Prevalencia y comportamiento clínico de la infección por metapneumovirus humano en pacientes pediátricos con infección respiratoria aguda en la Fundación Cardioinfantil de Bogotá del 2015-2017

57 páginas

Autores:: Obando Belalcázar, Evelyn Paola
Montoya Jiménez, David Leonardo

Tipo de recurso:

Fecha de publicación:: 2019

Institución:: Universidad de la Sabana

Repositorio:: Repositorio Universidad de la Sabana

Idioma:: spa

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dc.title.es_CO.fl_str_mv	Prevalencia y comportamiento clínico de la infección por metapneumovirus humano en pacientes pediátricos con infección respiratoria aguda en la Fundación Cardioinfantil de Bogotá del 2015-2017
title	Prevalencia y comportamiento clínico de la infección por metapneumovirus humano en pacientes pediátricos con infección respiratoria aguda en la Fundación Cardioinfantil de Bogotá del 2015-2017
spellingShingle	Prevalencia y comportamiento clínico de la infección por metapneumovirus humano en pacientes pediátricos con infección respiratoria aguda en la Fundación Cardioinfantil de Bogotá del 2015-2017 Metapneumovirus Enfermedades respiratorias pediátricas Insuficiencia respiratoria en niños -- Prevención y control
title_short	Prevalencia y comportamiento clínico de la infección por metapneumovirus humano en pacientes pediátricos con infección respiratoria aguda en la Fundación Cardioinfantil de Bogotá del 2015-2017
title_full	Prevalencia y comportamiento clínico de la infección por metapneumovirus humano en pacientes pediátricos con infección respiratoria aguda en la Fundación Cardioinfantil de Bogotá del 2015-2017
title_fullStr	Prevalencia y comportamiento clínico de la infección por metapneumovirus humano en pacientes pediátricos con infección respiratoria aguda en la Fundación Cardioinfantil de Bogotá del 2015-2017
title_full_unstemmed	Prevalencia y comportamiento clínico de la infección por metapneumovirus humano en pacientes pediátricos con infección respiratoria aguda en la Fundación Cardioinfantil de Bogotá del 2015-2017
title_sort	Prevalencia y comportamiento clínico de la infección por metapneumovirus humano en pacientes pediátricos con infección respiratoria aguda en la Fundación Cardioinfantil de Bogotá del 2015-2017
dc.creator.fl_str_mv	Obando Belalcázar, Evelyn Paola Montoya Jiménez, David Leonardo
dc.contributor.advisor.none.fl_str_mv	Fernández Sarmiento, Jaime Gamboa Garay, Oscar Andrés Acevedo, Lorena
dc.contributor.author.none.fl_str_mv	Obando Belalcázar, Evelyn Paola Montoya Jiménez, David Leonardo
dc.subject.es_CO.fl_str_mv	Metapneumovirus Enfermedades respiratorias pediátricas Insuficiencia respiratoria en niños -- Prevención y control
topic	Metapneumovirus Enfermedades respiratorias pediátricas Insuficiencia respiratoria en niños -- Prevención y control
description	57 páginas
publishDate	2019
dc.date.accessioned.none.fl_str_mv	2019-04-30T19:28:59Z
dc.date.available.none.fl_str_mv	2019-04-30T19:28:59Z
dc.date.issued.none.fl_str_mv	2019-01-25
dc.date.created.none.fl_str_mv	Especialista en Cuidado Intensivo Pediátrico
dc.type.es_CO.fl_str_mv	bachelorThesis
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dc.identifier.citation.none.fl_str_mv	Van den Hoogen BG, de Jong JC, Groen J, Kuiken T, de Groot R, Fouchier RA, Osterhaus AD. A newly discovered human metapneumovirus isolated from young children with respiratory tract disease. Nat Med. 2001;7(6):719–24. Betty E. Owor, Geoffrey N. Masankwa, et al. Human metapneumovirus epidemiological and evolutionary patterns in Coastal Kenya,2007-11, BMC Infectious Diseases (2016) 16:301 Skiadopoulos MH, Biacchesi et al. Individual contributions of the human metapneumovirus F, G, and SH surface glycoproteins to the induction of neutralizing antibodies and protective immunity. Virology. 2006;345(2):492–501. Jennifer E. Schuster and John V. Williams. BMC Infectious Diseases (2016) 16:301Pediatrics in Review 2013;34;558 Williams JV, Edwards KM, Weinberg GA et al. Population-based incidence of human metapneumovirus infection among hospitalized children. J Infect Dis. 2010;201:1890–8 Barbosa Ramirez J, Pulido Dominguez P, Rey Benito G, et al. Human respiratory syncytial virus and metapneumovirus in patients with acute respiratory infection in Colombia, 2000-2011. Rev Panam Salud Publica. 