Frecuencia de trombofilias en una población de pacientes con episodios trombóticos en un hospital universitario de III nivel

51 Páginas.

Autores:: Cancelado Jácome, Sergio Andrés
Chinchía Arias, Isabel Matilde
Salazar Muñoz, Johana Milena
Calderón Vargas, Carlos Mauricio

Tipo de recurso:

Fecha de publicación:: 2011

Institución:: Universidad de la Sabana

Repositorio:: Repositorio Universidad de la Sabana

Idioma:: spa

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dc.title.es_CO.fl_str_mv	Frecuencia de trombofilias en una población de pacientes con episodios trombóticos en un hospital universitario de III nivel
title	Frecuencia de trombofilias en una población de pacientes con episodios trombóticos en un hospital universitario de III nivel
spellingShingle	Frecuencia de trombofilias en una población de pacientes con episodios trombóticos en un hospital universitario de III nivel Trombofilia-Investigaciones
title_short	Frecuencia de trombofilias en una población de pacientes con episodios trombóticos en un hospital universitario de III nivel
title_full	Frecuencia de trombofilias en una población de pacientes con episodios trombóticos en un hospital universitario de III nivel
title_fullStr	Frecuencia de trombofilias en una población de pacientes con episodios trombóticos en un hospital universitario de III nivel
title_full_unstemmed	Frecuencia de trombofilias en una población de pacientes con episodios trombóticos en un hospital universitario de III nivel
title_sort	Frecuencia de trombofilias en una población de pacientes con episodios trombóticos en un hospital universitario de III nivel
dc.creator.fl_str_mv	Cancelado Jácome, Sergio Andrés Chinchía Arias, Isabel Matilde Salazar Muñoz, Johana Milena Calderón Vargas, Carlos Mauricio
dc.contributor.advisor.none.fl_str_mv	Feliciano Alfonso, John Edwin
dc.contributor.author.none.fl_str_mv	Cancelado Jácome, Sergio Andrés Chinchía Arias, Isabel Matilde Salazar Muñoz, Johana Milena Calderón Vargas, Carlos Mauricio
dc.subject.es_CO.fl_str_mv	Trombofilia-Investigaciones
topic	Trombofilia-Investigaciones
description	51 Páginas.
publishDate	2011
dc.date.issued.none.fl_str_mv	2011
dc.date.accessioned.none.fl_str_mv	2012-07-25T15:15:05Z
dc.date.available.none.fl_str_mv	2012-07-25T15:15:05Z
dc.date.created.none.fl_str_mv	2012-07-25
dc.type.none.fl_str_mv	bachelorThesis
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dc.type.local.none.fl_str_mv	Tesis de especialización
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dc.identifier.citation.none.fl_str_mv	Dahlbäch B, Carlson M, Svenson P. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated Protein C. Proc Natl Acad Sci 1993; 90: 1004. Guidelines on the investigation and management of thrombophilia. J Clin Pathol 1990; 49: 703. GRIFFIN V, SELIGSOH U, RAPPORT S. Coagulation abnormalities in thrombosis. American Society Hematology. Educational Session. Bocklet, Seattle, Washington 1995; 51‐8. CONRAD F. Thrombophilia: diagnosis and management. En: Poller L, Thomas JM (eds): Thrombosis and its Management. London: Churchill‐Livingstone Inc 1993; 113‐ 25. . Bauer K, Goodnight S, Ridkes P. Hypercoagulable States‐Translation of Risk Factors to Clinical Practice. The American Society of Hematology Education Program Book. Janine Editor 1998; 255‐73. Arnaud E, Reny J, Emmerich J, Aiach M. Thrombose veineusse et anomalies genétiques de l’hémostase. Sang Thrombose et Vaissaux 2000; 7: 426‐32. Heijboer H, Brandjes D, Büller H, Sturka A, Ten Cate J. Deficiencies of coagulation‐ inhibitingand fibrinolytic proteins in outpatients with deep venous thrombosis. N Engl J Med 1990; 323: 1512‐6. Hach‐Wunderle V, Scharrer