Associations of the Levels of C4d-bearing Reticulocytes and High-avidity Anti-dsDNA Antibodies with Disease Activity in Systemic Lupus Erythematosus

9 páginas

Autores:: Mora Karam, Claudia Marcela
Medina Rosas, Jorge
Santos Granados, Ana María
Jaimes Fernández, Diego Alejandro
Arbeláez, Ana Milena
Romero, Consuelo
Cortes, Annie
Londoño Patiño, John Darío

Tipo de recurso:

Fecha de publicación:: 2016

Institución:: Universidad de la Sabana

Repositorio:: Repositorio Universidad de la Sabana

Idioma:: eng

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spelling	Mora Karam, Claudia MarcelaMedina Rosas, JorgeSantos Granados, Ana MaríaJaimes Fernández, Diego AlejandroArbeláez, Ana MilenaRomero, ConsueloCortes, AnnieLondoño Patiño, John Darío5/6/2019 10:072019-05-06T15:07:28Z2016-050315-162Xhttp://www.jrheum.org/content/early/2016/04/22/jrheum.150486.abstracthttp://www.jrheum.org/content/jrheum/early/2016/04/22/jrheum.150486.full.pdfhttp://hdl.handle.net/10818/354729 páginasObjective There are no laboratory tools that detect early flares in systemic lupus erythematosus (SLE). Our aim was to validate in our population the previous findings of the association of C4d-bearing reticulocytes (R-C4d) compared to anti-dsDNA antibodies, with disease activity assessed by the Safety of Estrogens in Lupus Erythematosus National Assessment–Systemic Lupus Erythematosus Disease Activity Index (SELENA-SLEDAI) and the British Isles Lupus Assessment Group (BILAG) 2004 scales. Methods All patients who met the 1987 American College of Rheumatology classification criteria and were seen consecutively in 2013 at a specialized SLE care clinic were included. Disease activity was established by the SELENA-SLEDAI and BILAG 2004. Anti-dsDNA and R-C4d were quantified in peripheral blood. Comparisons were made between values of active and inactive patients, and the correlations between the SELENA-SLEDAI and serum levels of anti-dsDNA and R-C4d were measured. Results Sixty-two patients (83.9% women) were included. A total of 32.3% had active disease according to the SELENA-SLEDAI. There was a significant statistical difference (p = 0.0001) in the distribution of R-C4d between disease activity groups. The correlation coefficient between R-C4d and the SELENA-SLEDAI score was rs = 0.738 (p = 0.0001). R-C4d differed between patients with and without activity in the BILAG 2004 constitutional, mucocutaneous, gastrointestinal, renal, and hematological domains. Conclusion R-C4d showed a higher correlation with SLE activity measured by the SELENA-SLEDAI and BILAG 2004 than anti-dsDNA did, suggesting a possible involvement in diagnosing disease activity. Prospective studies that confirm these findings and evaluate its involvement in followup are needed.application/pdfengThe Journal of RheumatologyThe Journal of Rheumatology 2016; 43:7Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaSYSTEMIC LUPUS ERYTHEMATOSUSSYSTEMIC LUPUS ERYTHEMATOSUS DISEASE ACTIVITY INDEXCD ANTIGENSDISEASE ACTIVITYSLEDAIBIOLOGICAL MARKERSAssociations of the Levels of C4d-bearing Reticulocytes and High-avidity Anti-dsDNA Antibodies with Disease Activity in Systemic Lupus ErythematosusarticlepublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/35472/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://intellectum.unisabana.edu.co/bitstream/10818/35472/2/license_rdf4460e5956bc1d1639be9ae6146a50347MD5210818/35472oai:intellectum.unisabana.edu.co:10818/354722022-05-10 05:18:14.06Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.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
