New ABCC2 rs3740066 and rs2273697 Polymorphisms Identified in a Healthy Colombian Cohort

5 páginas

Autores:: Bustos Cruz, Rosa Helena
Martínez, Luis Rafael
García Casallas, Julio César
Barreto, George E.
Suárez, Fernando

Tipo de recurso:

Fecha de publicación:: 2018

Institución:: Universidad de la Sabana

Repositorio:: Repositorio Universidad de la Sabana

Idioma:: eng

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dc.title.es_CO.fl_str_mv	New ABCC2 rs3740066 and rs2273697 Polymorphisms Identified in a Healthy Colombian Cohort
dc.title.alternative.es_CO.fl_str_mv	Nuevos polimorfismos ABCC2 rs3740066 y rs2273697 identificados en una cohorte colombiana sana
title	New ABCC2 rs3740066 and rs2273697 Polymorphisms Identified in a Healthy Colombian Cohort
spellingShingle	New ABCC2 rs3740066 and rs2273697 Polymorphisms Identified in a Healthy Colombian Cohort ATP-Binding-casete (ABC) MRP1 y MRP2 Resistencia a las drogas Variabilidad genética Polimorfismos
title_short	New ABCC2 rs3740066 and rs2273697 Polymorphisms Identified in a Healthy Colombian Cohort
title_full	New ABCC2 rs3740066 and rs2273697 Polymorphisms Identified in a Healthy Colombian Cohort
title_fullStr	New ABCC2 rs3740066 and rs2273697 Polymorphisms Identified in a Healthy Colombian Cohort
title_full_unstemmed	New ABCC2 rs3740066 and rs2273697 Polymorphisms Identified in a Healthy Colombian Cohort
title_sort	New ABCC2 rs3740066 and rs2273697 Polymorphisms Identified in a Healthy Colombian Cohort
dc.creator.fl_str_mv	Bustos Cruz, Rosa Helena Martínez, Luis Rafael García Casallas, Julio César Barreto, George E. Suárez, Fernando
dc.contributor.author.none.fl_str_mv	Bustos Cruz, Rosa Helena Martínez, Luis Rafael García Casallas, Julio César Barreto, George E. Suárez, Fernando
dc.subject.es_CO.fl_str_mv	ATP-Binding-casete (ABC) MRP1 y MRP2 Resistencia a las drogas Variabilidad genética Polimorfismos
topic	ATP-Binding-casete (ABC) MRP1 y MRP2 Resistencia a las drogas Variabilidad genética Polimorfismos
description	5 páginas
publishDate	2018
dc.date.accessioned.none.fl_str_mv	10/20/2020 10:38
dc.date.issued.none.fl_str_mv	2018-07-17
dc.date.available.none.fl_str_mv	2020-10-20T15:38:26Z
dc.type.en.fl_str_mv	article
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dc.identifier.issn.none.fl_str_mv	1999-4923
dc.identifier.other.none.fl_str_mv	https://pubmed.ncbi.nlm.nih.gov/30018187/ https://www.mdpi.com/1999-4923/10/3/93/htm
dc.identifier.uri.none.fl_str_mv	http://hdl.handle.net/10818/43730
dc.identifier.doi.none.fl_str_mv	10.3390/pharmaceutics10030093
identifier_str_mv	1999-4923 10.3390/pharmaceutics10030093
url	https://pubmed.ncbi.nlm.nih.gov/30018187/ https://www.mdpi.com/1999-4923/10/3/93/htm http://hdl.handle.net/10818/43730
dc.language.iso.es_CO.fl_str_mv	eng
language	eng
dc.relation.ispartofseries.none.fl_str_mv	Farmacia . 2018 17 de julio;10 (3): 93
dc.rights.*.fl_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.coar.fl_str_mv	http://purl.org/coar/access_right/c_abf2
dc.rights.uri.*.fl_str_mv	http://creativecommons.org/licenses/by-nc-nd/4.0/
rights_invalid_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2
dc.format.es_CO.fl_str_mv	application/pdf
dc.publisher.es_CO.fl_str_mv	Pharmaceutics
dc.source.es_CO.fl_str_mv	Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana
institution	Universidad de la Sabana
bitstream.url.fl_str_mv	https://intellectum.unisabana.edu.co/bitstream/10818/43730/2/license_rdf https://intellectum.unisabana.edu.co/bitstream/10818/43730/3/license.txt