I. Prevalence of hereditary deficiency of antithrombin III, Protein C en Protein S. Dtsch Med Wochenschr 1993; 118: 187‐90. Dahlbäch B. New molecular insights into the genetics of thrombophilia. Resistance to activated protein C caused by Arg (506) to Gln mutation in factor V as a pathogenic risk factor for venous thrombosis. Thromb Haemost 1995; 74: 139‐48. Bertina RM, Reitsma PH, Rosendaal FR, Vandenbroucke JP. Resistance to activated protein C and Factor V as risk factors for venous thrombosis. Thromb Haemost 1995; 74: 449‐53. Mercier E, Queré I, Gris J‐C. Variant 20210 A dugène de la Prothrombine et Thrombose. STV 2001; 4: 13‐23. Grinsberg JS. Management of venous thromboembolism. N Engl J Med 1996; 335: 1816‐28. Derksen Rh, De Groot Pg, Kater L, Nieuwenhuis Hk. Patients with antiphospholipid antibodies and venous thrombosis should receive long term anticoagulant treatment. Ann Rheum Dis 1993; 52: 689‐92. Khamashta Ma, Cuadrado Mj, Mujic F, Taub Na, Hunt Bj, Hughes Gr. The management of thrombosis in the antiphospholipid antibody syndrome. N Eng J Med 1995; 332: 993‐7 Torres, J. Inherited Thrombophilia is Associated With Deep Vein Thrombosis in a Colombian Population. American Journal of Hematology 81:933–937 (2006). Alfirevic, Z, Alfirevic, V. Hypercoagulable state, pathophysiology, classification and epidemiology. Clin Chem Lab Med 2010;48(Suppl 1):S15–S26 . Stegnar, M. Thrombophilia screening – at the right time, for the right patient, with a good reason. Clin Chem Lab Med 2010;48(Suppl 1):S105–S113 2010 Alfirevic, Z, Alfirevic, V. Hypercoagulable state, pathophysiology, classification and epidemiology. Clin Chem Lab Med 2010;48(Suppl 1):S15–S26 . Olson ST, Björk I. Regulation of thrombin activity by antithrombin and heparin. Semin Thromb Hemost 1994;20(4):373e409. Anderson J, Witz J. Hypercoagulable States. Clin Chest Med 31 (2010) 659–673 Hirsh J, Bauer KA, Donati MB, et al. Parenteral anticoagulants: American College of Chest Physicians Evidence‐Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133:141S. Martinelli I, Mannucci PM, De Stefano V, et al. Different risks of thrombosis in four coagulation defects associated with inherited thrombophilia: a study of 150 families. Blood 1998; 92:2353. Mosnier LO, Zlokovic BV, Griffin JH. The cytoprotective protein C pathway. Blood 2007; 109:3161. Tait RC, Walker ID, Reitsma PH, et al. Prevalence of protein C deficiency in the healthy population. Thromb Haemost 1995; 73:87. Bruijn SF, Stam J, Koopman MM, Vandenbroucke JP. Case‐control study of risk of cerebral sinus thrombosis in oral contraceptive users and in [correction of who are] carriers of hereditary prothrombotic conditions. The Cerebral Venous Sinus Thrombosis Study Group. BMJ 1998; 316:589 Nazarian RM, Van Cott EM, Zembowicz A, Duncan LM. Warfarin‐induced skin necrosis. J Am Acad Dermatol 2009; 61:325. Rezende SM, Simmonds RE, Lane DA. Coagulation, inflammation, and apoptosis: different roles for protein S and the protein S‐C4b binding protein complex. Blood 2004; 103:1192 Rezende SM, Simmonds RE, Lane DA. Coagulation, inflammation, and apoptosis: different roles for protein S and the protein S‐C4b binding protein complex. Blood 2004; 103:1192. Mustafa S, Mannhalter C, Rintelen C, et al. Clinical features of thrombophilia in families with gene defects in protein C or protein S combined with factor V . Blood Coagul Fibrinolysis 1998; 9:85. Mateo J, Oliver A, Borrell M, et al. Laboratory evaluation and clinical characteristics of 2,132 consecutive unselected patients with venous thromboembolism‐‐results of the Spanish Multicentric Study on Thrombophilia (EMET‐Study). Thromb Haemost 1997; 77:444. Castoldi E, Brugge JM, Nicolaes GA, et al. Impaired APC cofactor activity of factor V plays a major role in the APC resistance associated with the factor V Leiden (R506Q) and R2 (H1299R) mutations. Blood 2004; 103:4173 Castoldi E, Rosing J. APC resistance: biological basis and acquired influences. J Thromb Haemost 2010; 8:445. Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3'‐untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88:3698. Rosendaal FR, Doggen CJ, Zivelin A, et al. Geographic distribution of the 20210 G to A prothrombin variant. Thromb Haemost 1998; 79:706 O'Donnell J, Tuddenham EG, Manning R, et al. High prevalence of elevated factor VIII levels in patients referred for thrombophilia screening: role of increased synthesis and relationship to the acute phase reaction. Thromb Haemost 1997; 77:825. Viel KR, Machiah DK, Warren DM, et al. A sequence variation scan of the coagulation factor VIII (FVIII) structural gene and associations with plasma FVIII activity levels. Blood 2007; 109:3713. Lodi S, Isa L, Pollini E, et al. Defective intrinsic fibrinolytic activity in a patient with severe factor XII‐deficiency and myocardial infarction. Scand J Haematol 1984; 33:80. Goldhaber SZ. Risk factors for venous thromboembolism. J Am Coll Cardiol 2010; 56:1 Anderson J, Witz J. Hypercoagulable States. Clin Chest Med 31 (2010) 659–673 Miyakis S, Lockshin MD, Atsumi T, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006; 4:295. Geerts, W. Pineo,G. Prevention of Venous Thromboembolism. The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy Kujovich JL. Hormones and pregnancy: thromboembolic risks for women. Br J Haematol 2004; 126:443. Spencer FA, Emery C, Lessard D, et al. The Worcester Venous Thromboembolism study: a population‐based study of the clinical epidemiology of venous thromboembolism. J Gen Intern Med 2006; 21:722. Pomp ER, Rosendaal FR, Doggen CJ. Smoking increases the risk of venous thrombosis and acts synergistically with oral contraceptive use. Am J Hematol 2008; 83:97 Ministerio de Salud .Resolución No. 008430 de 1993.
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dc.identifier.local.none.fl_str_mv	152679 TE00280
identifier_str_mv	Dahlbäch B, Carlson M, Svenson P. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated Protein C. Proc Natl Acad Sci 1993; 90: 1004. Guidelines on the investigation and management of thrombophilia. J Clin Pathol 1990; 49: 703. GRIFFIN V, SELIGSOH U, RAPPORT S. Coagulation abnormalities in thrombosis. American Society Hematology. Educational Session. Bocklet, Seattle, Washington 1995; 51‐8. CONRAD F. Thrombophilia: diagnosis and management. En: Poller L, Thomas JM (eds): Thrombosis and its Management. London: Churchill‐Livingstone Inc 1993; 113‐ 25. . Bauer K, Goodnight S, Ridkes P. Hypercoagulable States‐Translation of Risk Factors to Clinical Practice. The American Society of Hematology Education Program Book. Janine Editor 1998; 255‐73. Arnaud E, Reny J, Emmerich J, Aiach M. Thrombose veineusse et anomalies genétiques de l’hémostase. Sang Thrombose et Vaissaux 2000; 7: 426‐32. Heijboer H, Brandjes D, Büller H, Sturka A, Ten Cate J. Deficiencies of coagulation‐ inhibitingand fibrinolytic proteins in outpatients with deep venous thrombosis. N Engl J Med 1990; 323: 1512‐6. Hach‐Wunderle V, Scharrer I. Prevalence of hereditary deficiency of antithrombin III, Protein C en Protein S. Dtsch Med Wochenschr 1993; 118: 187‐90. Dahlbäch B. New molecular insights into the genetics of thrombophilia. Resistance to activated protein C caused by Arg (506) to Gln mutation in factor V as a pathogenic risk factor for venous thrombosis. Thromb