Core/shell fibers of Carboxymethylcellulose/Poly(lactic acid) loaded with Curcumin.
To dose curcumin (Cur) while avoiding its degradation, a polymeric material consisting of fibers with core/shell structure was designed. Coaxial electrospinning allowed us to obtain fibers with poly(lactic acid) (PLA) core, and carboxymethylcellulose (CMC) shell. CMC/PLA fibers were compared with co...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2020
- Institución:
- Universidad Pedagógica y Tecnológica de Colombia
- Repositorio:
- RiUPTC: Repositorio Institucional UPTC
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.uptc.edu.co:001/15291
- Acceso en línea:
- https://revistas.uptc.edu.co/index.php/ciencia_en_desarrollo/article/view/10864
https://repositorio.uptc.edu.co/handle/001/15291
- Palabra clave:
- Carboximetilcelulosa, Poli(ácido láctico), Curcumina, Fibras Núcleo/Coraza, Electrohilado Coaxial.
Carboxymethylcellulose, Poly (lactic acid), Curcumin, Core/Shell Fibers, Coaxial Electro-spinning.
- Rights
- License
- Derechos de autor 2020 CIENCIA EN DESARROLLO
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2020-06-042024-07-08T14:24:00Z2024-07-08T14:24:00Zhttps://revistas.uptc.edu.co/index.php/ciencia_en_desarrollo/article/view/1086410.19053/01217488.v11.n2.2020.10864https://repositorio.uptc.edu.co/handle/001/15291To dose curcumin (Cur) while avoiding its degradation, a polymeric material consisting of fibers with core/shell structure was designed. Coaxial electrospinning allowed us to obtain fibers with poly(lactic acid) (PLA) core, and carboxymethylcellulose (CMC) shell. CMC/PLA fibers were compared with conventional PLA fibers. Scanning electron microscopy images allowed us to characterize the core/shell structure of CMC/PLA-Cur fibers. The presence of Cur in the fibers was confirmed by Raman spectroscopy. Thermogravimetric analysis and differential scanning calorimetry showed the effect of Cur on the thermal behavior of the fibers, and showed contrasting behavior between CMC/PLA and PLA fibers. Cur release experiments were performed at physiological pH and the results were fitted with the Korsmeyer-Peppas model. The release rate of CMC/PLA fibers was significantly lower than that of PLA fibers.Para dosificar curcumina (Cur) evitando su degradación, se diseñó un material polimérico que consta de fibras con estructura núcleo/coraza. Se utilizó la técnica de electrohilado coaxial para obtener de fibras con núcleo de ácido poliláctico (PLA) y coraza de carboximetilcelulosa (CMC). Fibras de CMC/PLA fueron comparadas con fibras convencionales de PLA cargadas con curcumina. Imágenes de microscopia electrónica de barrido permitieron caracterizar la estructura núcleo/coraza de las fibras de CMC/PLA-Cur. La presencia de Cur en las fibras fue confirmada por espectroscopía Raman. Análisis termogravimétrico y calorimetría diferencial de barrido mostraron el efecto de la incorporación de Cur en el comportamiento térmico fibras y permitió contrastar las fibras de PLA con las de CMC/PLA. Se realizaron experimentos de liberación de Cur a pH fisiológico y los resultados se ajustaron al modelo de Korsmeyer-Peppas. La tasa de liberación de fibras de CMC/PLA es significativamente menor a la de fibras de PLA sin coraza.application/pdfspaspaUniversidad Pedagógica y Tecnológica de Colombiahttps://revistas.uptc.edu.co/index.php/ciencia_en_desarrollo/article/view/10864/10290Derechos de autor 2020 CIENCIA EN DESARROLLOhttp://purl.org/coar/access_right/c_abf2Ciencia En Desarrollo; Vol. 11 No. 2 (2020): Vol 11, Núm.2 (2020): Julio-Diciembre; 141-150Ciencia en Desarrollo; Vol. 11 Núm. 2 (2020): Vol 11, Núm.2 (2020): Julio-Diciembre; 141-1502462-76580121-7488Carboximetilcelulosa, Poli(ácido láctico), Curcumina, Fibras Núcleo/Coraza, Electrohilado Coaxial.Carboxymethylcellulose, Poly (lactic acid), Curcumin, Core/Shell Fibers, Coaxial Electro-spinning.Core/shell fibers of Carboxymethylcellulose/Poly(lactic acid) loaded with Curcumin.Fibras núcleo/coraza de Carboximetilcelulosa/Acido Poliláctico cargadas con Curcumina.info:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1León Pérez, Jadileyg GabrielaEstrada Villegas, Gethzemani MayeliMorales-Corona, JuanOlayo-Gonzalez, RobertoOlayo-Valles, Roberto001/15291oai:repositorio.uptc.edu.co:001/152912025-07-18 10:56:46.294metadata.onlyhttps://repositorio.uptc.edu.coRepositorio Institucional UPTCrepositorio.uptc@uptc.edu.co |
