Una comparación de pruebas de igualdad de dos riesgos competitivos

1 recurso en línea (páginas 97-111).

Autores:
Molina Blanco, Liliana Carolina
Lopera Gómez, Carlos Mario
Tipo de recurso:
Article of journal
Fecha de publicación:
2018
Institución:
Universidad Pedagógica y Tecnológica de Colombia
Repositorio:
RiUPTC: Repositorio Institucional UPTC
Idioma:
spa
OAI Identifier:
oai:repositorio.uptc.edu.co:001/2146
Acceso en línea:
http://repositorio.uptc.edu.co/handle/001/2146
Palabra clave:
Prueba de hipótesis estadística
investigación estadística
Función de incidencia acumulada
Tasa de riesgo de causa-específica
Bootstrap
Aproximación de simetrización aleatoria
Remuestreo y supremo generalizado
Rights
openAccess
License
Copyright (c) 2018 Universidad Pedagógica y Tecnológica de Colombia
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dc.title.spa.fl_str_mv Una comparación de pruebas de igualdad de dos riesgos competitivos
dc.title.alternative.eng.fl_str_mv A comparison test of equality of two competing risks
title Una comparación de pruebas de igualdad de dos riesgos competitivos
spellingShingle Una comparación de pruebas de igualdad de dos riesgos competitivos
Prueba de hipótesis estadística
investigación estadística
Función de incidencia acumulada
Tasa de riesgo de causa-específica
Bootstrap
Aproximación de simetrización aleatoria
Remuestreo y supremo generalizado
title_short Una comparación de pruebas de igualdad de dos riesgos competitivos
title_full Una comparación de pruebas de igualdad de dos riesgos competitivos
title_fullStr Una comparación de pruebas de igualdad de dos riesgos competitivos
title_full_unstemmed Una comparación de pruebas de igualdad de dos riesgos competitivos
title_sort Una comparación de pruebas de igualdad de dos riesgos competitivos
dc.creator.fl_str_mv Molina Blanco, Liliana Carolina
Lopera Gómez, Carlos Mario
dc.contributor.author.none.fl_str_mv Molina Blanco, Liliana Carolina
Lopera Gómez, Carlos Mario
dc.subject.armarc.none.fl_str_mv Prueba de hipótesis estadística
investigación estadística
topic Prueba de hipótesis estadística
investigación estadística
Función de incidencia acumulada
Tasa de riesgo de causa-específica
Bootstrap
Aproximación de simetrización aleatoria
Remuestreo y supremo generalizado
dc.subject.proposal.spa.fl_str_mv Función de incidencia acumulada
Tasa de riesgo de causa-específica
Bootstrap
Aproximación de simetrización aleatoria
Remuestreo y supremo generalizado
description 1 recurso en línea (páginas 97-111).
publishDate 2018
dc.date.accessioned.none.fl_str_mv 2018-09-05T21:06:04Z
dc.date.available.none.fl_str_mv 2018-09-05T21:06:04Z
dc.date.issued.none.fl_str_mv 2018-03-02
dc.type.spa.fl_str_mv Artículo de revista
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dc.identifier.citation.spa.fl_str_mv Molina Blanco, L. C. & Lopera Gómez, C. M. (2018). Una comparación de pruebas de igualdad de dos riesgos competitivos. Ciencia en Desarrollo, 9(1), 97-111. https://doi.org/10.19053/01217488.v9.n1.2018.5625. http://repositorio.uptc.edu.co/handle/001/2146
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dc.identifier.doi.none.fl_str_mv 10.19053/01217488.v9.n1.2018.5625
identifier_str_mv Molina Blanco, L. C. & Lopera Gómez, C. M. (2018). Una comparación de pruebas de igualdad de dos riesgos competitivos. Ciencia en Desarrollo, 9(1), 97-111. https://doi.org/10.19053/01217488.v9.n1.2018.5625. http://repositorio.uptc.edu.co/handle/001/2146
2462-7658
10.19053/01217488.v9.n1.2018.5625
url http://repositorio.uptc.edu.co/handle/001/2146
dc.language.iso.spa.fl_str_mv spa
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dc.relation.references.spa.fl_str_mv M. Pintilie, Competing risks: A practical perspective. Canadá, John Wiley & Sons Ltd, 2006.
A. Aly, S. C. Kochar, y I. W. McKeague, “Some tests for comparing cumulative incidence functions and cause-specific hazard rates”, Journal of the American Statistical Association, Vol. 89, pp. 994-999, 1994.
S. C. Kochar, K. F. Law y P. Yip, “Generalized Supremum Tests for the Equality of Cause Specific Hazard Rates”, Lifetime Data Analysis, Vol.8, pp. 277-288, 2002.
C. Y. Kam, Z. Lixing y Z. Dixin, “Comparing k Cumulative Incidence Functions Through Resampling Methods”, Lifetime Data Analysis, Vol. 8, pp. 401-412, 2002.
