Principales hipótesis inmunológicas de la demodicosis canina
1 recurso en línea (páginas 61-69).
- Autores:
-
Cen Cen, Carlos Josué
Bolio González, Manuel Emilio
Rodríguez Vivas, Roger Iván
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2018
- Institución:
- Universidad Pedagógica y Tecnológica de Colombia
- Repositorio:
- RiUPTC: Repositorio Institucional UPTC
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.uptc.edu.co:001/2295
- Acceso en línea:
- http://repositorio.uptc.edu.co/handle/001/2295
- Palabra clave:
- Sarna demodecica canina
Perros - Enfermedades
Demodex canis
Parasitología veterinaria
Agrosavia
Demodicosis
Demodex spp
Sistema inmune
- Rights
- openAccess
- License
- Copyright (c) 2018 Universidad Pedagógica y Tecnológica de Colombia
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Principales hipótesis inmunológicas de la demodicosis canina |
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Main immunological hypotheses of the canine demodicosis |
| title |
Principales hipótesis inmunológicas de la demodicosis canina |
| spellingShingle |
Principales hipótesis inmunológicas de la demodicosis canina Sarna demodecica canina Perros - Enfermedades Demodex canis Parasitología veterinaria Agrosavia Demodicosis Demodex spp Sistema inmune |
| title_short |
Principales hipótesis inmunológicas de la demodicosis canina |
| title_full |
Principales hipótesis inmunológicas de la demodicosis canina |
| title_fullStr |
Principales hipótesis inmunológicas de la demodicosis canina |
| title_full_unstemmed |
Principales hipótesis inmunológicas de la demodicosis canina |
| title_sort |
Principales hipótesis inmunológicas de la demodicosis canina |
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Cen Cen, Carlos Josué Bolio González, Manuel Emilio Rodríguez Vivas, Roger Iván |
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Cen Cen, Carlos Josué Bolio González, Manuel Emilio Rodríguez Vivas, Roger Iván |
| dc.subject.armarc.none.fl_str_mv |
Sarna demodecica canina Perros - Enfermedades Demodex canis Parasitología veterinaria |
| topic |
Sarna demodecica canina Perros - Enfermedades Demodex canis Parasitología veterinaria Agrosavia Demodicosis Demodex spp Sistema inmune |
| dc.subject.armarc.spa.fl_str_mv |
Agrosavia |
| dc.subject.proposal.spa.fl_str_mv |
Demodicosis Demodex spp Sistema inmune |
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1 recurso en línea (páginas 61-69). |
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2018 |
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2018-11-16T20:11:43Z |
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2018-07-06 |
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Cen Cen, C. J., Bolio González, M. E.& Rodríguez Vivas, R.I. (2018). Principales hipótesis inmunológicas de la demodicosis canina. Ciencia y Agricultura, 15(2), 61-69. DOI: http://doi.org/10.19053/01228420.v15.n2.2018.8396. http://repositorio.uptc.edu.co/handle/001/2295 |
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Cen Cen, C. J., Bolio González, M. E.& Rodríguez Vivas, R.I. (2018). Principales hipótesis inmunológicas de la demodicosis canina. Ciencia y Agricultura, 15(2), 61-69. DOI: http://doi.org/10.19053/01228420.v15.n2.2018.8396. http://repositorio.uptc.edu.co/handle/001/2295 2539-0899 10.19053/01228420.v15.n2.2018.8396 |
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Ordeix L, Bardagí M, Scarampella F, Ferrer L, Fondati A. Demodex injai infestation and dorsal greasy skin and hair in eight wirehaired for terrier dogs. Vet. Dermatol. 2009; 20: 267-272. DOI: https://doi.org/10.1111/j.1365-3164.2009.00755.x. Molecular study on Three morphotypes of Demodex mites (Acarina: Domodicidae) from dogs. Kumari P, Nigam R, Singh A, Nakade UP, Sharma A, Garg SK, Singh SK. Demodex canis regulates cholinergic system mediated immunosuppressive pathways in canine demodicosis. Parasitol. 