Potencial de pftramp como candidato a vacuna: diversidad gen.tica y potencial inmunog.nico

Autores:
Puerto Riscanevo, Salomé
Soler Rivera, Heidy Alejandra
Garzón Ospina, Diego Edison
Tipo de recurso:
Article of journal
Fecha de publicación:
2026
Institución:
Universidad Pedagógica y Tecnológica de Colombia
Repositorio:
RiUPTC: Repositorio Institucional UPTC
Idioma:
spa
OAI Identifier:
oai:repositorio.uptc.edu.co:001/23141
Acceso en línea:
https://doi.org/10.19053/uptc.01217488.v16.n3E.2025.21047
Palabra clave:
Diversidad genética
PfTRAMP
Plasmodium falciparum
vacuna antimalárica
Genetic diversity
PfTRAMP
Plasmodium falciparum
antimalarial vaccine
Rights
openAccess
License
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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repository_id_str
dc.title.spa.fl_str_mv Potencial de pftramp como candidato a vacuna: diversidad gen.tica y potencial inmunog.nico
title Potencial de pftramp como candidato a vacuna: diversidad gen.tica y potencial inmunog.nico
spellingShingle Potencial de pftramp como candidato a vacuna: diversidad gen.tica y potencial inmunog.nico
Diversidad genética
PfTRAMP
Plasmodium falciparum
vacuna antimalárica
Genetic diversity
PfTRAMP
Plasmodium falciparum
antimalarial vaccine
title_short Potencial de pftramp como candidato a vacuna: diversidad gen.tica y potencial inmunog.nico
title_full Potencial de pftramp como candidato a vacuna: diversidad gen.tica y potencial inmunog.nico
title_fullStr Potencial de pftramp como candidato a vacuna: diversidad gen.tica y potencial inmunog.nico
title_full_unstemmed Potencial de pftramp como candidato a vacuna: diversidad gen.tica y potencial inmunog.nico
title_sort Potencial de pftramp como candidato a vacuna: diversidad gen.tica y potencial inmunog.nico
dc.creator.fl_str_mv Puerto Riscanevo, Salomé
Soler Rivera, Heidy Alejandra
Garzón Ospina, Diego Edison
dc.contributor.author.spa.fl_str_mv Puerto Riscanevo, Salomé
Soler Rivera, Heidy Alejandra
Garzón Ospina, Diego Edison
dc.subject.none.fl_str_mv Diversidad genética
PfTRAMP
Plasmodium falciparum
vacuna antimalárica
Genetic diversity
PfTRAMP
Plasmodium falciparum
antimalarial vaccine
topic Diversidad genética
PfTRAMP
Plasmodium falciparum
vacuna antimalárica
Genetic diversity
PfTRAMP
Plasmodium falciparum
antimalarial vaccine
publishDate 2026
dc.date.accessioned.none.fl_str_mv 2026-10-17 23:15:06
dc.date.available.none.fl_str_mv 2026-10-17 23:15:06
dc.date.issued.none.fl_str_mv 2026-10-17
dc.type.spa.fl_str_mv Artículo de revista
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dc.type.local.eng.fl_str_mv Journal article
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dc.type.content.spa.fl_str_mv Text
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dc.identifier.doi.none.fl_str_mv 10.19053/uptc.01217488.v16.n3E.2025.21047
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identifier_str_mv 0121-7488
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url https://doi.org/10.19053/uptc.01217488.v16.n3E.2025.21047
dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.references.spa.fl_str_mv World Health Organization, “World malaria report 2024”, World Health Organization, Geneva, Switzerland, Rep., ISBN 978-92-4-011782-2, 2024.
White NJ. Antimalarial drug resistance. J Clin Invest. 2004;113(8):1084–1092. doi:https://doi.org/10.1172/JCI21682.
Suh PF, Elanga-Ndille E, Tchouakui M, Sandeu MM, Tagne D, Wondji C, Ndo C. Impact of insecticide resistance on malaria vector competence: a literature review. Malar J. 2023;22(1):19. doi:10.1186/s12936-023-04444-2.
S. W. Scally, T. Triglia, C. Evelyn et al., “PCRCR complex is essential for invasion of human erythrocytes by Plasmodium falciparum”, Nat. Microbiol., vol. 7, pp. 2039–2053, Nov. 2022. https://doi.org/10.1038/s41564-022-01261-2
Ng YL, Lau YL, Abdul Hamid MH, Jelip J, Ooi CH, Mudin RN, Jaimin JJ, Fong MY. Genetic polymorphism of the thrombospondin-related apical merozoite protein (TRAMP) of Plasmodium knowlesi in Malaysia. Parasitol Res. 2022;121(12):3479–3487. doi:10.1007/s00436-022-07716-z.
