Gastrointestinal Symptoms and Elevated Levels of Anti- Saccharomyces cerevisiae Antibodies Are Associated with Higher Disease Activity in Colombian Patients with Spondyloarthritis

9 páginas

Autores:: Romero Sánchez, C.
Bautista Molano, W.
Parra, V.
Avila, J. De
Rueda, J. C.
Bello Gualtero, J. M.
Londoño Patiño, John Darío
Valle Oñate, R.

Tipo de recurso:

Fecha de publicación:: 2017

Institución:: Universidad de la Sabana

Repositorio:: Repositorio Universidad de la Sabana

Idioma:: eng

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spelling	Romero Sánchez, C.Bautista Molano, W.Parra, V.Avila, J. DeRueda, J. C.Bello Gualtero, J. M.Londoño Patiño, John DaríoValle Oñate, R.9/4/2020 11:432020-09-04T16:43:35Z2017-10-291687-9260https://pubmed.ncbi.nlm.nih.gov/29213287/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682082/https://www.hindawi.com/journals/ijr/2017/4029584/http://hdl.handle.net/10818/4319810.1155/2017/40295849 páginasBackground. Spondyloarthritis (SpA) is a group of articular inflammatory rheumatic diseases that their gastrointestinal manifestations are around 10% of their extra-articular symptoms, supporting that the inflammatory response of the intestinal mucosa could be associated with the clinical status. Objectives. To investigate the association between gastrointestinal symptoms and autoantibodies and disease activity between SpA patients, healthy subjects (HS), and patients with inflammatory bowel disease (IBD). Methods. 102 SpA patients, 29 IBD patients, and 117 HS were included. Autoantibodies as ASCA, ANCA, anti-tTG, anti-DGP, ANA, and IgA were measured. The patients were assessed to evaluate clinical and gastrointestinal symptoms. An association analysis was performed using Chi square test and a logistic regression. Results. Significant differences were found for ASCA levels in SpA (28.2%) compared to IBD (14.2%) and HS (6.0%) (), as well as for ANAS in SpA (49.5%) and IBD (37.9%) () and abdominal pain () between SpA (54.3%) and IBD (27.5%). Significant associations were found between BASDAI > 4 and gastrointestinal symptoms () and IgA (). The association for abdominal bloating was maintained (OR: 3.93, CI-95%, 1.14–13.56; ). Conclusions. Gastrointestinal symptoms, ASCA, ANAS, and IgA levels were associated with high disease activity in SpA compared with IBD and HS.application/pdfengInternational Journal of RheumatologyInternational Journal of RheumatologyInt J Rheumatol . 2017;2017:4029584Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaAnti-Saccharomyces cerevisiaeSpondyloarthritisGastrointestinal Symptoms and Elevated Levels of Anti- Saccharomyces cerevisiae Antibodies Are Associated with Higher Disease Activity in Colombian Patients with SpondyloarthritisarticlepublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://intellectum.unisabana.edu.co/bitstream/10818/43198/2/license_rdf4460e5956bc1d1639be9ae6146a50347MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/43198/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD5310818/43198oai:intellectum.unisabana.edu.co:10818/431982022-05-10 05:20:30.443Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.coPGEgcmVsPSJsaWNlbnNlIiBocmVmPSJodHRwOi8vY3JlYXRpdmVjb21tb25zLm9yZy9saWNlbnNlcy9ieS1uYy1uZC8zLjAvIj48aW1nIGFsdD0iTGljZW5jaWEgQ3JlYXRpdmUgQ29tbW9ucyIgc3R5bGU9ImJvcmRlci13aWR0aDowIiBzcmM9Imh0dHA6Ly9pLmNyZWF0aXZlY29tbW9ucy5vcmcvbC9ieS1uYy1uZC8zLjAvODh4MzEucG5nIiAvPjwvYT48YnIgLz5Fc3RlIDxzcGFuIHhtbG5zOmRjdD0iaHR0cDovL3B1cmwub3JnL2RjL3Rlcm1zLyIgaHJlZj0iaHR0cDovL3B1cmwub3JnL2RjL2RjbWl0eXBlL1RleHQiIHJlbD0iZGN0OnR5cGUiPm9icmE8L3NwYW4+IGVzdMOhIGJham8gdW5hIDxhIHJlbD0ibGljZW5zZSIgaHJlZj0iaHR0cDovL2NyZWF0aXZlY29tbW9ucy5vcmcvbGljZW5zZXMvYnktbmMtbmQvMy4wLyI+bGljZW5jaWEgQ3JlYXRpdmUgQ29tbW9ucyBSZWNvbm9jaW1pZW50by1Ob0NvbWVyY2lhbC1TaW5PYnJhRGVyaXZhZGEgMy4wIFVucG9ydGVkPC9hPi4K
