KDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast Cancer

7 páginas

Autores:: García Serrano, Jeison
Lizcano Losada, Fernando

Tipo de recurso:

Fecha de publicación:: 2016

Institución:: Universidad de la Sabana

Repositorio:: Repositorio Universidad de la Sabana

Idioma:: eng

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spelling	García Serrano, JeisonLizcano Losada, Fernando5/21/2018 11:012018-05-21T16:01:40Z2016-11Garcia and Lizcano. KDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast Cancer. Breast Cancer: Basic and Clinical Research 2016:10 169–175 doi:10.4137/BCBCR.S40182.1178-2234http://journals.sagepub.com/doi/abs/10.4137/BCBCR.S40182http://journals.sagepub.com/doi/pdf/10.4137/BCBCR.S40182http://hdl.handle.net/10818/329757 páginasThe Jumonji-containing domain protein, KDM4C, is a histone demethylase associated with the development of several forms of human cancer. However, its specific function in the viability of tumoral lineages is yet to be determined. This work investigates the importance of KDM4C activity in cell proliferation and chromosome segregation of three triple-negative breast cancer cell lines using a specific demethylase inhibitor. Immunofluorescence assays show that KDM4C is recruited to mitotic chromosomes and that the modulation of its activity increases the number of mitotic segregation errors. However, 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) cell proliferation assays demonstrate that the demethylase activity is required for cell viability. These results suggest that the histone demethylase activity of KDM4C is essential for breast cancer progression given its role in the maintenance of chromosomal stability and cell growth, thus highlighting it as a potential therapeutic target.application/pdfengBreast Cancer: Basic and Clinical ResearchAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaKDM4CBreast cancerChromosome segregationHistone demethylationKDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast CancerarticlepublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/32975/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81223https://intellectum.unisabana.edu.co/bitstream/10818/32975/2/license_rdf7c9ab7f006165862d8ce9ac5eac01552MD5210818/32975oai:intellectum.unisabana.edu.co:10818/329752022-05-10 05:16:57.31Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.coPGEgcmVsPSJsaWNlbnNlIiBocmVmPSJodHRwOi8vY3JlYXRpdmVjb21tb25zLm9yZy9saWNlbnNlcy9ieS1uYy1uZC8zLjAvIj48aW1nIGFsdD0iTGljZW5jaWEgQ3JlYXRpdmUgQ29tbW9ucyIgc3R5bGU9ImJvcmRlci13aWR0aDowIiBzcmM9Imh0dHA6Ly9pLmNyZWF0aXZlY29tbW9ucy5vcmcvbC9ieS1uYy1uZC8zLjAvODh4MzEucG5nIiAvPjwvYT48YnIgLz5Fc3RlIDxzcGFuIHhtbG5zOmRjdD0iaHR0cDovL3B1cmwub3JnL2RjL3Rlcm1zLyIgaHJlZj0iaHR0cDovL3B1cmwub3JnL2RjL2RjbWl0eXBlL1RleHQiIHJlbD0iZGN0OnR5cGUiPm9icmE8L3NwYW4+IGVzdMOhIGJham8gdW5hIDxhIHJlbD0ibGljZW5zZSIgaHJlZj0iaHR0cDovL2NyZWF0aXZlY29tbW9ucy5vcmcvbGljZW5zZXMvYnktbmMtbmQvMy4wLyI+bGljZW5jaWEgQ3JlYXRpdmUgQ29tbW9ucyBSZWNvbm9jaW1pZW50by1Ob0NvbWVyY2lhbC1TaW5PYnJhRGVyaXZhZGEgMy4wIFVucG9ydGVkPC9hPi4K
dc.title.es_CO.fl_str_mv	KDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast Cancer
title	KDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast Cancer
spellingShingle	KDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast Cancer KDM4C Breast cancer Chromosome segregation Histone demethylation
title_short	KDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast Cancer
title_full	KDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast Cancer
title_fullStr	KDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast Cancer
title_full_unstemmed	KDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast Cancer
title_sort	KDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast Cancer
dc.creator.fl_str_mv	García Serrano, Jeison Lizcano Losada, Fernando
dc.contributor.author.none.fl_str_mv	García Serrano, Jeison Lizcano Losada, Fernando
dc.subject.es_CO.fl_str_mv	KDM4C Breast cancer Chromosome segregation Histone demethylation
topic	KDM4C Breast cancer Chromosome segregation Histone demethylation
description	7 páginas
publishDate	2016
dc.date.issued.none.fl_str_mv	2016-11
dc.date.available.none.fl_str_mv	2018-05-21T16:01:40Z
dc.date.accessioned.none.fl_str_mv	5/21/2018 11:01
dc.type.en.fl_str_mv	article
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dc.identifier.citation.es_CO.fl_str_mv	Garcia and Lizcano. KDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast Cancer. Breast Cancer: Basic and Clinical Research 2016:10 169–175 doi:10.4137/BCBCR.S40182.
dc.identifier.issn.none.fl_str_mv	1178-2234
dc.identifier.other.none.fl_str_mv	http://journals.sagepub.com/doi/abs/10.4137/BCBCR.S40182 http://journals.sagepub.com/doi/pdf/10.4137/BCBCR.S40182
dc.identifier.uri.none.fl_str_mv	http://hdl.handle.net/10818/32975
identifier_str_mv	Garcia and Lizcano. KDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast Cancer. Breast Cancer: Basic and Clinical Research 2016:10 169–175 doi:10.4137/BCBCR.S40182. 1178-2234
url	http://journals.sagepub.com/doi/abs/10.4137/BCBCR.S40182 http://journals.sagepub.com/doi/pdf/10.4137/BCBCR.S40182 http://hdl.handle.net/10818/32975
dc.language.iso.es_CO.fl_str_mv	eng
language	eng
dc.rights.*.fl_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International
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dc.rights.uri.*.fl_str_mv	http://creativecommons.org/licenses/by-nc-nd/4.0/
rights_invalid_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2
dc.format.es_CO.fl_str_mv	application/pdf
dc.publisher.es_CO.fl_str_mv	Breast Cancer: Basic and Clinical Research
dc.source.es_CO.fl_str_mv	Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana
institution	Universidad de la Sabana
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KDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast Cancer

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