Efecto del manejo con concentrado de protrombina en comparación al plasma fresco congelado, en la hemorragia Intracerebral asociada a warfarina: Ensayo Clínico Aleatorizado; Estudio scorpio

86 Páginas.

Autores:
Salazar Triviño, Carlos Hernando
Tipo de recurso:
Fecha de publicación:
2012
Institución:
Universidad de la Sabana
Repositorio:
Repositorio Universidad de la Sabana
Idioma:
spa
OAI Identifier:
oai:intellectum.unisabana.edu.co:10818/9368
Acceso en línea:
http://hdl.handle.net/10818/9368
Palabra clave:
Hemorragia encefálica cerebral
Hemorragia intracerebral
Plasma fresco congelado
Protrombina
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License
http://purl.org/coar/access_right/c_abf2
id REPOUSABA2_320f0936c99cbd8b04e79ba40e0ddc08
oai_identifier_str oai:intellectum.unisabana.edu.co:10818/9368
network_acronym_str REPOUSABA2
network_name_str Repositorio Universidad de la Sabana
repository_id_str
dc.title.es_CO.fl_str_mv Efecto del manejo con concentrado de protrombina en comparación al plasma fresco congelado, en la hemorragia Intracerebral asociada a warfarina: Ensayo Clínico Aleatorizado; Estudio scorpio
title Efecto del manejo con concentrado de protrombina en comparación al plasma fresco congelado, en la hemorragia Intracerebral asociada a warfarina: Ensayo Clínico Aleatorizado; Estudio scorpio
spellingShingle Efecto del manejo con concentrado de protrombina en comparación al plasma fresco congelado, en la hemorragia Intracerebral asociada a warfarina: Ensayo Clínico Aleatorizado; Estudio scorpio
Hemorragia encefálica cerebral
Hemorragia intracerebral
Plasma fresco congelado
Protrombina
title_short Efecto del manejo con concentrado de protrombina en comparación al plasma fresco congelado, en la hemorragia Intracerebral asociada a warfarina: Ensayo Clínico Aleatorizado; Estudio scorpio
title_full Efecto del manejo con concentrado de protrombina en comparación al plasma fresco congelado, en la hemorragia Intracerebral asociada a warfarina: Ensayo Clínico Aleatorizado; Estudio scorpio
title_fullStr Efecto del manejo con concentrado de protrombina en comparación al plasma fresco congelado, en la hemorragia Intracerebral asociada a warfarina: Ensayo Clínico Aleatorizado; Estudio scorpio
title_full_unstemmed Efecto del manejo con concentrado de protrombina en comparación al plasma fresco congelado, en la hemorragia Intracerebral asociada a warfarina: Ensayo Clínico Aleatorizado; Estudio scorpio
title_sort Efecto del manejo con concentrado de protrombina en comparación al plasma fresco congelado, en la hemorragia Intracerebral asociada a warfarina: Ensayo Clínico Aleatorizado; Estudio scorpio
dc.creator.fl_str_mv Salazar Triviño, Carlos Hernando
dc.contributor.advisor.none.fl_str_mv Carreño Rodríguez, José Nel
Giraldo Cadavid, Luis Fernando
dc.contributor.author.none.fl_str_mv Salazar Triviño, Carlos Hernando
dc.subject.none.fl_str_mv Hemorragia encefálica cerebral
Hemorragia intracerebral
Plasma fresco congelado
Protrombina
topic Hemorragia encefálica cerebral
Hemorragia intracerebral
Plasma fresco congelado
Protrombina
description 86 Páginas.
publishDate 2012
dc.date.issued.none.fl_str_mv 2012
dc.date.accessioned.none.fl_str_mv 2013-12-16T17:45:32Z
dc.date.available.none.fl_str_mv 2013-12-16T17:45:32Z
dc.date.created.none.fl_str_mv 2013-12-16
dc.type.none.fl_str_mv bachelorThesis
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.local.none.fl_str_mv Tesis de especialización
dc.type.hasVersion.none.fl_str_mv publishedVersion
dc.identifier.citation.none.fl_str_mv Adeoye, O., Woo, D., Haverbusch, M., Tao, H., Sekar, P., Moomaw, C. J., Flaherty, M. L. (2008). Eligibility for the surgical trial in intracerebral hemorrhage II study in a population-based cohort. Neurocritical Care, 9(2), 237-41. doi:10.1007/s12028-007-9045-8.