J.Y. Dauxois, S. N. U. A. Kirmani. “On testing the proportionality of two cumulative incidence functions in a competing risks setup”. Journal of Nonparametric Statistics, Vol. 16(3-4), pa- ges 479-491, 2004.
1980 J. D Kalbfleisch, R. L. Prentice, The Statistical Analysis of Failure Time Data. New York, John Wiley & Sons Ltd, 1980.
T. R. Fleming y D. P. Harrington, Counting Processes and Survival Analysis. New York, John Wiley & Sons Ltd, 1991.
W. Feller, “The asymptotic distribution of the range of sums of independent random variables”, Annals of Mathematical Statistics, Vol. 22, pp. 427-432, 1951.
M. D. Burke y K. C. Yuen, “Goodness-offit tests for the Cox model via bootstrap method”, Journal of Statistical Planning Inference, Vol. 47, pp. 237-256, 1995.
K. C. Yuen, M. D. Burke, “A test of fit for a semiparametric additive risk model”, Biometrika, Vol. 84, pp. 631-639, 1997.
D. Pollard, Convergence of Stochastic Processes. New York, Springer-Verlag, 1984.
H. Block y A. Basu, “A Continuous bivariate exponential extension”, Journal of the American Statistical Association, Vol. 69, pp.1031- 1037, 1974.
R. Leandro, y J. Achcar, “Generation of bivariate lifetime data assuming the Block & Basu exponential distribution”, Revista de matemática e estatística, Sao Paulo, Vol. 14, pp. 43-52, 1996.
D, S. Friday y G. P. Patil, “A Bivariate Exponential Model With Applications to Reliability and Computer Generation of Random Variables”, The Theory and Applications of Reliabi- lity With Emphasis on Bayesian and Nonpara- metric Methods Vol.1, pp. 527-549, 1977. eds. C. P. Tsokos and I. N. Shimi, New York: Aca- demic Pres.
Y. Sun y R. C. Tiwari,“Comparing Cause- Specific Hazard Rates of a Competing Risks Model with Censored Data”, Institute of Mathematical Statistics, Vol. 27, pp. 225- 270, 1995.
P. M. Petersen, M. Gospodarowicz, R. Tsang, M. Pintilie,W. Wells, D. Hodgson, A. Sun,M. Crump, B. Patterson, y D. Bailey, “Long-term outcome in stage I and II follicular lymphoma following treatment with involved field radiation therapy alone”, Journal of Clinical Oncology, vol. 22, pp. 563S, 2004.
N. Davarzani, J. A. Achcar, y R. Peeters,“ Bivariate lifetime geometric distribution in presence of cure fractions”, Journal of Data Science, Vol. 13, pp. 755- 770, 2015.
dc.relation.ispartofjournal.spa.fl_str_mv Ciencia en Desarrollo;Volumen 9, número 1 (Enero-Junio 2018)
dc.rights.spa.fl_str_mv Copyright (c) 2018 Universidad Pedagógica y Tecnológica de Colombia
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spelling Molina Blanco, Liliana CarolinaLopera Gómez, Carlos Mario2018-09-05T21:06:04Z2018-09-05T21:06:04Z2018-03-02Molina Blanco, L. C. & Lopera Gómez, C. M. (2018). Una comparación de pruebas de igualdad de dos riesgos competitivos. Ciencia en Desarrollo, 9(1), 97-111. https://doi.org/10.19053/01217488.v9.n1.2018.5625. http://repositorio.uptc.edu.co/handle/001/21462462-7658http://repositorio.uptc.edu.co/handle/001/214610.19053/01217488.v9.n1.2018.56251 recurso en línea (páginas 97-111).En este artículo se abordó la problemática de dos riesgos que están compitiendo para causar la falla de un sujeto; en particular determinar si los riesgos o probabilidad de falla asociada a cada tipo de falla son igualmente importantes o si un riesgo es más serio que el otro. Para este fin se hizo un estudio de la prueba de hipótesis para la igualdad de las dos funciones de incidencia acumulada asociadas a los riesgos. Se realizó un estudio de simulación donde se comparan algunos de los procedimientos de prueba que han sido propuestos para este fin; y así, poder determinar el comportamiento de estos procedimientos de prueba bajo varios escenarios que permitan evaluar el desempeño de los mismos. Se incluye una aplicación de los procedimientos de prueba usando datos reales de pacientes con linfoma.In this paper, it is tackled the problematic of the risks that are competing to cause the failure from the subject; in particular whether the risks or likelihood of failure associated with each type of failure are equally important or whether a risk is more serious than the other. For this purpose will be made a study of hypothesis tests for equality of cumulative incidence functions of associated with risks. A comparative study of some of the test procedures that have been proposed for this purpose, and thus able to determine the behavior of the different tests