Functional Characterization of Preadipocytes Derived from Human Periaortic Adipose Tissue

10 páginas

Autores:: Vargas, Diana
Camacho Mackenzie, Jaime
Duque, Juan
Carreño Jaimes, Marisol
Acero Mondragón, Edward Javier
Pérez, Máximo
Ramirez, Sergio
Umaña, Juan
Obando, Carlos
Guerrero, Albert
Sandoval, Néstor
Rodríguez, Gina
Lizcano Losada, Fernando

Tipo de recurso:

Fecha de publicación:: 2017

Institución:: Universidad de la Sabana

Repositorio:: Repositorio Universidad de la Sabana

Idioma:: eng

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spelling	Vargas, DianaCamacho Mackenzie, JaimeDuque, JuanCarreño Jaimes, MarisolAcero Mondragón, Edward JavierPérez, MáximoRamirez, SergioUmaña, JuanObando, CarlosGuerrero, AlbertSandoval, NéstorRodríguez, GinaLizcano Losada, Fernando2018-06-21T13:56:42Z2017-10-25Vargas, D., Camacho, J., Duque, J., Carreño, M., Acero, E., Pérez, M., Ramírez, S., Umaña, J., Obando, C., Guerrero, A., Sandoval, N., Rodríguez, G., Lizcano, F., (2017) Functional Characterization of Preadipocytes Derived from Human Periaortic Adipose Tissue. International Journal Endocinology.https://www.hindawi.com/journals/ije/2017/2945012/http://hdl.handle.net/10818/3318210.1155/2017/294501210 páginasAdipose tissue can affect the metabolic control of the cardiovascular system, and its anatomic location can affect the vascular function differently. In this study, biochemical and phenotypical characteristics of adipose tissue from periaortic fat were evaluated. Periaortic and subcutaneous adipose tissues were obtained from areas surrounding the ascending aorta and sternotomy incision, respectively. Adipose tissues were collected from patients undergoing myocardial revascularization or mitral valve replacement surgery. Morphological studies with hematoxylin/eosin and immunohistochemical assay were performed in situ to quantify adipokine expression. To analyze adipogenic capacity, adipokine expression, and the levels of thermogenic proteins, adipocyte precursor cells were isolated from periaortic and subcutaneous adipose tissues and induced to differentiation. The precursors of adipocytes from the periaortic tissue accumulated less triglycerides than those from the subcutaneous tissue after differentiation and were smaller than those from subcutaneous adipose tissue. The levels of proteins involved in thermogenesis and energy expenditure increased significantly in periaortic adipose tissue. Additionally, the expression levels of adipokines that affect carbohydrate metabolism, such as FGF21, increased significantly in mature adipocytes induced from periaortic adipose tissue. These results demonstrate that precursors of periaortic adipose tissue in humans may affect cardiovascular events and might serve as a target for preventing vascular diseases.application/pdfengInternational Journal of EndocrinologyInternational Journal of Endocrinology Volume 2017, Article ID 2945012, 9 pagesAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaHuman periaorticAdiposeVascular diseasesFunctional Characterization of Preadipocytes Derived from Human Periaortic Adipose TissuearticlepublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/33182/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81223https://intellectum.unisabana.edu.co/bitstream/10818/33182/2/license_rdf7c9ab7f006165862d8ce9ac5eac01552MD5210818/33182oai:intellectum.unisabana.edu.co:10818/331822022-05-10 05:17:37.568Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.coPGEgcmVsPSJsaWNlbnNlIiBocmVmPSJodHRwOi8vY3JlYXRpdmVjb21tb25zLm9yZy9saWNlbnNlcy9ieS1uYy1uZC8zLjAvIj48aW1nIGFsdD0iTGljZW5jaWEgQ3JlYXRpdmUgQ29tbW9ucyIgc3R5bGU9ImJvcmRlci13aWR0aDowIiBzcmM9Imh0dHA6Ly9pLmNyZWF0aXZlY29tbW9ucy5vcmcvbC9ieS1uYy1uZC8zLjAvODh4MzEucG5nIiAvPjwvYT48YnIgLz5Fc3RlIDxzcGFuIHhtbG5zOmRjdD0iaHR0cDovL3B1cmwub3JnL2RjL3Rlcm1zLyIgaHJlZj0iaHR0cDovL3B1cmwub3JnL2RjL2RjbWl0eXBlL1RleHQiIHJlbD0iZGN0OnR5cGUiPm9icmE8L3NwYW4+IGVzdMOhIGJham8gdW5hIDxhIHJlbD0ibGljZW5zZSIgaHJlZj0iaHR0cDovL2NyZWF0aXZlY29tbW9ucy5vcmcvbGljZW5zZXMvYnktbmMtbmQvMy4wLyI+bGljZW5jaWEgQ3JlYXRpdmUgQ29tbW9ucyBSZWNvbm9jaW1pZW50by1Ob0NvbWVyY2lhbC1TaW5PYnJhRGVyaXZhZGEgMy4wIFVucG9ydGVkPC9hPi4K