2017; 144 (10): 1412-1416. DOI: https://doi.org/10.1017/ S0031182017000774. Moskvina TV. Two morphologically distinct forms of Demodex mites found in dogs with canine demodicosis from vladivostok, Russia. Acta Vet. 2017; 67(1): 82-91. DOI: https://doi. org/10.1515/acve-2017-0008. Chen Y, Lin R, Zhou D, Song H, Chen F, Yuan Z, Zhu X, Weng Y, Zhao G. Prevalence of Demodex infection in pet dogs in Southern China. Afr. J. Microbiol. Res. 2012; 6(6): 1279-1282. DOI: https://doi.org/10.5897/AJMR11.1530. Mueller RS, Bensignor E, Ferrer L, Holm B, Lemarie S, Paradis M, Shipstone MA. Treatment of demodicosis in dogs: 2011 clinical practice guidelines. Vet. Dermatol. 2012; 23(2): 86-96. DOI: https://doi.org/10.1111/j.1365-3164.2011.01026.x. Ferrer L, Ravera I, Silbermayr K. Immunology and pathogenesis of canine demodicosis. Vet. Dermatol. 2014; 25(5): 427-435. DOI: https://doi.org/10.1111/vde.12136. Ravera I, Ferreira D, Gallego LS, Bardagí M, Ferrer L. Serum detection of IgG antibodies against Demodex canis by western blot in healthy dogs and dogs with juvenile generalized demodicosis. Res. Vet. Sci. 2015; 101: 161-164. DOI: https://doi. org/10.1016/j.rvsc.2015.06.011. Ravera I. Deconstructing canine demodicosis. Tesis de Doctorado. Facultad de Medicina Veterinaria, Departamento de Medicina y Cirugía Animal, Universidad Autónoma de Barcelona, 2015. Sgarbossa RS, Sechi GV, Pacheco BD, Lucina SB, Paulo MR, Monti FD, Farias MR. The epidemiological and clinical aspects of Demodex injai demodicosis in dogs: a report of eight cases. Semin. Cienc. Agrar. 2017; 38(5): 3387-3393. DOI: https://doi. org/10.5433/1679-0359.2017v38n5p3387. Singh SK, Dimri U. The immuno-pathological conversions of canine demodicosis. Vet. Parasitol. 2014; 203: 1-5. DOI: https:// doi.org/10.1016/j.vetpar.2014.03.00. Scott DW, Miller WH, Griffin CE, Scott DW, Miller WH, Griffin CE. Muller & Kirk’s Small Animal Dermatology. Chapter 6. Seven Edition. Missouri, USA 2013; pp. 432-500. Kumari P, Nigam R, Choudhury S, Singh SK, Yadav B, Kumar D, Garg SK. Demodex canis targets TLRs to evade host immunity and induce canine demodicosis. Parasite. Immunol. 2018; 40(3): 1-5. DOI: https://doi.org/10.1111/pim.12509. Singh SK, Dimri U, Sharma MC, Swarup D, Sharma B, Pandey HO, Kumari P. The role of apoptosis in immunosuppression of dogs with demodicosis. Vet. Immunol. Immunopathol. 2011; 144: 487-492. DOI: 10.1016/j.vetimm.2011.08.008. Saavedra-Hernández D. La molécula CD28 y su función en la activación de células T. Rev. Cuba Hematol. Inmunol. Hemoter. 2013; 29(4): 359-367. Oliveira CD, Larsson CE, Camargo MM. Longitudinal assessment of T-lymphocyte subpopulations during generalized demodicosis in dogs and their relationship with remission. Vet. Dermatol. 2015; 26: 18-22. DOI: https://doi.org/10.1111/vde.12183. Huisinga M, Failing K, Reinacher M. MHC class II expression by follicular keratinocytes in canine demodicosis-An immunohistochemical study. Vet. Immunol. Immunopathol. 2007; 118: 210-220. DOI: https://doi.org/10.1016/j.vetimm.2007.05.020. Yarim GF, Yagci BB, Yarim M, Sozmen M, Pekmezci D, Cenesiz S, Pekmezci GZ, Karaca E. Serum concentration and skin tissue expression of insulin-like growth factor 2 in canine generalized demodicosis. Vet. Dermatol. 2015; 26: 421-425. DOI: https:// doi.org/10.1111/vde.12270. Yarim GF, Yagci BB, Ciftci G. Increased circulating concentracions of PDGF-BB and TGF-β1 in canine generalised demodicosis. Revue. Méd. Vét. 2013; 164(1): 13-17. Martínez-Subiela S, Bernal LJ, Tvarijonaviciute A, Garcia-Martinez JD, Tecles F, Cerón JJ. Canine demodicosi: the relationship between response to treatment of generalised disease and markers for inflammation and oxidative status. Vet. Dermatol. 2014; 25: 72-76. DOI: https://doi.org/10.1111/vde.12108. Dimri U, Ranjan R, Kumar N, Sharma MC, Swarup D, Sharma B, Kataria M. Changes in oxidative stress indices, zinc and copper concentrations in blood in canine demodicosis. Vet. Parasitol. 2008; 154: 98-102. DOI: https://doi.org/10.1016/j.vetpar. 2008.03.001. |
