“Terapias convencionales y regenerativas en tendinopatias del flexor digital superficial en equinos de deporte”
1 recurso en línea (89 páginas) : ilustraciones color, tablas.
- Autores:
-
Castro Rodríguez, Edwin Leonardo
- Tipo de recurso:
- Trabajo de grado de pregrado
- Fecha de publicación:
- 2017
- Institución:
- Universidad Pedagógica y Tecnológica de Colombia
- Repositorio:
- RiUPTC: Repositorio Institucional UPTC
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.uptc.edu.co:001/2338
- Acceso en línea:
- http://repositorio.uptc.edu.co/handle/001/2338
- Palabra clave:
- Medicina deportiva equina
Caballos - Heridas, lesiones, etc. - Tratamiento
Caballos - Terapias
Medicina equina
Equinos - Tratamiento de fracturas
Medicina Veterinaria y Zootecnia - Tesis y disertaciones académicas
Agrosavia
- Rights
- openAccess
- License
- Copyright (c) 2017 Universidad Pedagógica y Tecnológica de Colombia
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“Terapias convencionales y regenerativas en tendinopatias del flexor digital superficial en equinos de deporte” |
| title |
“Terapias convencionales y regenerativas en tendinopatias del flexor digital superficial en equinos de deporte” |
| spellingShingle |
“Terapias convencionales y regenerativas en tendinopatias del flexor digital superficial en equinos de deporte” Medicina deportiva equina Caballos - Heridas, lesiones, etc. - Tratamiento Caballos - Terapias Medicina equina Equinos - Tratamiento de fracturas Medicina Veterinaria y Zootecnia - Tesis y disertaciones académicas Agrosavia |
| title_short |
“Terapias convencionales y regenerativas en tendinopatias del flexor digital superficial en equinos de deporte” |
| title_full |
“Terapias convencionales y regenerativas en tendinopatias del flexor digital superficial en equinos de deporte” |
| title_fullStr |
“Terapias convencionales y regenerativas en tendinopatias del flexor digital superficial en equinos de deporte” |
| title_full_unstemmed |
“Terapias convencionales y regenerativas en tendinopatias del flexor digital superficial en equinos de deporte” |
| title_sort |
“Terapias convencionales y regenerativas en tendinopatias del flexor digital superficial en equinos de deporte” |
| dc.creator.fl_str_mv |
Castro Rodríguez, Edwin Leonardo |
| dc.contributor.advisor.spa.fl_str_mv |
Ariza Suárez, Angela Cristina |
| dc.contributor.author.none.fl_str_mv |
Castro Rodríguez, Edwin Leonardo |
| dc.subject.armarc.none.fl_str_mv |
Medicina deportiva equina Caballos - Heridas, lesiones, etc. - Tratamiento Caballos - Terapias Medicina equina Equinos - Tratamiento de fracturas Medicina Veterinaria y Zootecnia - Tesis y disertaciones académicas |
| topic |
Medicina deportiva equina Caballos - Heridas, lesiones, etc. - Tratamiento Caballos - Terapias Medicina equina Equinos - Tratamiento de fracturas Medicina Veterinaria y Zootecnia - Tesis y disertaciones académicas Agrosavia |
| dc.subject.armarc.spa.fl_str_mv |
Agrosavia |
| description |
1 recurso en línea (89 páginas) : ilustraciones color, tablas. |
| publishDate |
2017 |
| dc.date.issued.none.fl_str_mv |
2017 |
| dc.date.accessioned.none.fl_str_mv |
2018-12-12T20:35:58Z |
| dc.date.available.none.fl_str_mv |
2018-12-12T20:35:58Z |
| dc.type.spa.fl_str_mv |
Trabajo de grado - Pregrado |
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http://purl.org/coar/resource_type/c_7a1f |
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info:eu-repo/semantics/bachelorThesis |
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Text |
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https://purl.org/redcol/resource_type/TP |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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Castro Rodríguez, E. L. (2017). “Terapias convencionales y regenerativas en tendinopatias del flexor digital superficial en equinos de deporte”. (Trabajo de grado). Universidad Pedagógica y Tecnológica de Colombia, Tunja. http://repositorio.uptc.edu.co/handle/001/2338 |
| dc.identifier.uri.none.fl_str_mv |
http://repositorio.uptc.edu.co/handle/001/2338 |
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Castro Rodríguez, E. L. (2017). “Terapias convencionales y regenerativas en tendinopatias del flexor digital superficial en equinos de deporte”. (Trabajo de grado). Universidad Pedagógica y Tecnológica de Colombia, Tunja. http://repositorio.uptc.edu.co/handle/001/2338 |
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http://repositorio.uptc.edu.co/handle/001/2338 |
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spa |
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spa |
| dc.relation.references.spa.fl_str_mv |
