Synthesis, antibacterial activity and interaction of DNA with lanthanide-β-cyclodextrin inclusion complexes
In this work, lanthanide complexes were synthesized starting from the corresponding La (III), Ce (III), Sm (III) and Yb (III) chlorides and cinnamate ligands which present bidentate coordination between the carboxyl group of the ligand and the lanthanide metal. These compounds were used as...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2018
- Institución:
- Universidad Pedagógica y Tecnológica de Colombia
- Repositorio:
- RiUPTC: Repositorio Institucional UPTC
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.uptc.edu.co:001/15239
- Acceso en línea:
- https://revistas.uptc.edu.co/index.php/ciencia_en_desarrollo/article/view/7365
https://repositorio.uptc.edu.co/handle/001/15239
- Palabra clave:
- actividad antibacteriana
complejos de inclusión
complejos lantánidos
interacción con ADN
antibacterial activity, inclusion complexes, interaction with DNA, lanthanide complexes
- Rights
- License
- Derechos de autor 2018 CIENCIA EN DESARROLLO
| id |
REPOUPTC2_b2950fee08281fc24c495848b9eb9c53 |
|---|---|
| oai_identifier_str |
oai:repositorio.uptc.edu.co:001/15239 |
| network_acronym_str |
REPOUPTC2 |
| network_name_str |
RiUPTC: Repositorio Institucional UPTC |
| repository_id_str |
|
| dc.title.en-US.fl_str_mv |
Synthesis, antibacterial activity and interaction of DNA with lanthanide-β-cyclodextrin inclusion complexes |
| dc.title.es-ES.fl_str_mv |
Síntesis, actividad antibacteriana e interacción del ADN con complejos de inclusión entre compuestos lantánidos y β-ciclodextrina |
| title |
Synthesis, antibacterial activity and interaction of DNA with lanthanide-β-cyclodextrin inclusion complexes |
| spellingShingle |
Synthesis, antibacterial activity and interaction of DNA with lanthanide-β-cyclodextrin inclusion complexes actividad antibacteriana complejos de inclusión complejos lantánidos interacción con ADN antibacterial activity, inclusion complexes, interaction with DNA, lanthanide complexes |
| title_short |
Synthesis, antibacterial activity and interaction of DNA with lanthanide-β-cyclodextrin inclusion complexes |
| title_full |
Synthesis, antibacterial activity and interaction of DNA with lanthanide-β-cyclodextrin inclusion complexes |
| title_fullStr |
Synthesis, antibacterial activity and interaction of DNA with lanthanide-β-cyclodextrin inclusion complexes |
| title_full_unstemmed |
Synthesis, antibacterial activity and interaction of DNA with lanthanide-β-cyclodextrin inclusion complexes |
| title_sort |
Synthesis, antibacterial activity and interaction of DNA with lanthanide-β-cyclodextrin inclusion complexes |
| dc.subject.es-ES.fl_str_mv |
actividad antibacteriana complejos de inclusión complejos lantánidos interacción con ADN |
| topic |
actividad antibacteriana complejos de inclusión complejos lantánidos interacción con ADN antibacterial activity, inclusion complexes, interaction with DNA, lanthanide complexes |
| dc.subject.en-US.fl_str_mv |
antibacterial activity, inclusion complexes, interaction with DNA, lanthanide complexes |
| description |
