Carbapenem Therapeutic Drug Monitoring in Critically Ill Adult Patients and Clinical Outcomes: A Systematic Review with Meta-Analysis

17 páginas

Autores:
Lechtig Wasserman, Sharon
Liebisch Rey, Hans
Diaz Pinilla, Nicolas
Blanco, Jhosep
Fuentes Barreiro, Yuli-Viviana
Bustos, Rosa Helena
Tipo de recurso:
Fecha de publicación:
2021
Institución:
Universidad de la Sabana
Repositorio:
Repositorio Universidad de la Sabana
Idioma:
eng
OAI Identifier:
oai:intellectum.unisabana.edu.co:10818/48222
Acceso en línea:
https://www.mdpi.com/2079-6382/10/2/177
http://hdl.handle.net/10818/48222
Palabra clave:
Critical illness
Septic shock
Sepsis
Carbapenems
Therapeutic drug monitoring;
Antibiotic treatment outcome
Antimicrobial drug resistance
Gram-negative bacteria
Rights
License
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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spelling Lechtig Wasserman, SharonLiebisch Rey, HansDiaz Pinilla, NicolasBlanco, JhosepFuentes Barreiro, Yuli-VivianaBustos, Rosa Helena8/31/2021 11:362021-08-31T16:36:13Z2021-02-10Lechtig-Wasserman S., Liebisch-Rey H., Diaz-Pinilla N., Blanco J., Fuentes-Barreiro Y-V., Bustos R-H.* Carbapenem Therapeutic Drug Monitoring in Critically Ill Adult Patients and Clinical Outcomes: A Systematic Review with Meta-Analysis. Antibiotics. 2021; 10(2):177. https://doi.org/10.3390/antibiotics10020177. ISSN 2079-63822079-6382https://www.mdpi.com/2079-6382/10/2/177http://hdl.handle.net/10818/4822210.3390/antibiotics1002017717 páginasDrug monitoring is one strategy of antibiotic stewardship to face antimicrobial resistance. This strategy could have a determinant role in critically ill patients treated with carbapenems to overcome pharmacokinetic variability, reduce the risk of subtherapeutic dosage or toxicity, and reduce the risks inherent to treatment. However, the effectiveness of therapeutic drug monitoring (TDM) is unknown. This paper aims to identify TDM effectiveness in critically ill patients treated with carbapenems. English and ClinicalTrials.gov databases were searched to identify relevant studies evaluating carbapenem TDM. Randomized controlled trials (RCTs) and comparative cohort studies were selected for inclusion if they compared carbapenem TDM to standard care in adult critically ill or sepsis/septic shock patients. The primary outcome was mortality. Secondary outcomes included morbidity, clinical cure, microbiological eradication, antimicrobial resistance, drug-related side effects, and achievement of target plasma concentrations. Overall, performing carbapenem TDM was not associated with a decrease in mortality. However, it could be evidence for a relationship with clinical cure as well as target attainment. Some studies found favorable outcomes related to clinical and microbiological responses, such as lower procalcitonin levels at the end of the monitored therapy compared to standard care. For the primary and secondary outcomes analyzed, strong evidence was not identified, which could be due to the size, risk of bias, and design of selected studies.application/pdfengAntibioticsAntibiotics. 2021; 10(2):177Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaCritical illnessSeptic shockSepsisCarbapenemsTherapeutic drug monitoring;Antibiotic treatment outcomeAntimicrobial drug resistanceGram-negative bacteriaCarbapenem Therapeutic Drug Monitoring in Critically Ill Adult Patients and Clinical Outcomes: A Systematic Review with Meta-AnalysisarticlepublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://intellectum.unisabana.edu.co/bitstream/10818/48222/2/license_rdf4460e5956bc1d1639be9ae6146a50347MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/48222/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD5310818/48222oai:intellectum.unisabana.edu.co:10818/482222023-02-27 09:18:52.692Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.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