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Obtenido de (http://www.sciencedirect.com/science/article/pii/S0272271210001551) Burk, J., Badylak, F., Kelly, J., Brehm, W., (2013) Equine cellular therapy—from stall to bench to bedside Cytometry Part volumen (83), p.103-113.Bueno, I. M. (2008) tendón. Valoración y tratamiento en fisioterapia.primera ed., Volumen (1). barcelona : Editorial Paidotribo. Butchera, H., Hermansonc, N., Ducharmed, L.M., Mitchelld, V., Soderholmd, A., Bertrame. (2009) Contractile behavior of the forelimb digital flexors during steady-state locomotion in horses (Equus caballus): An initial test of muscle architectural hypotheses about in vivo function. Integrative Physiology,volumen (152), p.100-114. Obtenido de http://biblio.uptc.edu.co:2054/science/article/pii/S1095643308011288 Botero, L., (2007) tenoscopía como tratamiento quirúrgico en casos de tenosinovitis traumática en un caballo de silla francesa. Revista CES / Medicina Veterinaria y Zootecnia /, Volumen (2), p.6. Tomado de http://revistas.ces.edu.co/index.php/mvz/article/view/366/1868 Cano, H., (2008) el uso de células madre de la medula ósea en la terapia de tendinitis en equinos. monografia , mexico . Obtenido de http://repositorio.uaaan.mx:8080/xmlui/bitstream/handle/123456789/2904/MONOGRAFIA%20ERIC.pdf?sequence=1 Carol, G. (2007) Ultrasonography for Monitoring Healing and Rehabilitation. Clinical Techniques in Equine Practice, volumen(11),p.174-178. Obtenido de http://biblio.uptc.edu.co:2054/science/article/pii/S1534751607000327 Carvalho, A. (2009) Isolation and immunophenotypic characterization of mesenchymal stem cells derived from equinespecies adipose tissue,. Veterinary Immunology and Immunopathology, Volume 132(2–4,), Pag 303-306,. Obtenido de http://www.sciencedirect.com/science/article/pii/S016524270900214 Carvajal, J. A. (2013). Tendinopatias del tendon digital superficial: dignostico y tratamientos. Tesis, universidad autonoma agraria, torreon,coahuila,mexico. Carmona, L. (2011) Tendinopatía del tendón flexor digital superficial y desmopatía del ligamento suspensorio en caballos fisiopatología y terapias regenerativas. scielo,volumen (113), p. 12-13Recuperado de http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0301-732X2011000300002 Castro, P. (2015) ondas de choque en pacientes que acudieron con diagnóstico de tendinopatía rotuliana al Centro de Rehabilitación Física y Deportiva Logroño´ s fisioterapia. universidad catolica de ecuador, 18. tesis trabajo de grado. Obtenido de http://repositorio.puce.edu.ec/handle/22000/10097 Clinic T. A. (2014) tenosinovitis plantar.atlanta equine, p.23. obtenido de http://www.atlantaequine.com/pages/client_lib_PDsynovitis.html Dahlgren, L.A., Meulen, M.C., Bertram, j.e., (2002) Insulin-like growth factorI improves cellular and molecular aspects of healing in a collagenase-induced model of flexor tendinitis. Journal of Orthopaedic, volumen (20), p. 910-919. Dahlgren, L. A. (2007) Pathobiology of Tendon and Ligament Injuries. Clinical Techniques in Equine Practice, volumen (3), pag 168–173. Obtenido de http://biblio.uptc.edu.co:2054/science/article/pii/S1534751607000315 Daniela, P. V. (2012) plasma rico em plaquetas:uso em esoes tendineas en equinos. tesis U. F. Veterinária, p.28-40. Obtenido de http://www.lume.ufrgs.br/bitstream/handle/10183/69649/000872982.pdf?sequence=1 Dochevaa, D., Müllerb, MAJEWSKIB, M., H., EVANSC. (2015) Biologics for tendon repair. Advanced Drug Delivery Reviews, volumen (84), pag. 222-239. Obtenido de http://biblio.uptc.edu.co:2054/science/article/pii/S0169409X14002786 Dowling, B.A., Dart, A.J., Hodgson, D.R., Smith, RK (2000) Superficial digital flexor tendonitis in the horse, Equine Veterinary Journal. volumen (32), p. 369-378. Dyson, S.J. (2004) Medical management of superficial digital flexor tendonitis: a comparative study in 219 horses (1992-2000), Equine Veterinary Journal, volumen (36), p. 415-419. tomado de: http://onlinelibrary.wiley.com/doi/10.2746/0425164044868422/abstract Dyson, S. (2014) Incomplete Tears of the Medial Calcaneal Insertion of the Superficial Digital Flexor Tendon of a Hind Limb in Three Horses. Journal of Equine Veterinary Science, volumen (10), p. 11-88 Obtenido de http://biblio.uptc.edu.co:2054/science/article/pii/S0737080614002792 Estrada R., Van, W., Boere, J., Reyes, M., Ionita, Jc., Estrada M., Lischer Cj. (2014) Comparison of healing in forelimb and hindlimb surgically induced core lesions of the equine superficial digital flexor tendon. Veterinary and Comparative Orthopaedics and Traumatology: volumen (5), p. 358-365. Floyd A, R. M. (2007). Libro Equine podiatry (1 ed.). Elsevier Health Sciences. pag 78-144 Fortier, L.A., Smith, R.K. (2008) Regenerative medicine for tendinous and ligamentous injuries of sport horses, Veterinary Clinics of North America.Equine Practice. volumen (24) p. 191-201. Obtenido de http://www.sciencedirect.com/science/article/pii/S0749073907000685 Frati, M. C. (2012) Glicosaminoglicanos en las enfermedades vasculares. Revista Mexicana de angiologia,volumen (40), p. 89-99. Gillis, C. (2007) Ultrasonography for Monitoring Healing and Rehabilitation. Clinical Techniques in Equine Practice,volumen (6), p. 174–178. Obtenido de http://biblio.uptc.edu.co:2054/science/article/pii/S1534751607000327?np=y