Tintes capilares permanentes y genotoxicidad: un desafío emergente para la evaluación de la seguridad química

Autores:: Martínez-Carrascal, Mailyn
Rondón-Lagos, Milena

Tipo de recurso:: Article of journal

Fecha de publicación:: 2026

Institución:: Universidad Pedagógica y Tecnológica de Colombia

Repositorio:: RiUPTC: Repositorio Institucional UPTC

Idioma:: spa

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dc.title.spa.fl_str_mv	Tintes capilares permanentes y genotoxicidad: un desafío emergente para la evaluación de la seguridad química
title	Tintes capilares permanentes y genotoxicidad: un desafío emergente para la evaluación de la seguridad química
spellingShingle	Tintes capilares permanentes y genotoxicidad: un desafío emergente para la evaluación de la seguridad química Tintes capilares permanentes genotoxicidad daño en el ADN aminas aromáticas estrés oxidativo biomarcadores exposición ocupacional Tintes capilares permanentes genotoxicidad daño en el ADN aminas aromáticas estrés oxidativo biomarcadores exposición ocupacional Permanent hair dyes genotoxicity DNA damage aromatic amines oxidative stress biomarkers occupational exposure Permanent hair dyes genotoxicity DNA damage aromatic amines oxidative stress biomarkers occupational exposure
title_short	Tintes capilares permanentes y genotoxicidad: un desafío emergente para la evaluación de la seguridad química
title_full	Tintes capilares permanentes y genotoxicidad: un desafío emergente para la evaluación de la seguridad química
title_fullStr	Tintes capilares permanentes y genotoxicidad: un desafío emergente para la evaluación de la seguridad química
title_full_unstemmed	Tintes capilares permanentes y genotoxicidad: un desafío emergente para la evaluación de la seguridad química
title_sort	Tintes capilares permanentes y genotoxicidad: un desafío emergente para la evaluación de la seguridad química
dc.creator.fl_str_mv	Martínez-Carrascal, Mailyn Rondón-Lagos, Milena
dc.contributor.author.spa.fl_str_mv	Martínez-Carrascal, Mailyn Rondón-Lagos, Milena
dc.subject.none.fl_str_mv	Tintes capilares permanentes genotoxicidad daño en el ADN aminas aromáticas estrés oxidativo biomarcadores exposición ocupacional Tintes capilares permanentes genotoxicidad daño en el ADN aminas aromáticas estrés oxidativo biomarcadores exposición ocupacional Permanent hair dyes genotoxicity DNA damage aromatic amines oxidative stress biomarkers occupational exposure Permanent hair dyes genotoxicity DNA damage aromatic amines oxidative stress biomarkers occupational exposure
topic	Tintes capilares permanentes genotoxicidad daño en el ADN aminas aromáticas estrés oxidativo biomarcadores exposición ocupacional Tintes capilares permanentes genotoxicidad daño en el ADN aminas aromáticas estrés oxidativo biomarcadores exposición ocupacional Permanent hair dyes genotoxicity DNA damage aromatic amines oxidative stress biomarkers occupational exposure Permanent hair dyes genotoxicity DNA damage aromatic amines oxidative stress biomarkers occupational exposure
publishDate	2026
dc.date.accessioned.none.fl_str_mv	2026-10-17 23:15:06
dc.date.available.none.fl_str_mv	2026-10-17 23:15:06
dc.date.issued.none.fl_str_mv	2026-10-17
dc.type.spa.fl_str_mv	Artículo de revista
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dc.type.local.eng.fl_str_mv	Journal article
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dc.type.content.spa.fl_str_mv	Text
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dc.identifier.issn.none.fl_str_mv	0121-7488