Haemost 1995; 74: 139‐48. Bertina RM, Reitsma PH, Rosendaal FR, Vandenbroucke JP. Resistance to activated protein C and Factor V as risk factors for venous thrombosis. Thromb Haemost 1995; 74: 449‐53. Mercier E, Queré I, Gris J‐C. Variant 20210 A dugène de la Prothrombine et Thrombose. STV 2001; 4: 13‐23. Grinsberg JS. Management of venous thromboembolism. N Engl J Med 1996; 335: 1816‐28. Derksen Rh, De Groot Pg, Kater L, Nieuwenhuis Hk. Patients with antiphospholipid antibodies and venous thrombosis should receive long term anticoagulant treatment. Ann Rheum Dis 1993; 52: 689‐92. Khamashta Ma, Cuadrado Mj, Mujic F, Taub Na, Hunt Bj, Hughes Gr. The management of thrombosis in the antiphospholipid antibody syndrome. N Eng J Med 1995; 332: 993‐7 Torres, J. Inherited Thrombophilia is Associated With Deep Vein Thrombosis in a Colombian Population. American Journal of Hematology 81:933–937 (2006). Alfirevic, Z, Alfirevic, V. Hypercoagulable state, pathophysiology, classification and epidemiology. Clin Chem Lab Med 2010;48(Suppl 1):S15–S26 . Stegnar, M. Thrombophilia screening – at the right time, for the right patient, with a good reason. Clin Chem Lab Med 2010;48(Suppl 1):S105–S113 2010 . Olson ST, Björk I. Regulation of thrombin activity by antithrombin and heparin. Semin Thromb Hemost 1994;20(4):373e409. Anderson J, Witz J. Hypercoagulable States. Clin Chest Med 31 (2010) 659–673 Hirsh J, Bauer KA, Donati MB, et al. Parenteral anticoagulants: American College of Chest Physicians Evidence‐Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133:141S. Martinelli I, Mannucci PM, De Stefano V, et al. Different risks of thrombosis in four coagulation defects associated with inherited thrombophilia: a study of 150 families. Blood 1998; 92:2353. Mosnier LO, Zlokovic BV, Griffin JH. The cytoprotective protein C pathway. Blood 2007; 109:3161. Tait RC, Walker ID, Reitsma PH, et al. Prevalence of protein C deficiency in the healthy population. Thromb Haemost 1995; 73:87. Bruijn SF, Stam J, Koopman MM, Vandenbroucke JP. Case‐control study of risk of cerebral sinus thrombosis in oral contraceptive users and in [correction of who are] carriers of hereditary prothrombotic conditions. The Cerebral Venous Sinus Thrombosis Study Group. BMJ 1998; 316:589 Nazarian RM, Van Cott EM, Zembowicz A, Duncan LM. Warfarin‐induced skin necrosis. J Am Acad Dermatol 2009; 61:325. Rezende SM, Simmonds RE, Lane DA. Coagulation, inflammation, and apoptosis: different roles for protein S and the protein S‐C4b binding protein complex. Blood 2004; 103:1192 Rezende SM, Simmonds RE, Lane DA. Coagulation, inflammation, and apoptosis: different roles for protein S and the protein S‐C4b binding protein complex. Blood 2004; 103:1192. Mustafa S, Mannhalter C, Rintelen C, et al. Clinical features of thrombophilia in families with gene defects in protein C or protein S combined with factor V . Blood Coagul Fibrinolysis 1998; 9:85. Mateo J, Oliver A, Borrell M, et al. Laboratory evaluation and clinical characteristics of 2,132 consecutive unselected patients with venous thromboembolism‐‐results of the Spanish Multicentric Study on Thrombophilia (EMET‐Study). Thromb Haemost 1997; 77:444. Castoldi E, Brugge JM, Nicolaes GA, et al. Impaired APC cofactor activity of factor V plays a major role in the APC resistance associated with the factor V Leiden (R506Q) and R2 (H1299R) mutations. Blood 2004; 103:4173 Castoldi E, Rosing J. APC resistance: biological basis and acquired influences. J Thromb Haemost 2010; 8:445. Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3'‐untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88:3698. Rosendaal FR, Doggen CJ, Zivelin A, et al. Geographic distribution of the 20210 G to A prothrombin variant. Thromb Haemost 1998; 79:706 O'Donnell J, Tuddenham EG, Manning R, et al. High prevalence of elevated factor VIII levels in patients referred for thrombophilia screening: role of increased synthesis and relationship to the acute phase reaction. Thromb Haemost 1997; 77:825. Viel KR, Machiah DK, Warren DM, et al. A sequence variation scan of the coagulation factor VIII (FVIII) structural gene and associations with plasma FVIII activity levels. Blood 2007; 109:3713. Lodi S, Isa L, Pollini E, et al. Defective intrinsic fibrinolytic activity in a patient with severe factor XII‐deficiency and myocardial infarction. Scand J Haematol 1984; 33:80. Goldhaber SZ. Risk factors for venous thromboembolism. J Am Coll Cardiol 2010; 56:1 Miyakis S, Lockshin MD, Atsumi T, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006; 4:295. Geerts, W. Pineo,G. Prevention of Venous Thromboembolism. The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy Kujovich JL. Hormones and pregnancy: thromboembolic risks for women. Br J Haematol 2004; 126:443. Spencer FA, Emery C, Lessard D, et al. The Worcester Venous Thromboembolism study: a population‐based study of the clinical epidemiology of venous thromboembolism. J Gen Intern Med 2006; 21:722. Pomp ER, Rosendaal FR, Doggen CJ. Smoking increases the risk of venous thrombosis and acts synergistically with oral contraceptive use. Am J Hematol 2008; 83:97 Ministerio de Salud .Resolución No. 008430 de 1993. 152679 TE00280
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spelling	Feliciano Alfonso, John EdwinCancelado Jácome, Sergio AndrésChinchía Arias, Isabel MatildeSalazar Muñoz, Johana MilenaCalderón Vargas, Carlos MauricioEspecialista en Medicina Interna2012-07-25T15:15:05Z2012-07-25T15:15:05Z2012-07-252011Dahlbäch B, Carlson M, Svenson P. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated Protein C. Proc Natl Acad Sci 1993; 90: 1004.Guidelines on the investigation and management of thrombophilia. J Clin Pathol 1990; 49: 703.GRIFFIN V, SELIGSOH U, RAPPORT S. Coagulation abnormalities in thrombosis. American Society Hematology. Educational Session. Bocklet, Seattle, Washington 1995; 51‐8.CONRAD F. Thrombophilia: diagnosis and management. En: Poller L, Thomas JM (eds): Thrombosis and its Management. London: Churchill‐Livingstone Inc 1993; 113‐ 25.. Bauer K, Goodnight S, Ridkes P. Hypercoagulable States‐Translation of Risk Factors to Clinical Practice. The American Society of Hematology Education Program Book. Janine Editor 1998; 255‐73.Arnaud E, Reny J, Emmerich J, Aiach M. Thrombose veineusse et anomalies genétiques de l’hémostase. Sang Thrombose et Vaissaux 2000; 7: 426‐32.Heijboer H, Brandjes D, Büller H, Sturka A, Ten Cate J. Deficiencies of coagulation‐ inhibitingand fibrinolytic proteins in outpatients with deep venous thrombosis. N Engl J Med 1990; 323: 1512‐6.Hach‐Wunderle V, Scharrer I. Prevalence of hereditary deficiency of antithrombin III, Protein C en Protein S. Dtsch Med Wochenschr 1993; 118: 187‐90. Dahlbäch B. New molecular insights into the genetics of thrombophilia. Resistance to activated protein C caused by Arg (506) to Gln mutation in factor V as a pathogenic risk factor for venous thrombosis. Thromb Haemost 1995; 74: 139‐48.Bertina RM, Reitsma PH, Rosendaal FR, Vandenbroucke JP. Resistance to activated protein C and Factor V as risk factors for venous thrombosis. Thromb Haemost 1995; 74: 449‐53.Mercier E, Queré I, Gris J‐C. Variant 20210 A dugène de la Prothrombine et Thrombose. STV 2001; 4: 13‐23.Grinsberg JS. Management of venous thromboembolism. N Engl J Med 1996; 