A combined study of behavior and Fos expression in limbic structures after re-testing Wistar rats in the elevated plus-maze

5 páginas

Autores:: Galvis Alonso, Orfa Yineth
García Becerra, Andrea Milena
Orejarena, M.J.
Lamprea Rodríguez, Marisol
Botelho De Oliveira, Silvia
Conde, C.A.
Moratoc, S.
Garcia Cairasco, Norberto

Tipo de recurso:

Fecha de publicación:: 2010

Institución:: Universidad de la Sabana

Repositorio:: Repositorio Universidad de la Sabana

Idioma:: eng

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dc.title.es_CO.fl_str_mv	A combined study of behavior and Fos expression in limbic structures after re-testing Wistar rats in the elevated plus-maze
title	A combined study of behavior and Fos expression in limbic structures after re-testing Wistar rats in the elevated plus-maze
spellingShingle	A combined study of behavior and Fos expression in limbic structures after re-testing Wistar rats in the elevated plus-maze Anxiety Hypothalamus Septal nucleus Memory Fos protein
title_short	A combined study of behavior and Fos expression in limbic structures after re-testing Wistar rats in the elevated plus-maze
title_full	A combined study of behavior and Fos expression in limbic structures after re-testing Wistar rats in the elevated plus-maze
title_fullStr	A combined study of behavior and Fos expression in limbic structures after re-testing Wistar rats in the elevated plus-maze
title_full_unstemmed	A combined study of behavior and Fos expression in limbic structures after re-testing Wistar rats in the elevated plus-maze
title_sort	A combined study of behavior and Fos expression in limbic structures after re-testing Wistar rats in the elevated plus-maze
dc.creator.fl_str_mv	Galvis Alonso, Orfa Yineth García Becerra, Andrea Milena Orejarena, M.J. Lamprea Rodríguez, Marisol Botelho De Oliveira, Silvia Conde, C.A. Moratoc, S. Garcia Cairasco, Norberto
dc.contributor.author.none.fl_str_mv	Galvis Alonso, Orfa Yineth García Becerra, Andrea Milena Orejarena, M.J. Lamprea Rodríguez, Marisol Botelho De Oliveira, Silvia Conde, C.A. Moratoc, S. Garcia Cairasco, Norberto
dc.subject.none.fl_str_mv	Anxiety Hypothalamus Septal nucleus Memory Fos protein
topic	Anxiety Hypothalamus Septal nucleus Memory Fos protein
description	5 páginas
publishDate	2010
dc.date.accessioned.none.fl_str_mv	10/4/2016 14:14
dc.date.issued.none.fl_str_mv	2010
dc.date.available.none.fl_str_mv	2016-10-04T19:14:30Z
dc.type.en.fl_str_mv	article
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dc.identifier.citation.es_CO.fl_str_mv	OY Galvis-Alonso, AMB García, MJ Orejarena, MR Lamprea, S. Botelho, CA Conde, S. Morato, N. García-Cairasco, un estudio combinado de comportamiento y expresión de Fos en las estructuras límbicas después de volver a probar ratas Wistar en el laberinto elevado en cruz, Brain Research Bulletin, Volumen 81, Número 6, 5 de Abril de 2010, páginas 595-599, ISSN 0361 a 9.230, http://dx.doi.org/10.1016/j.brainresbull.2010.01.007. (Http://www.sciencedirect.com/science/article/pii/S0361923010000262)
dc.identifier.issn.none.fl_str_mv	0361-9230
dc.identifier.other.none.fl_str_mv	https://www.ncbi.nlm.nih.gov/pubmed/20100550 http://www.sciencedirect.com/science/article/pii/S0361923010000262
dc.identifier.uri.none.fl_str_mv	http://hdl.handle.net/10818/27265
dc.identifier.doi.none.fl_str_mv	10.1016/j.brainresbull.2010.01.007
identifier_str_mv	OY Galvis-Alonso, AMB García, MJ Orejarena, MR Lamprea, S. Botelho, CA Conde, S. Morato, N. García-Cairasco, un estudio combinado de comportamiento y expresión de Fos en las estructuras límbicas después de volver a probar ratas Wistar en el laberinto elevado en cruz, Brain Research Bulletin, Volumen 81, Número 6, 5 de Abril de 2010, páginas 595-599, ISSN 0361 a 9.230, http://dx.doi.org/10.1016/j.brainresbull.2010.01.007. (Http://www.sciencedirect.com/science/article/pii/S0361923010000262) 0361-9230 10.1016/j.brainresbull.2010.01.007
url	https://www.ncbi.nlm.nih.gov/pubmed/20100550 http://www.sciencedirect.com/science/article/pii/S0361923010000262 http://hdl.handle.net/10818/27265
dc.language.iso.es_CO.fl_str_mv	eng
language	eng