dc.title.es_CO.fl_str_mv	Associations of the Levels of C4d-bearing Reticulocytes and High-avidity Anti-dsDNA Antibodies with Disease Activity in Systemic Lupus Erythematosus
title	Associations of the Levels of C4d-bearing Reticulocytes and High-avidity Anti-dsDNA Antibodies with Disease Activity in Systemic Lupus Erythematosus
spellingShingle	Associations of the Levels of C4d-bearing Reticulocytes and High-avidity Anti-dsDNA Antibodies with Disease Activity in Systemic Lupus Erythematosus SYSTEMIC LUPUS ERYTHEMATOSUS SYSTEMIC LUPUS ERYTHEMATOSUS DISEASE ACTIVITY INDEX CD ANTIGENS DISEASE ACTIVITY SLEDAI BIOLOGICAL MARKERS
title_short	Associations of the Levels of C4d-bearing Reticulocytes and High-avidity Anti-dsDNA Antibodies with Disease Activity in Systemic Lupus Erythematosus
title_full	Associations of the Levels of C4d-bearing Reticulocytes and High-avidity Anti-dsDNA Antibodies with Disease Activity in Systemic Lupus Erythematosus
title_fullStr	Associations of the Levels of C4d-bearing Reticulocytes and High-avidity Anti-dsDNA Antibodies with Disease Activity in Systemic Lupus Erythematosus
title_full_unstemmed	Associations of the Levels of C4d-bearing Reticulocytes and High-avidity Anti-dsDNA Antibodies with Disease Activity in Systemic Lupus Erythematosus
title_sort	Associations of the Levels of C4d-bearing Reticulocytes and High-avidity Anti-dsDNA Antibodies with Disease Activity in Systemic Lupus Erythematosus
dc.creator.fl_str_mv	Mora Karam, Claudia Marcela Medina Rosas, Jorge Santos Granados, Ana María Jaimes Fernández, Diego Alejandro Arbeláez, Ana Milena Romero, Consuelo Cortes, Annie Londoño Patiño, John Darío
dc.contributor.author.none.fl_str_mv	Mora Karam, Claudia Marcela Medina Rosas, Jorge Santos Granados, Ana María Jaimes Fernández, Diego Alejandro Arbeláez, Ana Milena Romero, Consuelo Cortes, Annie Londoño Patiño, John Darío
dc.subject.es_CO.fl_str_mv	SYSTEMIC LUPUS ERYTHEMATOSUS SYSTEMIC LUPUS ERYTHEMATOSUS DISEASE ACTIVITY INDEX CD ANTIGENS DISEASE ACTIVITY SLEDAI BIOLOGICAL MARKERS
topic	SYSTEMIC LUPUS ERYTHEMATOSUS SYSTEMIC LUPUS ERYTHEMATOSUS DISEASE ACTIVITY INDEX CD ANTIGENS DISEASE ACTIVITY SLEDAI BIOLOGICAL MARKERS
description	9 páginas
publishDate	2016
dc.date.issued.none.fl_str_mv	2016-05
dc.date.available.none.fl_str_mv	2019-05-06T15:07:28Z
dc.date.accessioned.none.fl_str_mv	5/6/2019 10:07
dc.type.en.fl_str_mv	article
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dc.identifier.issn.none.fl_str_mv	0315-162X
dc.identifier.other.none.fl_str_mv	http://www.jrheum.org/content/early/2016/04/22/jrheum.150486.abstract http://www.jrheum.org/content/jrheum/early/2016/04/22/jrheum.150486.full.pdf
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identifier_str_mv	0315-162X
url	http://www.jrheum.org/content/early/2016/04/22/jrheum.150486.abstract http://www.jrheum.org/content/jrheum/early/2016/04/22/jrheum.150486.full.pdf http://hdl.handle.net/10818/35472
dc.language.iso.es_CO.fl_str_mv	eng
language	eng
dc.relation.ispartofseries.none.fl_str_mv	The Journal of Rheumatology 2016; 43:7
dc.rights.*.fl_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International
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rights_invalid_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2
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dc.publisher.es_CO.fl_str_mv	The Journal of Rheumatology
dc.source.es_CO.fl_str_mv	Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana
institution	Universidad de la Sabana
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Associations of the Levels of C4d-bearing Reticulocytes and High-avidity Anti-dsDNA Antibodies with Disease Activity in Systemic Lupus Erythematosus

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