.Aguilar, M. I., Hart, R. G., Kase, C. S., Freeman, W. D., Hoeben, B. J., García, R. C., Yasaka, M. (2007). Treatment of warfarin-associated intracerebral hemorrhage: Literature review and expert opinion. Mayo Clinic Proceedings. Mayo Clinic, 82(1), 82-92.
Aiyagari, V. (2009). Correction of coagulopathy secondary to oral and parenteral anticoagulants. Continuum Lifelong Learning Neurol 2009;15(3).
Aiyagari, V., & Testai, F. D. (2009). Correction of coagulopathy in warfarin associated cerebral hemorrhage. Current Opinion in Critical Care, 15(2), 87-92. doi:10.1097/MCC.0b013e3283269e4d
Anderson, C. S. (2009). Medical management of acute intracerebral hemorrhage. Current Opinion in Critical Care, 15(2), 93-8. doi:10.1097/MCC. 0b013e328325d12c.
Ansell, J., Hirsh, J., Hylek, E., Jacobson, A., Crowther, M., Palareti, G., & American College of Chest Physicians. (2008). Pharmacology and management of the vitamin K antagonists: American college of chest physicians evidence-based clinical practice guidelines (8th edition). Chest, 133(6 Suppl), 160S-198S. doi:10.1378/chest.08-0670
Baglin, T. P., Keeling, D. M., Watson, H. G., & British Committee for Standards in Haematology. (2006). Guidelines on oral anticoagulation (warfarin): Third edition--2005 update. British Journal of Haematology, 132(3), 277-85. doi:10.1111/j.1365-2141.2005.05856.x.
Baker, R. I., Coughlin, P. B., Gallus, A. S., Harper, P. L., Salem, H. H., Wood, E. M., & Warfarin Reversal Consensus Group. (2004). Warfarin reversal: Consensus guidelines, on behalf of the australasian society of thrombosis and haemostasis. The Medical Journal of Australia, 181(9), 492-7
Bechtel, B. F., Nunez, T. C., Lyon, J. A., Cotton, B. A., & Barrett, T. W. (2011). Treatments for reversing warfarin anticoagulation in patients with acute intracranial hemorrhage: A structured literature review. International Journal of Emergency Medicine, 4(1), 40. doi:10.1186/1865-1380-4-40.
Broderick, J., Connolly, S., Feldmann, E., Hanley, D., Kase, C., Krieger, D., Quality of Care and Outcomes in Research Interdisciplinary Working Group. (2007). Guidelines for the management of spontaneous intracerebral hemorrhage in adults: 2007 update: A guideline from the american heart association/american stroke association stroke council, high blood pressure research council, and the quality of care and outcomes in research interdisciplinary working group. Stroke; A Journal of Cerebral Circulation, 38(6), 2001-23. doi:10.1161/STROKEAHA.107.183689
Cartmill, M., Dolan, G., Byrne, J. L., & Byrne, P. O. (2000). Prothrombin complex concentrate for oral anticoagulant reversal in neurosurgical emergencies. British Journal of Neurosurgery, 14(5), 458-61.
Cohen, D. B., Rinker, C., & Wilberger, J. E. (2006). Traumatic brain injury in anticoagulated patients. The Journal of Trauma, 60(3), 553-7. doi: 10.1097/01.ta.0000196542.54344.05.
Demeyere, R., Gillardin, S., Arnout, J., & Strengers, P. F. (2010). Comparison of fresh frozen plasma and prothrombin complex concentrate for the reversal of oral anticoagulants in patients undergoing cardiopulmonary bypass surgery: A randomized study. Vox Sanguinis, 99(3), 251-60. doi:10.1111/j.1423-0410.2010.01339.x.
Douketis, J. D., Berger, P. B., Dunn, A. S., Jaffer, A. K., Spyropoulos, A. C., Becker, R. C., American College of Chest Physicians. (2008). The perioperative management of antithrombotic therapy: American college of chest physicians evidence-based clinical practice guidelines (8th edition). Chest, 133(6 Suppl), 299S-339S. doi:10.1378/chest.08-0675.
Dusel, C. H., Grundmann, C., Eich, S., Seitz, R., & König, H. (2004). Identification of prothrombin as a major thrombogenic agent in prothrombin complex concentrates. Blood Coagulation & Fibrinolysis : An International Journal in Haemostasis and Thrombosis, 15(5), 405-11.
Elliott, J., & Smith, M. (2010). The acute management of intracerebral hemorrhage: A clinical review. Anesthesia and Analgesia, 110(5), 1419-27. doi:10.1213/ANE.0b013e3181d568c8.
