Thermogenic capacity of human periaortic adipose tissue is transformed by body weight

10 páginas

Autores:: Vargas, Diana
López, Carolina
Acero, Edward
Benitez, Edgar
Wintaco, Angélica
Camacho, Jaime
Carreño, Marisol
Umaña, Juan
Jimenez, Daniela
Díaz, Said
Lizcano Losada, Fernando

Tipo de recurso:

Fecha de publicación:: 2018

Institución:: Universidad de la Sabana

Repositorio:: Repositorio Universidad de la Sabana

Idioma:: eng

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spelling	Vargas, DianaLópez, CarolinaAcero, EdwardBenitez, EdgarWintaco, AngélicaCamacho, JaimeCarreño, MarisolUmaña, JuanJimenez, DanielaDíaz, SaidLizcano Losada, Fernando12/1/2020 9:102020-12-01T14:10:58Z2018-03-191932-6203https://pubmed.ncbi.nlm.nih.gov/29554135/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0194269https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858771/http://hdl.handle.net/10818/4565510.1371/journal.pone.019426910 páginasThe anatomical location of adipose tissue might have direct implications for its functionality and risk of cardiovascular disease. Adipose tissue surrounding blood vessels may be thermogenically more active in specific areas of the body, releasing substances that regulate vascular metabolism. In humans, the phenotypic characteristics of adipose tissue surrounding the aorta and the cardiovascular disease risk that it might entail remain largely unknown. Here, we compared thermogenesis-related molecular features of human periaortic adipose tissue samples with those of subcutaneous adipose tissue, obtained by sternotomy from 42 patients undergoing cardiovascular surgery. To determine the expression of genes related to energy expenditure and the levels of some adipokines, histological examinations, quantitative PCR, and protein expression measurements in adipocyte precursor cells were performed. Periaortic adipocytes were smaller than those from subcutaneous tissue. Moreover, weight gain induced periaortic adipocyte hypertrophy (r = -0.91, p<0.01). Compared to subcutaneous tissue, adiponectin, FABP4, IL-4 and IL-6 was decreased in periaortic adipocytes, whereas FGF21, UCP-1, PGC-1a, CITED1, Omentin and TFAM (Mitochondrial protein) increased. Upon analyzing patients' clinical conditions, it emerged that the levels of PGC-1a both in male (r = -0.48 p<0.04) and female (r = -0.61, p<0.05) and TFAM in male (r = -0.72, p<0.0008) and female (r = -0.86, p<0.002) decreased significantly with progressive weight gain. However, no differences were observed in patients with diabetes mellitus 2 or Hyperlipidemia. Adipocytes surrounding the ascending aorta present markers of major thermogenic activity than those in subcutaneous tissue. Nevertheless, this characteristic might change, due to unfavorable metabolic conditions such as obesity, which is a risk factor for cardiovascular disease.application/pdfengPLoS OnePLoS One. 2018;13(3)Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaThermogenicHuman periaorticCardiovascular surgeryThermogenic capacity of human periaortic adipose tissue is transformed by body weightarticlepublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://intellectum.unisabana.edu.co/bitstream/10818/45655/2/license_rdf4460e5956bc1d1639be9ae6146a50347MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/45655/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD5310818/45655oai:intellectum.unisabana.edu.co:10818/456552022-05-10 05:20:42.111Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.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
dc.title.es_CO.fl_str_mv	Thermogenic capacity of human periaortic adipose tissue is transformed by body weight
title	Thermogenic capacity of human periaortic adipose tissue is transformed by body weight
spellingShingle	Thermogenic capacity of human periaortic adipose tissue is transformed by body weight Thermogenic Human periaortic Cardiovascular surgery
title_short	Thermogenic capacity of human periaortic adipose tissue is transformed by body weight
title_full	Thermogenic capacity of human periaortic adipose tissue is transformed by body weight
title_fullStr	Thermogenic capacity of human periaortic adipose tissue is transformed by body weight
title_full_unstemmed	Thermogenic capacity of human periaortic adipose tissue is transformed by body weight
title_sort	Thermogenic capacity of human periaortic adipose tissue is transformed by body weight
dc.creator.fl_str_mv	Vargas, Diana López, Carolina Acero, Edward Benitez, Edgar Wintaco, Angélica Camacho, Jaime Carreño, Marisol Umaña, Juan Jimenez, Daniela Díaz, Said Lizcano Losada, Fernando
dc.contributor.author.none.fl_str_mv	Vargas, Diana López, Carolina Acero, Edward Benitez, Edgar Wintaco, Angélica Camacho, Jaime Carreño, Marisol Umaña, Juan Jimenez, Daniela Díaz, Said Lizcano Losada, Fernando
dc.subject.es_CO.fl_str_mv	Thermogenic Human periaortic Cardiovascular surgery
topic	Thermogenic Human periaortic Cardiovascular surgery
description	10 páginas
publishDate	2018
dc.date.accessioned.none.fl_str_mv	12/1/2020 9:10
dc.date.issued.none.fl_str_mv	2018-03-19
dc.date.available.none.fl_str_mv	2020-12-01T14:10:58Z
dc.type.en.fl_str_mv	article
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dc.identifier.issn.none.fl_str_mv	1932-6203
dc.identifier.other.none.fl_str_mv	https://pubmed.ncbi.nlm.nih.gov/29554135/ https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0194269 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858771/
dc.identifier.uri.none.fl_str_mv	http://hdl.handle.net/10818/45655
dc.identifier.doi.none.fl_str_mv	10.1371/journal.pone.0194269
identifier_str_mv	1932-6203 10.1371/journal.pone.0194269
url	https://pubmed.ncbi.nlm.nih.gov/29554135/ https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0194269 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858771/ http://hdl.handle.net/10818/45655
dc.language.iso.es_CO.fl_str_mv	eng
language	eng
dc.relation.ispartofseries.none.fl_str_mv	PLoS One. 2018;13(3)
dc.rights.*.fl_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International
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rights_invalid_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2
dc.format.es_CO.fl_str_mv	application/pdf
dc.publisher.es_CO.fl_str_mv	PLoS One
dc.source.es_CO.fl_str_mv	Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana
institution	Universidad de la Sabana
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Thermogenic capacity of human periaortic adipose tissue is transformed by body weight

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