Atypical pathogens in hospitalized patients with community-acquired pneumonia: a worldwide perspective

11 páginas

Autores:: Gramegna, Andrea
Sotgiu, Giovanni
Pasquale, Marta Di
Radovanovic, Dejan
Terraneo, Silvia
Reyes, Luis F.
Vendrell, Ester
Neves, Joao
Menzella, Francesco
Blasi, Francesco
Aliberti, Stefano
Restrepo, Marcos I.

Tipo de recurso:

Fecha de publicación:: 2018

Institución:: Universidad de la Sabana

Repositorio:: Repositorio Universidad de la Sabana

Idioma:: eng

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dc.title.es_CO.fl_str_mv	Atypical pathogens in hospitalized patients with community-acquired pneumonia: a worldwide perspective
dc.title.alternative.es_CO.fl_str_mv	Patógenos atípicos en pacientes hospitalizados con neumonía adquirida en la comunidad: una perspectiva mundial
title	Atypical pathogens in hospitalized patients with community-acquired pneumonia: a worldwide perspective
spellingShingle	Atypical pathogens in hospitalized patients with community-acquired pneumonia: a worldwide perspective CAP Atypical pathogens Epidemiology
title_short	Atypical pathogens in hospitalized patients with community-acquired pneumonia: a worldwide perspective
title_full	Atypical pathogens in hospitalized patients with community-acquired pneumonia: a worldwide perspective
title_fullStr	Atypical pathogens in hospitalized patients with community-acquired pneumonia: a worldwide perspective
title_full_unstemmed	Atypical pathogens in hospitalized patients with community-acquired pneumonia: a worldwide perspective
title_sort	Atypical pathogens in hospitalized patients with community-acquired pneumonia: a worldwide perspective
dc.creator.fl_str_mv	Gramegna, Andrea Sotgiu, Giovanni Pasquale, Marta Di Radovanovic, Dejan Terraneo, Silvia Reyes, Luis F. Vendrell, Ester Neves, Joao Menzella, Francesco Blasi, Francesco Aliberti, Stefano Restrepo, Marcos I.
dc.contributor.author.none.fl_str_mv	Gramegna, Andrea Sotgiu, Giovanni Pasquale, Marta Di Radovanovic, Dejan Terraneo, Silvia Reyes, Luis F. Vendrell, Ester Neves, Joao Menzella, Francesco Blasi, Francesco Aliberti, Stefano Restrepo, Marcos I.
dc.subject.es_CO.fl_str_mv	CAP Atypical pathogens Epidemiology
topic	CAP Atypical pathogens Epidemiology
description	11 páginas
publishDate	2018
dc.date.issued.none.fl_str_mv	2018-12-18
dc.date.available.none.fl_str_mv	2020-05-30T14:54:09Z
dc.date.accessioned.none.fl_str_mv	5/30/2020 9:54
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dc.identifier.citation.es_CO.fl_str_mv	BMC Infectious Diseases (2018) 18:677
dc.identifier.other.none.fl_str_mv	https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-018-3565-z https://bmcinfectdis.biomedcentral.com/track/pdf/10.1186/s12879-018-3565-z
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dc.identifier.doi.none.fl_str_mv	10.1186/s12879-018-3565-z
identifier_str_mv	BMC Infectious Diseases (2018) 18:677 10.1186/s12879-018-3565-z
url	https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-018-3565-z https://bmcinfectdis.biomedcentral.com/track/pdf/10.1186/s12879-018-3565-z http://hdl.handle.net/10818/41343
dc.language.iso.es_CO.fl_str_mv	eng
language	eng
dc.relation.ispartofseries.none.fl_str_mv	BMC Infectious Diseases (2018) 18:677
dc.rights.*.fl_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International
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rights_invalid_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2
dc.format.es_CO.fl_str_mv	application/pdf
dc.publisher.es_CO.fl_str_mv	Enfermedades infecciosas BMC
dc.source.es_CO.fl_str_mv	Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana
institution	Universidad de la Sabana
bitstream.url.fl_str_mv	https://intellectum.unisabana.edu.co/bitstream/10818/41343/3/license.txt https://intellectum.unisabana.edu.co/bitstream/10818/41343/2/license_rdf
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spelling	Gramegna, AndreaSotgiu, GiovanniPasquale, Marta DiRadovanovic, DejanTerraneo, SilviaReyes, Luis F.Vendrell, EsterNeves, JoaoMenzella, FrancescoBlasi, FrancescoAliberti, StefanoRestrepo, Marcos I.5/30/2020 9:542020-05-30T14:54:09Z2018-12-18BMC Infectious Diseases (2018) 18:677https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-018-3565-zhttps://bmcinfectdis.biomedcentral.com/track/pdf/10.1186/s12879-018-3565-zhttp://hdl.handle.net/10818/4134310.1186/s12879-018-3565-z11 páginasBackground: Empirical antibiotic coverage for atypical pathogens in community-acquired pneumonia (CAP) has long been debated, mainly because of a lack of epidemiological data. We aimed to assess both testing for atypical pathogens and their prevalence in hospitalized patients with CAP worldwide, especially in relation with disease severity. Methods: A secondary analysis of the GLIMP database, an international, multicentre, point-prevalence study of adult patients admitted for CAP in 222 hospitals across 6 continents in 2015, was performed. The study evaluated frequency of testing for atypical pathogens, including L. pneumophila, M. pneumoniae, C. pneumoniae, and their prevalence. Risk factors for testing and prevalence for atypical pathogens were assessed through univariate analysis. Results: Among 3702 CAP patients 1250 (33.8%) underwent at least one test for atypical pathogens. Testing varies greatly among countries and its frequency was higher in Europe than elsewhere (46.0% vs. 12.7%, respectively, p < 0. 0001). Detection of L. pneumophila urinary antigen was the most common test performed worldwide (32.0%). Patients with severe CAP were less likely to be tested for both atypical pathogens considered together (30.5% vs. 35.0%, p = 0.009) and specifically for legionellosis (28.3% vs. 33.5%, p = 0.003) than the rest of the population. Similarly, L. pneumophila testing was lower in ICU patients. At least one atypical pathogen was isolated in 62 patients (4.7%), including M. pneumoniae (26/251 patients, 10.3%), L. pneumophila (30/1186 patients, 2.5%), and C. pneumoniae (8/228 patients, 3.5%). Patients with CAP due to atypical pathogens were significantly younger, showed less cardiovascular, renal, and metabolic comorbidities in comparison to adult patients hospitalized due to non-atypical pathogen CAP. Conclusions: Testing for atypical pathogens in patients admitted for CAP in poorly standardized in real life and does not mirror atypical prevalence in different settings. Further evidence on the impact of atypical pathogens, expecially in the low-income countries, is needed to guidelines implementation.application/pdfengEnfermedades infecciosas BMCBMC Infectious Diseases (2018) 18:677Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaCAPAtypical pathogensEpidemiologyAtypical pathogens in hospitalized patients with community-acquired pneumonia: a worldwide perspectivePatógenos atípicos en pacientes hospitalizados con neumonía adquirida en la comunidad: una perspectiva mundialarticlepublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/41343/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://intellectum.unisabana.edu.co/bitstream/10818/41343/2/license_rdf4460e5956bc1d1639be9ae6146a50347MD5210818/41343oai:intellectum.unisabana.edu.co:10818/413432022-05-10 05:20:04.417Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.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

Atypical pathogens in hospitalized patients with community-acquired pneumonia: a worldwide perspective

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