Desarrollo de un modelo matemático para establecer la relación fisiológica entre inflamación y sistema nervioso autónomo
211 páginas
- Autores:
-
León Ariza, Henry Humberto
- Tipo de recurso:
- Fecha de publicación:
- 2017
- Institución:
- Universidad de la Sabana
- Repositorio:
- Repositorio Universidad de la Sabana
- Idioma:
- spa
- OAI Identifier:
- oai:intellectum.unisabana.edu.co:10818/31980
- Acceso en línea:
- http://hdl.handle.net/10818/31980
- Palabra clave:
- Sistema nervioso autónomo
Frecuencia cardíaca
Sistema inmune
- Rights
- License
- Attribution-NonCommercial-NoDerivatives 4.0 International
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Desarrollo de un modelo matemático para establecer la relación fisiológica entre inflamación y sistema nervioso autónomo |
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Desarrollo de un modelo matemático para establecer la relación fisiológica entre inflamación y sistema nervioso autónomo |
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Desarrollo de un modelo matemático para establecer la relación fisiológica entre inflamación y sistema nervioso autónomo Sistema nervioso autónomo Frecuencia cardíaca Sistema inmune |
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Desarrollo de un modelo matemático para establecer la relación fisiológica entre inflamación y sistema nervioso autónomo |
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Desarrollo de un modelo matemático para establecer la relación fisiológica entre inflamación y sistema nervioso autónomo |
| title_fullStr |
Desarrollo de un modelo matemático para establecer la relación fisiológica entre inflamación y sistema nervioso autónomo |
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Desarrollo de un modelo matemático para establecer la relación fisiológica entre inflamación y sistema nervioso autónomo |
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Desarrollo de un modelo matemático para establecer la relación fisiológica entre inflamación y sistema nervioso autónomo |
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León Ariza, Henry Humberto |
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Botero Rosas, Daniel Alfonso |
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León Ariza, Henry Humberto |
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Sistema nervioso autónomo Frecuencia cardíaca Sistema inmune |
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Sistema nervioso autónomo Frecuencia cardíaca Sistema inmune |
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211 páginas |
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2017 |
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11/16/2017 10:22 |
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2017-11-16 |
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Botero Rosas, Daniel AlfonsoLeón Ariza, Henry Humberto11/16/2017 10:2211/16/2017 10:222017-11-16http://hdl.handle.net/10818/31980267052TE09375211 páginasEl sistema nervioso autónomo (SNA) es responsable entre otras de la regulación inmediata de las funciones vitales, este recibe información constante que se genera tanto interna como externamente, generando respuestas adaptativas inmediatas. Uno de los órganos blanco del SNA es el corazón, el cual modula de manera constante el tiempo entre un latido y otro, haciendo que el estudio de estas variaciones sea un excelente marcador de actividad autonómica. La evidencia sugiere que un estímulo aferente fundamental para la modulación del SNA está en la actividad del sistema inmune, a través de una comunicación mediada por citoquinas. Esta tesis encontró que el sistema inmune efectivamente tiene un impacto en las respuestas del SNA, el cual es explicado por medio de una relación matemática. Para llegar a esta conclusión se cumplieron cinco etapas: 1. Se reprodujo el análisis matemático de la variabilidad de la frecuencia cardiaca desarrollando modelos propios de evaluación. 2. Se determinó la influencia de la composición corporal en el SNA, encontrándose que el tejido adiposo se asocia a una mayor actividad simpática y menor de tipo parasimpático, mientras que la masa muscular se asocia a mayores respuestas parasimpáticas y menores simpáticas, esto especialmente en hombres. 3. Se encontró que la concentración plasmática de marcadores inflamatorios como la Interleucina 6 (IL-6) y especialmente su factor soluble (sIL6R) tienen una alta relación con las respuestas del SNA. 4. Se estableció la influencia que tiene la actividad corteza cerebral en la modulación de las respuestas del SNA. 5. Se generó un modelo matemático que demostró que la IL-6 y el sIL6R son responsables del 50% de los cambios de la actividad autonómica en reposo.application/pdfspaUniversidad de La SabanaAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2instname:Universidad de La Sabanareponame:Intellectum Repositorio Universidad de La SabanaSistema nervioso autónomoFrecuencia cardíacaSistema inmuneDesarrollo de un modelo matemático para establecer la relación fisiológica entre inflamación y sistema nervioso autónomodoctoralThesisTesis de doctoradopublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_db06Tresguerres JAF, Ariznavarreta C, Cachofeiro V, Cardinati D, Escrich E, Gil-Loyzaga P, et al. Fisiología Humana. Cuarta ed. 2010. }Reyes-Juarez JL, Zarain-Herzberg A. Función del retículo sarcoplásmico y su papel en las enfermedades cardíacas. 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Soluble interleukin-6 receptorFacultad de IngenieríaUniversidad de La SabanaDoctorado en BiocienciasDoctor en BiocienciasORIGINALHenry Humberto León Ariza (Tesis).pdfHenry Humberto León Ariza (Tesis).pdfVer documento en PDFapplication/pdf9159735https://intellectum.unisabana.edu.co/bitstream/10818/31980/1/Henry%20Humberto%20Le%c3%b3n%20Ariza%20%28Tesis%29.pdf6346ad74e2f1255161cb248fcf16a287MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81223https://intellectum.unisabana.edu.co/bitstream/10818/31980/2/license_rdf7c9ab7f006165862d8ce9ac5eac01552MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/31980/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD53Henry Humberto León Ariza (Carta).pdfHenry Humberto León Ariza (Carta).pdfapplication/pdf1508284https://intellectum.unisabana.edu.co/bitstream/10818/31980/4/Henry%20Humberto%20Le%c3%b3n%20Ariza%20%28Carta%29.pdf151f71f6ab01b43f50caa3cdccc17d74MD54TEXTHenry Humberto León Ariza (Tesis).pdf.txtHenry Humberto León Ariza (Tesis).pdf.txtExtracted Texttext/plain342904https://intellectum.unisabana.edu.co/bitstream/10818/31980/5/Henry%20Humberto%20Le%c3%b3n%20Ariza%20%28Tesis%29.pdf.txtae6124e1f6ff69d07f3936163df9ee22MD5510818/31980oai:intellectum.unisabana.edu.co:10818/319802022-02-18 12:08:55.686Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.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 |