Collins CR, Hackett F, Howell SA, Snijders AP, Russell MR, Collinson LM, Blackman MJ. The malaria parasite sheddase SUB2 governs host red blood cell membrane sealing during invasion. eLife. 2020;9:e61121. doi:10.7554/eLife.61121.
Favuzza P, Guffart E, Tamborrini M, Scherer B, Dreyer AM, Rufer AC, Erny J, Hoernschemeyer J, Thoma R, Schmid G, Gsell B, Lamelas A, Benz J, Joseph C, Matile H, Pluschke G, Rudolph MG. Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion–inhibitory antibody. eLife. 2017;6:e20383. doi:10.7554/eLife.20383.
Takala SL, Plowe CV. Genetic diversity and malaria vaccine design, testing and efficacy: preventing and overcoming ‘strain-specific’ immunity. PLoS Med. 2009;6(12):e1000103. doi:10.1371/journal.pmed.1000103.
A. F. Cowman, B. A. Seager, P. S. Lim, K. H. Lai, L. Feufack-Donfack, S. Dass et al., “PTRAMP, CSS and Ripr form a conserved complex required for merozoite invasion of Plasmodium species into erythrocytes”, Res. Sq., pp. 1–34, Apr. 2025. https://doi.org/10.21203/rs.3.rs-6292540/v1
K. Katoh, J. Rozewicki y K. Yamada, “MAFFT online service sequence alignment, interactive sequence choice and visualization”, [online]. Disponible en: https://mafft.cbrc.jp/alignment/server/index.html.
[H. Nielsen, “SignalP 6.0 predicts all five types of signal using protein language models”, [online]. Disponible en: https://services.healthtech.dtu.dk/services/SignalP-6.0/ [12] F. Madeira et al., “Phobius, A combined transmembrane topology and signal peptide predictor”, [online]. Disponible en: https://www.ebi.ac.uk/jdispatcher/pfa/phobius [13] I. Letunic y P. Bork, “SMART (Simple Modular Architecture Research Tool”, [online]. Disponible en: https://smart.embl.de/smart/change_mode.cgi [14] J. Rozas et al., “DnaSP 6: DNA Sequence Polymorphism Analysis of Large Data Sets”, [online]. Disponible en: https://www.ub.edu/dnasp/ [15] F. Tajima, “Statistical method for testing the neutral mutation hypothesis by DNA polymorphism”, Genetics, vol 123, pp. 585-595, 1989. https://doi.org/10.1093/genetics/123.3.585 [16] Y.X. Fu y W.H. Li, “Statistical tests of neutrality of mutations”, Genetics, vol 133, pp. 693-709, 1993. https://doi.org/10.1093/genetics/133.3.693 [17] M. Nei y T. Gojobori, “Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions”, Mol. Biol. Evol, vol 3, pp. 418-426, 1986 [18] B. Murrell et al., “Gene-Wide Identification of Episodic Selection”, Mol. Biol. Evol, vol 32, pp. 1365-1371, 2015. https://doi.org/10.1093/molbev/msv035 [19] S.L. Kosakovsky y S.D. Frost, “Not so different after all: a comparison of methods for detecting amino acid sites under selection”, Mol. Biol. Evol, vol 22, pp. 1208-1222, 2005 https://doi.org/10.1093/molbev/msi105 [20] J. Rozas, M. Gullaud, G. Blandin y M. Aguade, “DNA variation at the rp49 gene region of Drosophila simulans: evolutionary inferences from an unusual haplotype structure”, Genetics, vol 158, pp. 1147-1155, 2001. https://doi.org/10.1093/genetics/158.3.1147] [21] S.L. Kosakovsky, D. Posada, M.B. Gravenor, C.H. Woelk y S.D. Frost, “Automated phylogenetic detection of recombination using a genetic algorithm”, Mol. Biol. Evol, vol 23, pp. 1891-1901, 2006. https://doi.org/10.1093/molbev/msl051 [22] M. C. Jespersen, B. Peters, M. Nielsen y P. Marcatili, “BepiPred-2.0 (Prediction of Potential Lineal B-cells Epitopes)”, [online]. Disponible en: https://services.healthtech.dtu.dk/services/BepiPred-2.0/ [23] N. Rapin, O. Lund y F. Castiglone, “C-ImmSim (Immune system simulation online”), [Online]. Disponible en: https://bio.tools/c-immsim [24] B.A. Seager et al., “PTRAMP, CSS and Ripr form a conserved complex required for merozoite invasion of Plasmodium species into erythrocytes” Nat commun., vol 17, 1780, 2026. https://doi.org/10.1038/s41467-026-68486-1 [25] S.W. Scally et al., “PCRCR complex is essential for invasion of human erythrocytes by Plasmodium falciparum”, Nat Microbiol, vol. 7, pp. 2039-2053, 2022. https://doi.org/10.1038/s41564-022-01261-2.
