.fl_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.coar.fl_str_mv	http://purl.org/coar/access_right/c_abf2
dc.rights.uri.*.fl_str_mv	http://creativecommons.org/licenses/by-nc-nd/4.0/
rights_invalid_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2
dc.format.es_CO.fl_str_mv	application/pdf
dc.publisher.es_CO.fl_str_mv	Genetics and Molecular Biology
dc.source.es_CO.fl_str_mv	Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana
institution	Universidad de la Sabana
bitstream.url.fl_str_mv	https://intellectum.unisabana.edu.co/bitstream/10818/27525/2/license_rdf https://intellectum.unisabana.edu.co/bitstream/10818/27525/3/license.txt
bitstream.checksum.fl_str_mv	7c9ab7f006165862d8ce9ac5eac01552 f52a2cfd4df262e08e9b300d62c85cab
bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5
repository.name.fl_str_mv	Intellectum Universidad de la Sabana
repository.mail.fl_str_mv	contactointellectum@unisabana.edu.co
_version_	1811952260366729216

Regulation of adipogenesis by nucelar receptor PPARγ is modulated by the histone demethylase JMJD2C

Publicaciones similares