2014;36(2):101–109. Panda S, Mohakud N, Pena L, Kumar S. Human metapneumovirus: review of an important respiratory pathogen. International Journal of Infectious Diseases (2014) 25 e45–e52 Erickson JJ, Gilchuk P, Hastings AK, et al. Viral acute lower respiratory infections impair CD8þ T cells through PD-1. J Clin Invest. 2012;122(8):2967–2982 Spaulding, Harris PA, Tollefson SJ, et al. Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children. N Engl J Med. 2004;350(5): 443–450 Williams JV, Tollefson SJ, Nair S, Chonmaitree T. Association of human metapneumovirus with acute otitis media. Int J Pediatr Otorhinolaryngol 2006;70(7):1189–1193 Madhi SA, Ludewick H, Kuwanda L, et al. Pneumococcal coinfection with human metapneumovirus. J Infect Dis. 2006;193 (9):1236–1243 García-García ML, Calvo C, Casas I, et al. Human metapneumovirus bronchiolitis in infancy is an important risk factor for asthma at age 5. Pediatr Pulmonol 2007 Widmer K, Zhu Y, Williams JV, Griffin MR, Edwards KM, Talbot HK. Rates of hospitalizations for respiratory syncytial virus, human metapneumovirus, and influenza virus in older adults. J Infect Dis. 2012;206(1):56–62 Estrada B, Carter M, Barik S, Vidal R, Herbert D, Ramsey KM. Severe human metapneumovirus infection in hospitalized children. Clin Pediatr (Phila) 2007;46(3):258–262 Van den Hoogen BG, Osterhaus DM, Fouchier RA. Clinical impact and diagnosis of human metapneumovirus infection. Pediatr Infect Dis J 2004;23(1, Suppl):S25–S32 Paget SP, Andresen DN, Kesson AM, Egan JR. Comparison of human metapneumovirus and respiratory syncytial virus in children admitted to a paediatric intensive care unit. J Paediatr Child Health 2011;47(10):737–741 Hahn A, Wang W, Jaggi P, et al. Human metapneumovirus infections are associated with severe morbidity in hospitalized children of all ages. Epidemiol Infect 2013;141(10): 2213–2223 Maertzdorf J, Wang CK, Brown JB, et al. Real-time reverse transcriptase PCR assay for detection of human metapneumoviruses from all known genetic lineages. J Clin Microbiol 2004; 42(3):981–986 Principi N, Bosis S, Esposito S. Human metapneumovirus in paediatric patients. Clin Microbiol Infect 2006;12(4):301–308 Piralla A, Lunghi G, Percivalle E et al. FilmArray respiratory panel performance in respiratory samples from neonatal care units. Diagn Microbiol Infect Dis [Internet]. Elsevier Inc.; 2014;79(2):183–6. Pardo J, Klinker KP, Borgert SJ, Butler BM, Giglio PG, Rand KH. Clinical and economic impact of antimicrobial stewardship interventions with the FilmArray blood culture identification panel. Diagn Microbiol Infect Dis. 2016 Feb;84(2):159- 64 Marcone, D. N., Carballal, G., Ricarte, C., & Echavarria, M. (2015). Diagnóstico de virus respiratorios utilizando un sistema automatizado de PCR múltiples (FilmArray) y su comparación con métodos convencionales. Revista Argentina de Microbiologia, 47(1), 29–35 Graci JD, Cameron CE. Mechanisms of action of ribavirin against distinct viruses. Rev Med Virol 2006;16(1):37–48 Leévy C, Aerts L, Hamelin ME, et al. Virus-like particle vaccine induces crossprotection against human metapneumovirus infections in mice. Vaccine 2013;31(25):2778–2785 Ren, J., Phan, T., & Bao, X. (2015). Recent vaccine development for human metapneumovirus. Journal of General Virology, 96(7), 1515–1520 McCracken JP, Arvelo W, Ortíz J, et al. Comparative epidemiology of human metapneumovirus- and respiratory syncytial virus-associated hospitalizations in Guatemala. Influenza Other Respir Viruses 2014;8:414–21. United nations children´s fund (UNICEF). Levels and trends in child mortality. Report 2018. Disponible en: https://data.unicef.org/wpcontent/uploads/2018/10/Child-Mortality-Report-2018.pdf Avila Adarme, Leidy Viviana. Identificación de la presencia de dos paramixovirus (virus sincitial respiratorio y metapneumovirus humano) en muestras de secreciones respiratorias recolectadas durante la vigilancia centinela en Colombia del 2000 al 2009. Maestría thesis, Universidad Nacional de Colombia. (2014) Liu P, Xu M. Epidemiology of Respiratory Pathogens in Children with Lower Respiratory Tract Infections in Shanghai, China, from 2013 to 2015. Jpn J Infect Dis. 2018 Jan 23;71(1):39-44. Appak, Duman et al. Viral respiratory infections diagnosed by multiplex polymerase chain reaction in pediatric patients. J Med Virol. 