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spelling	Bustos Cruz, Rosa HelenaMartínez, Luis RafaelGarcía Casallas, Julio CésarBarreto, George E.Suárez, Fernando10/20/2020 10:382020-10-20T15:38:26Z2018-07-171999-4923https://pubmed.ncbi.nlm.nih.gov/30018187/https://www.mdpi.com/1999-4923/10/3/93/htmhttp://hdl.handle.net/10818/4373010.3390/pharmaceutics100300935 páginasMultidrug resistance-associated proteins (MRP) 1 and 2 belong to the ABC (ATP-Binding Cassette) transporters. These transport proteins are involved in the removal of various drugs and xenobiotics, as well as in multiple physiological, pathological, and pharmacological processes. There is a strong correlation between different polymorphisms and their clinical implication in resistance to antiepileptic drugs, anticancer, and anti-infective agents. In our study, we evaluated exon regions of MRP1 (ABCC1)/MRP2 (ABCC2) in a Colombian cohort of healthy subjects to determine single nucleotide polymorphisms (SNPs) and to determine the allelic and genomic frequency. Results showed there are SNPs in our population that have been previously reported for both MRP1/ABCC1 (rs200647436, rs200624910, rs150214567) and MRP2/ABCC2 (rs2273697, rs3740066, rs142573385, rs17216212). Additionally, 13 new SNPs were identified. Evidence also shows a significant clinical correlation for polymorphisms rs3740066 and rs2273697 in the transport of multiple drugs, which suggests a genetic variability in regards to that reported in other populations.Las proteínas asociadas a la resistencia a múltiples fármacos (MRP) 1 y 2 pertenecen a los transportadores ABC (ATP-Binding Cassette). Estas proteínas de transporte intervienen en la eliminación de diversos fármacos y xenobióticos, así como en múltiples procesos fisiológicos, patológicos y farmacológicos. Existe una fuerte correlación entre los diferentes polimorfismos y su implicación clínica en la resistencia a los fármacos antiepilépticos, anticancerígenos y antiinfecciosos. En nuestro estudio, evaluamos las regiones del exón de MRP1 (ABCC1) / MRP2 (ABCC2) en una cohorte colombiana de sujetos sanos para determinar los polimorfismos de un solo nucleótido (SNP) y para determinar la frecuencia alélica y genómica. Los resultados mostraron que hay SNP en nuestra población que se han informado previamente tanto para MRP1 / ABCC1 (rs200647436, rs200624910, rs150214567) como para MRP2 / ABCC2 (rs2273697, rs3740066, rs142573385, rs17216212). Además, se identificaron 13 nuevos SNP. La evidencia también muestra una correlación clínica significativa para los polimorfismos rs3740066 y rs2273697 en el transporte de múltiples fármacos, lo que sugiere una variabilidad genética con respecto a lo reportado en otras poblaciones.application/pdfengPharmaceuticsFarmacia . 2018 17 de julio;10 (3): 93Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaATP-Binding-casete (ABC)MRP1 y MRP2Resistencia a las drogasVariabilidad genéticaPolimorfismosNew ABCC2 rs3740066 and rs2273697 Polymorphisms Identified in a Healthy Colombian CohortNuevos polimorfismos ABCC2 rs3740066 y rs2273697 identificados en una cohorte colombiana sanaarticlepublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://intellectum.unisabana.edu.co/bitstream/10818/43730/2/license_rdf4460e5956bc1d1639be9ae6146a50347MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/43730/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD5310818/43730oai:intellectum.unisabana.edu.co:10818/437302022-05-10 05:20:20.908Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.coPGEgcmVsPSJsaWNlbnNlIiBocmVmPSJodHRwOi8vY3JlYXRpdmVjb21tb25zLm9yZy9saWNlbnNlcy9ieS1uYy1uZC8zLjAvIj48aW1nIGFsdD0iTGljZW5jaWEgQ3JlYXRpdmUgQ29tbW9ucyIgc3R5bGU9ImJvcmRlci13aWR0aDowIiBzcmM9Imh0dHA6Ly9pLmNyZWF0aXZlY29tbW9ucy5vcmcvbC9ieS1uYy1uZC8zLjAvODh4MzEucG5nIiAvPjwvYT48YnIgLz5Fc3RlIDxzcGFuIHhtbG5zOmRjdD0iaHR0cDovL3B1cmwub3JnL2RjL3Rlcm1zLyIgaHJlZj0iaHR0cDovL3B1cmwub3JnL2RjL2RjbWl0eXBlL1RleHQiIHJlbD0iZGN0OnR5cGUiPm9icmE8L3NwYW4+IGVzdMOhIGJham8gdW5hIDxhIHJlbD0ibGljZW5zZSIgaHJlZj0iaHR0cDovL2NyZWF0aXZlY29tbW9ucy5vcmcvbGljZW5zZXMvYnktbmMtbmQvMy4wLyI+bGljZW5jaWEgQ3JlYXRpdmUgQ29tbW9ucyBSZWNvbm9jaW1pZW50by1Ob0NvbWVyY2lhbC1TaW5PYnJhRGVyaXZhZGEgMy4wIFVucG9ydGVkPC9hPi4K

New ABCC2 rs3740066 and rs2273697 Polymorphisms Identified in a Healthy Colombian Cohort

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