Ultrastructural analysis of olfactory ensheathing cells derived from olfactory bulb and nerve of neonatal and juvenile rats

8 páginas

Autores:: Gómez Bello, Rosa Margarita
Ghotme Ghotme, Kemel Ahmed
Botero Espinosa, Lucía
Bernal Villegas, Jaime Eduardo
Pérez, Rosalía
Sampaio Barreto, George Emílio
Bustos Cruz, Rosa Helena

Tipo de recurso:

Fecha de publicación:: 2015

Institución:: Universidad de la Sabana

Repositorio:: Repositorio Universidad de la Sabana

Idioma:: spa

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spelling	Gómez Bello, Rosa MargaritaGhotme Ghotme, Kemel AhmedBotero Espinosa, LucíaBernal Villegas, Jaime EduardoPérez, RosalíaSampaio Barreto, George EmílioBustos Cruz, Rosa Helena11/2/2016 14:342016-11-02T19:34:02Z2015-08-061097-4547https://repository.javeriana.edu.co/bitstream/handle/10554/47779/sart.pdf?sequence=2&isAllowed=yhttp://hdl.handle.net/10818/2797310.1016/j.neures.2015.07.0128 páginasOlfactory nerve derived and olfactory bulb derived olfactory ensheathing cells (OECs) have the ability to promote axonal regeneration and remyelination, both of which are essential in a successful cell transplant. Thus, morphological identification of OECs is a key aspect to develop an applicable cell therapy for injuries to the nervous system. However, there is no clear definition regarding which developmental stage or anatomical origin of OECs is more adequate for neural repair. In the present study, an ultrastructural comparison was made between OECs recovered from primary cultures of olfactory nerve and bulb in two developmental stages. The most notorious difference between cells obtained from olfactory nerve and bulb was the presence of indented nuclei in bulb derived OECs, suggesting a greater ability for possible chemotaxis. In neonatal OECs abundant mitochondria, lipid vacuoles, and smooth endoplasmic reticulum were detected, suggesting an active lipid metabolism, probably involved in synthesis of myelin. Our results suggest that neonatal OECs obtained from olfactory bulb have microscopic properties that could make them more suitable for neural repair.application/pdfspaNeuroscience Research Volume 103, February 2016, Pages 10-17Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaOlfactory ensheathing cellsElectron microscopyRegenerationNeural repairCell therapyUltrastructural analysis of olfactory ensheathing cells derived from olfactory bulb and nerve of neonatal and juvenile ratsarticlepublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81223https://intellectum.unisabana.edu.co/bitstream/10818/27973/2/license_rdf7c9ab7f006165862d8ce9ac5eac01552MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/27973/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD5310818/27973oai:intellectum.unisabana.edu.co:10818/279732022-05-10 05:17:00.216Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.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
dc.title.es_CO.fl_str_mv	Ultrastructural analysis of olfactory ensheathing cells derived from olfactory bulb and nerve of neonatal and juvenile rats
title	Ultrastructural analysis of olfactory ensheathing cells derived from olfactory bulb and nerve of neonatal and juvenile rats
spellingShingle	Ultrastructural analysis of olfactory ensheathing cells derived from olfactory bulb and nerve of neonatal and juvenile rats Olfactory ensheathing cells Electron microscopy Regeneration Neural repair Cell therapy
title_short	Ultrastructural analysis of olfactory ensheathing cells derived from olfactory bulb and nerve of neonatal and juvenile rats
title_full	Ultrastructural analysis of olfactory ensheathing cells derived from olfactory bulb and nerve of neonatal and juvenile rats
title_fullStr	Ultrastructural analysis of olfactory ensheathing cells derived from olfactory bulb and nerve of neonatal and juvenile rats
title_full_unstemmed	Ultrastructural analysis of olfactory ensheathing cells derived from olfactory bulb and nerve of neonatal and juvenile rats
title_sort	Ultrastructural analysis of olfactory ensheathing cells derived from olfactory bulb and nerve of neonatal and juvenile rats
dc.creator.fl_str_mv	Gómez Bello, Rosa Margarita Ghotme Ghotme, Kemel Ahmed Botero Espinosa, Lucía Bernal Villegas, Jaime Eduardo Pérez, Rosalía Sampaio Barreto, George Emílio Bustos Cruz, Rosa Helena
dc.contributor.author.none.fl_str_mv	Gómez Bello, Rosa Margarita Ghotme Ghotme, Kemel Ahmed Botero Espinosa, Lucía Bernal Villegas, Jaime Eduardo Pérez, Rosalía Sampaio Barreto, George Emílio Bustos Cruz, Rosa Helena
dc.subject.none.fl_str_mv	Olfactory ensheathing cells Electron microscopy Regeneration Neural repair Cell therapy
topic	Olfactory ensheathing cells Electron microscopy Regeneration Neural repair Cell therapy
description	8 páginas
publishDate	2015
dc.date.accessioned.none.fl_str_mv	11/2/2016 14:34
dc.date.issued.none.fl_str_mv	2015-08-06
dc.date.available.none.fl_str_mv	2016-11-02T19:34:02Z
dc.type.en.fl_str_mv	article
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dc.identifier.uri.none.fl_str_mv	http://hdl.handle.net/10818/27973
dc.identifier.doi.none.fl_str_mv	10.1016/j.neures.2015.07.012
identifier_str_mv	1097-4547 10.1016/j.neures.2015.07.012
url	https://repository.javeriana.edu.co/bitstream/handle/10554/47779/sart.pdf?sequence=2&isAllowed=y http://hdl.handle.net/10818/27973
dc.language.iso.es_CO.fl_str_mv	spa
language	spa
dc.relation.ispartofseries.none.fl_str_mv	Neuroscience Research Volume 103, February 2016, Pages 10-17
dc.rights.*.fl_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International
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rights_invalid_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2
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dc.source.es_CO.fl_str_mv	Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana
institution	Universidad de la Sabana
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Ultrastructural analysis of olfactory ensheathing cells derived from olfactory bulb and nerve of neonatal and juvenile rats

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