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Cen Cen, Carlos JosuéBolio González, Manuel EmilioRodríguez Vivas, Roger Iván2018-11-16T20:11:43Z2018-11-16T20:11:43Z2018-07-06Cen Cen, C. J., Bolio González, M. E.& Rodríguez Vivas, R.I. (2018). Principales hipótesis inmunológicas de la demodicosis canina. Ciencia y Agricultura, 15(2), 61-69. DOI: http://doi.org/10.19053/01228420.v15.n2.2018.8396. http://repositorio.uptc.edu.co/handle/001/22952539-0899http://repositorio.uptc.edu.co/handle/001/229510.19053/01228420.v15.n2.2018.83961 recurso en línea (páginas 61-69).Canine demodicosis is a common cutaneous condition in dogs, characterized by a proliferative increase of mites from the genus Demodex. Despite its high prevalence, the onset and development of demodicosis are still unknown; however, they are primarily associated to an immune dysfunction. The immune system plays an important role controlling mites in healthy animals as well as on the development of the disease in sick animals. The immune mechanisms that lead to an unbalance in the innate and adaptive systems, as well as the mite mechanisms to evade the immune system remain unknown. Consequently, various hypotheses have been proposed to try explaining possible immune mechanisms. This paper aims to conduct an updated review of the main hypotheses related to the immune mechanisms associated to demodicosis in dogs.La demodicosis canina es una enfermedad dermatológica común en perros; se presenta por un aumento en la proliferación de los ácaros del género Demodex spp., pero, a pesar de su alta prevalencia, su aparición y desarrollo son aún desconocidos, sin embargo, se asocian, principalmente, a una inmunodisfunción. El sistema inmune juega un papel importante tanto en el control del ácaro en animales sanos como en el desarrollo de la enfermedad en enfermos; en estos últimos se desconocen los mecanismos inmunitarios que llevan al desbalance en el sistema innato y adaptativo y a la evasión del sistema inmune por el ácaro; debido a esto se han postulado hipótesis que, en conjunto, tratan de explicar los posibles mecanismos inmunológicos. El presente artículo revisa las principales hipótesis inmunológicas relacionadas con la presentación de demodicosis en perros.Bibliografía: página 69.application/pdfspaUniversidad Pedagógica y Tecnológica de ColombiaCopyright (c) 2018 Universidad Pedagógica y Tecnológica de Colombiahttps://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)http://purl.org/coar/access_right/c_abf2https://revistas.uptc.edu.co/index.php/ciencia_agricultura/article/view/8396/7085Principales hipótesis inmunológicas de la demodicosis caninaMain immunological hypotheses of the canine demodicosisArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionTexthttps://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85Ordeix L, Bardagí M, Scarampella F, Ferrer L, Fondati A. Demodex injai infestation and dorsal greasy skin and hair in eight wirehaired for terrier dogs. Vet. Dermatol. 2009; 20: 267-272. DOI: https://doi.org/10.1111/j.1365-3164.2009.00755.x.Molecular study on Three morphotypes of Demodex mites (Acarina: Domodicidae) from dogs.Kumari P, Nigam R, Singh A, Nakade UP, Sharma A, Garg SK, Singh SK. Demodex canis regulates cholinergic system mediated immunosuppressive pathways in canine demodicosis. Parasitol. 2017; 144 (10): 1412-1416. DOI: https://doi.org/10.1017/ S0031182017000774.Moskvina TV. Two morphologically distinct forms of Demodex mites found in dogs with canine demodicosis from vladivostok, Russia. Acta Vet. 2017; 67(1): 82-91. DOI: https://doi. org/10.1515/acve-2017-0008.Chen Y, Lin R, Zhou D, Song H, Chen F, Yuan Z, Zhu X, Weng Y, Zhao G. Prevalence of Demodex infection in pet dogs in Southern China. Afr. J. Microbiol. Res. 2012; 6(6): 1279-1282. DOI: https://doi.org/10.5897/AJMR11.1530.Mueller RS, Bensignor E, Ferrer L, Holm B, Lemarie S, Paradis M, Shipstone MA. Treatment of demodicosis in dogs: 2011 clinical practice guidelines. Vet. Dermatol. 2012; 23(2): 86-96. DOI: https://doi.org/10.1111/j.1365-3164.2011.01026.x.Ferrer L, Ravera I, Silbermayr K. Immunology and pathogenesis of canine demodicosis. Vet. Dermatol. 