2018 Dec 20 Jain S, Williams DJ, Arnold SR, et al. Community-Acquired Pneumonia Requiring Hospitalization among U.S. Children. N Engl J Med. 2015; 372:835-45. Nor'e SS, Sam IC, Mohamad Fakri EF, et al. Phylogenetic analysisof hu man metapneumovirus among children with acute respiratory infections in Kuala Lumpur, Malaysia. Trop Biomed 2014;31:562–6. García-García ML1,2,3, Calvo C. Human metapnuemovirus infections in hospitalized children and comparison with other respiratory viruses. 2005-2014 prospective study. PLoS One. 2017 Mar 16;12(3):e0173504 Broor S, Bharaj P, Chahar HS. Human metapneumovirus: a new respiratory pathogen. J Biosci 2008;33:483–93. Loo LH, Tan BH, Ng LM, Tee NW, Lin RT, Sugrue RJ. Human metapneumovirus in children, Singapore. Emerging infectious diseases. 2007;13(9):1396. Schuster JE, Khuri-Bulos N, Faouri S, Shehabi A, Johnson M, Wang L, et al. Human Metapneumovirus Infection in Jordanian Children. Epidemiology and Risk Factors for Severe Disease. Pediatr Infect Dis J 2015;34:1335–1341 McAdam AJ, Hasenbein ME, Feldman HA, et al. Human metapneumovirus in children tested at a tertiary-care hospital. J Infect Dis 2004;190:20–6. Samransamruajkit R, Thanasugarn W, Prapphal N, Theamboonlers A, Poovorawan Y. Human metapneumovirus in infants and young children in Thailand with lower respiratory tract infections; molecular characteristics and clinical presentations. Journal of Infection. 2006;52(4):254-263. Lim FJ, de Klerk N et al Systematic review and meta-analysis of respiratory viral coinfections in children. 2016 Respirology.May;21(4):648-55. Rodriguez PE, Adamo MP, Paglini MG, et al. [Monoinfection of human metapneumovirus in Cordoba: first clinical and epidemiological research in children with respiratory infection in 2011]. Rev Fac Cien Med Univ Nac Cordoba 2016;73:170–5. Zhang L, Liu W et al. Epidemiological and clinical features of human metapneumovirus in hospitalised paediatric patients with acute respiratory illness: a cross-sectional study in Southern China, from 2013 to 2016. BMJ Open. 2018 Feb 6;8(2):e019308.
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dc.identifier.local.none.fl_str_mv	271090 TE10077
identifier_str_mv	Van den Hoogen BG, de Jong JC, Groen J, Kuiken T, de Groot R, Fouchier RA, Osterhaus AD. A newly discovered human metapneumovirus isolated from young children with respiratory tract disease. Nat Med. 2001;7(6):719–24. Betty E. Owor, Geoffrey N. Masankwa, et al. Human metapneumovirus epidemiological and evolutionary patterns in Coastal Kenya,2007-11, BMC Infectious Diseases (2016) 16:301 Skiadopoulos MH, Biacchesi et al. Individual contributions of the human metapneumovirus F, G, and SH surface glycoproteins to the induction of neutralizing antibodies and protective immunity. Virology. 2006;345(2):492–501. Jennifer E. Schuster and John V. Williams. BMC Infectious Diseases (2016) 16:301Pediatrics in Review 2013;34;558 Williams JV, Edwards KM, Weinberg GA et al. Population-based incidence of human metapneumovirus infection among hospitalized children. J Infect Dis. 2010;201:1890–8 Barbosa Ramirez J, Pulido Dominguez P, Rey Benito G, et al. Human respiratory syncytial virus and metapneumovirus in patients with acute respiratory infection in Colombia, 2000-2011. Rev Panam Salud Publica. 2014;36(2):101–109. Panda S, Mohakud N, Pena L, Kumar S. Human metapneumovirus: review of an important respiratory pathogen. International Journal of Infectious Diseases (2014) 25 e45–e52 Erickson JJ, Gilchuk P, Hastings AK, et al. Viral acute lower respiratory infections impair CD8þ T cells through PD-1. J Clin Invest. 2012;122(8):2967–2982 Spaulding, Harris PA, Tollefson SJ, et al. Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children. N Engl J Med. 2004;350(5): 443–450 Williams JV, Tollefson SJ, Nair S, Chonmaitree T. Association of human metapneumovirus with acute otitis media. Int J Pediatr Otorhinolaryngol 2006;70(7):1189–1193 Madhi SA, Ludewick H, Kuwanda L, et al. Pneumococcal coinfection with human metapneumovirus. J Infect Dis. 2006;193 (9):1236–1243 García-García ML, Calvo C, Casas I, et al. Human metapneumovirus bronchiolitis in infancy is an important risk factor for asthma at age 5. Pediatr Pulmonol 2007 Widmer K, Zhu Y, Williams JV, Griffin MR, Edwards KM, Talbot HK. Rates of hospitalizations for respiratory syncytial virus, human metapneumovirus, and