dc.title.es_CO.fl_str_mv Carbapenem Therapeutic Drug Monitoring in Critically Ill Adult Patients and Clinical Outcomes: A Systematic Review with Meta-Analysis
title Carbapenem Therapeutic Drug Monitoring in Critically Ill Adult Patients and Clinical Outcomes: A Systematic Review with Meta-Analysis
spellingShingle Carbapenem Therapeutic Drug Monitoring in Critically Ill Adult Patients and Clinical Outcomes: A Systematic Review with Meta-Analysis
Critical illness
Septic shock
Sepsis
Carbapenems
Therapeutic drug monitoring;
Antibiotic treatment outcome
Antimicrobial drug resistance
Gram-negative bacteria
title_short Carbapenem Therapeutic Drug Monitoring in Critically Ill Adult Patients and Clinical Outcomes: A Systematic Review with Meta-Analysis
title_full Carbapenem Therapeutic Drug Monitoring in Critically Ill Adult Patients and Clinical Outcomes: A Systematic Review with Meta-Analysis
title_fullStr Carbapenem Therapeutic Drug Monitoring in Critically Ill Adult Patients and Clinical Outcomes: A Systematic Review with Meta-Analysis
title_full_unstemmed Carbapenem Therapeutic Drug Monitoring in Critically Ill Adult Patients and Clinical Outcomes: A Systematic Review with Meta-Analysis
title_sort Carbapenem Therapeutic Drug Monitoring in Critically Ill Adult Patients and Clinical Outcomes: A Systematic Review with Meta-Analysis
dc.creator.fl_str_mv Lechtig Wasserman, Sharon
Liebisch Rey, Hans
Diaz Pinilla, Nicolas
Blanco, Jhosep
Fuentes Barreiro, Yuli-Viviana
Bustos, Rosa Helena
dc.contributor.author.none.fl_str_mv Lechtig Wasserman, Sharon
Liebisch Rey, Hans
Diaz Pinilla, Nicolas
Blanco, Jhosep
Fuentes Barreiro, Yuli-Viviana
Bustos, Rosa Helena
dc.subject.other.en.fl_str_mv Critical illness
Septic shock
Sepsis
Carbapenems
Therapeutic drug monitoring;
Antibiotic treatment outcome
Antimicrobial drug resistance
Gram-negative bacteria
topic Critical illness
Septic shock
Sepsis
Carbapenems
Therapeutic drug monitoring;
Antibiotic treatment outcome
Antimicrobial drug resistance
Gram-negative bacteria
description 17 páginas
publishDate 2021
dc.date.available.none.fl_str_mv 2021-08-31T16:36:13Z
dc.date.issued.none.fl_str_mv 2021-02-10
dc.date.accessioned.none.fl_str_mv 8/31/2021 11:36
dc.type.en.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.hasVersion.es_CO.fl_str_mv publishedVersion
dc.identifier.citation.es_CO.fl_str_mv Lechtig-Wasserman S., Liebisch-Rey H., Diaz-Pinilla N., Blanco J., Fuentes-Barreiro Y-V., Bustos R-H.* Carbapenem Therapeutic Drug Monitoring in Critically Ill Adult Patients and Clinical Outcomes: A Systematic Review with Meta-Analysis. Antibiotics. 2021; 10(2):177. https://doi.org/10.3390/antibiotics10020177. ISSN 2079-6382
dc.identifier.issn.none.fl_str_mv 2079-6382
dc.identifier.other.none.fl_str_mv https://www.mdpi.com/2079-6382/10/2/177
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/10818/48222
dc.identifier.doi.none.fl_str_mv 10.3390/antibiotics10020177
identifier_str_mv Lechtig-Wasserman S., Liebisch-Rey H., Diaz-Pinilla N., Blanco J., Fuentes-Barreiro Y-V., Bustos R-H.* Carbapenem Therapeutic Drug Monitoring in Critically Ill Adult Patients and Clinical Outcomes: A Systematic Review with Meta-Analysis. Antibiotics. 2021; 10(2):177. https://doi.org/10.3390/antibiotics10020177. ISSN 2079-6382
2079-6382
10.3390/antibiotics10020177
url https://www.mdpi.com/2079-6382/10/2/177
http://hdl.handle.net/10818/48222
dc.language.iso.es_CO.fl_str_mv eng
language eng
dc.relation.ispartofseries.none.fl_str_mv Antibiotics. 2021; 10(2):177
dc.rights.*.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
http://purl.org/coar/access_right/c_abf2
dc.format.es_CO.fl_str_mv application/pdf
dc.publisher.es_CO.fl_str_mv Antibiotics
dc.source.es_CO.fl_str_mv Universidad de La Sabana
Intellectum Repositorio Universidad de La Sabana
institution Universidad de la Sabana
bitstream.url.fl_str_mv https://intellectum.unisabana.edu.co/bitstream/10818/48222/2/license_rdf
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