dc.identifier.doi.none.fl_str_mv	10.19053/uptc.01217488.v16.n3E.2025.21042
dc.identifier.eissn.none.fl_str_mv	2462-7658
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identifier_str_mv	0121-7488 10.19053/uptc.01217488.v16.n3E.2025.21042 2462-7658
url	https://doi.org/10.19053/uptc.01217488.v16.n3E.2025.21042
dc.language.iso.spa.fl_str_mv	spa
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dc.relation.references.spa.fl_str_mv	K.-H. Kim, E. Kabir, and S. A. Jahan, “The use of personal hair dye and its implications for human health,” Environ. Int., vol. 89–90, pp. 222–227, Apr. 2016, doi: 10.1016/j.envint.2016.01.018. Grand View Research, “Hair Color Market Size, Share & Trends Analysis Report, 2025-2033”, San Francisco, CA, USA, 2025 A. Yildirim et al., “THE CHEMISTRY MECHANISM OF HAIR DYES,” Middle East J. Sci., vol. 8, no. 2, pp. 173–193, Dec. 2022, doi: 10.51477/mejs.1172246. G. J. Nohynek, R. Fautz, F. Benech-Kieffer, and H. Toutain, “Toxicity and human health risk of hair dyes,” Food Chem. Toxicol., vol. 42, no. 4, pp. 517–543, Apr. 2004, doi: 10.1016/j.fct.2003.11.003. International Agency for Research on Cancer, Some aromatic amines, organic dyes and related exposures: this publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 5-12 Februar 2008. in IARC monographs on the evaluation of carcinogenic risks to humans, no. 99. Lyon: WHO, 2010. B. N. Ames, H. O. Kammen, and E. Yamasaki, “Hair dyes are mutagenic: identification of a variety of mutagenic ingredients.,” Proc. Natl. Acad. Sci., vol. 72, no. 6, pp. 2423–2427, Jun. 1975, doi: 10.1073/pnas.72.6.2423. B. L. Van Duuren, “Carcinogenicity of hair dye components,” J. Environ. Pathol. Toxicol., vol. 3, no. 4 Spec No, pp. 237–251, Mar. 1980. M. Hayashi, “Opinion: regulatory genotoxicity: past, present and future,” Genes Environ., vol. 44, no. 1, p. 13, Dec. 2022, doi: 10.1186/s41021-022-00242-5. J. Menz et al., “Genotoxicity assessment: opportunities, challenges and perspectives for quantitative evaluations of dose–response data,” Arch. Toxicol., vol. 97, no. 9, pp. 2303–2328, Sep. 2023, doi: 10.1007/s00204-023-03553-w. W. Alyounes, S. Barguil, and C. Soukkarieh, “p-Toluenediamine hair dyes induce cellular proliferation and genotoxicity,” Toxicol. Anal. Clin., vol. 34, no. 4, pp. 238–246, Dec. 2022, doi: 10.1016/j.toxac.2022.05.018. J.-L. Garrigue et al., “In vitro genotoxicity of para-phenylenediamine and its N-monoacetyl or N,N′-diacetyl metabolites,” Mutat. Res. Toxicol. Environ. Mutagen., vol. 608, no. 1, pp. 58–71, Sep. 2006, doi: 10.1016/j.mrgentox.2006.05.001. M. Qin et al., “Application of the in vivo Pig-a gene mutation assay to test the potential genotoxicity of p-phenylenediamine,” Food Chem. Toxicol., vol. 123, pp. 424–430, Jan. 2019, doi: 10.1016/j.fct.2018.10.061. M. Gube, K. Heinrich, P. Dewes, P. Brand, T. Kraus, and T. Schettgen, “Internal exposure of hairdressers to permanent hair dyes: a biomonitoring study using urinary aromatic diamines as biomarkers of exposure,” Int. Arch. Occup. Environ. Health, vol. 84, no. 3, pp. 287–292, Mar. 2011, doi: 10.1007/s00420-010-0539-x. L. He, F. Michailidou, H. L. Gahlon, and W. Zeng, “Hair Dye Ingredients and Potential Health Risks from Exposure to Hair Dyeing,” Chem. Res. Toxicol., vol. 35, no. 6, pp. 901–915, Jun. 2022, doi: 10.1021/acs.chemrestox.1c00427. R. L. Bronaugh and H. I. Maibach, Eds., Topical Absorption of Dermatological Products, 0 ed. CRC Press, 2002. doi: 