influenza virus in older adults. J Infect Dis. 2012;206(1):56–62 Estrada B, Carter M, Barik S, Vidal R, Herbert D, Ramsey KM. Severe human metapneumovirus infection in hospitalized children. Clin Pediatr (Phila) 2007;46(3):258–262 Van den Hoogen BG, Osterhaus DM, Fouchier RA. Clinical impact and diagnosis of human metapneumovirus infection. Pediatr Infect Dis J 2004;23(1, Suppl):S25–S32 Paget SP, Andresen DN, Kesson AM, Egan JR. Comparison of human metapneumovirus and respiratory syncytial virus in children admitted to a paediatric intensive care unit. J Paediatr Child Health 2011;47(10):737–741 Hahn A, Wang W, Jaggi P, et al. Human metapneumovirus infections are associated with severe morbidity in hospitalized children of all ages. Epidemiol Infect 2013;141(10): 2213–2223 Maertzdorf J, Wang CK, Brown JB, et al. Real-time reverse transcriptase PCR assay for detection of human metapneumoviruses from all known genetic lineages. J Clin Microbiol 2004; 42(3):981–986 Principi N, Bosis S, Esposito S. Human metapneumovirus in paediatric patients. Clin Microbiol Infect 2006;12(4):301–308 Piralla A, Lunghi G, Percivalle E et al. FilmArray respiratory panel performance in respiratory samples from neonatal care units. Diagn Microbiol Infect Dis [Internet]. Elsevier Inc.; 2014;79(2):183–6. Pardo J, Klinker KP, Borgert SJ, Butler BM, Giglio PG, Rand KH. Clinical and economic impact of antimicrobial stewardship interventions with the FilmArray blood culture identification panel. Diagn Microbiol Infect Dis. 2016 Feb;84(2):159- 64 Marcone, D. N., Carballal, G., Ricarte, C., & Echavarria, M. (2015). Diagnóstico de virus respiratorios utilizando un sistema automatizado de PCR múltiples (FilmArray) y su comparación con métodos convencionales. Revista Argentina de Microbiologia, 47(1), 29–35 Graci JD, Cameron CE. Mechanisms of action of ribavirin against distinct viruses. Rev Med Virol 2006;16(1):37–48 Leévy C, Aerts L, Hamelin ME, et al. Virus-like particle vaccine induces crossprotection against human metapneumovirus infections in mice. Vaccine 2013;31(25):2778–2785 Ren, J., Phan, T., & Bao, X. (2015). Recent vaccine development for human metapneumovirus. Journal of General Virology, 96(7), 1515–1520 McCracken JP, Arvelo W, Ortíz J, et al. Comparative epidemiology of human metapneumovirus- and respiratory syncytial virus-associated hospitalizations in Guatemala. Influenza Other Respir Viruses 2014;8:414–21. United nations children´s fund (UNICEF). Levels and trends in child mortality. Report 2018. Disponible en: https://data.unicef.org/wpcontent/uploads/2018/10/Child-Mortality-Report-2018.pdf Avila Adarme, Leidy Viviana. Identificación de la presencia de dos paramixovirus (virus sincitial respiratorio y metapneumovirus humano) en muestras de secreciones respiratorias recolectadas durante la vigilancia centinela en Colombia del 2000 al 2009. Maestría thesis, Universidad Nacional de Colombia. (2014) Liu P, Xu M. Epidemiology of Respiratory Pathogens in Children with Lower Respiratory Tract Infections in Shanghai, China, from 2013 to 2015. Jpn J Infect Dis. 2018 Jan 23;71(1):39-44. Appak, Duman et al. Viral respiratory infections diagnosed by multiplex polymerase chain reaction in pediatric patients. J Med Virol. 2018 Dec 20 Jain S, Williams DJ, Arnold SR, et al. Community-Acquired Pneumonia Requiring Hospitalization among U.S. Children. N Engl J Med. 2015; 372:835-45. Nor'e SS, Sam IC, Mohamad Fakri EF, et al. Phylogenetic analysisof hu man metapneumovirus among children with acute respiratory infections in Kuala Lumpur, Malaysia. Trop Biomed 2014;31:562–6. García-García ML1,2,3, Calvo C. Human metapnuemovirus infections in hospitalized children and comparison with other respiratory viruses. 2005-2014 prospective study. PLoS One. 2017 Mar 16;12(3):e0173504 Broor S, Bharaj P, Chahar HS. Human metapneumovirus: a new respiratory pathogen. J Biosci 2008;33:483–93. Loo LH, Tan BH, Ng LM, Tee NW, Lin RT, Sugrue RJ. Human metapneumovirus in children, Singapore. Emerging infectious diseases. 