Manufacture of titanium dioxide scaffolds for medical applications

The skeletal system is vulnerable to injuries and bone loss over the years, making the use of autologous or allogeneic implants necessary. However, these implants have complications, such as the limited amount of bone to be extracted and the cell death at the extraction site; hence, biomaterials hav...

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Tipo de recurso:
Fecha de publicación:
2018
Institución:
Universidad Pedagógica y Tecnológica de Colombia
Repositorio:
RiUPTC: Repositorio Institucional UPTC
Idioma:
eng
OAI Identifier:
oai:repositorio.uptc.edu.co:001/14216
Acceso en línea:
https://revistas.uptc.edu.co/index.php/ingenieria/article/view/8017
https://repositorio.uptc.edu.co/handle/001/14216
Palabra clave:
compression molding
infiltration
lyophilization
scaffolds
infiltración
moldeo por compresión
liofilización
scaffolds
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License
http://purl.org/coar/access_right/c_abf40
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network_name_str RiUPTC: Repositorio Institucional UPTC
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dc.title.en-US.fl_str_mv Manufacture of titanium dioxide scaffolds for medical applications
dc.title.es-ES.fl_str_mv Elaboración de scaffolds de dióxido de titanio para aplicaciones médicas
title Manufacture of titanium dioxide scaffolds for medical applications
spellingShingle Manufacture of titanium dioxide scaffolds for medical applications
compression molding
infiltration
lyophilization
scaffolds
infiltración
moldeo por compresión
liofilización
scaffolds
title_short Manufacture of titanium dioxide scaffolds for medical applications
title_full Manufacture of titanium dioxide scaffolds for medical applications
title_fullStr Manufacture of titanium dioxide scaffolds for medical applications
title_full_unstemmed Manufacture of titanium dioxide scaffolds for medical applications
title_sort Manufacture of titanium dioxide scaffolds for medical applications
dc.subject.en-US.fl_str_mv compression molding
infiltration
lyophilization
scaffolds
topic compression molding
infiltration
lyophilization
scaffolds
infiltración
moldeo por compresión
liofilización
scaffolds
dc.subject.es-ES.fl_str_mv infiltración
moldeo por compresión
liofilización
scaffolds
description The skeletal system is vulnerable to injuries and bone loss over the years, making the use of autologous or allogeneic implants necessary. However, these implants have complications, such as the limited amount of bone to be extracted and the cell death at the extraction site; hence, biomaterials have been developed as platforms for cell growth (scaffolds). Biomaterials and bones have similar properties that facilitate the integration between the material and the bone tissue, helping the tissue to regenerate. Traditional ceramic implants are hydroxyapatite, but given their low mechanical properties, they have been replaced with better inert ceramics. Therefore, this study aims at manufacturing titanium dioxide scaffolds through various techniques, using collagen, polyvinyl alcohol (PVA), sodium chloride, and corn flour as binders to influence pore size. Scaffolds were characterized by a Scanning Electron Microscope (SEM) and evaluated by compression and degradability tests in a Simulated Body Fluid (SBF). The prepared scaffolds had mechanical behaviors with ranges within the bone parameters; among them, the scaffold obtained by infiltration with 10% PVA presented values of compression strength (6.75 MPa), elastic modulus (0.23 GPa), and porosities (54-67%) closer to the values of the trabecular bone.
publishDate 2018
dc.date.accessioned.none.fl_str_mv 2024-07-05T19:11:36Z
dc.date.available.none.fl_str_mv 2024-07-05T19:11:36Z
dc.date.none.fl_str_mv 2018-05-15
dc.type.en-US.fl_str_mv research
dc.type.es-ES.fl_str_mv investigación
dc.type.none.fl_str_mv info:eu-repo/semantics/article
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.coarversion.spa.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a123
status_str publishedVersion
dc.identifier.none.fl_str_mv https://revistas.uptc.edu.co/index.php/ingenieria/article/view/8017
10.19053/01211129.v27.n48.2018.8017
dc.identifier.uri.none.fl_str_mv https://repositorio.uptc.edu.co/handle/001/14216
url https://revistas.uptc.edu.co/index.php/ingenieria/article/view/8017
https://repositorio.uptc.edu.co/handle/001/14216
identifier_str_mv 10.19053/01211129.v27.n48.2018.8017
dc.language.none.fl_str_mv eng
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://revistas.uptc.edu.co/index.php/ingenieria/article/view/8017/6461
https://revistas.uptc.edu.co/index.php/ingenieria/article/view/8017/7185
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.coar.spa.fl_str_mv http://purl.org/coar/access_right/c_abf40
rights_invalid_str_mv http://purl.org/coar/access_right/c_abf40
