Central and peripheral nervous system involvement by COVID-19: A systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings

páginas

Autores:: Guerrero, Juan I.
Barragán, Luis A.
Martínez, Juan D.
Montoya, Juan P.
Peña, Alejandra
Sobrino, Fidel E.
Tovar Spinoza, Zulma
Ghotme Ghotme, Kemel Ahmed

Tipo de recurso:

Fecha de publicación:: 2020

Institución:: Universidad de la Sabana

Repositorio:: Repositorio Universidad de la Sabana

Idioma:: eng

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dc.title.es_CO.fl_str_mv	Central and peripheral nervous system involvement by COVID-19: A systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings
title	Central and peripheral nervous system involvement by COVID-19: A systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings
spellingShingle	Central and peripheral nervous system involvement by COVID-19: A systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings Central and peripheral nervous system SARS-CoV-2 COVID-19 Pathophysiology Clinical manifestations Neuropathology Neuroimaging Electrophysiology Cerebrospinal fluid findings
title_short	Central and peripheral nervous system involvement by COVID-19: A systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings
title_full	Central and peripheral nervous system involvement by COVID-19: A systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings
title_fullStr	Central and peripheral nervous system involvement by COVID-19: A systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings
title_full_unstemmed	Central and peripheral nervous system involvement by COVID-19: A systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings
title_sort	Central and peripheral nervous system involvement by COVID-19: A systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings
dc.creator.fl_str_mv	Guerrero, Juan I. Barragán, Luis A. Martínez, Juan D. Montoya, Juan P. Peña, Alejandra Sobrino, Fidel E. Tovar Spinoza, Zulma Ghotme Ghotme, Kemel Ahmed
dc.contributor.author.none.fl_str_mv	Guerrero, Juan I. Barragán, Luis A. Martínez, Juan D. Montoya, Juan P. Peña, Alejandra Sobrino, Fidel E. Tovar Spinoza, Zulma Ghotme Ghotme, Kemel Ahmed
dc.subject.es_CO.fl_str_mv	Central and peripheral nervous system SARS-CoV-2 COVID-19 Pathophysiology Clinical manifestations Neuropathology Neuroimaging Electrophysiology Cerebrospinal fluid findings
topic	Central and peripheral nervous system SARS-CoV-2 COVID-19 Pathophysiology Clinical manifestations Neuropathology Neuroimaging Electrophysiology Cerebrospinal fluid findings
description	páginas
publishDate	2020
dc.date.accessioned.none.fl_str_mv	11/10/2020 18:38
dc.date.available.none.fl_str_mv	2020-11-10T23:38:57Z
dc.date.issued.none.fl_str_mv	2020-07-24
dc.type.en.fl_str_mv	article
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url	http://hdl.handle.net/10818/44055
dc.language.iso.es_CO.fl_str_mv	eng
language	eng
dc.rights.*.fl_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International
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dc.rights.uri.*.fl_str_mv	http://creativecommons.org/licenses/by-nc-nd/4.0/
rights_invalid_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2
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dc.source.es_CO.fl_str_mv	Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana
institution	Universidad de la Sabana
bitstream.url.fl_str_mv	https://intellectum.unisabana.edu.co/bitstream/10818/44055/2/license_rdf https://intellectum.unisabana.edu.co/bitstream/10818/44055/3/license.txt https://intellectum.unisabana.edu.co/bitstream/10818/44055/4/ARTICLES%20INCLUDED%20IN%20NEUROCOVID%20SYSTEMATIC%20REVIEW.pdf
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spelling	Guerrero, Juan I.Barragán, Luis A.Martínez, Juan D.Montoya, Juan P.Peña, AlejandraSobrino, Fidel E.Tovar Spinoza, ZulmaGhotme Ghotme, Kemel Ahmed11/10/2020 18:382020-11-10T23:38:57Z2020-07-24http://hdl.handle.net/10818/44055páginasBackground: SARS-CoV-2 can affect the human brain and other neurological structures. An increasing number of publications report neurological manifestations in patients with COVID-19. However, no studies have comprehensively reviewed the clinical and paraclinical characteristics of the central and peripheral nervous system's involvement in these patients. This study aimed to describe the features of the central and peripheral nervous system involvement by COVID-19 in terms of pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings. Methods: We conducted a comprehensive systematic review of all the original studies reporting patients with neurological involvement by COVID-19, from December 2019 to June 2020, without language restriction. We excluded studies with animal subjects, studies not related to the nervous system, and opinion articles. Data analysis combined descriptive measures, frequency measures, central tendency measures, and dispersion measures for all studies reporting neurological conditions and abnormal ancillary tests in patients with confirmed COVID-19. Results: A total of 143 observational and descriptive studies reported central and peripheral nervous system involvement by COVID-19 in 10723 patients. Fifty-one studies described pathophysiologic mechanisms of neurological involvement by COVID-19, 119 focused on clinical manifestations, 4 described neuropathology findings, 62 described neuroimaging findings, 28 electrophysiology findings, and 60 studies reported cerebrospinal fluid results. The reviewed studies reflect a significant prevalence of the nervous system's involvement in patients with COVID-19, ranging from 22.5% to 36.4% among different studies, without mortality rates explicitly associated with neurological involvement by SARS-COV-2. We thoroughly describe the clinical and paraclinical characteristics of neurological involvement in these patients. Conclusions: Our evidence synthesis led to a categorical analysis of the central and peripheral involvement by COVID-19 and provided a comprehensive explanation of the reported pathophysiological mechanisms by which SARS-CoV-2 infection may cause neurological impairment. International collaborative efforts and exhaustive neurological registries will enhance the translational knowledge of COVID-19's CNS and PNS involvement and generate strategies for therapeutic decision-making.application/pdfengAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaCentral and peripheral nervous systemSARS-CoV-2COVID-19PathophysiologyClinical manifestationsNeuropathologyNeuroimagingElectrophysiologyCerebrospinal fluid findingsCentral and peripheral nervous system involvement by COVID-19: A systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findingsarticlepublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://intellectum.unisabana.edu.co/bitstream/10818/44055/2/license_rdf4460e5956bc1d1639be9ae6146a50347MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/44055/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD53ORIGINALARTICLES INCLUDED IN NEUROCOVID SYSTEMATIC REVIEW.pdfARTICLES INCLUDED IN NEUROCOVID SYSTEMATIC REVIEW.pdfVer Articles included in NEUROCOVID systematic reviewapplication/pdf322879https://intellectum.unisabana.edu.co/bitstream/10818/44055/4/ARTICLES%20INCLUDED%20IN%20NEUROCOVID%20SYSTEMATIC%20REVIEW.pdf8d540bea4bc8b399440892b6cc58910aMD5410818/44055oai:intellectum.unisabana.edu.co:10818/440552022-05-10 05:21:51.741Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.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

Central and peripheral nervous system involvement by COVID-19: A systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings

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