Micronutrient status in middle childhood and age at menarche: results from the Bogotá School Children Cohort

9 páginas

Autores:: Villamor, Eduardo
Marín, Constanza
Mora Plazas, Mercedes
Oliveros Rodríguez, Henry

Tipo de recurso:

Fecha de publicación:: 2017

Institución:: Universidad de la Sabana

Repositorio:: Repositorio Universidad de la Sabana

Idioma:: eng

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spelling	Villamor, EduardoMarín, ConstanzaMora Plazas, MercedesOliveros Rodríguez, Henry7/17/2019 10:152019-07-17T15:15:04Z2017-121475-2662https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/micronutrient-status-in-middle-childhood-and-age-at-menarche-results-from-the-bogota-school-children-cohort/D4396E109CB362F8B6CA4087E4AAD2E0http://hdl.handle.net/10818/3619310.1017/S00071145170031309 páginasChildhood intake of animal foods is associated with age at first menstrual period (menarche). It is unknown whether the micronutrients present in these foods could explain this association. Our objective was to investigate the associations of micronutrient status biomarkers in middle childhood with age at menarche. We quantified circulating Hb, ferritin, mean corpuscular volume, Zn, vitamin B12, erythrocyte folate and retinol in 1464 pre-menarcheal girls aged 5–12 years in Bogotá, Colombia, and followed them for a median 5·7 years for the occurrence and date of menarche. We estimated median age at menarche and hazard ratios (HR) with 95 % CI by levels of each biomarker with use of Kaplan–Meier survival probabilities and Cox regression, respectively. Median age at menarche was 12·4 years. Middle childhood Hb was inversely related to age at menarche whereas plasma ferritin was positively associated with this outcome in a linear manner. HR of menarche for every 1 sd of Hb (11 g/l) and ferritin (23·2 µg/l) were 1·11 (95 % CI 1·04, 1·18; P=0·001) and 0·94 (95 % CI 0·88, 0·99; P=0·02), respectively, after adjustment for baseline age, C-reactive protein concentration, maternal age at menarche and parity and socioeconomic status. The association with ferritin was stronger in girls aged 9–10 years at baseline. Additional adjustment for baseline height- and BMI-for-age did not change the results. We conclude that higher Fe status in middle childhood is related to later age at menarche whereas Hb concentrations are inversely associated with age at onset of menses.application/pdfengBritish Journal of NutritionBritish Journal of Nutrition (2017), 118, 1097–1105Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaMenarcheHbFerritinMicronutrientsMiddle childhoodMicronutrient status in middle childhood and age at menarche: results from the Bogotá School Children CohortarticlepublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://intellectum.unisabana.edu.co/bitstream/10818/36193/2/license_rdf4460e5956bc1d1639be9ae6146a50347MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/36193/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD5310818/36193oai:intellectum.unisabana.edu.co:10818/361932022-05-10 05:18:18.332Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.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
dc.title.es_CO.fl_str_mv	Micronutrient status in middle childhood and age at menarche: results from the Bogotá School Children Cohort
title	Micronutrient status in middle childhood and age at menarche: results from the Bogotá School Children Cohort
spellingShingle	Micronutrient status in middle childhood and age at menarche: results from the Bogotá School Children Cohort Menarche Hb Ferritin Micronutrients Middle childhood
title_short	Micronutrient status in middle childhood and age at menarche: results from the Bogotá School Children Cohort
title_full	Micronutrient status in middle childhood and age at menarche: results from the Bogotá School Children Cohort
title_fullStr	Micronutrient status in middle childhood and age at menarche: results from the Bogotá School Children Cohort
title_full_unstemmed	Micronutrient status in middle childhood and age at menarche: results from the Bogotá School Children Cohort
title_sort	Micronutrient status in middle childhood and age at menarche: results from the Bogotá School Children Cohort
dc.creator.fl_str_mv	Villamor, Eduardo Marín, Constanza Mora Plazas, Mercedes Oliveros Rodríguez, Henry
dc.contributor.author.none.fl_str_mv	Villamor, Eduardo Marín, Constanza Mora Plazas, Mercedes Oliveros Rodríguez, Henry
dc.subject.es_CO.fl_str_mv	Menarche Hb Ferritin Micronutrients Middle childhood
topic	Menarche Hb Ferritin Micronutrients Middle childhood
description	9 páginas
publishDate	2017
dc.date.issued.none.fl_str_mv	2017-12
dc.date.available.none.fl_str_mv	2019-07-17T15:15:04Z
dc.date.accessioned.none.fl_str_mv	7/17/2019 10:15
dc.type.en.fl_str_mv	article
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dc.type.hasVersion.es_CO.fl_str_mv	publishedVersion
dc.identifier.issn.none.fl_str_mv	1475-2662
dc.identifier.other.none.fl_str_mv	https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/micronutrient-status-in-middle-childhood-and-age-at-menarche-results-from-the-bogota-school-children-cohort/D4396E109CB362F8B6CA4087E4AAD2E0
dc.identifier.uri.none.fl_str_mv	http://hdl.handle.net/10818/36193
dc.identifier.doi.none.fl_str_mv	10.1017/S0007114517003130
identifier_str_mv	1475-2662 10.1017/S0007114517003130
url	https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/micronutrient-status-in-middle-childhood-and-age-at-menarche-results-from-the-bogota-school-children-cohort/D4396E109CB362F8B6CA4087E4AAD2E0 http://hdl.handle.net/10818/36193
dc.language.iso.es_CO.fl_str_mv	eng
language	eng
dc.relation.ispartofseries.none.fl_str_mv	British Journal of Nutrition (2017), 118, 1097–1105
dc.rights.*.fl_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.coar.fl_str_mv	http://purl.org/coar/access_right/c_abf2
dc.rights.uri.*.fl_str_mv	http://creativecommons.org/licenses/by-nc-nd/4.0/
rights_invalid_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2
dc.format.es_CO.fl_str_mv	application/pdf
dc.publisher.es_CO.fl_str_mv	British Journal of Nutrition
dc.source.es_CO.fl_str_mv	Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana
institution	Universidad de la Sabana
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Micronutrient status in middle childhood and age at menarche: results from the Bogotá School Children Cohort

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