Y. Ling et al., “Genetic polymorphism of the thrombospondin-related apical merozoite protein (TRAMP) of the Plasmodium knowlesi in Malaysia”, Parasitol res, vol. 122 (1), pp. 195-200, Nov 15. https://doi.org/10.1007/s00436-022-07716-z
J. Baum, R. T. Tonkin-Hill, D. J. Paul, T. Rug y A. F. Cowman, “A conserved molecular motor drives cell invasion and gliding motility across malaria life cycle stages and other apicomplexan parasites”, PLoS Pathog., vol. 9, no. 3, pp. e1002991, Mar. 2013. https://doi.org/10.1371/journal.ppat.1002991
A. Outtara et al., “Molecular basis of allele-specific efficacy of a blood-stage malaria vaccine: vaccine development implications”, J Infect Dis, vol. 207 (3), pp. 511-9, Nov 2013. https://doi.org/10.1093/infdis/jis709.
O. Uchime et al., “Analysis of the Conformation and Function of the Plasmodium falciparum Merozoite Proteins MTRAP and PTRAMP”, Eukaryot cell, vol. 11 (5), pp. 615-625, 2012. https://doi.org/10.1128/ec.00039-12.
AJ. Laurenson, E. Stucke, R. Scalsky y MB. Laurens, “Bioinformatic Approach to Design a Plasmodium falciparum PfRipr Multi-Epitope Vaccine Construct”, Open Forum Infect Dis, vol. 10 (2), pp. ofad 500.693, Nov 2023. https://doi.org/10.1093/ofid/ofad500.693
J. Thompson, RE. Cooke, S. Moore, LF, Anderson, CJ. Janse y AP Waters, “PTRAMP; a conserved Plasmodium thrombospondin-related apical merozoite protein”, Mol Biochem Parasitol, vol. 134 (2), pp. 225-232, Abr 2004. DOI 10.1016/j.molbiopara.2003.12.003. PMID: 15003842.
F. Pouyet, S. Aeschbacher, A. Thiéry, L.Excoffier, “Background selection and biased gene conversion affect more than 95% of the human genome and bias demographic inferences”, eLife, vol. 7, pp. e36317, Ago 2018. https://doi.org/10.7554/eLife.36317
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spelling Puerto Riscanevo, SaloméSoler Rivera, Heidy AlejandraGarzón Ospina, Diego Edison2026-10-17 23:15:062026-10-17 23:15:062026-10-170121-748810.19053/uptc.01217488.v16.n3E.2025.210472462-7658https://doi.org/10.19053/uptc.01217488.v16.n3E.2025.21047application/pdfspaUniversidad Pedagógica y Tecnológica de Colombiahttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.esinfo:eu-repo/semantics/openAccessEsta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0.http://purl.org/coar/access_right/c_abf2https://revistas.uptc.edu.co/index.php/ciencia_en_desarrollo/article/view/21047Diversidad genéticaPfTRAMPPlasmodium falciparumvacuna antimaláricaGenetic diversityPfTRAMPPlasmodium falciparumantimalarial vaccinePotencial de pftramp como candidato a vacuna: diversidad gen.tica y potencial inmunog.nicoArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleJournal articleinfo:eu-repo/semantics/publishedVersionTexthttp://purl.org/coar/version/c_970fb48d4fbd8a85World Health Organization, “World malaria report 2024”, World Health Organization, Geneva, Switzerland, Rep., ISBN 978-92-4-011782-2, 2024.White NJ. Antimalarial drug resistance. J Clin Invest. 