2007;13(9):1396. Schuster JE, Khuri-Bulos N, Faouri S, Shehabi A, Johnson M, Wang L, et al. Human Metapneumovirus Infection in Jordanian Children. Epidemiology and Risk Factors for Severe Disease. Pediatr Infect Dis J 2015;34:1335–1341 McAdam AJ, Hasenbein ME, Feldman HA, et al. Human metapneumovirus in children tested at a tertiary-care hospital. J Infect Dis 2004;190:20–6. Samransamruajkit R, Thanasugarn W, Prapphal N, Theamboonlers A, Poovorawan Y. Human metapneumovirus in infants and young children in Thailand with lower respiratory tract infections; molecular characteristics and clinical presentations. Journal of Infection. 2006;52(4):254-263. Lim FJ, de Klerk N et al Systematic review and meta-analysis of respiratory viral coinfections in children. 2016 Respirology.May;21(4):648-55. Rodriguez PE, Adamo MP, Paglini MG, et al. [Monoinfection of human metapneumovirus in Cordoba: first clinical and epidemiological research in children with respiratory infection in 2011]. Rev Fac Cien Med Univ Nac Cordoba 2016;73:170–5. Zhang L, Liu W et al. Epidemiological and clinical features of human metapneumovirus in hospitalised paediatric patients with acute respiratory illness: a cross-sectional study in Southern China, from 2013 to 2016. BMJ Open. 2018 Feb 6;8(2):e019308. 271090 TE10077
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spelling	Fernández Sarmiento, JaimeGamboa Garay, Oscar AndrésAcevedo, LorenaObando Belalcázar, Evelyn PaolaMontoya Jiménez, David Leonardo2019-04-30T19:28:59Z2019-04-30T19:28:59ZEspecialista en Cuidado Intensivo Pediátrico2019-01-25Van den Hoogen BG, de Jong JC, Groen J, Kuiken T, de Groot R, Fouchier RA, Osterhaus AD. A newly discovered human metapneumovirus isolated from young children with respiratory tract disease. Nat Med. 2001;7(6):719–24.Betty E. Owor, Geoffrey N. Masankwa, et al. Human metapneumovirus epidemiological and evolutionary patterns in Coastal Kenya,2007-11, BMC Infectious Diseases (2016) 16:301Skiadopoulos MH, Biacchesi et al. Individual contributions of the human metapneumovirus F, G, and SH surface glycoproteins to the induction of neutralizing antibodies and protective immunity. Virology. 2006;345(2):492–501.Jennifer E. Schuster and John V. Williams. BMC Infectious Diseases (2016) 16:301Pediatrics in Review 2013;34;558Williams JV, Edwards KM, Weinberg GA et al. Population-based incidence of human metapneumovirus infection among hospitalized children. J Infect Dis. 2010;201:1890–8Barbosa Ramirez J, Pulido Dominguez P, Rey Benito G, et al. Human respiratory syncytial virus and metapneumovirus in patients with acute respiratory infection in Colombia, 2000-2011. Rev Panam Salud Publica. 2014;36(2):101–109.Panda S, Mohakud N, Pena L, Kumar S. Human metapneumovirus: review of an important respiratory pathogen. International Journal of Infectious Diseases (2014) 25 e45–e52Erickson JJ, Gilchuk P, Hastings AK, et al. Viral acute lower respiratory infections impair CD8þ T cells through PD-1. J Clin Invest. 2012;122(8):2967–2982Spaulding, Harris PA, Tollefson SJ, et al. Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children. N Engl J Med. 2004;350(5): 443–450Williams JV, Tollefson SJ, Nair S, Chonmaitree T. Association of human metapneumovirus with acute otitis media. Int J Pediatr Otorhinolaryngol 2006;70(7):1189–1193Madhi SA, Ludewick H, Kuwanda L, et al. Pneumococcal coinfection with human metapneumovirus. J Infect Dis. 2006;193 (9):1236–1243García-García ML, Calvo C, Casas I, et al. Human metapneumovirus bronchiolitis in infancy is an important risk factor for asthma at age 5. Pediatr Pulmonol 2007Widmer K, Zhu Y, Williams JV, Griffin MR, Edwards KM, Talbot HK. Rates of hospitalizations for respiratory syncytial virus, human metapneumovirus, and influenza virus in older adults. J Infect Dis. 2012;206(1):56–62Estrada B, Carter M, Barik S, Vidal R, Herbert D, Ramsey KM. Severe human metapneumovirus infection in hospitalized children. Clin Pediatr (Phila) 2007;46(3):258–262Van den Hoogen BG, Osterhaus DM, Fouchier RA. Clinical impact and diagnosis of human metapneumovirus infection. Pediatr Infect Dis J 2004;23(1, Suppl):S25–S32Paget SP, Andresen DN, Kesson AM, Egan JR. Comparison of human metapneumovirus and respiratory syncytial virus in children admitted to a paediatric intensive care unit. J Paediatr Child Health 2011;47(10):737–741Hahn A, Wang W, Jaggi P, et al. Human metapneumovirus infections are associated with severe morbidity in hospitalized children of all ages. Epidemiol Infect 2013;141(10): 2213–2223Maertzdorf J, Wang CK, Brown JB, et al. Real-time reverse transcriptase PCR assay for detection of