Flaherty, M. L., Tao, H., Haverbusch, M., Sekar, P., Kleindorfer, D., Kissela, B., Woo, D. (2008). Warfarin use leads to larger intracerebral hematomas. Neurology, 71(14), 1084-9. doi:10.1212/01.wnl.0000326895.58992.27
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dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/10818/9368
dc.identifier.local.none.fl_str_mv 254629
TE05922
identifier_str_mv Adeoye, O., Woo, D., Haverbusch, M., Tao, H., Sekar, P., Moomaw, C. J., Flaherty, M. L. (2008). Eligibility for the surgical trial in intracerebral hemorrhage II study in a population-based cohort. Neurocritical Care, 9(2), 237-41. doi:10.1007/s12028-007-9045-8.
.Aguilar, M. I., Hart, R. G., Kase, C. S., Freeman, W. D., Hoeben, B. J., García, R. C., Yasaka, M. (2007). Treatment of warfarin-associated intracerebral hemorrhage: Literature review and expert opinion. Mayo Clinic Proceedings. Mayo Clinic, 82(1), 82-92.
Aiyagari, V. (2009). Correction of coagulopathy secondary to oral and parenteral anticoagulants. Continuum Lifelong Learning Neurol 2009;15(3).
Aiyagari, V., & Testai, F. D. (2009). Correction of coagulopathy in warfarin associated cerebral hemorrhage. Current Opinion in Critical Care, 15(2), 87-92. doi:10.1097/MCC.0b013e3283269e4d
Anderson, C. S. (2009). Medical management of acute intracerebral hemorrhage. Current Opinion in Critical Care, 15(2), 93-8. doi:10.1097/MCC. 0b013e328325d12c.
Ansell, J., Hirsh, J., Hylek, E., Jacobson, A., Crowther, M., Palareti, G., & American College of Chest Physicians. (2008). Pharmacology and management of the vitamin K antagonists: American college of chest physicians evidence-based clinical practice guidelines (8th edition). Chest, 133(6 Suppl), 160S-198S. doi:10.1378/chest.08-0670
Baglin, T. P., Keeling, D. M., Watson, H. G., & British Committee for Standards in Haematology. (2006). Guidelines on oral anticoagulation (warfarin): Third edition--2005 update. British Journal of Haematology, 132(3), 277-85. doi:10.1111/j.1365-2141.2005.05856.x.
Baker, R. I., Coughlin, P. B., Gallus, A. S., Harper, P. L., Salem, H. H., Wood, E. M., & Warfarin Reversal Consensus Group. (2004). Warfarin reversal: Consensus guidelines, on behalf of the australasian society of thrombosis and haemostasis. The Medical Journal of Australia, 181(9), 492-7
Bechtel, B. F., Nunez, T. C., Lyon, J. A., Cotton, B. A., & Barrett, T. W. (2011). Treatments for reversing warfarin anticoagulation in patients with acute intracranial hemorrhage: A structured literature review. International Journal of Emergency Medicine, 4(1), 40. doi:10.1186/1865-1380-4-40.
Broderick, J., Connolly, S., Feldmann, E., Hanley, D., Kase, C., Krieger, D., Quality of Care and Outcomes in Research Interdisciplinary Working Group. (2007). Guidelines for the management of spontaneous intracerebral hemorrhage in adults: 2007 update: A guideline from the american heart association/american stroke association stroke council, high blood pressure research council, and the quality of care and outcomes in research interdisciplinary working group. Stroke; A Journal of Cerebral Circulation, 38(6), 2001-23. doi:10.1161/STROKEAHA.107.183689
Cartmill, M., Dolan, G., Byrne, J. L., & Byrne, P. O. (2000). Prothrombin complex concentrate for oral anticoagulant reversal in neurosurgical emergencies. British Journal of Neurosurgery, 14(5), 458-61.
Cohen, D. B., Rinker, C., & Wilberger, J. E. (2006). Traumatic brain injury in anticoagulated patients. The Journal of Trauma, 60(3), 553-7. doi: 10.1097/01.ta.0000196542.54344.05.
Demeyere, R., Gillardin, S., Arnout, J., & Strengers, P. F. (2010). Comparison of fresh frozen plasma and prothrombin complex concentrate for the reversal of oral anticoagulants in patients undergoing cardiopulmonary bypass surgery: A randomized study. Vox Sanguinis, 99(3), 251-60. doi:10.1111/j.1423-0410.2010.01339.x.