2004;113(8):1084–1092. doi:https://doi.org/10.1172/JCI21682.Suh PF, Elanga-Ndille E, Tchouakui M, Sandeu MM, Tagne D, Wondji C, Ndo C. Impact of insecticide resistance on malaria vector competence: a literature review. Malar J. 2023;22(1):19. doi:10.1186/s12936-023-04444-2.S. W. Scally, T. Triglia, C. Evelyn et al., “PCRCR complex is essential for invasion of human erythrocytes by Plasmodium falciparum”, Nat. Microbiol., vol. 7, pp. 2039–2053, Nov. 2022. https://doi.org/10.1038/s41564-022-01261-2Ng YL, Lau YL, Abdul Hamid MH, Jelip J, Ooi CH, Mudin RN, Jaimin JJ, Fong MY. Genetic polymorphism of the thrombospondin-related apical merozoite protein (TRAMP) of Plasmodium knowlesi in Malaysia. Parasitol Res. 2022;121(12):3479–3487. doi:10.1007/s00436-022-07716-z.Collins CR, Hackett F, Howell SA, Snijders AP, Russell MR, Collinson LM, Blackman MJ. The malaria parasite sheddase SUB2 governs host red blood cell membrane sealing during invasion. eLife. 2020;9:e61121. doi:10.7554/eLife.61121.Favuzza P, Guffart E, Tamborrini M, Scherer B, Dreyer AM, Rufer AC, Erny J, Hoernschemeyer J, Thoma R, Schmid G, Gsell B, Lamelas A, Benz J, Joseph C, Matile H, Pluschke G, Rudolph MG. Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion–inhibitory antibody. eLife. 2017;6:e20383. doi:10.7554/eLife.20383.Takala SL, Plowe CV. Genetic diversity and malaria vaccine design, testing and efficacy: preventing and overcoming ‘strain-specific’ immunity. PLoS Med. 2009;6(12):e1000103. doi:10.1371/journal.pmed.1000103.A. F. Cowman, B. A. Seager, P. S. Lim, K. H. Lai, L. Feufack-Donfack, S. Dass et al., “PTRAMP, CSS and Ripr form a conserved complex required for merozoite invasion of Plasmodium species into erythrocytes”, Res. Sq., pp. 1–34, Apr. 2025. https://doi.org/10.21203/rs.3.rs-6292540/v1K. Katoh, J. Rozewicki y K. Yamada, “MAFFT online service sequence alignment, interactive sequence choice and visualization”, [online]. Disponible en: https://mafft.cbrc.jp/alignment/server/index.html.[H. Nielsen, “SignalP 6.0 predicts all five types of signal using protein language models”, [online]. Disponible en: https://services.healthtech.dtu.dk/services/SignalP-6.0/ [12] F. Madeira et al., “Phobius, A combined transmembrane topology and signal peptide predictor”, [online]. Disponible en: https://www.ebi.ac.uk/jdispatcher/pfa/phobius [13] I. Letunic y P. Bork, “SMART (Simple Modular Architecture Research Tool”, [online]. Disponible en: https://smart.embl.de/smart/change_mode.cgi [14] J. Rozas et al., “DnaSP 6: DNA Sequence Polymorphism Analysis of Large Data Sets”, [online]. Disponible en: https://www.ub.edu/dnasp/ [15] F. Tajima, “Statistical method for testing the neutral mutation hypothesis by DNA polymorphism”, Genetics, vol 123, pp. 585-595, 1989. https://doi.org/10.1093/genetics/123.3.585 [16] Y.X. Fu y W.H. Li, “Statistical tests of neutrality of mutations”, Genetics, vol 133, pp. 693-709, 1993. https://doi.org/10.1093/genetics/133.3.693 [17] M. Nei y T. Gojobori, “Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions”, Mol. Biol. Evol, vol 3, pp. 418-426, 1986 [18] B. Murrell et al., “Gene-Wide Identification of Episodic Selection”, Mol. Biol. Evol, vol 32, pp. 1365-1371, 2015. https://doi.org/10.1093/molbev/msv035 [19] S.L. Kosakovsky y S.D. Frost, “Not so different after all: a comparison of methods for detecting amino acid sites under selection”, Mol. Biol. Evol, vol 22, pp. 1208-1222, 2005 https://doi.org/10.1093/molbev/msi105 [20] J. Rozas, M. Gullaud, G. Blandin y M. Aguade, “DNA variation at the rp49 gene region of Drosophila simulans: evolutionary inferences from an unusual haplotype structure”, Genetics, vol 158, pp. 1147-1155, 2001. https://doi.org/10.1093/genetics/158.3.1147] [21] S.L. Kosakovsky, D. Posada, M.B. Gravenor, C.H. Woelk