Giraldo, C. C. (2011) Use of autologous platelet concentrates as regenerative therapy for chronic diseases of the equine musculoskeletal system. scielo chile, volumen (43), p. 1-10. Obtenido de http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0301-732X2011000100002 Guercio., casella, s., russotto, l., puglisi, f., majolino, c., giudice, e., di bella, s., purpari, g., cannella, V. (2015) Mesenchymal Stem Cells Derived From Subcutaneous Fat and Platelet-Rich Plasma Used in Athletic Horses With Lameness of the Superficial Digital Flexor Tendon. Journal of Equine Veterinary Science, volumen (35), p. 19-26. Hawkins, J.F., Ross, W. (1995) Transection of the accessory ligament of the superficial digital flexor muscle for the treatment of superficial digital flexor tendinitis in standardbreds: 40 cases (1988-1992). Journal of the American Veterinary Medical Association, volumen (206), p. 674-678. Hernández, R. P., & Dorticos, E. (2004) Medicina regenerativa. Células madre embrionarias y adultas. Revista Cubana de Hematología, Inmunología y Hemoterapia, volumen (20), p. 7. Obtenido de http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-0289200400030000 Hernández, H.O. (2012) Tendinitis equina: revisión de casos clínicos tratados con plasma rico en plaquetas. Tesis Facultad de Ciencias Veterinarias. Buenos Aires- Argentina 45p. Hosakaa,. H. (2005) Mechanism of Cell Death in Inflamed Superficial Digital Flexor Tendon in the Horse. Journal of Comparative Pathology, VOLUMEN (132), p.51-58. Obtenido de http://biblio.uptc.edu.co:2054/science/article/pii/S0021997504000830 Iacono, E. B. (2015) Equine Bone Marrow and Adipose Tissue Mesenchymal Stem Cells:Cytofluorimetric Characterization, In Vitro Differentiation, and Clinical Application. Journal of Equine Veterinary Science,volumen (35), P. 130-140. Obtenido de http://www.sciencedirect.com/science/article/pii/S0737080614004717 Ivone bruno, R. M. (2014) Characterization of Nucleated Cells From Equine Adipose Tissue and Bone Marrow Aspirate Processed for Point-of-Care Use. Journal of Equine Veterinary Science, (34), P. 1118-1127. Obtenido de http://www.sciencedirect.com/science/article/pii/S0737080614002688) Lauren, S. L. (2013) Therapeutic use of stem cells in horses: Which type, how, and when? The Veterinary Journal, volumen (197), P. 570-577. Obtenido de http://www.sciencedirect.com/science/article/pii/S1090023313001895) Lees, P. L. (2013) Toxicology and residues of phenylbutazone in humans and horses,. The Veterinary Journal, volumen (196), p. 294-303. Obtenido de http://www.sciencedirect.com/science/article/pii/S1090023313001901) Lucas, E. &. (2015) Tratamiento fisioterápico en las lesiones del ligamento suspensorio del caballo. reduca, volumen (6) p.17-38 tomado de: http://revistareduca.es/index.php/reduca-enfermeria/article/view/1776/1792 Mafulli, N. W. (2003) Types and epidemiology of tendinopathy. Clin sport medicine, volumen (22), p. 675-692. Mafulli n. (2010) Novel Approaches for the Management of Tendinopath. The Journal of Bone and Joint Surgery, volumen (11), p. 23-34 Malanga, G. Reina Nakamura (2014) the role of regenerative medicine in the treatment of sports injuries. physical medicine and rehabilitation clinics of north america, volumen (25), p. 881-895. Obtenido de http://www.sciencedirect.com/science/article/pii/S1047965114000564 Martínez, M. D. (2005) estudio ecográfico (ecogenicidad y área). departamento de medicina y cirugia animal tesis doctoral univercidad de Murcia, Murcia p. 20-80. Moraes, J.R., Facco, G.G., Moraes, F.R., Filho, J.R, MIyazato, L.G., Beretta, D.C. (2009) Effects of glycosaminoglycan polysulphate on the organisation of collagen fibres in experimentally induced tendonitis in horses. The Veterinary Record, volumen 165, p. 203-205 Moya, A. D. (2002) Terapia por onda de choque extracorpórea para el tratamiento de lesiones musculo esqueleticas. Rev. Asoc. Arg. Ortop. y Traumatol, volumen (67), p. 286. Obtenido de http://www.aaot.org.ar/revista/1993_2002/2002/2002_4/670408.pdf Nixon, M., Ashlee, E., Watts, D, Schnabel, J. (2012) Cell- and gene-based approaches to tendon regeneration. Journal of Shoulder and Elbow Surgery, volumen (21), p. 278-294. Obtenido de http://biblio.uptc.edu.co:2091/10.1016/j.jse.2011.11.015 O’sullivan, C. B. (2007) Injuries of the Flexor Tendons: Focus on the Superficial Digital Flexor Tendon. Clinical Techniques in Equine Practice, volumen (6), P.189-19. Obtenido de http://www.sciencedirect.com/science/article/pii/S1534751607000340 Parra, M. (2014) Correlacion entre la evaluacion clinica y la ultrasonografia de las lesiones en tendones flexores del miembro anterior en equinos pura sangre ingresa dse carreras en venezuela. Revista cientifica univercidad de zulia, XIV volumen (6), p. 506-512. Recuperado el 2 de 4 de 2016, de http://www.fcv.luz.edu.ve/index.php?option=com_content&task=view&id=602&Itemid=186 Patterson, J.C., Becker,D., T. Rich. (2012). The Pathogenesis of Tendon