dc.title.es_CO.fl_str_mv	Gastrointestinal Symptoms and Elevated Levels of Anti- Saccharomyces cerevisiae Antibodies Are Associated with Higher Disease Activity in Colombian Patients with Spondyloarthritis
title	Gastrointestinal Symptoms and Elevated Levels of Anti- Saccharomyces cerevisiae Antibodies Are Associated with Higher Disease Activity in Colombian Patients with Spondyloarthritis
spellingShingle	Gastrointestinal Symptoms and Elevated Levels of Anti- Saccharomyces cerevisiae Antibodies Are Associated with Higher Disease Activity in Colombian Patients with Spondyloarthritis Anti-Saccharomyces cerevisiae Spondyloarthritis
title_short	Gastrointestinal Symptoms and Elevated Levels of Anti- Saccharomyces cerevisiae Antibodies Are Associated with Higher Disease Activity in Colombian Patients with Spondyloarthritis
title_full	Gastrointestinal Symptoms and Elevated Levels of Anti- Saccharomyces cerevisiae Antibodies Are Associated with Higher Disease Activity in Colombian Patients with Spondyloarthritis
title_fullStr	Gastrointestinal Symptoms and Elevated Levels of Anti- Saccharomyces cerevisiae Antibodies Are Associated with Higher Disease Activity in Colombian Patients with Spondyloarthritis
title_full_unstemmed	Gastrointestinal Symptoms and Elevated Levels of Anti- Saccharomyces cerevisiae Antibodies Are Associated with Higher Disease Activity in Colombian Patients with Spondyloarthritis
title_sort	Gastrointestinal Symptoms and Elevated Levels of Anti- Saccharomyces cerevisiae Antibodies Are Associated with Higher Disease Activity in Colombian Patients with Spondyloarthritis
dc.creator.fl_str_mv	Romero Sánchez, C. Bautista Molano, W. Parra, V. Avila, J. De Rueda, J. C. Bello Gualtero, J. M. Londoño Patiño, John Darío Valle Oñate, R.
dc.contributor.author.none.fl_str_mv	Romero Sánchez, C. Bautista Molano, W. Parra, V. Avila, J. De Rueda, J. C. Bello Gualtero, J. M. Londoño Patiño, John Darío Valle Oñate, R.
dc.subject.es_CO.fl_str_mv	Anti-Saccharomyces cerevisiae Spondyloarthritis
topic	Anti-Saccharomyces cerevisiae Spondyloarthritis
description	9 páginas
publishDate	2017
dc.date.issued.none.fl_str_mv	2017-10-29
dc.date.available.none.fl_str_mv	2020-09-04T16:43:35Z
dc.date.accessioned.none.fl_str_mv	9/4/2020 11:43
dc.type.en.fl_str_mv	article
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dc.identifier.issn.none.fl_str_mv	1687-9260
dc.identifier.other.none.fl_str_mv	https://pubmed.ncbi.nlm.nih.gov/29213287/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682082/ https://www.hindawi.com/journals/ijr/2017/4029584/
dc.identifier.uri.none.fl_str_mv	http://hdl.handle.net/10818/43198
dc.identifier.doi.none.fl_str_mv	10.1155/2017/4029584
identifier_str_mv	1687-9260 10.1155/2017/4029584
url	https://pubmed.ncbi.nlm.nih.gov/29213287/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682082/ https://www.hindawi.com/journals/ijr/2017/4029584/ http://hdl.handle.net/10818/43198
dc.language.iso.es_CO.fl_str_mv	eng
language	eng
dc.relation.ispartofseries.none.fl_str_mv	Int J Rheumatol . 2017;2017:4029584
dc.rights.*.fl_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International
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dc.format.es_CO.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	International Journal of Rheumatology
dc.publisher.es_CO.fl_str_mv	International Journal of Rheumatology
publisher.none.fl_str_mv	International Journal of Rheumatology
dc.source.es_CO.fl_str_mv	Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana
institution	Universidad de la Sabana
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Gastrointestinal Symptoms and Elevated Levels of Anti- Saccharomyces cerevisiae Antibodies Are Associated with Higher Disease Activity in Colombian Patients with Spondyloarthritis

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