In this work, lanthanide complexes were synthesized starting from the corresponding La (III), Ce (III), Sm (III) and Yb (III) chlorides and cinnamate ligands which present bidentate coordination between the carboxyl group of the ligand and the lanthanide metal. These compounds were used as hosts of β-cyclodextrin to obtain new inclusion complexes by a co-precipitation method using N,N-dimethylformamide as solvent. The inclusion products were characterized by IR-ATR spectroscopy, Raman, UV-vis, 1H and 13C NMR, XRD, TGA-DSC, elemental analysis and EDTA complexometry. Antibacterial activity tests were performed using six ATTC strains (S. aureus ATCC 25923, S. aureus ATCC 29213, E. coli ATCC 25922, P. aeruginosa ATCC 27853, S. Typhimurium ATCC 14028 and K. pneumoniae ATCC BAA-2146) by the microdilution method with Mueller-Hinton broth. The results of the biological activity for the lanthanide complexes showed the synergistic effect between the lanthanide cation and the cinnamate ligand. For the inclusion complexes, a decrease of the minimum inhibitory concentration (MIC) was observed with respect to the initial lanthanide complexes. The results obtained with the bovine thymus DNA and the plasmid pBR322 DNA allow to propose an electrostatic interaction between the evaluated complexes and the molécular structure of the DNA. |
| publishDate |
2018 |
| dc.date.accessioned.none.fl_str_mv |
2024-07-08T14:23:54Z |
| dc.date.available.none.fl_str_mv |
2024-07-08T14:23:54Z |
| dc.date.none.fl_str_mv |
2018-07-04 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.identifier.none.fl_str_mv |
https://revistas.uptc.edu.co/index.php/ciencia_en_desarrollo/article/view/7365 10.19053/01217488.v9.n2.2018.7365 |
| dc.identifier.uri.none.fl_str_mv |
https://repositorio.uptc.edu.co/handle/001/15239 |
| url |
https://revistas.uptc.edu.co/index.php/ciencia_en_desarrollo/article/view/7365 https://repositorio.uptc.edu.co/handle/001/15239 |
| identifier_str_mv |
10.19053/01217488.v9.n2.2018.7365 |
| dc.language.none.fl_str_mv |
spa |
| dc.language.iso.none.fl_str_mv |
spa |
| language |
spa |
| dc.relation.none.fl_str_mv |
https://revistas.uptc.edu.co/index.php/ciencia_en_desarrollo/article/view/7365/7263 |
| dc.rights.es-ES.fl_str_mv |
Derechos de autor 2018 CIENCIA EN DESARROLLO |
| dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
| rights_invalid_str_mv |
Derechos de autor 2018 CIENCIA EN DESARROLLO http://purl.org/coar/access_right/c_abf2 |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.es-ES.fl_str_mv |
Universidad Pedagógica y Tecnológica de Colombia |
| dc.source.en-US.fl_str_mv |
Ciencia En Desarrollo; Vol. 9 No. 2 (2018): Vol 9, Núm. 2 (2018): Vol 9, Núm 2(2018): Julio- Diciembre; 99-117 |
| dc.source.es-ES.fl_str_mv |
Ciencia en Desarrollo; Vol. 9 Núm. 2 (2018): Vol 9, Núm. 2 (2018): Vol 9, Núm 2(2018): Julio- Diciembre; 99-117 |
| dc.source.none.fl_str_mv |
2462-7658 0121-7488 |
| institution |
Universidad Pedagógica y Tecnológica de Colombia |
| repository.name.fl_str_mv |
Repositorio Institucional UPTC |
| repository.mail.fl_str_mv |
repositorio.uptc@uptc.edu.co |
| _version_ |
1839633857114013696 |
| spelling |
2018-07-042024-07-08T14:23:54Z2024-07-08T14:23:54Zhttps://revistas.uptc.edu.co/index.php/ciencia_en_desarrollo/article/view/736510.19053/01217488.v9.n2.2018.7365https://repositorio.uptc.edu.co/handle/001/15239In this work, lanthanide complexes were synthesized starting from the corresponding La (III), Ce (III), Sm (III) and Yb (III) chlorides and cinnamate ligands which present bidentate coordination between the carboxyl group of the ligand and the lanthanide metal. These compounds were used as hosts of β-cyclodextrin to obtain new inclusion complexes by a co-precipitation method using N,N-dimethylformamide as solvent. The inclusion products were characterized by IR-ATR