Douketis, J. D., Berger, P. B., Dunn, A. S., Jaffer, A. K., Spyropoulos, A. C., Becker, R. C., American College of Chest Physicians. (2008). The perioperative management of antithrombotic therapy: American college of chest physicians evidence-based clinical practice guidelines (8th edition). Chest, 133(6 Suppl), 299S-339S. doi:10.1378/chest.08-0675.
Dusel, C. H., Grundmann, C., Eich, S., Seitz, R., & König, H. (2004). Identification of prothrombin as a major thrombogenic agent in prothrombin complex concentrates. Blood Coagulation & Fibrinolysis : An International Journal in Haemostasis and Thrombosis, 15(5), 405-11.
Elliott, J., & Smith, M. (2010). The acute management of intracerebral hemorrhage: A clinical review. Anesthesia and Analgesia, 110(5), 1419-27. doi:10.1213/ANE.0b013e3181d568c8.
Flaherty, M. L., Tao, H., Haverbusch, M., Sekar, P., Kleindorfer, D., Kissela, B., Woo, D. (2008). Warfarin use leads to larger intracerebral hematomas. Neurology, 71(14), 1084-9. doi:10.1212/01.wnl.0000326895.58992.27
Foerch, C., Arai, K., Van Cott, E. M., van Leyen, K., & Lo, E. H. (2009). Rapid reversal of anticoagulation reduces hemorrhage volume in a mouse model of warfarin-associated intracerebral hemorrhage. Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 29(5), 1015-21. doi:10.1038/jcbfm. 2009.27.
Fric-Shamji, E. C., Shamji, M. F., Cole, J., & Benoit, B. G. (2008). Modifiable risk factors for intracerebral hemorrhage. Canadian Family Physician, 54(8), 1138.
Goldstein, J. N., Rosand, J., & Schwamm, L. H. (2008). Warfarin reversal in anticoagulant-associated intracerebral hemorrhage. Neurocritical Care, 9(2), 277-83. doi:10.1007/s12028-008-9049-z
Grobler, C., Callum, J., & McCluskey, S. A. (2010). Reversal of vitamin K antagonists prior to urgent surgery. Canadian Journal of Anaesthesia, 57(5), 458-67. doi:10.1007/s12630-009-9250-3.
Huttner, H. B., Schellinger, P. D., Hartmann, M., Köhrmann, M., Juettler, E., Wikner, J., Steiner, T. (2006). Hematoma growth and outcome in treated neurocritical care patients with intracerebral hemorrhage related to oral anticoagulant therapy: Comparison of acute treatment strategies using vitamin K, fresh frozen plasma, and prothrombin complex concentrates. Stroke; A Journal of Cerebral Circulation, 37(6), 1465-70. doi: 10.1161/01.STR.0000221786.81354.d6
Kirkman, M. A., Mahattanakul, W., Gregson, B. A., & Mendelow, A. D. (2008). The effect of the results of the STICH trial on the management of spontaneous supratentorial intracerebral haemorrhage in newcastle. British Journal of Neurosurgery, 22(6), 739-46; discussion 747. doi: 10.1080/02688690802346091.
Kraai, E. P., Lopes, R. D., Alexander, J. H., & Garcia, D. (2009). Perioperative management of anticoagulation: Guidelines translated for the clinician. Journal of Thrombosis and Thrombolysis, 28(1), 16-22. doi: 10.1007/s11239-009-0313-7
Leissinger, C. A., Blatt, P. M., Hoots, W. K., & Ewenstein, B. (2008). Role of prothrombin complex concentrates in reversing warfarin anticoagulation: A review of the literature. American Journal of Hematology, 83(2), 137-43. doi:10.1002/ajh.21046.
Levi, M. (2009). Epidemiology and management of bleeding in patients using vitamin K antagonists. Journal of Thrombosis and Haemostasis : JTH, 7 Suppl 1, 103-6. doi:10.1111/j.1538-7836.2009.03389.x.
Levi, M., Levy, J. H., Andersen, H. F., & Truloff, D. (2010). Safety of recombinant activated factor VII in randomized clinical trials. New England Journal of Medicine, 363(19), 1791-1800.
