The association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritis

10 páginas

Autores:: Londoño Patiño, John Darío
Romero Sanchez, Maria Consuelo
García Torres, Viviana
Bautista Molano, Wilson Armando
Jaimes Fernández, Diego Alejandro
De Ávila Quiroga, Julitte
Valle Oñate, Rafael
Santos Granados, Ana María
Medina, Juan Francisco

Tipo de recurso:

Fecha de publicación:: 2012

Institución:: Universidad de la Sabana

Repositorio:: Repositorio Universidad de la Sabana

Idioma:: eng

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dc.title.es_CO.fl_str_mv	The association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritis
title	The association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritis
spellingShingle	The association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritis Spondyloarthritis Spondyloarthropathies Reactive arthritis Ankylosing spondylitis Ankylosing spondyloarthritis Rheumatic diseases Enthesopathy Low back pain Arthritis Biomarkers
title_short	The association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritis
title_full	The association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritis
title_fullStr	The association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritis
title_full_unstemmed	The association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritis
title_sort	The association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritis
dc.creator.fl_str_mv	Londoño Patiño, John Darío Romero Sanchez, Maria Consuelo García Torres, Viviana Bautista Molano, Wilson Armando Jaimes Fernández, Diego Alejandro De Ávila Quiroga, Julitte Valle Oñate, Rafael Santos Granados, Ana María Medina, Juan Francisco
dc.contributor.author.none.fl_str_mv	Londoño Patiño, John Darío Romero Sanchez, Maria Consuelo García Torres, Viviana Bautista Molano, Wilson Armando Jaimes Fernández, Diego Alejandro De Ávila Quiroga, Julitte Valle Oñate, Rafael Santos Granados, Ana María Medina, Juan Francisco
dc.subject.other.en.fl_str_mv	Spondyloarthritis Spondyloarthropathies Reactive arthritis Ankylosing spondylitis Ankylosing spondyloarthritis Rheumatic diseases Enthesopathy Low back pain Arthritis Biomarkers
topic	Spondyloarthritis Spondyloarthropathies Reactive arthritis Ankylosing spondylitis Ankylosing spondyloarthritis Rheumatic diseases Enthesopathy Low back pain Arthritis Biomarkers
description	10 páginas
publishDate	2012
dc.date.accessioned.none.fl_str_mv	10/18/2016 15:49
dc.date.issued.none.fl_str_mv	2012-08-05
dc.date.available.none.fl_str_mv	2016-10-18T20:49:46Z
dc.type.en.fl_str_mv	article
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dc.identifier.uri.none.fl_str_mv	http://hdl.handle.net/10818/27580
dc.identifier.doi.none.fl_str_mv	10.1590/S0482-50042012000400006
identifier_str_mv	0482-5004 10.1590/S0482-50042012000400006
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dc.language.iso.es_CO.fl_str_mv	eng
language	eng
dc.relation.ispartofseries.none.fl_str_mv	Rev. Bras. Reumatol. vol.52 no.4 São Paulo July/Aug. 2012
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dc.publisher.es_CO.fl_str_mv	Revista Brasileira de Reumatologia
dc.source.es_CO.fl_str_mv	Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana
institution	Universidad de la Sabana
bitstream.url.fl_str_mv	https://intellectum.unisabana.edu.co/bitstream/10818/27580/3/license.txt https://intellectum.unisabana.edu.co/bitstream/10818/27580/2/license_rdf
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spelling	Londoño Patiño, John DaríoRomero Sanchez, Maria ConsueloGarcía Torres, VivianaBautista Molano, Wilson ArmandoJaimes Fernández, Diego AlejandroDe Ávila Quiroga, JulitteValle Oñate, RafaelSantos Granados, Ana MaríaMedina, Juan Francisco10/18/2016 15:492016-10-18T20:49:46Z2012-08-050482-5004http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042012000400006&lng=en&nrm=iso&tlng=enhttp://www.scielo.br/pdf/rbr/v52n4/en_v52n4a06.pdfhttp://hdl.handle.net/10818/2758010.1590/S0482-5004201200040000610 páginasBACKGROUND: Serum biomarkers traditionally associated with inflammatory activity and a poor prognosis in rheumatic diseases do not show the same relationship in spondyloarthritis. OBJECTIVE: To establish the association between serum levels of potential biomarkers with the presence of factors related to clinical activity and poor prognosis in spondyloarthritis. METHODS: Sixty-two patients were included: 13 with reactive arthritis, 19 with ankylosing spondylitis, and 30 with undifferentiated spondyloarthritis. The results were compared with those from 46 healthy controls. Clinical, radiological, and laboratory characteristics were assessed. The results were analyzed based on the presence of uveitis, enthesitis, inflammatory back pain, arthritis, HLA-B27 and sacroiliac involvement. The analyzed biomarkers included ESR, US-CRP, SAA, LBP, FSC-M, and MMP-3; and cytokine serum levels measured were: IL-17, IL-6, IL-1α , TNF-α , IFN-γ, and IL-23. RESULTS: Forty-three (69.4%) patients were male. The average age was 31.9 ± 9.9 years and the age at the onset of symptoms was 26.9 ± 7.3 years. HLA-B27 was positive in 26 (41.9%) patients, inflammatory back pain in 42 (67.7%), arthritis in 44 (71.0%), and enthesitis in 34 (54.8%). IL-17, IL-23, TNF-α , IL-6, IL-1α , and US-CRP levels were significantly higher in patients with SpA when compared to controls. US-CRP (P = 0.04), IL-6 (P = 0.003), IL-1α (P = 0.03), and LBP (P = 0.03) levels were associated with presence of HLA-B27, inflammatory back pain, and arthritis. CONCLUSION: An increase in serum levels of US-CRP, IL-6, IL-1α , and LBP was correlated with factors associated with clinical activity and poor prognosis in spondyloarthritis.application/pdfengRevista Brasileira de ReumatologiaRev. Bras. Reumatol. vol.52 no.4 São Paulo July/Aug. 2012Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaSpondyloarthritisSpondyloarthropathiesReactive arthritisAnkylosing spondylitisAnkylosing spondyloarthritisRheumatic diseasesEnthesopathyLow back painArthritisBiomarkersThe association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritisarticlepublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/27580/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81223https://intellectum.unisabana.edu.co/bitstream/10818/27580/2/license_rdf7c9ab7f006165862d8ce9ac5eac01552MD5210818/27580oai:intellectum.unisabana.edu.co:10818/275802022-05-10 05:16:25.541Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.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

The association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritis

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