10.3109/9780203904015. V. Santamaría and D. Araceli, “Flora cutánea como protección y barrera de la piel normal.,” Rev Cent Dermatol Pascua, vol. 11, no. 1, pp. 18–21, 2002. Centre international de recherche sur le cancer, Ed., Occupational exposures of hairdressers and barbers and personal use of hair colourants: some hair dyes, cosmetic colourants, industrial dyestuffs and aromatic amines. in IARC monographs on the evaluation of carcinogenic risks to humans, no. 57. Lyon: IARC, 1993. “Occupational Dermal Exposure to Permanent Hair Dyes Among Hairdressers,” Ann. Occup. Hyg., Aug. 2005, doi: 10.1093/annhyg/mei030. A. Ramirez-Martinez, P. Granda-Torres, N. Wesolek, A. S. Ficheux, and A. C. Roudot, “Exposure of hairdressers to the main cosmetics used in hairdressing salons in France: A preliminary study,” Arch. Environ. Occup. Health, vol. 71, no. 5, pp. 247–258, Sep. 2016, doi: 10.1080/19338244.2015.1024390. E. Ronda, B. E. Hollund, and B. E. Moen, “Airborne exposure to chemical substances in hairdresser salons,” Environ. Monit. Assess., vol. 153, no. 1–4, pp. 83–93, Jun. 2009, doi: 10.1007/s10661-008-0338-y. M. C. Kheirabadi, E. Hesari, M. Shariat, and M. Gharagozlou, “Respiratory Health Risks in Hairdressing: A Cross-sectional Study of Occupational Subgroups,” Iran. J. Allergy Asthma Immunol., Sep. 2025, doi: 10.18502/ijaai.v24i5.19744. A. Bernard et al., “Consumption of hair dye products by the French women population: Usage pattern and exposure assessment,” Food Chem. Toxicol., vol. 88, pp. 123–132, Feb. 2016, doi: 10.1016/j.fct.2016.01.002. L. J. Wolfram and H. I. Maibach, “Percutaneous penetration of hair dyes,” Arch. Dermatol. Res., vol. 277, no. 3, pp. 235–241, Feb. 1985, doi: 10.1007/BF00404323. G. J. Nohynek et al., “Human systemic exposure to [14C]-paraphenylenediamine-containing oxidative hair dyes: Absorption, kinetics, metabolism, excretion and safety assessment,” Food Chem. Toxicol., vol. 81, pp. 71–80, Jul. 2015, doi: 10.1016/j.fct.2015.04.003. T. B. Zanoni et al., “The oxidation of p-phenylenediamine, an ingredient used for permanent hair dyeing purposes, leads to the formation of hydroxyl radicals: Oxidative stress and DNA damage in human immortalized keratinocytes,” Toxicol. Lett., vol. 239, no. 3, pp. 194–204, Dec. 2015, doi: 10.1016/j.toxlet.2015.09.026. C. A. Juan, J. M. Pérez De La Lastra, F. J. Plou, and E. Pérez-Lebeña, “The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies,” Int. J. Mol. Sci., vol. 22, no. 9, p. 4642, Apr. 2021, doi: 10.3390/ijms22094642. J. Wang and J. Yi, “Cancer cell killing via ROS: To increase or decrease, that is the question,” Cancer Biol. Ther., vol. 7, no. 12, pp. 1875–1884, Dec. 2008, doi: 10.4161/cbt.7.12.7067. C. Chatgilialoglu, C. Ferreri, M. G. Krokidis, A. Masi, and M. A. Terzidis, “On the relevance of hydroxyl radical to purine DNA damage,” Free Radic. Res., vol. 55, no. 4, pp. 384–404, Apr. 2021, doi: 10.1080/10715762.2021.1876855. M. Cao and X. Zhang, “DNA Adductomics: A Narrative Review of Its Development, Applications, and Future,” Biomolecules, vol. 14, no. 9, p. 1173, Sep. 2024, doi: 10.3390/biom14091173. B. Hwa Yun, J. Guo, M. Bellamri, and R. J. Turesky, “DNA adducts: Formation, biological effects, and new biospecimens for mass spectrometric measurements in humans,” Mass Spectrom. Rev., vol. 39, no. 1–2, pp. 55–82, Mar. 2020, doi: 10.1002/mas.21570. S. M. Chye et al., “Apoptosis induced by para-phenylenediamineinvolves formation of ROS and activation of p38 