Microdamage in Athletes: the Horse as a Natural Model for Basic Cellular Research. Journal of Comparative Pathology, volumen (147), p. 227–247. Obtenido de http://biblio.uptc.edu.co:2054/science/article/pii/S0021997512001065 Pelissiera, P. Aleta., A. Morchikhb., h. Choughria, V. Casolia, C. (2015) Arterial vascularization of the flexor digitorum superficialis synovial flap. An anatomical study. Research in Veterinary Science, volumen 34, p. 193-196. Obtenido de http://biblio.uptc.edu.co:2054/science/article/pii/S1297320315000888 Peroni, D. L. (2011) Anti-Inflammatory and Immunomodulatory Activities of Stem Cells. Veterinary Clinics of North America: Equine Practice, volumen (27), 351-362. Obtenido de www.sciencedirect.com/science/article/pii/S0749073911000290 Plum d, C. (2010) manual de farmacología veterinaria sexta edición. Buenos aires , argentina: intermedica Pineda, A. A. (2010) medicina regeneratva aplicada en equinos. regenevet, volumen (1), p. 45-47. Possap, V. D. (2012) plasma rico em plaquetas:uso em esoes tendineas en equinos. U. F. Veterinária., Ed. digital repository, volumen (28), p.67-82 Obtenido de http://www.lume.ufrgs.br/bitstream/handle/10183/69649/000872982.pdf?sequence=1 Sharma, N. M Affulli. (2006) Biology of tendon injury: healing, modeling and remodeling. hylonome, volumen (6), p. 1-10. Recuperado el 20 de abril de 2016 Schlachter, C. V. (2016) Electrophysical Therapies for the Equine Athlete. Veterinary Clinics of North America. Equine Practice, volumen (32), p. 127–147. Obtenido de http://biblio.uptc.edu.co:2054/science/article/pii/S0749073915000966?np=y Scott, M. T. (2003) Extracorporeal shock wave therapy: Clinical applications and regulation,. Clinical Techniques in Equine Practice, Volume (4), p. 358-367. Spurlock, S. L., Gareth H. Spurlock, D. M., bernstad, D., permichanek, d. P., theodore. C. (1999) treatment of acute superficial flexor tendon injuries in performance horses with high molecular weight sodium hyaluronate. journal of equine veterinary science, volumen(19), p. 338-344. Sullivan, C. (2007) Injuries of the Flexor Tendons: Focus on the Superficial Digital Flexor Tendon. Clinical Techniques in Equine Practice, volumen (6), p. 189–197. Obtenido de http://biblio.uptc.edu.co:2054/science/article/pii/S1534751607000340?np=y Radice, D. F. (2012) lesiones tendinosas en medicina del deporte: ciencias basicas aplicadas al tratamiento actual . Revista Medica Clinica Las Condes, volumen (23), p.285-291. Rehabilitabiobio. (2014) Tendon: Anatomia y Fisiologia. fisioterapy, volumen (3), p. 1-44. Recuperado de http://kineyrehabilitacion.blogspot.com.co/2014/07/tendon-anatomia-y-fisiologia.html Renzi, S., Riccò, S., Dotti, l., Sesso, S. Grolli, M. Cornali, S. Carlin, M. Patruno, S. Cinotti, M. (2013) Autologous bone marrow mesenchymal stromal cells for regeneration of injured equine ligaments and tendons. Veterinary Science, volumen (85), P. 272-277. Obtenido de http://www.sciencedirect.com/science/article/pii/S0034528813000192 Reyesa, H., Jahrb, H., schiec, D, H., Weinansa, a. (2014) Prediction of the elastic strain limit of tendons. Journal of the Mechanical Behavior of Biomedical Materials, volumen(11), p.324–338. Obtenido de http://biblio.uptc.edu.co:2091/10.1016/j.jmbbm.2013.11.020 Ribeiro, Júnior., Maia, Maria Verônica De Souza, José Ivo Aécio Carlos De Oliveira, Geraldo Eleno Silveira Alves, Laércio Dos Anjos Benjamin, Yamê Fabres Robaina Sancler Silva, Bruna Mota Zandim, José Do Carmo Lopes Moreira (2009). IvoPlatelet-Rich Plasma in the Treatment of Induced Tendinopathy in Horses. Journal of Equine Veterinary Science, volumen (29), p.618-626. Obtenido de http://www.sciencedirect.com/science/article/pii/S0737080609005437 Richardson, J. D. (2007) Stem cells in veterinary medicine – attempts at regenerating equine tendon after injury. Trends in Biotechnology, volumen (25), p. 409-416. Obtenido de http://www.sciencedirect.com/science/article/pii/S0167779907001886 Romagno, L. G. ( 2015) Clinical Evaluation of Intralesional Injection of Platelet-Rich Plasma for the Treatment of Proximal Suspensory Ligament Desmitis in Horses. journal of equine veterinary science, volumen (35), p. 141-146. Obtenido de (http://www.sciencedirect.com/science/article/pii/S0737080614004729) Romero a. (2016) Tratamiento de las tendinitis inducidas en caballos: estudio comparativo entre plasma rico en plaquetas PRP y células mesénquimales MSCS. Tesis Doctoral. Universidad de Zaragoza, p. 14-200. Ross, W.S., Dyson, S.J. (2003) Diagnosis and Management of Lameness in the Horse, First edn, Saunder, Philadelphia, p. 8- 614. Sakaguchi, Y., Sekiya, I., Yagishita, k. (2005) Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source, Arthritis and Rheumatism, volumen 52, p. 252-259. Sànchez, Ibàñez, Fernández, M., Monllau, J., Alonso,A., Sánchez J., garcía.,Sánchez, L., (2015) New Treatments for Degenerative Tendinopathy, focused on the Region-Specific of the Tendon. Rheumatology Current Research, volumen (5), P. 2-12. Schlachter, C. V. (2016) Electrophysical Therapies for the Equine Athlete. Veterinary Clinics of North America: Equine Practice, volumen 3(30), p. 127–147. Obtenido de http://biblio.uptc.edu.co:2054/science/article/pii/S0749073915000966?np=y Scott, M. T. ( 2003) Extracorporeal shock wave therapy: Clinical applications and regulation,. Clinical Techniques in Equine Practice, Volume (4), p. 358-367. Obtenido de http://dx.doi.org/10.1053/j.ctep.2004.04.00. (http://www.sciencedirect.com/science/article/pii/S1534751604000125) Sharma, P y Maffulli, N. (2006) Biology of tendon injury: healing, modeling and remodeling. Journal of Musculoskeletal & Neuronal Interactions, volumen (6) p. 181-190. Sisson, & Grossman. (1982) Anatomia de los animales domesticos Tomo 1 quinta edicion. En Sisson, & Grossman, Anatomia de los animales domesticos p. 49-80. España: Elsevier masson. Stashak, & al, E. (2003) Adams Claudicaciones en el caballo quinta edicion. Ciudad buenos aries argentina: Inter-medical. p.120-123. Stewart, A.A., Barrett, J.G., BYRON. (2009) Comparison of equine tendon, muscle, and bone marrow-derived cells cultured on tendon matrix, American Journal of Veterinary Research, volumen (70), p. 750-757. Sumano H, & Ocampo L, (2006) farmacologia veterinaria tercera edición 3,mexico d.f. mexico. Mc Graw hill. Sutter, l. (2007). Autologous Cell-Based Therapy for Tendon and Ligament Injuries. Clinical Techniques in Equine Practice,volumen (6), p. 198-208. Obtenido de www.sciencedirect.com/science/article/pii/S1534751607000352 Taralyn, M. M. (2015) Therapy in Equine Medicine. sciencedirect, volmen (7), p. 813-817. Tasto, J. P. (2003) The tendon treatment center: new horizons in the treatment of tendinosis. The Journal of Arthroscopic & Related Surgery, volumen (19), p. 213–223. Obtenido de http://biblio.uptc.edu.co:2054/science/article/pii/S074980630300906X Textor, J. (2011) Autologous Biologic Treatment for Equine Musculoskeletal Injuries. Veterinary Clinics of North America: Equine Practice,volumen (27), P. 275-298. Obtenido de http://www.sciencedirect.com/science/article/pii/S0749073911000241 Thorpe, C.T., Clegg, P.D., Birch, H.L. (2010) A review of tendon injury: Why is the equine superficial digital flexor tendon most at risk, Equine Veterinary Journal, volumen. 42, p. 174-180 Vázquez, f. j. (2012)Medicina regenerativa: aplicacion en la clínica equina. Revista Complutense de Ciencias Veterinarias,volumen ( 6), p. 38-47. Obtenido de http://revistas.ucm.es/index.php/RCCV/article/viewFile/40079/38508 Wavreille G., F. C. (2008) Tendon normal : anatomie, physiologie. EMC. Elsevier,volumen (14), p. 34. 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Ariza Suárez, Angela CristinaCastro Rodríguez, Edwin Leonardo2018-12-12T20:35:58Z2018-12-12T20:35:58Z2017Castro Rodríguez, E. L. (2017). “Terapias convencionales y regenerativas en tendinopatias del flexor digital superficial en equinos de deporte”. (Trabajo de grado). Universidad Pedagógica y Tecnológica de Colombia, Tunja. http://repositorio.uptc.edu.co/handle/001/2338http://repositorio.uptc.edu.co/handle/001/23381 recurso en línea (89 páginas) : ilustraciones color, tablas.Las lesiones tendinosas son unas de las más frecuentes afecciones que padecen los equinos, en especial los dedicados deportes de alto rendimiento. Dichas lesiones tienen una recuperación complicada, que no sucede por si misma necesitando de la intervención del médico veterinario, tratamientos convencionales se han utilizado a lo largo de la historia dentro de ellos fármacos antinflamatorios, sustancias irritantes, glicosaminoglicanos los cuales no han demostrado sus beneficios a largo plazo, cuando el animal es sometido a un esfuerzo competitivo. Por ende esta revisión de literatura se ha encaminado a la búsqueda de terapias regenerativas, las cuales consisten en la aplicación de materiales biológicos, tales como los es la terapia con células madre o Plasma rico en plaquetas, que interactúan a nivel molecular brindan una regeneración en tiempos mucho más cortos de lo habitual resultando en un tejidos con contenido menor de fibrina tipo lll (cicatriz), procurando así que las fibras regeneradas sean lo más elásticas y resistentes posibles, evitando reincidencias, y/o perdidas de los ejemplares.Bibliografía y webgrafía: páginas 76-89.PregradoMédico Veterinario Zootecnistaapplication/pdfspaUniversidad Pedagógica y Tecnológica de ColombiaEscuela de Medicina Veterinaria y ZootecniaFacultad de Ciencias AgropecuariasCopyright (c) 2017 Universidad Pedagógica y Tecnológica de Colombiahttps://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)http://purl.org/coar/access_right/c_abf2“Terapias convencionales y regenerativas en tendinopatias del flexor digital superficial en equinos de deporte”Trabajo de grado - Pregradohttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/publishedVersionTexthttps://purl.org/redcol/resource_type/TPhttp://purl.org/coar/version/c_970fb48d4fbd8a85Ahmad, Z;Wardale, J,. Brooks, R,. Henson, F,. Noorani, A,. Rushton, N. (2012) Exploring