Levy, J. H., Tanaka, K. A., & Dietrich, W. (2008). Perioperative hemostatic management of patients treated with vitamin K antagonists. Anesthesiology, 109(5), 918-26. doi:10.1097/ALN.0b013e3181895bd8
Liumbruno, G., Bennardello, F., Lattanzio, A., Piccoli, P., Rossetti, G., & Italian Society of Transfusion Medicine and Immunohaematology (SIMTI) Working Party. (2009). Recommendations for the use of antithrombin concentrates and prothrombin complex concentrates. Blood Transfusion, 7(4), 325-34. doi:10.2450/2009.0116-09.
Lubetsky, A., Hoffman, R., Zimlichman, R., Eldor, A., Zvi, J., Kostenko, V., & Brenner, B. (2004). Efficacy and safety of a prothrombin complex concentrate (octaplex) for rapid reversal of oral anticoagulation. Thrombosis Research, 113(6), 371-8. doi:10.1016/j.thromres.2004.04.004
Maria, H., & Wexler, S. (2008). Guidelines for the management of warfarin reversal. Royal United Hospital Bath.
Mayer, S. A., Brun, N. C., Begtrup, K., Broderick, J., Davis, S., Diringer, M. N., FAST Trial Investigators. (2008). Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage. The New England Journal of Medicine, 358(20), 2127-37. doi:10.1056/NEJMoa0707534.
Mayer, S. A., Davis, S. M., Skolnick, B. E., Brun, N. C., Begtrup, K., Broderick, J. P., FAST trial investigators. (2009). Can a subset of intracerebral hemorrhage patients benefit from hemostatic therapy with recombinant activated factor VII? Stroke; A Journal of Cerebral Circulation, 40(3), 833-40. doi:10.1161/STROKEAHA.108.524470
Mendelow, A. D., Gregson, B. A., Fernandes, H. M., Murray, G. D., Teasdale, G. M., Hope, D. T., Barer, D. H. (2005). STICH investigators. Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the international surgical trial in intracerebral haemorrhage (STICH): A randomised trial. Lancet, 365(9457), 387-97.
Morgenstern, L. B., Hemphill, J. C., Anderson, C., Becker, K., Broderick, J. P., Connolly, E. S., American Heart Association Stroke Council and Council on Cardiovascular Nursing. (2010). Guidelines for the management of spontaneous intracerebral hemorrhage: A guideline for healthcare professionals from the american heart association/american stroke association. Stroke; A Journal of Cerebral Circulation, 41(9), 2108-29. doi: 10.1161/STR.0b013e3181ec611b.
Narayan, R. K., Maas, A. I., Marshall, L. F., Servadei, F., Skolnick, B. E., Tillinger, M. N., & rFVIIa Traumatic ICH Study Group. (2008). Recombinant factor VIIA in traumatic intracerebral hemorrhage: Results of a dose-escalation clinical trial. Neurosurgery, 62(4), 776-86; discussion 786-8. doi:10.1227/01.neu.0000316898.78371.74.
Pieracci, F. M., Eachempati, S. R., Shou, J., Hydo, L. J., & Barie, P. S. (2007). Degree of anticoagulation, but not warfarin use itself, predicts adverse outcomes after traumatic brain injury in elderly trauma patients. The Journal of Trauma, 63(3), 525-30. doi:10.1097/TA.0b013e31812e5216
Roback, J. D., Caldwell, S., Carson, J., Davenport, R., Drew, M. J., Eder, A., American Society of Hematology. (2010). Evidence-Based practice guidelines for plasma transfusion. Transfusion, 50(6), 1227-39. doi:10.1111/ j.1537-2995.2010.02632.x.
Rosovsky, R. P., & Crowther, M. A. (2008). What is the evidence for the offlabel use of recombinant factor viia (rfviia) in the acute reversal of warfarin? ASH evidence-based review 2008. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program, 36-8. doi:10.1182/asheducation-2008.1.36.
Rønning, P., Sorteberg, W., Nakstad, P., Russell, D., & Helseth, E. (2008). Aspects of intracerebral hematomas; an update. Acta Neurologica Scandinavica, 118(6), 347-61. doi:10.1111/j.1600-0404.2008.01023.x.
Schick, K. S., Fertmann, J. M., Jauch, K. W., & Hoffmann, J. N. (2009). Prothrombin complex concentrate in surgical patients: Retrospective evaluation of vitamin K antagonist reversal and treatment of severe bleeding. Critical Care (London, England), 13(6), R191. doi:10.1186/cc8186.