human metapneumoviruses from all known genetic lineages. J Clin Microbiol 2004; 42(3):981–986Principi N, Bosis S, Esposito S. Human metapneumovirus in paediatric patients. Clin Microbiol Infect 2006;12(4):301–308Piralla A, Lunghi G, Percivalle E et al. FilmArray respiratory panel performance in respiratory samples from neonatal care units. Diagn Microbiol Infect Dis [Internet]. Elsevier Inc.; 2014;79(2):183–6.Pardo J, Klinker KP, Borgert SJ, Butler BM, Giglio PG, Rand KH. Clinical and economic impact of antimicrobial stewardship interventions with the FilmArray blood culture identification panel. Diagn Microbiol Infect Dis. 2016 Feb;84(2):159- 64Marcone, D. N., Carballal, G., Ricarte, C., & Echavarria, M. (2015). Diagnóstico de virus respiratorios utilizando un sistema automatizado de PCR múltiples (FilmArray) y su comparación con métodos convencionales. Revista Argentina de Microbiologia, 47(1), 29–35Graci JD, Cameron CE. Mechanisms of action of ribavirin against distinct viruses. Rev Med Virol 2006;16(1):37–48Leévy C, Aerts L, Hamelin ME, et al. Virus-like particle vaccine induces crossprotection against human metapneumovirus infections in mice. Vaccine 2013;31(25):2778–2785Ren, J., Phan, T., & Bao, X. (2015). Recent vaccine development for human metapneumovirus. Journal of General Virology, 96(7), 1515–1520McCracken JP, Arvelo W, Ortíz J, et al. Comparative epidemiology of human metapneumovirus- and respiratory syncytial virus-associated hospitalizations in Guatemala. Influenza Other Respir Viruses 2014;8:414–21.United nations children´s fund (UNICEF). Levels and trends in child mortality. Report 2018. Disponible en: https://data.unicef.org/wpcontent/uploads/2018/10/Child-Mortality-Report-2018.pdfAvila Adarme, Leidy Viviana. Identificación de la presencia de dos paramixovirus (virus sincitial respiratorio y metapneumovirus humano) en muestras de secreciones respiratorias recolectadas durante la vigilancia centinela en Colombia del 2000 al 2009. Maestría thesis, Universidad Nacional de Colombia. (2014)Liu P, Xu M. Epidemiology of Respiratory Pathogens in Children with Lower Respiratory Tract Infections in Shanghai, China, from 2013 to 2015. Jpn J Infect Dis. 2018 Jan 23;71(1):39-44.Appak, Duman et al. Viral respiratory infections diagnosed by multiplex polymerase chain reaction in pediatric patients. J Med Virol. 2018 Dec 20Jain S, Williams DJ, Arnold SR, et al. Community-Acquired Pneumonia Requiring Hospitalization among U.S. Children. N Engl J Med. 2015; 372:835-45.Nor'e SS, Sam IC, Mohamad Fakri EF, et al. Phylogenetic analysisof hu man metapneumovirus among children with acute respiratory infections in Kuala Lumpur, Malaysia. Trop Biomed 2014;31:562–6.García-García ML1,2,3, Calvo C. Human metapnuemovirus infections in hospitalized children and comparison with other respiratory viruses. 2005-2014 prospective study. PLoS One. 2017 Mar 16;12(3):e0173504Broor S, Bharaj P, Chahar HS. Human metapneumovirus: a new respiratory pathogen. J Biosci 2008;33:483–93.Loo LH, Tan BH, Ng LM, Tee NW, Lin RT, Sugrue RJ. Human metapneumovirus in children, Singapore. Emerging infectious diseases. 2007;13(9):1396.Schuster JE, Khuri-Bulos N, Faouri S, Shehabi A, Johnson M, Wang L, et al. Human Metapneumovirus Infection in Jordanian Children. Epidemiology and Risk Factors for Severe Disease. Pediatr Infect Dis J 2015;34:1335–1341McAdam AJ, Hasenbein ME, Feldman HA, et al. Human metapneumovirus in children tested at a tertiary-care hospital. J Infect Dis 2004;190:20–6.Samransamruajkit R, Thanasugarn W, Prapphal N, Theamboonlers A, Poovorawan Y. Human metapneumovirus in infants and young children in Thailand with lower respiratory tract infections; molecular characteristics and clinical presentations. Journal of Infection. 2006;52(4):254-263.Lim FJ, de Klerk N et al Systematic review and meta-analysis of respiratory viral coinfections in children. 