http://purl.org/coar/access_right/c_abf2
dc.format.none.fl_str_mv application/pdf
application/xml
dc.publisher.en-US.fl_str_mv Universidad Pedagógica y Tecnológica de Colombia
dc.source.en-US.fl_str_mv Revista Facultad de Ingeniería; Vol. 27 No. 48 (2018); 17-25
dc.source.es-ES.fl_str_mv Revista Facultad de Ingeniería; Vol. 27 Núm. 48 (2018); 17-25
dc.source.none.fl_str_mv 2357-5328
0121-1129
institution Universidad Pedagógica y Tecnológica de Colombia
repository.name.fl_str_mv Repositorio Institucional UPTC
repository.mail.fl_str_mv repositorio.uptc@uptc.edu.co
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spelling 2018-05-152024-07-05T19:11:36Z2024-07-05T19:11:36Zhttps://revistas.uptc.edu.co/index.php/ingenieria/article/view/801710.19053/01211129.v27.n48.2018.8017https://repositorio.uptc.edu.co/handle/001/14216The skeletal system is vulnerable to injuries and bone loss over the years, making the use of autologous or allogeneic implants necessary. However, these implants have complications, such as the limited amount of bone to be extracted and the cell death at the extraction site; hence, biomaterials have been developed as platforms for cell growth (scaffolds). Biomaterials and bones have similar properties that facilitate the integration between the material and the bone tissue, helping the tissue to regenerate. Traditional ceramic implants are hydroxyapatite, but given their low mechanical properties, they have been replaced with better inert ceramics. Therefore, this study aims at manufacturing titanium dioxide scaffolds through various techniques, using collagen, polyvinyl alcohol (PVA), sodium chloride, and corn flour as binders to influence pore size. Scaffolds were characterized by a Scanning Electron Microscope (SEM) and evaluated by compression and degradability tests in a Simulated Body Fluid (SBF). The prepared scaffolds had mechanical behaviors with ranges within the bone parameters; among them, the scaffold obtained by infiltration with 10% PVA presented values of compression strength (6.75 MPa), elastic modulus (0.23 GPa), and porosities (54-67%) closer to the values of the trabecular bone.El sistema esquelético es vulnerable a lesiones y a perder hueso a lo largo de los años, lo que hace necesario el uso de implantes autólogos o alogénicos; sin embargo, estos implantes tienen complicaciones, como la cantidad limitada de hueso que se extrae y la muerte celular en el sitio de extracción; por lo tanto, se han desarrollado biomateriales como plataformas para el crecimiento celular (scaffolds). Los biomateriales tienen propiedades similares a las del hueso, lo que facilita su integración con el tejido óseo, ayudando a la regeneración de este. Tradicionales los implantes de cerámica son de hidroxiapatitas, pero, debido a sus pobres propiedades mecánicas, han sido reemplazados por cerámicas inertes, que tienen mejores propiedades mecánicas. Por lo tanto, el objetivo de este estudio fue fabricar scaffolds de dióxido de titanio, por medio de diferentes técnicas, utilizando colágeno, polivinil alcohol (PVA), cloruro de sodio y harina de maíz como aglutinante para influenciar el tamaño del poro. Los scaffolds se caracterizaron por medio de microscopía electrónica de barrido (SEM) y se evaluaron con pruebas de compresión y degradabilidad en un fluido corporal simulado (SBF). Los scaffolds elaborados presentaron comportamientos mecánicos que están entre el rango normal del hueso; el scaffold obtenido por medio de infiltración, con 10 % de PVA, presentó valores de fuerza de compresión (6.75 MPa), módulos elásticos (0.23 GPa) y porosidad (54-67 %) cercanos a aquellos reportados para el hueso trabecular.application/pdfapplication/xmlengengUniversidad Pedagógica y Tecnológica de Colombiahttps://revistas.uptc.edu.co/index.php/ingenieria/article/view/8017/6461https://revistas.uptc.edu.co/index.php/ingenieria/article/view/8017/7185Copyright (c) 2018 Giovanni Cuervo-Osorio, Ana María Jiménez-Valencia, Cristian Mosquera-Agualimpia, Diana Marcela Escobar-Sierrahttp://purl.org/coar/access_right/c_abf40http://purl.org/coar/access_right/c_abf2Revista Facultad de Ingeniería; Vol. 27 No. 48 (2018); 17-25Revista Facultad de Ingeniería; Vol. 27 Núm. 48 (2018); 17-252357-53280121-1129compression moldinginfiltrationlyophilizationscaffoldsinfiltraciónmoldeo por compresiónliofilizaciónscaffoldsManufacture of titanium dioxide scaffolds for medical applicationsElaboración de scaffolds de dióxido de titanio para aplicaciones médicasresearchinvestigacióninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a123http://purl.org/coar/version/c_970fb48d4fbd8a85Cuervo-Osorio, GiovanniJiménez-Valencia, Ana MaríaMosquera-Agualimpia, CristianEscobar-Sierra, Diana Marcela001/14216oai:repositorio.uptc.edu.co:001/142162025-07-18 11:53:14.365metadata.onlyhttps://repositorio.uptc.edu.coRepositorio Institucional UPTCrepositorio.uptc@uptc.edu.co