and JNK in chang liver cells,” Environ. Toxicol., vol. 29, no. 9, pp. 981–990, Sep. 2014, doi: 10.1002/tox.21828. K. Reena, K. Y. Ng, R. Y. Koh, P. Gnanajothy, and S. M. Chye, “para ‐Phenylenediamine induces apoptosis through activation of reactive oxygen species‐mediated mitochondrial pathway, and inhibition of the NF‐ΚB , m TOR , and W nt pathways in human urothelial cells,” Environ. Toxicol., vol. 32, no. 1, pp. 265–277, Jan. 2017, doi: 10.1002/tox.22233. Y. Sun, Y. Yin, J. Zhang, H. Yu, and X. Wang, “Bioaccumulation and ROS generation in liver of freshwater fish, goldfish Carassius auratus under HC Orange No. 1 exposure,” Environ. Toxicol., vol. 22, no. 3, pp. 256–263, Jun. 2007, doi: 10.1002/tox.20262. C. B. Ambrosone, S. M. Abrams, K. Gorlewska-Roberts, and F. F. Kadlubar, “Hair dye use, meat intake, and tobacco exposure and presence of carcinogen-DNA adducts in exfoliated breast ductal epithelial cells,” Arch. Biochem. Biophys., vol. 464, no. 2, pp. 169–175, Aug. 2007, doi: 10.1016/j.abb.2007.05.018. S. Khan et al., “4-Chloro-orthophenylenediamine alters DNA integrity and affects cell survival: inferences from a computational, biophysical/biochemical, microscopic and cell-based study,” J. Biomol. Struct. Dyn., vol. 40, no. 24, pp. 14176–14187, Dec. 2022, doi: 10.1080/07391102.2021.2001376. D. Sharma, S. Mishra, G. Jha, B. Tomar, and S. K. Rath, “Bacterial Reverse Mutation Test: Ames Test,” in Genotoxicity Assessment, vol. 2986, A. Dhawan and M. Bajpayee, Eds., in Methods in Molecular Biology, vol. 2986. , New York, NY: Springer US, 2025, pp. 3–15. doi: 10.1007/978-1-0716-4976-3_1. C. Ladeira et al., “The Comet Assay as a Tool in Human Biomonitoring Studies of Environmental and Occupational Exposure to Chemicals—A Systematic Scoping Review,” Toxics, vol. 12, no. 4, p. 270, Apr. 2024, doi: 10.3390/toxics12040270. H. Norppa, “Cytogenetic biomarkers,” IARC Sci. Publ., no. 157, pp. 179–205, 2004. U. Vijay, S. Gupta, P. Mathur, P. Suravajhala, and P. Bhatnagar, “Microbial Mutagenicity Assay: Ames Test,” BIO-Protoc., vol. 8, no. 6, 2018, doi: 10.21769/BioProtoc.2763. [40] T. Watanabe, T. Hirayama, and S. Fukui, “Mutagenicity of commercial hair dyes and detection of 2,7-diaminophenazine,” Mutat. Res. Lett., vol. 244, no. 4, pp. 303–308, Aug. 1990, doi: 10.1016/0165-7992(90)90077-W. S. Zhou et al., “Analysis of mutagenic components of oxidative hair dyes with the Ames test,” Hum. Exp. Toxicol., vol. 40, no. 11, pp. 1921–1937, Nov. 2021, doi: 10.1177/09603271211013433. N. P. Singh, M. T. McCoy, R. R. Tice, and E. L. Schneider, “A simple technique for quantitation of low levels of DNA damage in individual cells,” Exp. Cell Res., vol. 175, no. 1, pp. 184–191, Mar. 1988, doi: 10.1016/0014-4827(88)90265-0. S. Kumar, V. Vishwakarma, B. Yadav, R. Gupta, N. Aggarwal, and A. Yadav, “Antigenotoxic Effects of Epigallocatechin Gallate against Hair Dye Induced Genotoxicity in Cultured Human Peripheral Blood Lymphocytes,” J. Biol. Act. Prod. Nat., vol. 10, no. 2, pp. 141–152, Mar. 2020, doi: 10.1080/22311866.2020.1764866. J. Cho, E. Oh, E. Lee, and D. Sul, “Effects of Hair Dyeing on DNA Damage in Human Lymphocytes,” J. Occup. Health, vol. 45, no. 6, pp. 376–381, Nov. 2003, doi: 10.1539/joh.45.376. Y.-C. Huang, W.-C. Hung, W.-Y. Kang, W.-T. Chen, and C.-Y. Chai, “p-Phenylenediamine induced DNA damage in SV-40 immortalized human uroepithelial cells and expression of mutant p53 and COX-2 proteins,” Toxicol. Lett., vol. 170, no. 2, pp. 116–123, Apr. 2007, doi: 10.1016/j.toxlet.2007.02.011. S. M. Chye, Y. C. Hseu, S.