dc.title.es_CO.fl_str_mv	Functional Characterization of Preadipocytes Derived from Human Periaortic Adipose Tissue
title	Functional Characterization of Preadipocytes Derived from Human Periaortic Adipose Tissue
spellingShingle	Functional Characterization of Preadipocytes Derived from Human Periaortic Adipose Tissue Human periaortic Adipose Vascular diseases
title_short	Functional Characterization of Preadipocytes Derived from Human Periaortic Adipose Tissue
title_full	Functional Characterization of Preadipocytes Derived from Human Periaortic Adipose Tissue
title_fullStr	Functional Characterization of Preadipocytes Derived from Human Periaortic Adipose Tissue
title_full_unstemmed	Functional Characterization of Preadipocytes Derived from Human Periaortic Adipose Tissue
title_sort	Functional Characterization of Preadipocytes Derived from Human Periaortic Adipose Tissue
dc.creator.fl_str_mv	Vargas, Diana Camacho Mackenzie, Jaime Duque, Juan Carreño Jaimes, Marisol Acero Mondragón, Edward Javier Pérez, Máximo Ramirez, Sergio Umaña, Juan Obando, Carlos Guerrero, Albert Sandoval, Néstor Rodríguez, Gina Lizcano Losada, Fernando
dc.contributor.author.none.fl_str_mv	Vargas, Diana Camacho Mackenzie, Jaime Duque, Juan Carreño Jaimes, Marisol Acero Mondragón, Edward Javier Pérez, Máximo Ramirez, Sergio Umaña, Juan Obando, Carlos Guerrero, Albert Sandoval, Néstor Rodríguez, Gina Lizcano Losada, Fernando
dc.subject.none.fl_str_mv	Human periaortic Adipose Vascular diseases
topic	Human periaortic Adipose Vascular diseases
description	10 páginas
publishDate	2017
dc.date.issued.none.fl_str_mv	2017-10-25
dc.date.available.none.fl_str_mv	2018-06-21T13:56:42Z
dc.type.en.fl_str_mv	article
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dc.type.hasVersion.es_CO.fl_str_mv	publishedVersion
dc.identifier.citation.es_CO.fl_str_mv	Vargas, D., Camacho, J., Duque, J., Carreño, M., Acero, E., Pérez, M., Ramírez, S., Umaña, J., Obando, C., Guerrero, A., Sandoval, N., Rodríguez, G., Lizcano, F., (2017) Functional Characterization of Preadipocytes Derived from Human Periaortic Adipose Tissue. International Journal Endocinology.
dc.identifier.other.none.fl_str_mv	https://www.hindawi.com/journals/ije/2017/2945012/
dc.identifier.uri.none.fl_str_mv	http://hdl.handle.net/10818/33182
dc.identifier.doi.none.fl_str_mv	10.1155/2017/2945012
identifier_str_mv	Vargas, D., Camacho, J., Duque, J., Carreño, M., Acero, E., Pérez, M., Ramírez, S., Umaña, J., Obando, C., Guerrero, A., Sandoval, N., Rodríguez, G., Lizcano, F., (2017) Functional Characterization of Preadipocytes Derived from Human Periaortic Adipose Tissue. International Journal Endocinology. 10.1155/2017/2945012
url	https://www.hindawi.com/journals/ije/2017/2945012/ http://hdl.handle.net/10818/33182
dc.language.iso.es_CO.fl_str_mv	eng
language	eng
dc.relation.ispartofseries.none.fl_str_mv	International Journal of Endocrinology Volume 2017, Article ID 2945012, 9 pages
dc.rights.*.fl_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.coar.fl_str_mv	http://purl.org/coar/access_right/c_abf2
dc.rights.uri.*.fl_str_mv	http://creativecommons.org/licenses/by-nc-nd/4.0/
rights_invalid_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2
dc.format.es_CO.fl_str_mv	application/pdf
dc.publisher.es_CO.fl_str_mv	International Journal of Endocrinology
dc.source.es_CO.fl_str_mv	Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana
institution	Universidad de la Sabana
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Functional Characterization of Preadipocytes Derived from Human Periaortic Adipose Tissue

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