Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy

8 páginas

Autores:: Rosales, Wendy
Carulla, Juan
García Serrano, Jeison
Vargas, Diana
Lizcano Losada, Fernando

Tipo de recurso:

Fecha de publicación:: 2016

Institución:: Universidad de la Sabana

Repositorio:: Repositorio Universidad de la Sabana

Idioma:: eng

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spelling	Rosales, WendyCarulla, JuanGarcía Serrano, JeisonVargas, DianaLizcano Losada, Fernando6/13/2018 9:192018-06-13T14:19:37Z2016-09-18Rosales, W., Carulla. J., García, J., Vargas, D. y Lizcano, L. (2016).Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy. BioMed Research International, 2016 (1-7 )https://www.hindawi.com/journals/bmri/2016/2634976/http://hdl.handle.net/10818/3313610.1155/2016/26349768 páginasEpigenetic changes induced by histone demethylases play an important role in differentiation and pathological changes in cardiac cells. However, the role of the jumonji family of demethylases in the development of cardiac hypertrophy remains elusive. In this study, the presence of different histone demethylases in cardiac cells was evaluated after hypertrophy was induced with neurohormones. A cell line from rat cardiomyocytes was used as a biological model. The phenotypic profiles of the cells, as well as the expression of histone demethylases, were studied through immunofluorescence, transient transfection, western blot, and qRT-PCR analysis after inducing hypertrophy by angiotensin II and endothelin-1. An increase in fetal gene expression (ANP, BNP, and β-MHC) was observed in cardiomyocytes after treatment with angiotensin II and endothelin-1. A significant increase in JMJD2A expression, but not in UTX or JMJD2C expression, was observed. When JMJD2A was overexpressed in cardiomyocytes through transient transfection, the effect of neurohormones on fetal cardiac gene expression was increased. We conclude that JMJD2A plays a principal role in the regulation of fetal cardiac genes, which increase in expression during the pathological hypertrophic process.application/pdfengBioMed Research InternationalBioMed Research International Volume 2016, Article ID 2634976, 7 pagesAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaDemethylasesHypertrophyRole of Histone Demethylases in Cardiomyocytes Induced to HypertrophyarticlepublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/33136/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81223https://intellectum.unisabana.edu.co/bitstream/10818/33136/2/license_rdf7c9ab7f006165862d8ce9ac5eac01552MD5210818/33136oai:intellectum.unisabana.edu.co:10818/331362022-05-10 05:16:33.956Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.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
dc.title.es_CO.fl_str_mv	Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy
title	Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy
spellingShingle	Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy Demethylases Hypertrophy
title_short	Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy
title_full	Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy
title_fullStr	Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy
title_full_unstemmed	Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy
title_sort	Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy
dc.creator.fl_str_mv	Rosales, Wendy Carulla, Juan García Serrano, Jeison Vargas, Diana Lizcano Losada, Fernando
dc.contributor.author.none.fl_str_mv	Rosales, Wendy Carulla, Juan García Serrano, Jeison Vargas, Diana Lizcano Losada, Fernando
dc.subject.none.fl_str_mv	Demethylases Hypertrophy
topic	Demethylases Hypertrophy
description	8 páginas
publishDate	2016
dc.date.issued.none.fl_str_mv	2016-09-18
dc.date.available.none.fl_str_mv	2018-06-13T14:19:37Z
dc.date.accessioned.none.fl_str_mv	6/13/2018 9:19
dc.type.en.fl_str_mv	article
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dc.type.hasVersion.es_CO.fl_str_mv	publishedVersion
dc.identifier.citation.es_CO.fl_str_mv	Rosales, W., Carulla. J., García, J., Vargas, D. y Lizcano, L. (2016).Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy. BioMed Research International, 2016 (1-7 )
dc.identifier.other.none.fl_str_mv	https://www.hindawi.com/journals/bmri/2016/2634976/
dc.identifier.uri.none.fl_str_mv	http://hdl.handle.net/10818/33136
dc.identifier.doi.none.fl_str_mv	10.1155/2016/2634976
identifier_str_mv	Rosales, W., Carulla. J., García, J., Vargas, D. y Lizcano, L. (2016).Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy. BioMed Research International, 2016 (1-7 ) 10.1155/2016/2634976
url	https://www.hindawi.com/journals/bmri/2016/2634976/ http://hdl.handle.net/10818/33136
dc.language.iso.es_CO.fl_str_mv	eng
language	eng
dc.relation.ispartofseries.none.fl_str_mv	BioMed Research International Volume 2016, Article ID 2634976, 7 pages
dc.rights.*.fl_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.coar.fl_str_mv	http://purl.org/coar/access_right/c_abf2
dc.rights.uri.*.fl_str_mv	http://creativecommons.org/licenses/by-nc-nd/4.0/
rights_invalid_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2
dc.format.es_CO.fl_str_mv	application/pdf
dc.publisher.es_CO.fl_str_mv	BioMed Research International
dc.source.es_CO.fl_str_mv	Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana
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Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy

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