in various scenarios to evaluate the performance of the same will be made. Test procedures are included using real data of patients with lymphoma.Bibliografía: páginas 110-111.application/pdfspaUniversidad Pedagógica y Tecnológica de ColombiaCopyright (c) 2018 Universidad Pedagógica y Tecnológica de Colombiahttps://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)http://purl.org/coar/access_right/c_abf2https://revistas.uptc.edu.co/index.php/ciencia_en_desarrollo/article/view/5625/pdfUna comparación de pruebas de igualdad de dos riesgos competitivosA comparison test of equality of two competing risksArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionTexthttps://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85M. Pintilie, Competing risks: A practical perspective. Canadá, John Wiley & Sons Ltd, 2006.A. Aly, S. C. Kochar, y I. W. McKeague, “Some tests for comparing cumulative incidence functions and cause-specific hazard rates”, Journal of the American Statistical Association, Vol. 89, pp. 994-999, 1994.S. C. Kochar, K. F. Law y P. Yip, “Generalized Supremum Tests for the Equality of Cause Specific Hazard Rates”, Lifetime Data Analysis, Vol.8, pp. 277-288, 2002.C. Y. Kam, Z. Lixing y Z. Dixin, “Comparing k Cumulative Incidence Functions Through Resampling Methods”, Lifetime Data Analysis, Vol. 8, pp. 401-412, 2002.J.Y. Dauxois, S. N. U. A. Kirmani. “On testing the proportionality of two cumulative incidence functions in a competing risks setup”. Journal of Nonparametric Statistics, Vol. 16(3-4), pa- ges 479-491, 2004.1980 J. D Kalbfleisch, R. L. Prentice, The Statistical Analysis of Failure Time Data. New York, John Wiley & Sons Ltd, 1980.T. R. Fleming y D. P. Harrington, Counting Processes and Survival Analysis. New York, John Wiley & Sons Ltd, 1991.W. Feller, “The asymptotic distribution of the range of sums of independent random variables”, Annals of Mathematical Statistics, Vol. 22, pp. 427-432, 1951.M. D. Burke y K. C. Yuen, “Goodness-offit tests for the Cox model via bootstrap method”, Journal of Statistical Planning Inference, Vol. 47, pp. 237-256, 1995.K. C. Yuen, M. D. Burke, “A test of fit for a semiparametric additive risk model”, Biometrika, Vol. 84, pp. 631-639, 1997.D. Pollard, Convergence of Stochastic Processes. New York, Springer-Verlag, 1984.H. Block y A. Basu, “A Continuous bivariate exponential extension”, Journal of the American Statistical Association, Vol. 69, pp.1031- 1037, 1974.R. Leandro, y J. Achcar, “Generation of bivariate lifetime data assuming the Block & Basu exponential distribution”, Revista de matemática e estatística, Sao Paulo, Vol. 14, pp. 43-52, 1996.D, S. Friday y G. P. Patil, “A Bivariate Exponential Model With Applications to Reliability and Computer Generation of Random Variables”, The Theory and Applications of Reliabi- lity With Emphasis on Bayesian and Nonpara- metric Methods Vol.1, pp. 527-549, 1977. eds. C. P. Tsokos and I. N. Shimi, New York: Aca- demic Pres.Y. Sun y R. C. Tiwari,“Comparing Cause- Specific Hazard Rates of a Competing Risks Model with Censored Data”, Institute of Mathematical Statistics, Vol. 27, pp. 225- 270, 1995.P. M. Petersen, M. Gospodarowicz, R. Tsang, M. Pintilie,W. Wells, D. Hodgson, A. Sun,M. Crump, B. Patterson, y D. Bailey, “Long-term outcome in stage I and II follicular lymphoma following treatment with involved field radiation therapy alone”, Journal of Clinical Oncology, vol. 22, pp. 563S, 2004.N. Davarzani, J. A. Achcar, y R. Peeters,“ Bivariate lifetime geometric distribution in presence of cure fractions”, Journal of Data Science, Vol. 13, pp. 755- 770, 2015.Ciencia en Desarrollo;Volumen 9, número 1 (Enero-Junio 2018)Prueba de hipótesis estadísticainvestigación estadísticaFunción de incidencia acumuladaTasa de riesgo de causa-específicaBootstrapAproximación de simetrización aleatoriaRemuestreo y supremo generalizadoORIGINALPPS_870_Una_comparacion_pruebas.pdfPPS_870_Una_comparacion_pruebas.pdfArchivo principalapplication/pdf1103644https://repositorio.uptc.edu.co/bitstreams/eef4ae8a-932b-4707-af1d-1042760e2b2c/downloadc4ebb4ff26a3b5355e744c8cfaa21e19MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-814798https://repositorio.uptc.edu.co/bitstreams/6186a600-f568-4804-af53-efa3f79e3a91/download88794144ff048353b359a3174871b0d5MD52TEXTPPS-870.pdf.txtPPS-870.pdf.txtExtracted 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