-H. Liang, C.-H. Chen, and S. C. Chen, “Single Strand DNA Breaks in Human Lymphocytes Exposed to para-Phenylenediamine and its Derivatives,” Bull. Environ. Contam. Toxicol., vol. 80, no. 1, pp. 58–62, Jan. 2008, doi: 10.1007/s00128-007-9316-2. S. C. Chen, C. H. Chen, Y. L. Tioh, P. Y. Zhong, Y. S. Lin, and S. M. Chye, “Para-phenylenediamine induced DNA damage and apoptosis through oxidative stress and enhanced caspase-8 and -9 activities in Mardin–Darby canine kidney cells,” Toxicol. In Vitro, vol. 24, no. 4, pp. 1197–1202, Jun. 2010, doi: 10.1016/j.tiv.2010.02.011. A. Zeller and S. Pfuhler, “N-acetylation of three aromatic amine hair dye precursor molecules eliminates their genotoxic potential,” Mutagenesis, vol. 29, no. 1, pp. 37–48, Jan. 2014, doi: 10.1093/mutage/get053. Y. Tafurt-Cardona, P. Suares-Rocha, T. C. C. Fernandes, and M. A. Marin-Morales, “Cytotoxic and genotoxic effects of two hair dyes used in the formulation of black color,” Food Chem. Toxicol., vol. 86, pp. 9–15, Dec. 2015, doi: 10.1016/j.fct.2015.09.010. H. Kamiya and M. Kurokawa, “Mutagenic Bypass of 8-Oxo-7,8-dihydroguanine (8-Hydroxyguanine) by DNA Polymerase κ in Human Cells,” Chem. Res. Toxicol., vol. 25, no. 8, pp. 1771–1776, Aug. 2012, doi: 10.1021/tx300259x. M. Murata, R. Thanan, N. Ma, and S. Kawanishi, “Role of Nitrative and Oxidative DNA Damage in Inflammation-Related Carcinogenesis,” J. Biomed. Biotechnol., vol. 2012, pp. 1–11, 2012, doi: 10.1155/2012/623019. M. Murata, T. Nishimura, F. Chen, and S. Kawanishi, “Oxidative DNA damage induced by hair dye components ortho-phenylenediamines and the enhancement by superoxide dismutase,” Mutat. Res. Toxicol. Environ. Mutagen., vol. 607, no. 2, pp. 184–191, Sep. 2006, doi: 10.1016/j.mrgentox.2006.04.014. S. Khan et al., “Hepatocellular carcinoma antibodies preferably identify nitro-oxidative-DNA lesions induced by 4-Chloro-orthophenylenediamine and DEANO,” Sci. Rep., vol. 14, no. 1, p. 27620, Nov. 2024, doi: 10.1038/s41598-024-75649-x. M. S. Warsi et al., “4-Chloro-1,2-phenylenediamine induced structural perturbation and genotoxic aggregation in human serum albumin,” Front. Chem., vol. 10, p. 1016354, Sep. 2022, doi: 10.3389/fchem.2022.1016354. D. Vlastos and A. Ntinopoulos, “Induction of micronuclei on Greek hairdressers occupationally exposed to chemical mixtures,” Environ. Toxicol., vol. 26, no. 5, pp. 506–514, Oct. 2011, doi: 10.1002/tox.20579. A. A. Sukuroglu and S. Burgaz, “Micronuclei and other nuclear anomalies in exfoliated urothelial cells and urinary 8-hydroxy-deoxyguanosine levels among Turkish hairdressers,” Mutat. Res. - Genet. Toxicol. Environ. Mutagen., vol. 896, p. 503754, May 2024, doi: 10.1016/j.mrgentox.2024.503754. S. Farhadi, M. Jolehar, and F. Safapour, “Micronucleus Assay of Buccal Mucosal Cells in Hairdressers: The Importance of Occupational Exposure,” Asian Pac. J. Cancer Prev., vol. 19, no. 8, Aug. 2018, doi: 10.22034/APJCP.2018.19.8.2131. M. Soto, I. García-Santisteban, L. Krenning, R. H. Medema, and J. A. Raaijmakers, “Chromosomes trapped in micronuclei are liable to segregation errors,” J. Cell Sci., vol. 131, no. 13, p. jcs214742, Jul. 2018, doi: 10.1242/jcs.214742. F. Espinoza et al., “Micronuclei assessment in the urothelial cells of women using hair dyes and its modulation by genetic polymorphisms,” Cancer Lett., vol. 263, no. 2, pp. 259–266, May 2008, doi: 10.1016/j.canlet.2008.01.010. Ö. S. Aslantürk and