Determinación del efecto de la deficiencia de vitamina A sobre la homeostasis del hierro y su estado en modelo murino

122 páginas

Autores:: Restrepo Gallego, Mauricio

Tipo de recurso:

Fecha de publicación:: 2020

Institución:: Universidad de la Sabana

Repositorio:: Repositorio Universidad de la Sabana

Idioma:: spa

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dc.title.es_CO.fl_str_mv	Determinación del efecto de la deficiencia de vitamina A sobre la homeostasis del hierro y su estado en modelo murino
title	Determinación del efecto de la deficiencia de vitamina A sobre la homeostasis del hierro y su estado en modelo murino
spellingShingle	Determinación del efecto de la deficiencia de vitamina A sobre la homeostasis del hierro y su estado en modelo murino Vitamina A Anemia Homeostasis Vitamina A Anemia Homeostasis
title_short	Determinación del efecto de la deficiencia de vitamina A sobre la homeostasis del hierro y su estado en modelo murino
title_full	Determinación del efecto de la deficiencia de vitamina A sobre la homeostasis del hierro y su estado en modelo murino
title_fullStr	Determinación del efecto de la deficiencia de vitamina A sobre la homeostasis del hierro y su estado en modelo murino
title_full_unstemmed	Determinación del efecto de la deficiencia de vitamina A sobre la homeostasis del hierro y su estado en modelo murino
title_sort	Determinación del efecto de la deficiencia de vitamina A sobre la homeostasis del hierro y su estado en modelo murino
dc.creator.fl_str_mv	Restrepo Gallego, Mauricio
dc.contributor.advisor.none.fl_str_mv	Díaz Barrera, Luis Eduardo
dc.contributor.author.none.fl_str_mv	Restrepo Gallego, Mauricio
dc.subject.es_CO.fl_str_mv	Vitamina A Anemia Homeostasis
topic	Vitamina A Anemia Homeostasis Vitamina A Anemia Homeostasis
dc.subject.armarc.es_CO.fl_str_mv	Vitamina A Anemia Homeostasis
description	122 páginas
publishDate	2020
dc.date.accessioned.none.fl_str_mv	12/17/2020 14:39
dc.date.available.none.fl_str_mv	12/17/2020 14:39
dc.date.issued.none.fl_str_mv	2020-10-26
dc.type.es_CO.fl_str_mv	doctoralThesis
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dc.type.local.none.fl_str_mv	Tesis de doctorado
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spelling	Díaz Barrera, Luis EduardoRestrepo Gallego, Mauricio12/17/2020 14:3912/17/2020 14:392020-10-26http://hdl.handle.net/10818/46055279977TE11055122 páginasIron deficiency anemia (IDA) and vitamin A deficiency (VAD) belong to the micronutrient deficiencies defined by the WHO as worldwide concern. In Colombia, IDA prevalence for children from 1 to 4 years old is 14.8% and anemia is 24.7% for children from 6 to 59 months old, it is remarkable in a country where is mandatory to fortify wheat flour with iron since 1996. On the other hand, VAD prevalence for children from 1 to 4 years old is 27.3% and, in this case, there is no mandatory fortification programs in the country. Interactions between micronutrients are not unknown on health and nutrition field, the most recognized is that between calcium and vitamin D; besides, there is evidence from an epidemiological perspective that VAD and ID are linked in some way, fact supported for some studies using cellular and animal models. This study has the hypothesis that vitamin A regulates in some way the iron homeostasis and its metabolic role, and has three approaches: weight gain, biochemical and hematological parameters and molecular markers of iron homeostasis. We designed a study with four experimental diets with different ratios of iron and vitamin A (sufficient, insufficient and deficient) and a control diet with a sufficient supply of both micronutrients. The quantity of animals was calculated statistically giving seven animals per group for 35 animals. The rats started the experiment at weaning (21 days-old) and received food and water at libitum for six weeks, during this time food intake and weight were recorded each week. At sixth week the animals were euthanized and samples from blood and tissues of interest (liver, spleen and duodenum) were taken for analysis of biochemical and hematological indicators in blood and PCR and Western Blot test in tissues for the analysis of hepcidin, ferritin, transferrin receptors, transferrin and interleukin-6 as proteins of interest.La anemia por deficiencia de hierro (IDA) y la deficiencia de vitamina A (VAD) hacen parte del grupo de las deficiencias por micronutrientes definidas por la OMS como de interés mundial. En el caso de Colombia, la prevalencia de IDA en niños de 1 a 4 años es de 14.8% y la anemia está en 24.7% para niños entre 6 y 59 meses, algo paradójico si se tiene en cuenta que desde 1996 es obligatorio fortificar la harina de trigo con hierro. De otro lado, la prevalencia de VAD es de 27.3% para el mismo grupo poblacional, en este caso hasta el día de hoy no existe ningún tipo de fortificación obligatoria en el país. Las interacciones entre nutrientes no son algo desconocido en el campo de la salud y la nutrición, la más reconocida es la existente entre calcio y vitamina D; además, existe evidencia desde el punto de vista epidemiológico de que la VAD y la ID tienen algún tipo de relación, hecho que ha sido soportado por algunos estudios en modelos celulares y animales. Este estudio parte de la hipótesis de que la vitamina A regula de alguna forma la homeostasis del hierro y su rol metabólico, y aborda tres enfoques: ganancia de peso, parámetros bioquímicos y hematológicos y biomarcadores de la homeostasis del hierro.application/pdfspaUniversidad de La SabanaAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2instname:Universidad de La Sabanareponame:Intellectum Repositorio Universidad de La SabanaVitamina AAnemiaHomeostasisVitamina AAnemiaHomeostasisDeterminación del efecto de la deficiencia de vitamina A sobre la homeostasis del hierro y su estado en modelo murinodoctoralThesisTesis de doctoradopublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_db06Ganz T. Iron homeostasis: fitting the puzzle pieces together. 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Universidade de Brasília; 2012.Facultad de IngenieríaUniversidad de La SabanaDoctorado en BiocienciasDoctor en BiocienciasCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://intellectum.unisabana.edu.co/bitstream/10818/46055/2/license_rdf4460e5956bc1d1639be9ae6146a50347MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/46055/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD53Autorizacion Biblioteca.pdfAutorizacion Biblioteca.pdfCartaapplication/pdf722006https://intellectum.unisabana.edu.co/bitstream/10818/46055/4/Autorizacion%20Biblioteca.pdfaac4bf60ddbab0e6ccd622ff793e0c33MD54ORIGINALDeterminación del efecto de la deficiencia de vitamina A.pdfDeterminación del efecto de la deficiencia de vitamina A.pdfVer documento en PDFapplication/pdf6359682https://intellectum.unisabana.edu.co/bitstream/10818/46055/1/Determinaci%c3%b3n%20del%20efecto%20de%20la%20deficiencia%20de%20vitamina%20A.pdf64e350ebf7ee9166e44712b2acba60bbMD5110818/46055oai:intellectum.unisabana.edu.co:10818/460552022-02-18 12:08:43.441Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.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

Determinación del efecto de la deficiencia de vitamina A sobre la homeostasis del hierro y su estado en modelo murino

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