spectroscopy, Raman, UV-vis, 1H and 13C NMR, XRD, TGA-DSC, elemental analysis and EDTA complexometry. Antibacterial activity tests were performed using six ATTC strains (S. aureus ATCC 25923, S. aureus ATCC 29213, E. coli ATCC 25922, P. aeruginosa ATCC 27853, S. Typhimurium ATCC 14028 and K. pneumoniae ATCC BAA-2146) by the microdilution method with Mueller-Hinton broth. The results of the biological activity for the lanthanide complexes showed the synergistic effect between the lanthanide cation and the cinnamate ligand. For the inclusion complexes, a decrease of the minimum inhibitory concentration (MIC) was observed with respect to the initial lanthanide complexes. The results obtained with the bovine thymus DNA and the plasmid pBR322 DNA allow to propose an electrostatic interaction between the evaluated complexes and the molécular structure of the DNA.En este trabajo se han sintetizado complejos de lantánidos a partir de los derivados cloruros de La(III), Ce(III), Sm (III) e Yb(III) con ligandos cinamato, presentando coordinación bidentada entre el grupo carboxilo del ligando y el metal lantánido. Estos compuestos se utilizaron como huéspedes de la β-ciclodextrina con el fin de obtener complejos de inclusión mediante el método de co-precipitación, utilizando N,N-dimetilformamida como disolvente. Los productos de inclusión obtenidos fueron caracterizados mediante espectroscopia IR-ATR, Raman, UV-vis, RMN 1H, RMN 13C, DRX, TGA-DSC, análisis elemental y complexometría con EDTA. Se realizaron pruebas de actividad antibacteriana empleando 6 cepas ATTC (S. aureus ATCC 25923, S. aureus ATCC 29213, E. coli ATCC 25922, P. aeruginosa ATCC 27853, S. Typhimurium ATCC 14028 y K. pneumoniae ATCC BAA-2146) mediante el método de microdilución con caldo Mueller-Hinton; los resultados de actividad biológica para los complejos lantánidos permitieron evidenciar el efecto sinérgico entre el catión lantánido y el ligando cinamato. Igualmente, para los complejos de inclusión se observó una disminución de la concentración mínima inhibitoria (CMI) respecto a los complejos lantánidos iniciales. Los resultados obtenidos con el ADN de timo de ternera y el ADN plasmídico pBR322 permiten proponer una interacción electrostática entre los complejos evaluados y la estructura molecular del ADN.application/pdfspaspaUniversidad Pedagógica y Tecnológica de Colombiahttps://revistas.uptc.edu.co/index.php/ciencia_en_desarrollo/article/view/7365/7263Derechos de autor 2018 CIENCIA EN DESARROLLOhttp://purl.org/coar/access_right/c_abf2Ciencia En Desarrollo; Vol. 9 No. 2 (2018): Vol 9, Núm. 2 (2018): Vol 9, Núm 2(2018): Julio- Diciembre; 99-117Ciencia en Desarrollo; Vol. 9 Núm. 2 (2018): Vol 9, Núm. 2 (2018): Vol 9, Núm 2(2018): Julio- Diciembre; 99-1172462-76580121-7488actividad antibacterianacomplejos de inclusióncomplejos lantánidosinteracción con ADNantibacterial activity, inclusion complexes, interaction with DNA, lanthanide complexesSynthesis, antibacterial activity and interaction of DNA with lanthanide-β-cyclodextrin inclusion complexesSíntesis, actividad antibacteriana e interacción del ADN con complejos de inclusión entre compuestos lantánidos y β-ciclodextrinainfo:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1Polo Cerón, DorianMayor-Rivera, Angélica MaríaAragón-Muriel, Alberto001/15239oai:repositorio.uptc.edu.co:001/152392025-07-18 10:56:40.241metadata.onlyhttps://repositorio.uptc.edu.coRepositorio Institucional UPTCrepositorio.uptc@uptc.edu.co |