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Sjöblom, L., Hårdemark, H. G., Lindgren, A., Norrving, B., Fahlen, M., Samuelsson, M., Wallrup, L. (2001). Management and prognostic features of intracerebral hemorrhage during anticoagulant therapy. Stroke; A Journal of Cerebral Circulation, 32(11), 2567-2574. doi:10.1161/hs1101.098523.
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spelling Carreño Rodríguez, José NelGiraldo Cadavid, Luis FernandoSalazar Triviño, Carlos HernandoEspecialista en Medicina Interna2013-12-16T17:45:32Z2013-12-16T17:45:32Z2013-12-162012Adeoye, O., Woo, D., Haverbusch, M., Tao, H., Sekar, P., Moomaw, C. J., Flaherty, M. L. (2008). Eligibility for the surgical trial in intracerebral hemorrhage II study in a population-based cohort. Neurocritical Care, 9(2), 237-41. doi:10.1007/s12028-007-9045-8..Aguilar, M. I., Hart, R. G., Kase, C. S., Freeman, W. D., Hoeben, B. J., García, R. C., Yasaka, M. (2007). Treatment of warfarin-associated intracerebral hemorrhage: Literature review and expert opinion. Mayo Clinic Proceedings. Mayo Clinic, 82(1), 82-92.Aiyagari, V. (2009). Correction of coagulopathy secondary to oral and parenteral anticoagulants. Continuum Lifelong Learning Neurol 2009;15(3).Aiyagari, V., & Testai, F. D. (2009). Correction of coagulopathy in warfarin associated cerebral hemorrhage. Current Opinion in Critical Care, 15(2), 87-92. doi:10.1097/MCC.0b013e3283269e4dAnderson, C. S. (2009). Medical management of acute intracerebral hemorrhage. Current Opinion in Critical Care, 15(2), 93-8. doi:10.1097/MCC. 0b013e328325d12c.Ansell, J., Hirsh, J., Hylek, E., Jacobson, A., Crowther, M., Palareti, G., & American College of Chest Physicians. (2008). Pharmacology and management of the vitamin K antagonists: American college of chest physicians evidence-based clinical practice guidelines (8th edition). Chest, 133(6 Suppl), 160S-198S. doi:10.1378/chest.08-0670Baglin, T. P., Keeling, D. M., Watson, H. G., & British Committee for Standards in Haematology. (2006). Guidelines on oral anticoagulation (warfarin): Third edition--2005 update. British Journal of Haematology, 132(3), 277-85. doi:10.1111/j.1365-2141.2005.05856.x.Baker, R. I., Coughlin, P. B., Gallus, A. S., Harper, P. L., Salem, H. H., Wood, E. M., & Warfarin Reversal Consensus Group. (2004). Warfarin reversal: Consensus guidelines, on behalf of the australasian society of thrombosis and haemostasis. The Medical Journal of Australia, 181(9), 492-7Bechtel, B. F., Nunez, T. C., Lyon, J. A., Cotton, B. A., & Barrett, T. W. (2011). Treatments for reversing warfarin anticoagulation in patients with acute intracranial hemorrhage: A structured literature review. International Journal of Emergency Medicine, 4(1), 40. doi:10.1186/1865-1380-4-40.Broderick, J., Connolly, S., Feldmann, E., Hanley, D., Kase, C., Krieger, D., Quality of Care and Outcomes in Research Interdisciplinary Working Group. (2007). Guidelines for the management of spontaneous intracerebral hemorrhage in adults: 2007 update: A guideline from the american heart association/american stroke association stroke council, high blood pressure research council, and the quality of care and outcomes in research interdisciplinary working group. Stroke; A Journal of Cerebral Circulation, 38(6), 2001-23. doi:10.1161/STROKEAHA.107.183689Cartmill, M., Dolan, G., Byrne, J. L., & Byrne, P. O. (2000). Prothrombin complex concentrate for oral anticoagulant reversal in neurosurgical emergencies. British Journal of Neurosurgery, 14(5), 458-61.Cohen, D. B., Rinker, C., & Wilberger, J. E. (2006). Traumatic brain injury in anticoagulated patients. The Journal of Trauma, 60(3), 553-7. doi: 10.1097/01.ta.0000196542.54344.05.Demeyere, R., Gillardin, S., Arnout, J., & Strengers, P. F. (2010). Comparison of fresh frozen plasma and prothrombin complex concentrate for the reversal of oral anticoagulants in