the Application of Stem Cells in Tendon Repair and Regeneration, Arthroscopy. The Journal of Arthroscopic & Related Surgery, volumen (28), p.10. Obtenido de www.sciencedirect.com/science/article/pii/S0749806311013752Alves, a.,Stewart, j., Dudhia, y., Kasashima, a., Goodship, r., Smith. (2011) Cell-based Therapies for Tendon and Ligament Injuries. Veterinary Clinics of North America: Equine Practice,volumen (27), p.315-333. Obtenido de www.sciencedirect.com/science/article/pii/S0749073911000277Amaya, j. M., & Cruz, j. M. ( 2013) Tendinitis equina.albeitar, volumen (55),p.3-5. Recuperado de http://albeitar.portalveterinaria.com/noticia.asp?ref=3403&pos=445Andris, j. K. (2016) Practical Rehabilitation and Physical Therapy for the General Equine Practitioner. Veterinary Clinics of North America: Equine Practice, volumen (75), Pages 167–180. Obtenido de http://biblio.uptc.edu.co:2091/10.1016/j.cveq.2015.12.001Angeles, e. L. (2014) Tratamiento fisioterápico en las lesiones del ligamento suspensorio del caballo. Reduca (Enfermería, Fisioterapia y Podología), volumen (12), p. 38. Obtenido de http://revistareduca.es/index.php/reduca-enfermeria/article/viewFile/1776/1792Arias, j. I., & Beato, c. (2013) Terapia regenerativa en tendones y células madres en medicina equina. Avances en Ciencias Veterinarias, volumen (28), P.49-57. Obtenido de http://www.lenguasmodernas.uchile.cl/index.php/ACV/article/viewFile/30206/31980Asheim, A. (1964) Surgical treatment of tendon injuries in the horse. Vet Med Assoc, volumen (2) p. 145–451Awad, H.A., Butler, D.L., Boivin, G.P. (1999) Autologous mesenchymalstem cellmediated repair of tendon. Tissue Engineering, volumen (5), p. 267-277.Barritault, D., Desgranges, P., Meddahi, A., Jean,M., Jean, L. (2016) RGTA base matrix therapy - a new branch of regenerative medicine in locomotion. joint bone spine, volumen (12), p.297-319. Obtenido de http://www.sciencedirect.com/science/article/pii/S1297319X16301373Beccati, Ibliography F. (2015) Sympathetic innervation of the suprasesamoidean region of the deep digital flexor tendon in the forelimbs of horses. The Veterinary Journal, volumen(205), p.413-416. Obtenido de http://biblio.uptc.edu.co:2054/science/article/pii/S1090023315002464Beth, W. M. (2004) Ultrasonographic Evaluation of the Metacarpus, Metatarsus, and Pastern. Clinical Techniques in Equine Practice, volumen (3), p. 238-255. Obtenido de http://biblio.uptc.edu.co:2091/10.1053/j.ctep.2005.02.002Borjesson, D. L. (2011) The Regenerative Medicine Laboratory: Facilitating Stem Cell Therapy for Equine Disease. Clinics in Laboratory Medicine,volumen (31), P. 109-123. Obtenido de (http://www.sciencedirect.com/science/article/pii/S0272271210001551)Burk, J., Badylak, F., Kelly, J., Brehm, W., (2013) Equine cellular therapy—from stall to bench to bedside Cytometry Part volumen (83), p.103-113.Bueno, I. M. (2008) tendón. Valoración y tratamiento en fisioterapia.primera ed., Volumen (1). barcelona : Editorial Paidotribo.Butchera, H., Hermansonc, N., Ducharmed, L.M., Mitchelld, V., Soderholmd, A., Bertrame. (2009) Contractile behavior of the forelimb digital flexors during steady-state locomotion in horses (Equus caballus): An initial test of muscle architectural hypotheses about in vivo function. Integrative Physiology,volumen (152), p.100-114. Obtenido de http://biblio.uptc.edu.co:2054/science/article/pii/S1095643308011288Botero, L., (2007) tenoscopía como tratamiento quirúrgico en casos de tenosinovitis traumática en un caballo de silla francesa. Revista CES / Medicina Veterinaria y Zootecnia /, Volumen (2), p.6. Tomado de http://revistas.ces.edu.co/index.php/mvz/article/view/366/1868Cano, H., (2008) el uso de células madre de la medula ósea en la terapia de tendinitis en equinos. monografia , mexico . Obtenido de http://repositorio.uaaan.mx:8080/xmlui/bitstream/handle/123456789/2904/MONOGRAFIA%20ERIC.pdf?sequence=1Carol, G. (2007) Ultrasonography for Monitoring Healing and Rehabilitation. Clinical Techniques in Equine Practice, volumen(11),p.174-178. Obtenido de http://biblio.uptc.edu.co:2054/science/article/pii/S1534751607000327Carvalho, A. (2009) Isolation and immunophenotypic characterization of mesenchymal stem cells derived from equinespecies adipose tissue,. Veterinary Immunology and Immunopathology, Volume 132(2–4,), Pag 303-306,. Obtenido de http://www.sciencedirect.com/science/article/pii/S016524270900214Carvajal, J. A. (2013). Tendinopatias del tendon digital superficial: dignostico y tratamientos. Tesis, universidad autonoma agraria, torreon,coahuila,mexico.Carmona, L. (2011) Tendinopatía del tendón flexor digital superficial y desmopatía del ligamento suspensorio en caballos fisiopatología y terapias regenerativas. scielo,volumen (113), p. 12-13Recuperado de http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0301-732X2011000300002Castro, P. (2015) ondas de choque en pacientes que acudieron con diagnóstico