dc.relation.ispartofseries.none.fl_str_mv	Brain Res Bull. 2010 Apr 5;81(6):595-9
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dc.format.es_CO.fl_str_mv	application/pdf
dc.publisher.es_CO.fl_str_mv	Brain Research Bulletin
dc.source.es_CO.fl_str_mv	Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana
institution	Universidad de la Sabana
bitstream.url.fl_str_mv	https://intellectum.unisabana.edu.co/bitstream/10818/27265/2/license_rdf https://intellectum.unisabana.edu.co/bitstream/10818/27265/3/license.txt
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spelling	Galvis Alonso, Orfa YinethGarcía Becerra, Andrea MilenaOrejarena, M.J.Lamprea Rodríguez, MarisolBotelho De Oliveira, SilviaConde, C.A.Moratoc, S.Garcia Cairasco, Norberto10/4/2016 14:142016-10-04T19:14:30Z2010OY Galvis-Alonso, AMB García, MJ Orejarena, MR Lamprea, S. Botelho, CA Conde, S. Morato, N. García-Cairasco, un estudio combinado de comportamiento y expresión de Fos en las estructuras límbicas después de volver a probar ratas Wistar en el laberinto elevado en cruz, Brain Research Bulletin, Volumen 81, Número 6, 5 de Abril de 2010, páginas 595-599, ISSN 0361 a 9.230, http://dx.doi.org/10.1016/j.brainresbull.2010.01.007. (Http://www.sciencedirect.com/science/article/pii/S0361923010000262)0361-9230https://www.ncbi.nlm.nih.gov/pubmed/20100550http://www.sciencedirect.com/science/article/pii/S0361923010000262http://hdl.handle.net/10818/2726510.1016/j.brainresbull.2010.01.0075 páginasThe elevated plus-maze is an animal model used to study anxiety. In a second session, rats show a reduction in the exploratory behavior even when the two sessions are separated by intervals as large as 7 days. The aim of the present study was to investigate whether the reduction in the exploratory behavior is maintained after intervals larger than 7 days. Additionally, we aimed at investigating eventual correlations between behaviors in the plus-maze and activation of limbic structures as measured by Fos protein expression after the second session. Rats were tested for 5 min in the elevated plus-maze and re-tested 3, 9 or 33 days later. Other groups were tested only once. The rat brains were processed for immunohistochemical detection of Fos protein. The results show a decrease in the open arms exploration in the second trial with intervals of 3, 9 and 33 days. The expression of Fos protein in the piriform cortex, septal nucleus and paraventricular hypothalamic nucleus in the groups tested with intervals of 9 and 33 days were statistically different from the other groups. The alterations observed in exploratory behavior in the second session in the plus-maze did not correlate with Fos expression. In conclusion, although the specific test conditions were sufficient to evoke behavioral alterations in exploration in the elevated plus-maze, they were enough to induce significant Fos protein expression in piriform cortex, septal nucleus and thalamic and hypothalamic paraventricular nuclei but not in other areas such as dorsomedial nucleus of the hypothalamus and amygdala nuclei, known to be also active participants in circuits controlling fear and anxietyapplication/pdfengBrain Research BulletinBrain Res Bull. 2010 Apr 5;81(6):595-9Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaAnxietyHypothalamusSeptal nucleusMemoryFos proteinA combined study of behavior and Fos expression in limbic structures after re-testing Wistar rats in the elevated plus-mazearticlepublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81223https://intellectum.unisabana.edu.co/bitstream/10818/27265/2/license_rdf7c9ab7f006165862d8ce9ac5eac01552MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/27265/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD5310818/27265oai:intellectum.unisabana.edu.co:10818/272652022-05-10 05:16:48.405Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.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

A combined study of behavior and Fos expression in limbic structures after re-testing Wistar rats in the elevated plus-maze

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