patients undergoing cardiopulmonary bypass surgery: A randomized study. Vox Sanguinis, 99(3), 251-60. doi:10.1111/j.1423-0410.2010.01339.x.Douketis, J. D., Berger, P. B., Dunn, A. S., Jaffer, A. K., Spyropoulos, A. C., Becker, R. C., American College of Chest Physicians. (2008). The perioperative management of antithrombotic therapy: American college of chest physicians evidence-based clinical practice guidelines (8th edition). Chest, 133(6 Suppl), 299S-339S. doi:10.1378/chest.08-0675.Dusel, C. H., Grundmann, C., Eich, S., Seitz, R., & König, H. (2004). Identification of prothrombin as a major thrombogenic agent in prothrombin complex concentrates. Blood Coagulation & Fibrinolysis : An International Journal in Haemostasis and Thrombosis, 15(5), 405-11.Elliott, J., & Smith, M. (2010). The acute management of intracerebral hemorrhage: A clinical review. Anesthesia and Analgesia, 110(5), 1419-27. doi:10.1213/ANE.0b013e3181d568c8.Flaherty, M. L., Tao, H., Haverbusch, M., Sekar, P., Kleindorfer, D., Kissela, B., Woo, D. (2008). Warfarin use leads to larger intracerebral hematomas. Neurology, 71(14), 1084-9. doi:10.1212/01.wnl.0000326895.58992.27Foerch, C., Arai, K., Van Cott, E. M., van Leyen, K., & Lo, E. H. (2009). Rapid reversal of anticoagulation reduces hemorrhage volume in a mouse model of warfarin-associated intracerebral hemorrhage. Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 29(5), 1015-21. doi:10.1038/jcbfm. 2009.27.Fric-Shamji, E. C., Shamji, M. F., Cole, J., & Benoit, B. G. (2008). Modifiable risk factors for intracerebral hemorrhage. Canadian Family Physician, 54(8), 1138.Goldstein, J. N., Rosand, J., & Schwamm, L. H. (2008). Warfarin reversal in anticoagulant-associated intracerebral hemorrhage. Neurocritical Care, 9(2), 277-83. doi:10.1007/s12028-008-9049-zGrobler, C., Callum, J., & McCluskey, S. A. (2010). Reversal of vitamin K antagonists prior to urgent surgery. Canadian Journal of Anaesthesia, 57(5), 458-67. doi:10.1007/s12630-009-9250-3.Huttner, H. B., Schellinger, P. D., Hartmann, M., Köhrmann, M., Juettler, E., Wikner, J., Steiner, T. (2006). Hematoma growth and outcome in treated neurocritical care patients with intracerebral hemorrhage related to oral anticoagulant therapy: Comparison of acute treatment strategies using vitamin K, fresh frozen plasma, and prothrombin complex concentrates. Stroke; A Journal of Cerebral Circulation, 37(6), 1465-70. doi: 10.1161/01.STR.0000221786.81354.d6Kirkman, M. A., Mahattanakul, W., Gregson, B. A., & Mendelow, A. D. (2008). The effect of the results of the STICH trial on the management of spontaneous supratentorial intracerebral haemorrhage in newcastle. British Journal of Neurosurgery, 22(6), 739-46; discussion 747. doi: 10.1080/02688690802346091.Kraai, E. P., Lopes, R. D., Alexander, J. H., & Garcia, D. (2009). Perioperative management of anticoagulation: Guidelines translated for the clinician. Journal of Thrombosis and Thrombolysis, 28(1), 16-22. doi: 10.1007/s11239-009-0313-7Leissinger, C. A., Blatt, P. M., Hoots, W. K., & Ewenstein, B. (2008). Role of prothrombin complex concentrates in reversing warfarin anticoagulation: A review of the literature. American Journal of Hematology, 83(2), 137-43. doi:10.1002/ajh.21046.Levi, M. (2009). Epidemiology and management of bleeding in patients using vitamin K antagonists. Journal of Thrombosis and Haemostasis : JTH, 7 Suppl 1, 103-6. doi:10.1111/j.1538-7836.2009.03389.x.Levi, M., Levy, J. H., Andersen, H. F., & Truloff, D. (2010). Safety of recombinant activated factor VII in randomized clinical trials. New England Journal of Medicine, 363(19), 1791-1800.Levy, J. H., Tanaka, K. A., & Dietrich, W. (2008). Perioperative hemostatic management of patients treated with vitamin K antagonists. Anesthesiology, 109(5), 918-26. doi:10.1097/ALN.0b013e3181895bd8Liumbruno, G., Bennardello, F., Lattanzio, A., Piccoli, P., Rossetti, G., & Italian