de tendinopatía rotuliana al Centro de Rehabilitación Física y Deportiva Logroño´ s fisioterapia. universidad catolica de ecuador, 18. tesis trabajo de grado. Obtenido de http://repositorio.puce.edu.ec/handle/22000/10097Clinic T. A. (2014) tenosinovitis plantar.atlanta equine, p.23. obtenido de http://www.atlantaequine.com/pages/client_lib_PDsynovitis.htmlDahlgren, L.A., Meulen, M.C., Bertram, j.e., (2002) Insulin-like growth factorI improves cellular and molecular aspects of healing in a collagenase-induced model of flexor tendinitis. Journal of Orthopaedic, volumen (20), p. 910-919.Dahlgren, L. A. (2007) Pathobiology of Tendon and Ligament Injuries. Clinical Techniques in Equine Practice, volumen (3), pag 168–173. Obtenido de http://biblio.uptc.edu.co:2054/science/article/pii/S1534751607000315Daniela, P. V. (2012) plasma rico em plaquetas:uso em esoes tendineas en equinos. tesis U. F. Veterinária, p.28-40. Obtenido de http://www.lume.ufrgs.br/bitstream/handle/10183/69649/000872982.pdf?sequence=1Dochevaa, D., Müllerb, MAJEWSKIB, M., H., EVANSC. (2015) Biologics for tendon repair. Advanced Drug Delivery Reviews, volumen (84), pag. 222-239. Obtenido de http://biblio.uptc.edu.co:2054/science/article/pii/S0169409X14002786Dowling, B.A., Dart, A.J., Hodgson, D.R., Smith, RK (2000) Superficial digital flexor tendonitis in the horse, Equine Veterinary Journal. volumen (32), p. 369-378.Dyson, S.J. (2004) Medical management of superficial digital flexor tendonitis: a comparative study in 219 horses (1992-2000), Equine Veterinary Journal, volumen (36), p. 415-419. tomado de: http://onlinelibrary.wiley.com/doi/10.2746/0425164044868422/abstractDyson, S. (2014) Incomplete Tears of the Medial Calcaneal Insertion of the Superficial Digital Flexor Tendon of a Hind Limb in Three Horses. Journal of Equine Veterinary Science, volumen (10), p. 11-88 Obtenido de http://biblio.uptc.edu.co:2054/science/article/pii/S0737080614002792Estrada R., Van, W., Boere, J., Reyes, M., Ionita, Jc., Estrada M., Lischer Cj. (2014) Comparison of healing in forelimb and hindlimb surgically induced core lesions of the equine superficial digital flexor tendon. Veterinary and Comparative Orthopaedics and Traumatology: volumen (5), p. 358-365.Floyd A, R. M. (2007). Libro Equine podiatry (1 ed.). Elsevier Health Sciences. pag 78-144Fortier, L.A., Smith, R.K. (2008) Regenerative medicine for tendinous and ligamentous injuries of sport horses, Veterinary Clinics of North America.Equine Practice. volumen (24) p. 191-201. Obtenido de http://www.sciencedirect.com/science/article/pii/S0749073907000685Frati, M. C. (2012) Glicosaminoglicanos en las enfermedades vasculares. Revista Mexicana de angiologia,volumen (40), p. 89-99.Gillis, C. (2007) Ultrasonography for Monitoring Healing and Rehabilitation. Clinical Techniques in Equine Practice,volumen (6), p. 174–178. Obtenido de http://biblio.uptc.edu.co:2054/science/article/pii/S1534751607000327?np=yGiraldo, C. C. (2011) Use of autologous platelet concentrates as regenerative therapy for chronic diseases of the equine musculoskeletal system. scielo chile, volumen (43), p. 1-10. Obtenido de http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0301-732X2011000100002Guercio., casella, s., russotto, l., puglisi, f., majolino, c., giudice, e., di bella, s., purpari, g., cannella, V. (2015) Mesenchymal Stem Cells Derived From Subcutaneous Fat and Platelet-Rich Plasma Used in Athletic Horses With Lameness of the Superficial Digital Flexor Tendon. Journal of Equine Veterinary Science, volumen (35), p. 19-26.Hawkins, J.F., Ross, W. (1995) Transection of the accessory ligament of the superficial digital flexor muscle for the treatment of superficial digital flexor tendinitis in standardbreds: 40 cases (1988-1992). Journal of the American Veterinary Medical Association, volumen (206), p. 674-678.Hernández, R. P., & Dorticos, E. (2004) Medicina regenerativa. Células madre embrionarias y adultas. Revista Cubana de Hematología, Inmunología y Hemoterapia, volumen (20), p. 7. Obtenido de http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-0289200400030000Hernández, H.O. (2012) Tendinitis equina: revisión de casos clínicos tratados con plasma rico en plaquetas. Tesis Facultad de Ciencias Veterinarias. Buenos Aires- Argentina 45p.Hosakaa,. H. (2005) Mechanism of Cell Death in Inflamed Superficial Digital Flexor Tendon in the Horse. Journal of Comparative Pathology, VOLUMEN (132), p.51-58. Obtenido de http://biblio.uptc.edu.co:2054/science/article/pii/S0021997504000830Iacono, E. B. (2015) Equine Bone Marrow and Adipose Tissue Mesenchymal Stem Cells:Cytofluorimetric Characterization, In Vitro Differentiation, and Clinical Application. Journal of Equine Veterinary Science,volumen (35), P. 130-140. Obtenido de http://www.sciencedirect.com/science/article/pii/S0737080614004717Ivone bruno, R. M. (2014) Characterization of Nucleated Cells From Equine Adipose Tissue and Bone Marrow Aspirate Processed for Point-of-Care