335: 1816‐28. Derksen Rh, De Groot Pg, Kater L, Nieuwenhuis Hk. Patients with antiphospholipid antibodies and venous thrombosis should receive long term anticoagulant treatment. Ann Rheum Dis 1993; 52: 689‐92.Khamashta Ma, Cuadrado Mj, Mujic F, Taub Na, Hunt Bj, Hughes Gr. The management of thrombosis in the antiphospholipid antibody syndrome. N Eng J Med 1995; 332: 993‐7Torres, J. Inherited Thrombophilia is Associated With Deep Vein Thrombosis in a Colombian Population. American Journal of Hematology 81:933–937 (2006).Alfirevic, Z, Alfirevic, V. Hypercoagulable state, pathophysiology, classification and epidemiology. Clin Chem Lab Med 2010;48(Suppl 1):S15–S26. Stegnar, M. Thrombophilia screening – at the right time, for the right patient, with a good reason. Clin Chem Lab Med 2010;48(Suppl 1):S105–S113 2010Alfirevic, Z, Alfirevic, V. Hypercoagulable state, pathophysiology, classification and epidemiology. Clin Chem Lab Med 2010;48(Suppl 1):S15–S26. Olson ST, Björk I. Regulation of thrombin activity by antithrombin and heparin. Semin Thromb Hemost 1994;20(4):373e409.Anderson J, Witz J. Hypercoagulable States. Clin Chest Med 31 (2010) 659–673Hirsh J, Bauer KA, Donati MB, et al. Parenteral anticoagulants: American College of Chest Physicians Evidence‐Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133:141S. Martinelli I, Mannucci PM, De Stefano V, et al. Different risks of thrombosis in four coagulation defects associated with inherited thrombophilia: a study of 150 families. Blood 1998; 92:2353. Mosnier LO, Zlokovic BV, Griffin JH. The cytoprotective protein C pathway. Blood 2007; 109:3161.Tait RC, Walker ID, Reitsma PH, et al. Prevalence of protein C deficiency in the healthy population. Thromb Haemost 1995; 73:87. Bruijn SF, Stam J, Koopman MM, Vandenbroucke JP. Case‐control study of risk of cerebral sinus thrombosis in oral contraceptive users and in [correction of who are] carriers of hereditary prothrombotic conditions. The Cerebral Venous Sinus Thrombosis Study Group. BMJ 1998; 316:589Nazarian RM, Van Cott EM, Zembowicz A, Duncan LM. Warfarin‐induced skin necrosis. J Am Acad Dermatol 2009; 61:325.Rezende SM, Simmonds RE, Lane DA. Coagulation, inflammation, and apoptosis: different roles for protein S and the protein S‐C4b binding protein complex. Blood 2004; 103:1192Rezende SM, Simmonds RE, Lane DA. Coagulation, inflammation, and apoptosis: different roles for protein S and the protein S‐C4b binding protein complex. Blood 2004; 103:1192. Mustafa S, Mannhalter C, Rintelen C, et al. Clinical features of thrombophilia in families with gene defects in protein C or protein S combined with factor V . Blood Coagul Fibrinolysis 1998; 9:85.Mateo J, Oliver A, Borrell M, et al. Laboratory evaluation and clinical characteristics of 2,132 consecutive unselected patients with venous thromboembolism‐‐results of the Spanish Multicentric Study on Thrombophilia (EMET‐Study). Thromb Haemost 1997; 77:444.Castoldi E, Brugge JM, Nicolaes GA, et al. Impaired APC cofactor activity of factor V plays a major role in the APC resistance associated with the factor V Leiden (R506Q) and R2 (H1299R) mutations. Blood 2004; 103:4173Castoldi E, Rosing J. APC resistance: biological basis and acquired influences. J Thromb Haemost 2010; 8:445.Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3'‐untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88:3698.Rosendaal FR, Doggen CJ, Zivelin A, et al. Geographic distribution of the 20210 G to A prothrombin variant. Thromb Haemost 1998; 79:706O'Donnell J, Tuddenham EG, Manning R, et al. High prevalence of elevated factor VIII levels in patients referred for thrombophilia screening: role of increased synthesis and relationship to the acute phase reaction. Thromb Haemost 1997; 77:825.Viel KR, Machiah DK, Warren DM, et al. A sequence variation scan of the coagulation factor VIII (FVIII) structural gene and associations with plasma FVIII activity levels. Blood 2007; 109:3713.Lodi S, Isa L, Pollini E, et al. Defective intrinsic fibrinolytic activity in a patient with severe factor XII‐deficiency and myocardial infarction. Scand J Haematol 1984; 33:80.Goldhaber SZ. Risk factors for venous thromboembolism. J Am Coll Cardiol 2010; 56:1Anderson J, Witz J. Hypercoagulable States. Clin Chest Med 31 (2010) 659–673Miyakis S, Lockshin MD, Atsumi T, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006; 4:295.Geerts, W. Pineo,G. Prevention of Venous Thromboembolism. The Seventh ACCP Conference on Antithrombotic and Thrombolytic TherapyKujovich JL. Hormones and pregnancy: thromboembolic risks for women. Br J Haematol 2004; 126:443.Spencer FA, Emery C, Lessard D, et al. The Worcester Venous Thromboembolism study: a population‐based study of the clinical epidemiology of venous thromboembolism. J Gen Intern Med 2006; 21:722.Pomp ER, Rosendaal FR, Doggen CJ. Smoking increases the risk of venous thrombosis and acts synergistically with oral contraceptive use. Am J Hematol 2008; 83:97Ministerio de Salud .Resolución No. 008430 de 1993.http://hdl.handle.net/10818/3168152679TE0028051 Páginas.Las trombofilias se definen como tendencia a las trombosis, con variedad de manifestaciones clínicas. Se determinó la frecuencia de trombofilias en una población de pacientes con episodios trombóticos de la Consulta Externa de Hematología en un Hospital de III Nivel de Cundinamarca. Se incluyeron 94 pacientes, 70.2% presentó un evento trombótico, 16% presentó 2 eventos y 13.9% presentó 3 o más; en 47.9% pacientes se identifico alguna trombofilia. Las trombofilias encontradas fueron: Síndrome Antifosfolípidos, Déficit de Proteína S, Déficit de Proteína C, Déficit de Antitrombina III, Resistencia a la Proteína C – Factor V de Leiden, Hiper factor VIII, Mutación del Gen de la Protrombina 20210A. La mayoría de pacientes presentó eventos trombóticos venosos. El tratamiento más frecuente fue la anticoagulación.spaUniversidad de La SabanaEspecialización en Medicina InternaFacultad de MedicinaUniversidad de La SabanaIntellectum Repositorio Universidad de La SabanaTrombofilia-InvestigacionesFrecuencia de trombofilias en una población de pacientes con episodios trombóticos en un hospital universitario de III nivelbachelorThesisTesis de especializaciónpublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_7a1fhttp://purl.org/coar/access_right/c_abf2ORIGINALSergio Andrés Cancelado Jácome.pdfSergio Andrés Cancelado Jácome.pdfVer documento en PDFapplication/pdf1108083https://intellectum.unisabana.edu.co/bitstream/10818/3168/1/Sergio%20Andr%c3%a9s%20Cancelado%20J%c3%a1come.pdf85facec47813066d6cec9243187aace1MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/3168/2/license.txtf52a2cfd4df262e08e9b300d62c85cabMD52TEXTSergio Andrés Cancelado Jácome.pdf.txtSergio Andrés Cancelado Jácome.pdf.txtExtracted Texttext/plain97973https://intellectum.unisabana.edu.co/bitstream/10818/3168/3/Sergio%20Andr%c3%a9s%20Cancelado%20J%c3%a1come.pdf.txted51f26a231a501dff4df5d2b73d2208MD5310818/3168oai:intellectum.unisabana.edu.co:10818/31682019-08-13 15:17:30.557Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.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

Frecuencia de trombofilias en una población de pacientes con episodios trombóticos en un hospital universitario de III nivel

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