2016 Respirology.May;21(4):648-55.Rodriguez PE, Adamo MP, Paglini MG, et al. [Monoinfection of human metapneumovirus in Cordoba: first clinical and epidemiological research in children with respiratory infection in 2011]. Rev Fac Cien Med Univ Nac Cordoba 2016;73:170–5.Zhang L, Liu W et al. Epidemiological and clinical features of human metapneumovirus in hospitalised paediatric patients with acute respiratory illness: a cross-sectional study in Southern China, from 2013 to 2016. BMJ Open. 2018 Feb 6;8(2):e019308.http://hdl.handle.net/10818/35437271090TE1007757 páginasDe forma global, la infección respiratoria aguda es la enfermedad más frecuente independiente de la edad y el género, siendo los virus los patógenos más comunes. En la población pediátrica el virus sincitial respiratorio (VSR), el virus de parainfluenza e influenza han sido considerados durante muchos años los principales agentes etiológicos en infección respiratoria aguda baja. En el 2001 el doctor Van Den Hoogen y colaboradores, describieron en los Países Bajos un nuevo virus conocido como metapneumovirus humano (HMPV) perteneciente a la familia Paramyxoviridae que presenta una alta similitud filogenética al VSR, compartiendo una organización genómica similar, 1,2 . En los últimos años y gracias a la posibilidad diagnóstica de nuevos agentes etiológicos, la infección por HMPV ha cobrado mayor impacto atribuyéndole como agente causal de infecciones respiratorias agudas altas y bajas como croup, bronquiolitis, exacerbación de asma y neumonía en el escenario de hospitalización, con el potencial desarrollo de enfermedad severa y requerimiento de manejo en unidad de cuidado intensivo.spaUniversidad de La SabanaEspecialización en Cuidado Intensivo PediátricoFacultad de MedicinaAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaMetapneumovirusEnfermedades respiratorias pediátricasInsuficiencia respiratoria en niños -- Prevención y controlPrevalencia y comportamiento clínico de la infección por metapneumovirus humano en pacientes pediátricos con infección respiratoria aguda en la Fundación Cardioinfantil de Bogotá del 2015-2017bachelorThesishttp://purl.org/coar/resource_type/c_7a1fMlinaric-Galinovic G, Varda-Brkic D. Nosocomial respiratory syncytial virus infections in children's wards. Diagn Microbiol Infect Dis. 2000 Aug;37(4):237-46Kim S, Sung H, Im HJ, Hong SJ, Kim MN. Molecular epidemiological investigation of a nosocomial outbreak of human metapneumovirus infection in a pediatric hemato-oncology patient population. J Clin Microbiol. 2009;47(4):1221–1224Cheng VC, Wu AK.Outbreak of human metapneumovirus infection in psychiatric inpatients: implications for directly observed use of alcohol hand rub in prevention of nosocomial outbreaks. J Hosp Infect. 2007 Dec;67(4):336-43. Epub 2007 Nov 19Cheng VC, Wu AK.Outbreak of human metapneumovirus infection in psychiatric inpatients: implications for directly observed use of alcohol hand rub in prevention of nosocomial outbreaks. J Hosp Infect. 2007 Dec;67(4):336-43. Epub 2007 Nov 19Cattoir L, Vankeerberghen A. Epidemiology of RSV and hMPV in Belgium: a 10year follow-up. Acta Clin Belg. 2018 Jul 20:1-7.Kathryn M. Edwards, M.D., Yuwei Zhu. Burden of Human Metapneumovirus Infection in Young Children. N Engl J Med 2013; 368:633-64.Jin Li, Yue Tao. Rapid detection of respiratory organisms with the FilmArray respiratory panel in a large children’s hospital in China. BMC Infectious Diseases 201818:510.John V. Williams, Chiaoyin K. Wang et al. The Role of Human Metapneumovirus in Upper Respiratory Tract Infections in Children: A 20-Year Experience. J Infect Dis. 2006 Feb 1; 193(3): 387–395.Bierbaum S, Konigsfeld N, et al. Panning M (2012) Performance of a novel microarray multiplex PCR for the detection of 23 respiratory pathogens (SYMPARI study). Eur J Clin Microbiol Infect Dis 31:2851–2861.Bierbaum S, Konigsfeld N, et al. Panning M (2012) Performance of a novel microarray multiplex PCR for the detection of 23 respiratory pathogens (SYMPARI study). Eur J Clin Microbiol Infect Dis 31:2851–2861.Özgür Appak, Murat Duman. Viral respiratory infections diagnosed by multiplex polymerase chain reaction in pediatric patients. Journal of Medical Virology Dic 2018 : 0000 -0003 -1810 -8346Sollip Kim, Heungsup Sung. Molecular Epidemiological Investigation of a Nosocomial Outbreak of Human Metapneumovirus Infection in a Pediatric Hemato-Oncology Patient Population. J. Clin. Microbiol 2009;47(4)1221-4Hoellein A Hecker J Hoffmann D Göttle F Protzer U et. al. Serious outbreak of human metapneumovirus in patients with hematologic malignancies. Leukemia & Lymphoma 2016 vol: 57 (3) pp: 623-627Children Carly R. Davis, Chris Stockmann et al. Incidence, Morbidity, and Costs of Human Metapneumovirus Infection in Hospitalized