y S.D. Frost, “Automated phylogenetic detection of recombination using a genetic algorithm”, Mol. Biol. Evol, vol 23, pp. 1891-1901, 2006. https://doi.org/10.1093/molbev/msl051 [22] M. C. Jespersen, B. Peters, M. Nielsen y P. Marcatili, “BepiPred-2.0 (Prediction of Potential Lineal B-cells Epitopes)”, [online]. Disponible en: https://services.healthtech.dtu.dk/services/BepiPred-2.0/ [23] N. Rapin, O. Lund y F. Castiglone, “C-ImmSim (Immune system simulation online”), [Online]. Disponible en: https://bio.tools/c-immsim [24] B.A. Seager et al., “PTRAMP, CSS and Ripr form a conserved complex required for merozoite invasion of Plasmodium species into erythrocytes” Nat commun., vol 17, 1780, 2026. https://doi.org/10.1038/s41467-026-68486-1 [25] S.W. Scally et al., “PCRCR complex is essential for invasion of human erythrocytes by Plasmodium falciparum”, Nat Microbiol, vol. 7, pp. 2039-2053, 2022. https://doi.org/10.1038/s41564-022-01261-2.Y. Ling et al., “Genetic polymorphism of the thrombospondin-related apical merozoite protein (TRAMP) of the Plasmodium knowlesi in Malaysia”, Parasitol res, vol. 122 (1), pp. 195-200, Nov 15. https://doi.org/10.1007/s00436-022-07716-zJ. Baum, R. T. Tonkin-Hill, D. J. Paul, T. Rug y A. F. Cowman, “A conserved molecular motor drives cell invasion and gliding motility across malaria life cycle stages and other apicomplexan parasites”, PLoS Pathog., vol. 9, no. 3, pp. e1002991, Mar. 2013. https://doi.org/10.1371/journal.ppat.1002991A. Outtara et al., “Molecular basis of allele-specific efficacy of a blood-stage malaria vaccine: vaccine development implications”, J Infect Dis, vol. 207 (3), pp. 511-9, Nov 2013. https://doi.org/10.1093/infdis/jis709.O. Uchime et al., “Analysis of the Conformation and Function of the Plasmodium falciparum Merozoite Proteins MTRAP and PTRAMP”, Eukaryot cell, vol. 11 (5), pp. 615-625, 2012. https://doi.org/10.1128/ec.00039-12.AJ. Laurenson, E. Stucke, R. Scalsky y MB. Laurens, “Bioinformatic Approach to Design a Plasmodium falciparum PfRipr Multi-Epitope Vaccine Construct”, Open Forum Infect Dis, vol. 10 (2), pp. ofad 500.693, Nov 2023. https://doi.org/10.1093/ofid/ofad500.693J. Thompson, RE. Cooke, S. Moore, LF, Anderson, CJ. Janse y AP Waters, “PTRAMP; a conserved Plasmodium thrombospondin-related apical merozoite protein”, Mol Biochem Parasitol, vol. 134 (2), pp. 225-232, Abr 2004. DOI 10.1016/j.molbiopara.2003.12.003. PMID: 15003842.F. Pouyet, S. Aeschbacher, A. Thiéry, L.Excoffier, “Background selection and biased gene conversion affect more than 95% of the human genome and bias demographic inferences”, eLife, vol. 7, pp. e36317, Ago 2018. https://doi.org/10.7554/eLife.3631783E116Ciencia en Desarrollohttps://revistas.uptc.edu.co/index.php/ciencia_en_desarrollo/article/download/21047/17562Núm. 3E , Año 2025 : Vol. 16 Núm. 3E (2025): VIII Encuentro Internacional de la Facultad de Ciencias (IMFaS 2025)PublicationOREORE.xmltext/xml2743https://repositorio.uptc.edu.co/bitstreams/bdbe94d5-bce5-41bc-8df0-b1fdb372dc01/download5ff2dc20d5d6125feb8c1f5405a442faMD51falseAnonymousREAD001/23141oai:repositorio.uptc.edu.co:001/231412026-10-27 01:15:33.316https://creativecommons.org/licenses/by-nc-nd/4.0/deed.esmetadata.onlyhttps://repositorio.uptc.edu.coRepositorio Institucional UPTCbdigital@metabiblioteca.com

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