Use. Journal of Equine Veterinary Science, (34), P. 1118-1127. Obtenido de http://www.sciencedirect.com/science/article/pii/S0737080614002688)Lauren, S. L. (2013) Therapeutic use of stem cells in horses: Which type, how, and when? The Veterinary Journal, volumen (197), P. 570-577. Obtenido de http://www.sciencedirect.com/science/article/pii/S1090023313001895)Lees, P. L. (2013) Toxicology and residues of phenylbutazone in humans and horses,. The Veterinary Journal, volumen (196), p. 294-303. Obtenido de http://www.sciencedirect.com/science/article/pii/S1090023313001901)Lucas, E. &. (2015) Tratamiento fisioterápico en las lesiones del ligamento suspensorio del caballo. reduca, volumen (6) p.17-38 tomado de: http://revistareduca.es/index.php/reduca-enfermeria/article/view/1776/1792Mafulli, N. W. (2003) Types and epidemiology of tendinopathy. Clin sport medicine, volumen (22), p. 675-692.Mafulli n. (2010) Novel Approaches for the Management of Tendinopath. The Journal of Bone and Joint Surgery, volumen (11), p. 23-34Malanga, G. Reina Nakamura (2014) the role of regenerative medicine in the treatment of sports injuries. physical medicine and rehabilitation clinics of north america, volumen (25), p. 881-895. Obtenido de http://www.sciencedirect.com/science/article/pii/S1047965114000564Martínez, M. D. (2005) estudio ecográfico (ecogenicidad y área). departamento de medicina y cirugia animal tesis doctoral univercidad de Murcia, Murcia p. 20-80.Moraes, J.R., Facco, G.G., Moraes, F.R., Filho, J.R, MIyazato, L.G., Beretta, D.C. (2009) Effects of glycosaminoglycan polysulphate on the organisation of collagen fibres in experimentally induced tendonitis in horses. The Veterinary Record, volumen 165, p. 203-205Moya, A. D. (2002) Terapia por onda de choque extracorpórea para el tratamiento de lesiones musculo esqueleticas. Rev. Asoc. Arg. Ortop. y Traumatol, volumen (67), p. 286. Obtenido de http://www.aaot.org.ar/revista/1993_2002/2002/2002_4/670408.pdfNixon, M., Ashlee, E., Watts, D, Schnabel, J. (2012) Cell- and gene-based approaches to tendon regeneration. Journal of Shoulder and Elbow Surgery, volumen (21), p. 278-294. Obtenido de http://biblio.uptc.edu.co:2091/10.1016/j.jse.2011.11.015O’sullivan, C. B. (2007) Injuries of the Flexor Tendons: Focus on the Superficial Digital Flexor Tendon. Clinical Techniques in Equine Practice, volumen (6), P.189-19. Obtenido de http://www.sciencedirect.com/science/article/pii/S1534751607000340Parra, M. (2014) Correlacion entre la evaluacion clinica y la ultrasonografia de las lesiones en tendones flexores del miembro anterior en equinos pura sangre ingresa dse carreras en venezuela. Revista cientifica univercidad de zulia, XIV volumen (6), p. 506-512. Recuperado el 2 de 4 de 2016, de http://www.fcv.luz.edu.ve/index.php?option=com_content&task=view&id=602&Itemid=186Patterson, J.C., Becker,D., T. Rich. (2012). The Pathogenesis of Tendon Microdamage in Athletes: the Horse as a Natural Model for Basic Cellular Research. Journal of Comparative Pathology, volumen (147), p. 227–247. Obtenido de http://biblio.uptc.edu.co:2054/science/article/pii/S0021997512001065Pelissiera, P. Aleta., A. Morchikhb., h. Choughria, V. Casolia, C. (2015) Arterial vascularization of the flexor digitorum superficialis synovial flap. An anatomical study. Research in Veterinary Science, volumen 34, p. 193-196. Obtenido de http://biblio.uptc.edu.co:2054/science/article/pii/S1297320315000888Peroni, D. L. (2011) Anti-Inflammatory and Immunomodulatory Activities of Stem Cells. Veterinary Clinics of North America: Equine Practice, volumen (27), 351-362. Obtenido de www.sciencedirect.com/science/article/pii/S0749073911000290Plum d, C. (2010) manual de farmacología veterinaria sexta edición. Buenos aires , argentina: intermedicaPineda, A. A. (2010) medicina regeneratva aplicada en equinos. regenevet, volumen (1), p. 45-47.Possap, V. D. (2012) plasma rico em plaquetas:uso em esoes tendineas en equinos. U. F. 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(2014) Prediction of the elastic strain limit of tendons. Journal of the Mechanical Behavior of Biomedical Materials, volumen(11), p.324–338. Obtenido de http://biblio.uptc.edu.co:2091/10.1016/j.jmbbm.2013.11.020Ribeiro, Júnior., Maia, Maria Verônica De Souza, José Ivo Aécio Carlos De Oliveira, Geraldo Eleno Silveira Alves, Laércio Dos Anjos Benjamin, Yamê Fabres Robaina Sancler Silva, Bruna Mota Zandim, José Do Carmo Lopes Moreira (2009). IvoPlatelet-Rich Plasma in the Treatment of Induced Tendinopathy in Horses. Journal of Equine Veterinary Science, volumen (29), p.618-626. Obtenido de http://www.sciencedirect.com/science/article/pii/S0737080609005437Richardson, J. D. (2007) Stem cells in veterinary medicine – attempts at regenerating equine tendon after injury. Trends in Biotechnology, volumen (25), p. 409-416. Obtenido de http://www.sciencedirect.com/science/article/pii/S0167779907001886Romagno, L. G. 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