Analysis of HLA-B15 and HLA-B27 in spondyloarthritis with peripheral and axial clinical patterns
9 páginas
- Autores:
-
Londoño Patiño, John Darío
Santos Granados, Ana María
Peña, Paola
Calvo Páramo, Enrique
Espinosa, Luis R.
Reveille, John D.
Vargas-Alarcon, Gilberto
Jaramillo, Carlos A.
Valle-Oñate, Rafael
Ávila Portillo, Luz Mabel
Romero, Consuelo
Medina, Juan F.
- Tipo de recurso:
- Fecha de publicación:
- 2015
- Institución:
- Universidad de la Sabana
- Repositorio:
- Repositorio Universidad de la Sabana
- Idioma:
- eng
- OAI Identifier:
- oai:intellectum.unisabana.edu.co:10818/27831
- Acceso en línea:
- http://bmjopen.bmj.com/content/5/11/e009092.long
http://bmjopen.bmj.com/content/bmjopen/5/11/e009092.full.pdf
http://hdl.handle.net/10818/27831
- Palabra clave:
- HLA-B15
HLA-B27
spondyloarthritis
- Rights
- License
- Attribution-NonCommercial-NoDerivatives 4.0 International
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Londoño Patiño, John DaríoSantos Granados, Ana MaríaPeña, PaolaCalvo Páramo, EnriqueEspinosa, Luis R.Reveille, John D.Vargas-Alarcon, GilbertoJaramillo, Carlos A.Valle-Oñate, RafaelÁvila Portillo, Luz MabelRomero, ConsueloMedina, Juan F.10/28/2016 16:002016-10-28T21:00:28Z20152044-6055http://bmjopen.bmj.com/content/5/11/e009092.longhttp://bmjopen.bmj.com/content/bmjopen/5/11/e009092.full.pdfhttp://hdl.handle.net/10818/2783110.1136/bmjopen-2015-0090929 páginasAbstract Objective Human leucocyte antigen (HLA) B27 and HLA-B15 are associated with spondyloarthritis (SpA). Recent Assessment of SpondyloArthritis international Society (ASAS) criteria emphasise a distinction between SpA with axial and peripheral patterns. We analysed whether HLA-A, HLA-B and HLA-DRB1 alleles could associate with these patterns. Methods We studied 100 healthy individuals and 178 patients with SpA according to European Spondyloarthropathy Study Group (ESSG) criteria. Patients were then classified according to ASAS criteria, the axial spondyloarthritis pattern (axSpA) being defined by ascertained sacroiliitis and the peripheral pattern (pSpA) by enthesitis and/or arthritis in extremities. A combined ax/p pattern was also considered. Results Only HLA-B27 and HLA-B15 alleles were associated with SpA. ASAS criteria for axSpA were met in 152 patients (12 with isolated axSpA and 140 with a combined ax/p patterns). When the ASAS peripheral criteria were applied, 161 patients met these criteria (13 with isolated pSpA and 148 with a combined ax/p pattern). HLA-B27 was found in 83% of patients with axSpA and 43% of ax/pSpA patients according to axASAS. HLA-B27 occurred in 7% controls but not in any patient with isolated pSpA. HLA-B15 was encountered in 31% of patients with isolated pSpA and 20% of ax/pSpA patients according to pASAS criteria. Moreover, 2 healthy controls, but none of our patients with isolated axSpA were positive for HLA-B15. Conclusions Our data suggest that the presence of HLA-B15 favours the development of isolated/combined peripheral rather than isolated axSpA, while HLA-B27 promotes an isolated/combined axial disease and excludes a peripheral pattern. HLA-B15 should be considered in addition to HLA-B27 when diagnosing patients with SpA according to ASAS criteria.application/pdfengBMJ OpenBMJ Open 2015;5:e009092Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaHLA-B15HLA-B27spondyloarthritisAnalysis of HLA-B15 and HLA-B27 in spondyloarthritis with peripheral and axial clinical patternsarticlepublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/27831/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81223https://intellectum.unisabana.edu.co/bitstream/10818/27831/2/license_rdf7c9ab7f006165862d8ce9ac5eac01552MD5210818/27831oai:intellectum.unisabana.edu.co:10818/278312022-05-10 05:16:26.31Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.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 |
| dc.title.es_CO.fl_str_mv |
Analysis of HLA-B15 and HLA-B27 in spondyloarthritis with peripheral and axial clinical patterns |
| title |
Analysis of HLA-B15 and HLA-B27 in spondyloarthritis with peripheral and axial clinical patterns |
| spellingShingle |
Analysis of HLA-B15 and HLA-B27 in spondyloarthritis with peripheral and axial clinical patterns HLA-B15 HLA-B27 spondyloarthritis |
| title_short |
Analysis of HLA-B15 and HLA-B27 in spondyloarthritis with peripheral and axial clinical patterns |
| title_full |
Analysis of HLA-B15 and HLA-B27 in spondyloarthritis with peripheral and axial clinical patterns |
| title_fullStr |
Analysis of HLA-B15 and HLA-B27 in spondyloarthritis with peripheral and axial clinical patterns |
| title_full_unstemmed |
Analysis of HLA-B15 and HLA-B27 in spondyloarthritis with peripheral and axial clinical patterns |
| title_sort |
Analysis of HLA-B15 and HLA-B27 in spondyloarthritis with peripheral and axial clinical patterns |
| dc.creator.fl_str_mv |
Londoño Patiño, John Darío Santos Granados, Ana María Peña, Paola Calvo Páramo, Enrique Espinosa, Luis R. Reveille, John D. Vargas-Alarcon, Gilberto Jaramillo, Carlos A. Valle-Oñate, Rafael Ávila Portillo, Luz Mabel Romero, Consuelo Medina, Juan F. |
| dc.contributor.author.none.fl_str_mv |
Londoño Patiño, John Darío Santos Granados, Ana María Peña, Paola Calvo Páramo, Enrique Espinosa, Luis R. Reveille, John D. Vargas-Alarcon, Gilberto Jaramillo, Carlos A. Valle-Oñate, Rafael Ávila Portillo, Luz Mabel Romero, Consuelo Medina, Juan F. |
| dc.subject.none.fl_str_mv |
HLA-B15 HLA-B27 spondyloarthritis |
| topic |
HLA-B15 HLA-B27 spondyloarthritis |
| description |
9 páginas |
| publishDate |
2015 |
| dc.date.accessioned.none.fl_str_mv |
10/28/2016 16:00 |
| dc.date.issued.none.fl_str_mv |
2015 |
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2016-10-28T21:00:28Z |
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article |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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2044-6055 |
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http://bmjopen.bmj.com/content/5/11/e009092.long http://bmjopen.bmj.com/content/bmjopen/5/11/e009092.full.pdf |
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http://hdl.handle.net/10818/27831 |
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10.1136/bmjopen-2015-009092 |
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2044-6055 10.1136/bmjopen-2015-009092 |
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http://bmjopen.bmj.com/content/5/11/e009092.long http://bmjopen.bmj.com/content/bmjopen/5/11/e009092.full.pdf http://hdl.handle.net/10818/27831 |
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eng |
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eng |
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BMJ Open 2015;5:e009092 |
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Attribution-NonCommercial-NoDerivatives 4.0 International |
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