Papel de la histona demetilasa kdm4c en el desarrollo del cáncer de seno triple negativo

123 páginas

Autores:
García Serrano, Jeison
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Fecha de publicación:
2018
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Universidad de la Sabana
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Repositorio Universidad de la Sabana
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spa
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oai:intellectum.unisabana.edu.co:10818/35133
Acceso en línea:
http://hdl.handle.net/10818/35133
Palabra clave:
Macromoléculas
Genética
ADN
Cromatina
Enfermedades de la mama -- Cáncer
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Attribution-NonCommercial-NoDerivatives 4.0 International
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dc.title.es_CO.fl_str_mv Papel de la histona demetilasa kdm4c en el desarrollo del cáncer de seno triple negativo
title Papel de la histona demetilasa kdm4c en el desarrollo del cáncer de seno triple negativo
spellingShingle Papel de la histona demetilasa kdm4c en el desarrollo del cáncer de seno triple negativo
Macromoléculas
Genética
ADN
Cromatina
Enfermedades de la mama -- Cáncer
title_short Papel de la histona demetilasa kdm4c en el desarrollo del cáncer de seno triple negativo
title_full Papel de la histona demetilasa kdm4c en el desarrollo del cáncer de seno triple negativo
title_fullStr Papel de la histona demetilasa kdm4c en el desarrollo del cáncer de seno triple negativo
title_full_unstemmed Papel de la histona demetilasa kdm4c en el desarrollo del cáncer de seno triple negativo
title_sort Papel de la histona demetilasa kdm4c en el desarrollo del cáncer de seno triple negativo
dc.creator.fl_str_mv García Serrano, Jeison
dc.contributor.advisor.none.fl_str_mv Lizcano Losada, Fernando
dc.contributor.author.none.fl_str_mv García Serrano, Jeison
dc.subject.es_CO.fl_str_mv Macromoléculas
Genética
ADN
Cromatina
Enfermedades de la mama -- Cáncer
topic Macromoléculas
Genética
ADN
Cromatina
Enfermedades de la mama -- Cáncer
description 123 páginas
publishDate 2018
dc.date.issued.none.fl_str_mv 2018-11-14
dc.date.accessioned.none.fl_str_mv 3/12/2019 11:22
dc.date.available.none.fl_str_mv 3/12/2019 11:22
dc.type.es_CO.fl_str_mv doctoralThesis
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dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_db06
dc.type.local.none.fl_str_mv Tesis de doctorado
dc.type.hasVersion.es_CO.fl_str_mv publishedVersion
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/10818/35133
dc.identifier.local.none.fl_str_mv 270587
TE09992
url http://hdl.handle.net/10818/35133
identifier_str_mv 270587
TE09992
dc.language.iso.es_CO.fl_str_mv spa
language spa
dc.rights.*.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
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dc.publisher.es_CO.fl_str_mv Universidad de La Sabana
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instname_str Universidad de La Sabana
institution Universidad de la Sabana
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spelling Lizcano Losada, FernandoGarcía Serrano, Jeison3/12/2019 11:223/12/2019 11:222018-11-14http://hdl.handle.net/10818/35133270587TE09992123 páginasLa complejidad del ser humano se concentra en los más de 30000 genes que componen nuestro genoma, almacenando la información necesaria para la expresión de macromoléculas en espacio y tiempo específicos, permitiendo el mantenimiento del fenotipo celular [1]. La regulación de la expresión génica envuelve la modificación de la estructura compleja del ADN nuclear, alterando la complejidad del enrollamiento de la doble hebra en un octámero de proteínas histonas como parte de la unidad básica de la cromatina: el nucleosoma [2, 3]. El nucleosoma fue descrito por el premio nobel de química en 1974, Roger Kornberg [3], y está compuesto por un octámero de cuatro proteínas llamadas histonas (H3, H4, H2A y H2B), proteínas muy básicas alrededor de las cuales se enrollan 147 pares de bases de ADN dando 1,65 vueltas y cuya estructura se interconecta con los nucleosomas adyacentes mediante la histona H1.application/pdfspaUniversidad de La SabanaAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2instname:Universidad de La Sabanareponame:Intellectum Repositorio Universidad de La SabanaMacromoléculasGenéticaADNCromatinaEnfermedades de la mama -- CáncerPapel de la histona demetilasa kdm4c en el desarrollo del cáncer de seno triple negativodoctoralThesisTesis de doctoradopublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_db06B.S. Shruthi, P. 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Stein, Targeting deregulated epigenetic controlFacultad de IngenieríaUniversidad de La SabanaDoctorado en BiocienciasDoctor en BiocienciasORIGINALTESIS FINAL Jeison G.pdfTESIS FINAL Jeison G.pdfVer documento en PDFapplication/pdf1151351https://intellectum.unisabana.edu.co/bitstream/10818/35133/1/TESIS%20FINAL%20Jeison%20G.pdfe707eff2759a1c4d86628839e042165cMD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://intellectum.unisabana.edu.co/bitstream/10818/35133/2/license_rdf4460e5956bc1d1639be9ae6146a50347MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/35133/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD53carta jeison.pdfcarta jeison.pdfCartaapplication/pdf1981933https://intellectum.unisabana.edu.co/bitstream/10818/35133/4/carta%20jeison.pdf75e1bc895857998781138d8409374655MD54TEXTTESIS FINAL Jeison G.pdf.txtTESIS FINAL Jeison G.pdf.txtExtracted texttext/plain164912https://intellectum.unisabana.edu.co/bitstream/10818/35133/5/TESIS%20FINAL%20Jeison%20G.pdf.txt725c13491821235e72ca2f95aef8ea4eMD5510818/35133oai:intellectum.unisabana.edu.co:10818/351332022-02-18 12:09:01.185Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.coPGEgcmVsPSJsaWNlbnNlIiBocmVmPSJodHRwOi8vY3JlYXRpdmVjb21tb25zLm9yZy9saWNlbnNlcy9ieS1uYy1uZC8zLjAvIj48aW1nIGFsdD0iTGljZW5jaWEgQ3JlYXRpdmUgQ29tbW9ucyIgc3R5bGU9ImJvcmRlci13aWR0aDowIiBzcmM9Imh0dHA6Ly9pLmNyZWF0aXZlY29tbW9ucy5vcmcvbC9ieS1uYy1uZC8zLjAvODh4MzEucG5nIiAvPjwvYT48YnIgLz5Fc3RlIDxzcGFuIHhtbG5zOmRjdD0iaHR0cDovL3B1cmwub3JnL2RjL3Rlcm1zLyIgaHJlZj0iaHR0cDovL3B1cmwub3JnL2RjL2RjbWl0eXBlL1RleHQiIHJlbD0iZGN0OnR5cGUiPm9icmE8L3NwYW4+IGVzdMOhIGJham8gdW5hIDxhIHJlbD0ibGljZW5zZSIgaHJlZj0iaHR0cDovL2NyZWF0aXZlY29tbW9ucy5vcmcvbGljZW5zZXMvYnktbmMtbmQvMy4wLyI+bGljZW5jaWEgQ3JlYXRpdmUgQ29tbW9ucyBSZWNvbm9jaW1pZW50by1Ob0NvbWVyY2lhbC1TaW5PYnJhRGVyaXZhZGEgMy4wIFVucG9ydGVkPC9hPi4K

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