Diverse coactivator recruitment through differential PPARγ nuclear receptor agonism

5 páginas

Autores:: Lizcano Losada, Fernando
Vargas, Diana

Tipo de recurso:

Fecha de publicación:: 2013

Institución:: Universidad de la Sabana

Repositorio:: Repositorio Universidad de la Sabana

Idioma:: spa

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spelling	Lizcano Losada, FernandoVargas, Diana5/13/2016 11:322016-05-13T16:32:44Z2013-03-04Lizcano, F., & Vargas, D. (2013). Diverse coactivator recruitment through differential PPARγ nuclear receptor agonism. Genetics and Molecular Biology, 36(1), 134–139. http://doi.org/10.1590/S1415-475720130050000021415-4757http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615519/http://hdl.handle.net/10818/2394510.1590/S1415-475720130050000025 páginasThe PPARγ nuclear receptor regulates the expression of genes involved in lipid and carbohydrate metabolism, and it has protective effects in some patients with type 2 diabetes. Nevertheless, the therapeutic value of the PPARγ nuclear receptor protein is limited due to the secondary effects of some PPARγ ligands. Because the downstream effects of PPARγ are determined by the binding of specific cofactors that are mediated by ligand-induced conformational changes, we evaluated the differential effects of various ligands on the binding of certain cofactors associated with PPARγ. The ligands used were rosiglitazone for treating type 2 diabetes and telmisartan for treating arterial hypertension. Functional, phenotypic, and molecular studies were conducted on pre-adipocyte 3T3-L1 and functional studies in U2OS cells. The moderating influence of various cofactor families was evaluated using transient transfection assays. Our findings confirm that telmisartan has a partial modulating effect on PPARγ activity compared to rosiglitazone. The cofactors SRC1 and GRIP1 mediate the activity of telmisartan and rosiglitazone and partially determine the difference in their effects. Studying the modulating activity of these cofactors can provide interesting insights for developing new therapeutic approaches for certain metabolic diseases.Publicación sin clasificar en Sherpa Romeoapplication/pdfspaGenetics and Molecular BiologyGenet Mol Biol. 2013 Mar; 36(1): 134–139Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaDNA binding proteins co-activatoGene expressionTranscriptionTelmisartanDiverse coactivator recruitment through differential PPARγ nuclear receptor agonismarticlepublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81223https://intellectum.unisabana.edu.co/bitstream/10818/23945/2/license_rdf7c9ab7f006165862d8ce9ac5eac01552MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/23945/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD5310818/23945oai:intellectum.unisabana.edu.co:10818/239452022-05-10 05:17:53.411Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.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
dc.title.en.fl_str_mv	Diverse coactivator recruitment through differential PPARγ nuclear receptor agonism
title	Diverse coactivator recruitment through differential PPARγ nuclear receptor agonism
spellingShingle	Diverse coactivator recruitment through differential PPARγ nuclear receptor agonism DNA binding proteins co-activato Gene expression Transcription Telmisartan
title_short	Diverse coactivator recruitment through differential PPARγ nuclear receptor agonism
title_full	Diverse coactivator recruitment through differential PPARγ nuclear receptor agonism
title_fullStr	Diverse coactivator recruitment through differential PPARγ nuclear receptor agonism
title_full_unstemmed	Diverse coactivator recruitment through differential PPARγ nuclear receptor agonism
title_sort	Diverse coactivator recruitment through differential PPARγ nuclear receptor agonism
dc.creator.fl_str_mv	Lizcano Losada, Fernando Vargas, Diana
dc.contributor.author.none.fl_str_mv	Lizcano Losada, Fernando Vargas, Diana
dc.subject.es_CO.fl_str_mv	DNA binding proteins co-activato Gene expression Transcription Telmisartan
topic	DNA binding proteins co-activato Gene expression Transcription Telmisartan
description	5 páginas
publishDate	2013
dc.date.issued.none.fl_str_mv	2013-03-04
dc.date.available.none.fl_str_mv	2016-05-13T16:32:44Z
dc.date.accessioned.none.fl_str_mv	5/13/2016 11:32
dc.type.en.fl_str_mv	article
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dc.type.hasVersion.es_CO.fl_str_mv	publishedVersion
dc.identifier.citation.es_CO.fl_str_mv	Lizcano, F., & Vargas, D. (2013). Diverse coactivator recruitment through differential PPARγ nuclear receptor agonism. Genetics and Molecular Biology, 36(1), 134–139. http://doi.org/10.1590/S1415-47572013005000002
dc.identifier.issn.none.fl_str_mv	1415-4757
dc.identifier.other.none.fl_str_mv	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615519/
dc.identifier.uri.none.fl_str_mv	http://hdl.handle.net/10818/23945
dc.identifier.doi.none.fl_str_mv	10.1590/S1415-47572013005000002
identifier_str_mv	Lizcano, F., & Vargas, D. (2013). Diverse coactivator recruitment through differential PPARγ nuclear receptor agonism. Genetics and Molecular Biology, 36(1), 134–139. http://doi.org/10.1590/S1415-47572013005000002 1415-4757 10.1590/S1415-47572013005000002
url	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615519/ http://hdl.handle.net/10818/23945
dc.language.iso.es_CO.fl_str_mv	spa
language	spa
dc.relation.ispartofseries.none.fl_str_mv	Genet Mol Biol. 2013 Mar; 36(1): 134–139
dc.rights.*.fl_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.coar.fl_str_mv	http://purl.org/coar/access_right/c_abf2
dc.rights.uri.*.fl_str_mv	http://creativecommons.org/licenses/by-nc-nd/4.0/
rights_invalid_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2
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dc.publisher.es_CO.fl_str_mv	Genetics and Molecular Biology
dc.source.es_CO.fl_str_mv	Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana
institution	Universidad de la Sabana
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Diverse coactivator recruitment through differential PPARγ nuclear receptor agonism

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