| dc.title.en-US.fl_str_mv |
Core/shell fibers of Carboxymethylcellulose/Poly(lactic acid) loaded with Curcumin. |
| dc.title.es-ES.fl_str_mv |
Fibras núcleo/coraza de Carboximetilcelulosa/Acido Poliláctico cargadas con Curcumina. |
| title |
Core/shell fibers of Carboxymethylcellulose/Poly(lactic acid) loaded with Curcumin. |
| spellingShingle |
Core/shell fibers of Carboxymethylcellulose/Poly(lactic acid) loaded with Curcumin. Carboximetilcelulosa, Poli(ácido láctico), Curcumina, Fibras Núcleo/Coraza, Electrohilado Coaxial. Carboxymethylcellulose, Poly (lactic acid), Curcumin, Core/Shell Fibers, Coaxial Electro-spinning. |
| title_short |
Core/shell fibers of Carboxymethylcellulose/Poly(lactic acid) loaded with Curcumin. |
| title_full |
Core/shell fibers of Carboxymethylcellulose/Poly(lactic acid) loaded with Curcumin. |
| title_fullStr |
Core/shell fibers of Carboxymethylcellulose/Poly(lactic acid) loaded with Curcumin. |
| title_full_unstemmed |
Core/shell fibers of Carboxymethylcellulose/Poly(lactic acid) loaded with Curcumin. |
| title_sort |
Core/shell fibers of Carboxymethylcellulose/Poly(lactic acid) loaded with Curcumin. |
| dc.subject.es-ES.fl_str_mv |
Carboximetilcelulosa, Poli(ácido láctico), Curcumina, Fibras Núcleo/Coraza, Electrohilado Coaxial. |
| topic |
Carboximetilcelulosa, Poli(ácido láctico), Curcumina, Fibras Núcleo/Coraza, Electrohilado Coaxial. Carboxymethylcellulose, Poly (lactic acid), Curcumin, Core/Shell Fibers, Coaxial Electro-spinning. |
| dc.subject.en-US.fl_str_mv |
Carboxymethylcellulose, Poly (lactic acid), Curcumin, Core/Shell Fibers, Coaxial Electro-spinning. |
| description |
To dose curcumin (Cur) while avoiding its degradation, a polymeric material consisting of fibers with core/shell structure was designed. Coaxial electrospinning allowed us to obtain fibers with poly(lactic acid) (PLA) core, and carboxymethylcellulose (CMC) shell. CMC/PLA fibers were compared with conventional PLA fibers. Scanning electron microscopy images allowed us to characterize the core/shell structure of CMC/PLA-Cur fibers. The presence of Cur in the fibers was confirmed by Raman spectroscopy. Thermogravimetric analysis and differential scanning calorimetry showed the effect of Cur on the thermal behavior of the fibers, and showed contrasting behavior between CMC/PLA and PLA fibers. Cur release experiments were performed at physiological pH and the results were fitted with the Korsmeyer-Peppas model. The release rate of CMC/PLA fibers was significantly lower than that of PLA fibers. |
| publishDate |
2020 |
| dc.date.accessioned.none.fl_str_mv |
2024-07-08T14:24:00Z |
| dc.date.available.none.fl_str_mv |
2024-07-08T14:24:00Z |
| dc.date.none.fl_str_mv |
2020-06-04 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.identifier.none.fl_str_mv |
https://revistas.uptc.edu.co/index.php/ciencia_en_desarrollo/article/view/10864 10.19053/01217488.v11.n2.2020.10864 |
| dc.identifier.uri.none.fl_str_mv |
https://repositorio.uptc.edu.co/handle/001/15291 |
| url |
https://revistas.uptc.edu.co/index.php/ciencia_en_desarrollo/article/view/10864 https://repositorio.uptc.edu.co/handle/001/15291 |
| identifier_str_mv |
10.19053/01217488.v11.n2.2020.10864 |
| dc.language.none.fl_str_mv |
spa |
| dc.language.iso.none.fl_str_mv |
spa |
| language |
spa |
| dc.relation.none.fl_str_mv |
https://revistas.uptc.edu.co/index.php/ciencia_en_desarrollo/article/view/10864/10290 |
| dc.rights.es-ES.fl_str_mv |
Derechos de autor 2020 CIENCIA EN DESARROLLO |
| dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
| rights_invalid_str_mv |
Derechos de autor 2020 CIENCIA EN DESARROLLO http://purl.org/coar/access_right/c_abf2 |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.es-ES.fl_str_mv |
Universidad Pedagógica y Tecnológica de Colombia |
| dc.source.en-US.fl_str_mv |
Ciencia En Desarrollo; Vol. 11 No. 2 (2020): Vol 11, Núm.2 (2020): Julio-Diciembre; 141-150 |
| dc.source.es-ES.fl_str_mv |
Ciencia en Desarrollo; Vol. 11 Núm. 2 (2020): Vol 11, Núm.2 (2020): Julio-Diciembre; 141-150 |
| dc.source.none.fl_str_mv |
2462-7658 0121-7488 |
| institution |
Universidad Pedagógica y Tecnológica de Colombia |
| repository.name.fl_str_mv |
Repositorio Institucional UPTC |
| repository.mail.fl_str_mv |
repositorio.uptc@uptc.edu.co |
| _version_ |
1839633900791398400 |