Society of Transfusion Medicine and Immunohaematology (SIMTI) Working Party. (2009). Recommendations for the use of antithrombin concentrates and prothrombin complex concentrates. Blood Transfusion, 7(4), 325-34. doi:10.2450/2009.0116-09.Lubetsky, A., Hoffman, R., Zimlichman, R., Eldor, A., Zvi, J., Kostenko, V., & Brenner, B. (2004). Efficacy and safety of a prothrombin complex concentrate (octaplex) for rapid reversal of oral anticoagulation. Thrombosis Research, 113(6), 371-8. doi:10.1016/j.thromres.2004.04.004Maria, H., & Wexler, S. (2008). Guidelines for the management of warfarin reversal. Royal United Hospital Bath.Mayer, S. A., Brun, N. C., Begtrup, K., Broderick, J., Davis, S., Diringer, M. N., FAST Trial Investigators. (2008). Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage. The New England Journal of Medicine, 358(20), 2127-37. doi:10.1056/NEJMoa0707534.Mayer, S. A., Davis, S. M., Skolnick, B. E., Brun, N. C., Begtrup, K., Broderick, J. P., FAST trial investigators. (2009). 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Stroke, 42, 2383 - 84. doi:10.1161/ STROKEAHA.111.626739.Davis, S.M., Broderick, J., Hennerici, M., Brun, N.C., Diringer,; S.A. Mayer, ; K. Begtrup, ; and T. Steiner. (2006). Hematoma growth is a determinant of mortality and poor outcome after intracerebral hemorrhage. Neurology, 66, 1175 – 1181. 10.1212/01.wnl.0000256290.15120.37.http://hdl.handle.net/10818/9368254629TE0592286 Páginas.El ECV hemorrágico es una de las catástrofes más temidas con el uso de anticoagulantes orales, no solo por su mortalidad a corto plazo; estos tienden a crecer en las primeras horas aumentando significativamente su volumen, lo cual está estrechamente ligado al pronóstico neurológico. Por esa razón se plantea la necesidad de realizar un estudio clínico aleatorizado, para definir si el uso de PCC’s disminuye el tiempo de normalización del INR y la tasa de crecimiento del hematoma en pacientes con ECV hemorrágico asociado a anticoagulantes orales de tipo warfarina comparado con plasma fresco congelado y si a un año existe alguna diferencia en el estado neurológico de los pacientes de ambos grupos, medido a través de la escala mRankin.spaUniversidad de la SabanaEspecialización en Medicina InternaFacultad de MedicinaUniversidad de La SabanaIntellectum Repositorio Universidad de La SabanaHemorragia encefálica cerebralHemorragia intracerebralPlasma fresco congeladoProtrombinaEfecto del manejo con concentrado de protrombina en comparación al plasma fresco congelado, en la hemorragia Intracerebral asociada a warfarina: Ensayo Clínico Aleatorizado; Estudio scorpiobachelorThesisTesis de especializaciónpublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_7a1fhttp://purl.org/coar/access_right/c_abf2ORIGINALCarlos Hernando Salazar Triviño (TESIS).pdfCarlos Hernando Salazar Triviño (TESIS).pdfVer documento en PDFapplication/pdf1083504https://intellectum.unisabana.edu.co/bitstream/10818/9368/1/Carlos%20Hernando%20Salazar%20Trivi%c3%b1o%20%28TESIS%29.pdfe0db5eb8493b1fa17cd4ea2fbc529f06MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/9368/2/license.txtf52a2cfd4df262e08e9b300d62c85cabMD52Carlos Hernando Salazar Triviño (Cart).pdfCarlos Hernando Salazar Triviño (Cart).pdfapplication/pdf1080478https://intellectum.unisabana.edu.co/bitstream/10818/9368/4/Carlos%20Hernando%20Salazar%20Trivi%c3%b1o%20%28Cart%29.pdff53b6f155561f9d6a8a1d4d01718ff6aMD54TEXTCarlos Hernando Salazar Triviño (TESIS).pdf.txtCarlos Hernando Salazar Triviño (TESIS).pdf.txtExtracted Texttext/plain88https://intellectum.unisabana.edu.co/bitstream/10818/9368/3/Carlos%20Hernando%20Salazar%20Trivi%c3%b1o%20%28TESIS%29.pdf.txtf6ed2ea053e193f100f89461525c4277MD5310818/9368oai:intellectum.unisabana.edu.co:10818/93682019-08-13 14:40:50.28Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.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