2014; 25(5): 427-435. DOI: https://doi.org/10.1111/vde.12136.Ravera I, Ferreira D, Gallego LS, Bardagí M, Ferrer L. Serum detection of IgG antibodies against Demodex canis by western blot in healthy dogs and dogs with juvenile generalized demodicosis. Res. Vet. Sci. 2015; 101: 161-164. DOI: https://doi. org/10.1016/j.rvsc.2015.06.011.Ravera I. Deconstructing canine demodicosis. Tesis de Doctorado. Facultad de Medicina Veterinaria, Departamento de Medicina y Cirugía Animal, Universidad Autónoma de Barcelona, 2015.Sgarbossa RS, Sechi GV, Pacheco BD, Lucina SB, Paulo MR, Monti FD, Farias MR. The epidemiological and clinical aspects of Demodex injai demodicosis in dogs: a report of eight cases. Semin. Cienc. Agrar. 2017; 38(5): 3387-3393. DOI: https://doi. org/10.5433/1679-0359.2017v38n5p3387.Singh SK, Dimri U. The immuno-pathological conversions of canine demodicosis. Vet. Parasitol. 2014; 203: 1-5. DOI: https:// doi.org/10.1016/j.vetpar.2014.03.00.Scott DW, Miller WH, Griffin CE, Scott DW, Miller WH, Griffin CE. Muller & Kirk’s Small Animal Dermatology. Chapter 6. Seven Edition. Missouri, USA 2013; pp. 432-500.Kumari P, Nigam R, Choudhury S, Singh SK, Yadav B, Kumar D, Garg SK. Demodex canis targets TLRs to evade host immunity and induce canine demodicosis. Parasite. Immunol. 2018; 40(3): 1-5. DOI: https://doi.org/10.1111/pim.12509.Singh SK, Dimri U, Sharma MC, Swarup D, Sharma B, Pandey HO, Kumari P. The role of apoptosis in immunosuppression of dogs with demodicosis. Vet. Immunol. Immunopathol. 2011; 144: 487-492. DOI: 10.1016/j.vetimm.2011.08.008.Saavedra-Hernández D. La molécula CD28 y su función en la activación de células T. Rev. Cuba Hematol. Inmunol. Hemoter. 2013; 29(4): 359-367.Oliveira CD, Larsson CE, Camargo MM. Longitudinal assessment of T-lymphocyte subpopulations during generalized demodicosis in dogs and their relationship with remission. Vet. Dermatol. 2015; 26: 18-22. DOI: https://doi.org/10.1111/vde.12183.Huisinga M, Failing K, Reinacher M. MHC class II expression by follicular keratinocytes in canine demodicosis-An immunohistochemical study. Vet. Immunol. Immunopathol. 2007; 118: 210-220. DOI: https://doi.org/10.1016/j.vetimm.2007.05.020.Yarim GF, Yagci BB, Yarim M, Sozmen M, Pekmezci D, Cenesiz S, Pekmezci GZ, Karaca E. Serum concentration and skin tissue expression of insulin-like growth factor 2 in canine generalized demodicosis. Vet. Dermatol. 2015; 26: 421-425. DOI: https:// doi.org/10.1111/vde.12270.Yarim GF, Yagci BB, Ciftci G. Increased circulating concentracions of PDGF-BB and TGF-β1 in canine generalised demodicosis. Revue. Méd. Vét. 2013; 164(1): 13-17.Martínez-Subiela S, Bernal LJ, Tvarijonaviciute A, Garcia-Martinez JD, Tecles F, Cerón JJ. Canine demodicosi: the relationship between response to treatment of generalised disease and markers for inflammation and oxidative status. Vet. Dermatol. 2014; 25: 72-76. DOI: https://doi.org/10.1111/vde.12108.Dimri U, Ranjan R, Kumar N, Sharma MC, Swarup D, Sharma B, Kataria M. Changes in oxidative stress indices, zinc and copper concentrations in blood in canine demodicosis. Vet. Parasitol. 2008; 154: 98-102. DOI: https://doi.org/10.1016/j.vetpar. 2008.03.001.Revista Ciencia y Agricultura;Volumen 15, número 2 (Julio-Diciembre 2018)Sarna demodecica caninaPerros - EnfermedadesDemodex canisParasitología veterinariaAgrosaviaDemodicosisDemodex sppSistema inmuneORIGINALPPS_937_Principales_hipotesis_demodicosis.pdfPPS_937_Principales_hipotesis_demodicosis.pdfArchivo principalapplication/pdf492469https://repositorio.uptc.edu.co/bitstreams/1a6d302f-35aa-46a9-a1c7-050146c23ee5/download669fa6bea8b34c78b63470bc8326010fMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-814798https://repositorio.uptc.edu.co/bitstreams/f6d176d3-27a0-49e6-833b-d5ead6f24409/download88794144ff048353b359a3174871b0d5MD52TEXTPPS-937.pdf.txtPPS-937.pdf.txtExtracted texttext/plain28603https://repositorio.uptc.edu.co/bitstreams/ca849368-2706-487a-8de7-b51e5625ecec/download14cedb67cdd8eb0531cd83d9ebda7316MD53PPS_937_Principales_hipotesis_demodicosis.pdf.txtPPS_937_Principales_hipotesis_demodicosis.pdf.txtExtracted 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