Cytotoxic and Immunomodulatory Potential Activity of Physalis peruviana Fruit Extracts on Cervical Cancer (HeLa) and Fibroblast (L929) Cells
11 páginas
- Autores:
-
Mier Giraldo, Helen
Díaz Barrera, Luis Eduardo
Delgado Murcia, Lucy Gabriela
Valero Valdivieso, Manuel Fernando
Cáez Ramírez, Gabriela Rabe
- Tipo de recurso:
- Fecha de publicación:
- 2017
- Institución:
- Universidad de la Sabana
- Repositorio:
- Repositorio Universidad de la Sabana
- Idioma:
- eng
- OAI Identifier:
- oai:intellectum.unisabana.edu.co:10818/33130
- Acceso en línea:
- http://journals.sagepub.com/doi/full/10.1177/2156587217718751
http://journals.sagepub.com/doi/pdf/10.1177/2156587217718751
http://hdl.handle.net/10818/33130
- Palabra clave:
- Cytotoxicity
Immunomodulatory
Antioxidants
- Rights
- License
- Attribution-NonCommercial-NoDerivatives 4.0 International
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Mier Giraldo, HelenDíaz Barrera, Luis EduardoDelgado Murcia, Lucy GabrielaValero Valdivieso, Manuel FernandoCáez Ramírez, Gabriela Rabe6/12/2018 16:302018-06-12T21:30:17Z2017-05-23http://journals.sagepub.com/doi/full/10.1177/2156587217718751http://journals.sagepub.com/doi/pdf/10.1177/2156587217718751http://hdl.handle.net/10818/3313010.1177/215658721771875111 páginasIt was purposed to evaluate the biological potential of ethanol and isopropanol crude extracts of ripe Physalis peruviana fruits. Cytotoxic and immunomodulatory effects of the expression of interleukin-6, interleukin-8, and monocyte chemoattractant protein-1 (MCP-1) were evaluated on human cervical cancer (HeLa) and murine fibroblast (L929) cells. The composition was evaluated by high-performance liquid chromatography diode-array detection and high-performance liquid chromatography ultraviolet/visible detection. The presence of ursolic acid and rosmarinic acid was found in both solvents. However, gallic acid, quercetin, and epicatechin were higher in isopropanol extracts (P < .05). The results indicated a relationship among the total polyphenol content, antioxidant activity, and cytotoxic activity that was dependent on the solvent used. Isopropanol extracts presented a half-maximal inhibition concentration value (IC50) of 60.48 + 3.8 mg/mL for HeLa cells and 66.62 + 2.67 mg/mL for L929 fibroblasts. The extracts reduced the release of interleukin-6, interleukin-8, and MCP-1 in a dose-dependent manner. Extracts showed anticancer and immunomodulatory potential for new complementary pharmaceutical products development.application/pdfengJournal of Evidence-Based Complementary & Alternative MedicineJournal of Evidence-Based Complementary & Alternative Medicine 2017, Vol. 22(4) 777-787Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaCytotoxicityImmunomodulatoryAntioxidantsCytotoxic and Immunomodulatory Potential Activity of Physalis peruviana Fruit Extracts on Cervical Cancer (HeLa) and Fibroblast (L929) CellsarticlepublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81223https://intellectum.unisabana.edu.co/bitstream/10818/33130/2/license_rdf7c9ab7f006165862d8ce9ac5eac01552MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/33130/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD5310818/33130oai:intellectum.unisabana.edu.co:10818/331302022-05-10 05:17:22.635Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.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 |
| dc.title.es_CO.fl_str_mv |
Cytotoxic and Immunomodulatory Potential Activity of Physalis peruviana Fruit Extracts on Cervical Cancer (HeLa) and Fibroblast (L929) Cells |
| title |
Cytotoxic and Immunomodulatory Potential Activity of Physalis peruviana Fruit Extracts on Cervical Cancer (HeLa) and Fibroblast (L929) Cells |
| spellingShingle |
Cytotoxic and Immunomodulatory Potential Activity of Physalis peruviana Fruit Extracts on Cervical Cancer (HeLa) and Fibroblast (L929) Cells Cytotoxicity Immunomodulatory Antioxidants |
| title_short |
Cytotoxic and Immunomodulatory Potential Activity of Physalis peruviana Fruit Extracts on Cervical Cancer (HeLa) and Fibroblast (L929) Cells |
| title_full |
Cytotoxic and Immunomodulatory Potential Activity of Physalis peruviana Fruit Extracts on Cervical Cancer (HeLa) and Fibroblast (L929) Cells |
| title_fullStr |
Cytotoxic and Immunomodulatory Potential Activity of Physalis peruviana Fruit Extracts on Cervical Cancer (HeLa) and Fibroblast (L929) Cells |
| title_full_unstemmed |
Cytotoxic and Immunomodulatory Potential Activity of Physalis peruviana Fruit Extracts on Cervical Cancer (HeLa) and Fibroblast (L929) Cells |
| title_sort |
Cytotoxic and Immunomodulatory Potential Activity of Physalis peruviana Fruit Extracts on Cervical Cancer (HeLa) and Fibroblast (L929) Cells |
| dc.creator.fl_str_mv |
Mier Giraldo, Helen Díaz Barrera, Luis Eduardo Delgado Murcia, Lucy Gabriela Valero Valdivieso, Manuel Fernando Cáez Ramírez, Gabriela Rabe |
| dc.contributor.author.none.fl_str_mv |
Mier Giraldo, Helen Díaz Barrera, Luis Eduardo Delgado Murcia, Lucy Gabriela Valero Valdivieso, Manuel Fernando Cáez Ramírez, Gabriela Rabe |
| dc.subject.es_CO.fl_str_mv |
Cytotoxicity Immunomodulatory Antioxidants |
| topic |
Cytotoxicity Immunomodulatory Antioxidants |
| description |
11 páginas |
| publishDate |
2017 |
| dc.date.issued.none.fl_str_mv |
2017-05-23 |
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2018-06-12T21:30:17Z |
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6/12/2018 16:30 |
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article |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://purl.org/coar/resource_type/c_6501 |
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http://journals.sagepub.com/doi/full/10.1177/2156587217718751 http://journals.sagepub.com/doi/pdf/10.1177/2156587217718751 |
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http://hdl.handle.net/10818/33130 |
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10.1177/2156587217718751 |
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http://journals.sagepub.com/doi/full/10.1177/2156587217718751 http://journals.sagepub.com/doi/pdf/10.1177/2156587217718751 http://hdl.handle.net/10818/33130 |
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10.1177/2156587217718751 |
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eng |
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eng |
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Journal of Evidence-Based Complementary & Alternative Medicine 2017, Vol. 22(4) 777-787 |
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Attribution-NonCommercial-NoDerivatives 4.0 International |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2 |
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Journal of Evidence-Based Complementary & Alternative Medicine |
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Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana |
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Universidad de la Sabana |
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