KDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast Cancer
7 páginas
- Autores:
-
García Serrano, Jeison
Lizcano, Fernando
- Tipo de recurso:
- Fecha de publicación:
- 2016
- Institución:
- Universidad de la Sabana
- Repositorio:
- Repositorio Universidad de la Sabana
- Idioma:
- eng
- OAI Identifier:
- oai:intellectum.unisabana.edu.co:10818/43489
- Acceso en línea:
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094578/
http://hdl.handle.net/10818/43489
- Palabra clave:
- KDM4C
Breast cancer
Chromosome segregation
Histone demethylation
- Rights
- License
- Attribution-NonCommercial-NoDerivatives 4.0 International
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García Serrano, JeisonLizcano, Fernando10/2/2020 18:272020-10-02T23:27:24Z2016-11-021178-2234https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094578/http://hdl.handle.net/10818/4348910.4137/BCBCR.S401827 páginasThe Jumonji-containing domain protein, KDM4C, is a histone demethylase associated with the development of several forms of human cancer. However, its specific function in the viability of tumoral lineages is yet to be determined. This work investigates the importance of KDM4C activity in cell proliferation and chromosome segregation of three triple-negative breast cancer cell lines using a specific demethylase inhibitor. Immunofluorescence assays show that KDM4C is recruited to mitotic chromosomes and that the modulation of its activity increases the number of mitotic segregation errors. However, 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) cell proliferation assays demonstrate that the demethylase activity is required for cell viability. These results suggest that the histone demethylase activity of KDM4C is essential for breast cancer progression given its role in the maintenance of chromosomal stability and cell growth, thus highlighting it as a potential therapeutic target.application/pdfengBreast Cancer (Auckl)Breast Cancer (Auckl). 2016;10: 169–175Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaKDM4CBreast cancerChromosome segregationHistone demethylationKDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast CancerarticlepublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://intellectum.unisabana.edu.co/bitstream/10818/43489/2/license_rdf4460e5956bc1d1639be9ae6146a50347MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/43489/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD5310818/43489oai:intellectum.unisabana.edu.co:10818/434892022-05-10 05:20:11.393Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.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 |
| dc.title.es_CO.fl_str_mv |
KDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast Cancer |
| title |
KDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast Cancer |
| spellingShingle |
KDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast Cancer KDM4C Breast cancer Chromosome segregation Histone demethylation |
| title_short |
KDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast Cancer |
| title_full |
KDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast Cancer |
| title_fullStr |
KDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast Cancer |
| title_full_unstemmed |
KDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast Cancer |
| title_sort |
KDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast Cancer |
| dc.creator.fl_str_mv |
García Serrano, Jeison Lizcano, Fernando |
| dc.contributor.author.none.fl_str_mv |
García Serrano, Jeison Lizcano, Fernando |
| dc.subject.es_CO.fl_str_mv |
KDM4C Breast cancer Chromosome segregation Histone demethylation |
| topic |
KDM4C Breast cancer Chromosome segregation Histone demethylation |
| description |
7 páginas |
| publishDate |
2016 |
| dc.date.accessioned.none.fl_str_mv |
10/2/2020 18:27 |
| dc.date.issued.none.fl_str_mv |
2016-11-02 |
| dc.date.available.none.fl_str_mv |
2020-10-02T23:27:24Z |
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article |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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publishedVersion |
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1178-2234 |
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094578/ |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10818/43489 |
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10.4137/BCBCR.S40182 |
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1178-2234 10.4137/BCBCR.S40182 |
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094578/ http://hdl.handle.net/10818/43489 |
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eng |
| language |
eng |
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Breast Cancer (Auckl). 2016;10: 169–175 |
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Attribution-NonCommercial-NoDerivatives 4.0 International |
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http://purl.org/coar/access_right/c_abf2 |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2 |
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application/pdf |
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Breast Cancer (Auckl) |
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Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana |
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Universidad de la Sabana |
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