Epigenetic control and cancer: the potential of histone demethylases as therapeutic targets

28 páginas

Autores:: Lizcano Losada, Fernando
García Serrano, Jeison

Tipo de recurso:

Fecha de publicación:: 2012

Institución:: Universidad de la Sabana

Repositorio:: Repositorio Universidad de la Sabana

Idioma:: eng

id	REPOUSABA2_8d4a5cc3f43cae6fb11c19b2bb650102
oai_identifier_str	oai:intellectum.unisabana.edu.co:10818/27570
network_acronym_str	REPOUSABA2
network_name_str	Repositorio Universidad de la Sabana
repository_id_str
spelling	Lizcano Losada, FernandoGarcía Serrano, Jeison10/18/2016 14:542016-10-18T19:54:09Z2012-06-261424-8247http://www.mdpi.com/1424-8247/5/9/963http://hdl.handle.net/10818/2757010.3390/ph509096328 páginasThe development of cancer involves an immense number of factors at the molecular level. These factors are associated principally with alterations in the epigenetic mechanisms that regulate gene expression profiles. Studying the effects of chromatin structure alterations, which are caused by the addition/removal of functional groups to specific histone residues, are of great interest as a promising way to identify markers for cancer diagnosis, classify the disease and determine its prognosis, and these markers could be potential targets for the treatment of this disease in its different forms. This manuscript presents the current point of view regarding members of the recently described family of proteins that exhibit histone demethylase activity; histone demethylases are genetic regulators that play a fundamental role in both the activation and repression of genes and whose expression has been observed to increase in many types of cancer. Some fundamental aspects of their association with the development of cancer and their relevance as potential targets for the development of new therapeutic strategies at the epigenetic level are discussed in the following manuscript.application/pdfengPharmaceuticalsPharmaceuticals 2012, 5, 963-990Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaNeoplasiaEpigenomicsHistone demethylasesHistone demethylases with a jumonji domainEpigenetic control and cancer: the potential of histone demethylases as therapeutic targetsarticlepublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/27570/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81223https://intellectum.unisabana.edu.co/bitstream/10818/27570/2/license_rdf7c9ab7f006165862d8ce9ac5eac01552MD5210818/27570oai:intellectum.unisabana.edu.co:10818/275702022-05-10 05:17:12.077Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.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
dc.title.es_CO.fl_str_mv	Epigenetic control and cancer: the potential of histone demethylases as therapeutic targets
title	Epigenetic control and cancer: the potential of histone demethylases as therapeutic targets
spellingShingle	Epigenetic control and cancer: the potential of histone demethylases as therapeutic targets Neoplasia Epigenomics Histone demethylases Histone demethylases with a jumonji domain
title_short	Epigenetic control and cancer: the potential of histone demethylases as therapeutic targets
title_full	Epigenetic control and cancer: the potential of histone demethylases as therapeutic targets
title_fullStr	Epigenetic control and cancer: the potential of histone demethylases as therapeutic targets
title_full_unstemmed	Epigenetic control and cancer: the potential of histone demethylases as therapeutic targets
title_sort	Epigenetic control and cancer: the potential of histone demethylases as therapeutic targets
dc.creator.fl_str_mv	Lizcano Losada, Fernando García Serrano, Jeison
dc.contributor.author.none.fl_str_mv	Lizcano Losada, Fernando García Serrano, Jeison
dc.subject.none.fl_str_mv	Neoplasia Epigenomics Histone demethylases Histone demethylases with a jumonji domain
topic	Neoplasia Epigenomics Histone demethylases Histone demethylases with a jumonji domain
description	28 páginas
publishDate	2012
dc.date.accessioned.none.fl_str_mv	10/18/2016 14:54
dc.date.issued.none.fl_str_mv	2012-06-26
dc.date.available.none.fl_str_mv	2016-10-18T19:54:09Z
dc.type.en.fl_str_mv	article
dc.type.coarversion.fl_str_mv	http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv	http://purl.org/coar/resource_type/c_6501
dc.type.hasVersion.es_CO.fl_str_mv	publishedVersion
dc.identifier.issn.none.fl_str_mv	1424-8247
dc.identifier.other.none.fl_str_mv	http://www.mdpi.com/1424-8247/5/9/963
dc.identifier.uri.none.fl_str_mv	http://hdl.handle.net/10818/27570
dc.identifier.doi.none.fl_str_mv	10.3390/ph5090963
identifier_str_mv	1424-8247 10.3390/ph5090963
url	http://www.mdpi.com/1424-8247/5/9/963 http://hdl.handle.net/10818/27570
dc.language.iso.es_CO.fl_str_mv	eng
language	eng
dc.relation.ispartofseries.none.fl_str_mv	Pharmaceuticals 2012, 5, 963-990
dc.rights.*.fl_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.coar.fl_str_mv	http://purl.org/coar/access_right/c_abf2
dc.rights.uri.*.fl_str_mv	http://creativecommons.org/licenses/by-nc-nd/4.0/
rights_invalid_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2
dc.format.es_CO.fl_str_mv	application/pdf
dc.publisher.es_CO.fl_str_mv	Pharmaceuticals
dc.source.es_CO.fl_str_mv	Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana
institution	Universidad de la Sabana
bitstream.url.fl_str_mv	https://intellectum.unisabana.edu.co/bitstream/10818/27570/3/license.txt https://intellectum.unisabana.edu.co/bitstream/10818/27570/2/license_rdf
bitstream.checksum.fl_str_mv	f52a2cfd4df262e08e9b300d62c85cab 7c9ab7f006165862d8ce9ac5eac01552
bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5
repository.name.fl_str_mv	Intellectum Universidad de la Sabana
repository.mail.fl_str_mv	contactointellectum@unisabana.edu.co
_version_	1811952260369874944

Epigenetic control and cancer: the potential of histone demethylases as therapeutic targets

Publicaciones similares