T. Aşkin Çelik, “Genotoxic risk assessment in professionals working hairdressers area using buccal micronucleus assay, in Aydın City, Turkey,” Environ. Sci. Pollut. Res., vol. 24, no. 17, pp. 14700–14705, Jun. 2017, doi: 10.1007/s11356-017-9075-5. B. He, N. Gnawali, A. W. Hinman, A. J. Mattingly, A. Osimani, and D. Cimini, “Chromosomes missegregated into micronuclei contribute to chromosomal instability by missegregating at the next division,” Oncotarget, vol. 10, no. 28, pp. 2660–2674, Apr. 2019, doi: 10.18632/oncotarget.26853. Y.-F. Lin et al., “Mitotic clustering of pulverized chromosomes from micronuclei,” Nature, vol. 618, no. 7967, pp. 1041–1048, Jun. 2023, doi: 10.1038/s41586-023-05974-0. P. Mosesso and S. Cinelli, “In Vitro Cytogenetic Assays: Chromosomal Aberrations and Micronucleus Tests,” in Genotoxicity Assessment, vol. 2986, A. Dhawan and M. Bajpayee, Eds., in Methods in Molecular Biology, vol. 2986. , New York, NY: Springer US, 2026, pp. 109–137. doi: 10.1007/978-1-0716-4976-3_6. S. Sunada, J. S. Haskins, and T. A. Kato, “Sister Chromatid Exchange as a Genotoxic Stress Marker,” in Radiation Cytogenetics, vol. 1984, T. A. Kato and P. F. Wilson, Eds., in Methods in Molecular Biology, vol. 1984. , New York, NY: Springer New York, 2019, pp. 61–68. doi: 10.1007/978-1-4939-9432-8_7. H. Hofer, N. Bornatowicz, and E. Reindl, “Analysis of human chromosomes after repeated hair dyeing,” Food Chem. Toxicol., vol. 21, no. 6, pp. 785–789, Dec. 1983, doi: 10.1016/0278-6915(83)90213-2. J. Xie, Y. Liu, L. Li, and Y. Wu, “[A clinical analysis of fetal chromosomal aberration induced by paint and hair dye],” Nan Fang Yi Ke Da Xue Xue Bao, vol. 30, no. 7, pp. 1651–1653, Jul. 2010. K. Turanitz, R. Kovac, H. Tuschl, and E. Pavlicek, “Investigations on the effect of repeated hair dyeing on sister chromatid exchanges,” Food Chem. Toxicol., vol. 21, no. 6, pp. 791–793, Dec. 1983, doi: 10.1016/0278-6915(83)90214-4. D. J. Kirkland, S. D. Lawler, and S. Venitt, “Chromosomal Damage and Hair Dyes,” The Lancet, vol. 312, no. 8081, pp. 124–128, Jul. 1978, doi: 10.1016/S0140-6736(78)91508-8. B. Takkouche, C. Regueira-Mendez, and A. Montes-Martinez, “Risk of cancer among hairdressers and related workers: a meta-analysis,” Int. J. Epidemiol., vol. 38, no. 6, pp. 1512–1531, Dec. 2009, doi: 10.1093/ije/dyp283. Y. Zhang et al., “Personal use of permanent hair dyes and cancer risk and mortality in US women: prospective cohort study,” BMJ, p. m2942, Sep. 2020, doi: 10.1136/bmj.m2942. C. E. Eberle, D. P. Sandler, K. W. Taylor, and A. J. White, “Hair dye and chemical straightener use and breast cancer risk in a large US population of black and white women,” Int. J. Cancer, vol. 147, no. 2, pp. 383–391, Jul. 2020, doi: 10.1002/ijc.32738. E. E. McCall, A. F. Olshan, and J. L. Daniels, “Maternal hair dye use and risk of neuroblastoma in offspring*,” Cancer Causes Control, vol. 16, no. 6, pp. 743–748, Aug. 2005, doi: 10.1007/s10552-005-1229-y. H. M. Bolt and K. Golka, “The Debate on Carcinogenicity of Permanent Hair Dyes: New Insights,” Crit. Rev. Toxicol., vol. 37, no. 6, pp. 521–536, Jan. 2007, doi: 10.1080/10408440701385671. European Commission. Directorate General for Health and Food Safety., Opinion on resorcinol. LU: Publications Office, 2022. doi: 10.2875/527921. European Commission. Directorate General for Health and Consumers., Opinion on p-Phenylenediamine: COLIPA n° A7. Revision of 18 September 2012. LU: Publications Office, 2012. doi: 10.2772/8451.