children. J Pediatric Infect Dis Soc. 2016 Sep; 5(3): 303–311.Ausar SF, Rexroad J, Frolov VG, Look JL, Konar N, Middaugh CR. Analysis of the thermal and pH stability of human respiratory syncytial virus. Mol Pharm 20052:491– 499Ellen F. Foxman, James A et al. Temperature-dependent innate defense against the common cold virus limits viral replication at warm temperature in mouse airway cells. PNAS January 20, 2015 112 (3) 827-832.Aberle SW, Aberle JH, et al. Biennial spring activity of human metapneumovirus in Austria. Pediatr Infect Dis J. 2008;27(12):1065-8.Peret TC, Boivin G, Li Y, et al.: Characterization of human metapneumoviruses isolated from patients in North America. J Infect Dis. 2002; 185(11): 1660–3.Boivin G, Abed Y, Pelletier G, et al.: Virological features and clinical manifestations associated with human metapneumovirus: a new paramyxovirus responsible for acute respiratory-tract infections in all age groups. J Infect Dis. 2002; 186(9): 1330–4.. Williams JV, Harris PA, Tollefson SJ, et al.: Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children. N Engl J Med. 2004; 350(5): 443–50.Van den Hoogen BG, Bestebroer TM, Osterhaus AD, et al.: Analysis of the genomic sequence of a human metapneumovirus. Virology. 2002; 295(1): 119– 32.Van den Hoogen BG, Herfst S, Sprong L, et al.: Antigenic and genetic variability of human metapneumoviruses. Emerg Infect Dis. 2004; 10(4): 658–66.Kim JI, Park S, Lee I, et al.: Genome-Wide Analysis of Human Metapneumovirus Evolution. PLoS One. 2016; 11(4): e0152962.Thammawat S, Sadlon TA, Hallsworth PG, et al.: Role of cellular glycosaminoglycans and charged regions of viral G protein in human metapneumovirus infection. J Virol. 2008; 82(23): 11767–74.Cseke G, Maginnis MS, Cox RG, et al.: Integrin alphavbeta1 promotes infection by human metapneumovirus. Proc Natl Acad Sci U S A. 2009; 106(5): 1566– 71.Wen SC, Tollefson SJ, Johnson M, et al.: Acute clearance of human metapneumovirus occurs independently of natural killer cells. J Virol. 2014; 88(18): 10963–9.Van den Hoogen BG, van Doornum GJ, Fockens JC, et al.: Prevalence and clinical symptoms of human metapneumovirus infection in hospitalized patients.J Infect Dis. 2003; 188(10): 1571–7.Seki M, Yoshida H, Gotoh K, et al.: Severe respiratory failure due to coinfection with human metapneumovirus and Streptococcus pneumoniae. Respir Med Case Rep. 2014; 12: 13–5David Andrés Espinal, Isabel Cristina Hurtado. Metaneumovirus humano en niños: primeros casos en Colombia. Biomédica, vol. 32, núm. 2, junio, 2012, pp. 1-15. Instituto Nacional de Salud Bogotá, Colombia.Lozano C, Jaime et al. Infección por metapneumovirus humano en niños hospitalizados por una enfermedad respiratoria aguda grave: Descripción clínico- epidemiológica. Rev. chil. enferm. respir. [online]. 2009, vol.25, n.4, pp.211-217. ISSN 0717-7348.. Infección respiratoria aguda Colombia 2017 - Instituto Nacional de Salud. Ver en https://www.ins.gov.co/buscadoreventos/.../Informe%20IRA%20Final%202017. pdfCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://intellectum.unisabana.edu.co/bitstream/10818/35437/2/license_rdf4460e5956bc1d1639be9ae6146a50347MD52ORIGINALTESIS DE GRADO UCIP.pdfTESIS DE GRADO UCIP.pdfVer documento en PDFapplication/pdf609092https://intellectum.unisabana.edu.co/bitstream/10818/35437/1/TESIS%20DE%20GRADO%20UCIP.pdfec758b321c9eb7586205f9fdfe7a0e26MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/35437/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD53DERECHOS DE AUTOR .pdfDERECHOS DE AUTOR .pdfCartaapplication/pdf795776https://intellectum.unisabana.edu.co/bitstream/10818/35437/4/DERECHOS%20DE%20AUTOR%20.pdf0ad7e9c4da0227bfa5a86f8c0cf25a74MD54TEXTTESIS DE GRADO UCIP.pdf.txtTESIS DE GRADO UCIP.pdf.txtExtracted texttext/plain73805https://intellectum.unisabana.edu.co/bitstream/10818/35437/5/TESIS%20DE%20GRADO%20UCIP.pdf.txt4abdda0c09afe318b9be648e01299762MD5510818/35437oai:intellectum.unisabana.edu.co:10818/354372020-11-26 08:22:46.322Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.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

Prevalencia y comportamiento clínico de la infección por metapneumovirus humano en pacientes pediátricos con infección respiratoria aguda en la Fundación Cardioinfantil de Bogotá del 2015-2017

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