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spelling	Martínez-Carrascal, MailynRondón-Lagos, Milena2026-10-17 23:15:062026-10-17 23:15:062026-10-170121-748810.19053/uptc.01217488.v16.n3E.2025.210422462-7658https://doi.org/10.19053/uptc.01217488.v16.n3E.2025.21042spaUniversidad Pedagógica y Tecnológica de Colombiahttps://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2https://revistas.uptc.edu.co/index.php/ciencia_en_desarrollo/article/view/21042Tintes capilares permanentesgenotoxicidaddaño en el ADNaminas aromáticasestrés oxidativobiomarcadoresexposición ocupacionalTintes capilares permanentesgenotoxicidaddaño en el ADNaminas aromáticasestrés oxidativobiomarcadoresexposición ocupacionalPermanent hair dyesgenotoxicityDNA damagearomatic aminesoxidative stressbiomarkersoccupational exposurePermanent hair dyesgenotoxicityDNA damagearomatic aminesoxidative stressbiomarkersoccupational exposureTintes capilares permanentes y genotoxicidad: un desafío emergente para la evaluación de la seguridad químicaArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleJournal articleinfo:eu-repo/semantics/publishedVersionTexthttp://purl.org/coar/version/c_970fb48d4fbd8a85K.-H. Kim, E. Kabir, and S. A. Jahan, “The use of personal hair dye and its implications for human health,” Environ. Int., vol. 89–90, pp. 222–227, Apr. 2016, doi: 10.1016/j.envint.2016.01.018.Grand View Research, “Hair Color Market Size, Share & Trends Analysis Report, 2025-2033”, San Francisco, CA, USA, 2025A. Yildirim et al., “THE CHEMISTRY MECHANISM OF HAIR DYES,” Middle East J. Sci., vol. 8, no. 2, pp. 173–193, Dec. 2022, doi: 10.51477/mejs.1172246.G. J. Nohynek, R. Fautz, F. Benech-Kieffer, and H. Toutain, “Toxicity and human health risk of hair dyes,” Food Chem. Toxicol., vol. 42, no. 4, pp. 517–543, Apr. 2004, doi: 10.1016/j.fct.2003.11.003.International Agency for Research on Cancer, Some aromatic amines, organic dyes and related exposures: this publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 5-12 Februar 2008. in IARC monographs on the evaluation of carcinogenic risks to humans, no. 99. Lyon: WHO, 2010.B. N. Ames, H. O. Kammen, and E. Yamasaki, “Hair dyes are mutagenic: identification of a variety of mutagenic ingredients.,” Proc. Natl. Acad. Sci., vol. 72, no. 6, pp. 2423–2427, Jun. 1975, doi: 10.1073/pnas.72.6.2423.B. L. Van Duuren, “Carcinogenicity of hair dye components,” J. Environ. Pathol. Toxicol., vol. 3, no. 4 Spec No, pp. 237–251, Mar. 1980.M. Hayashi, “Opinion: regulatory genotoxicity: past, present and future,” Genes Environ., vol. 44, no. 1, p. 13, Dec. 2022, doi: 10.1186/s41021-022-00242-5.J. Menz et al., “Genotoxicity assessment: opportunities, challenges and perspectives for quantitative evaluations of dose–response data,” Arch. Toxicol., vol. 97, no. 9, pp. 2303–2328, Sep. 2023, doi: 10.1007/s00204-023-03553-w.W. Alyounes, S. Barguil, and C. Soukkarieh, “p-Toluenediamine hair dyes induce cellular proliferation and genotoxicity,” Toxicol. Anal. Clin., vol. 34, no. 4, pp. 238–246, Dec. 2022, doi: 10.1016/j.toxac.2022.05.018.J.-L. Garrigue et al., “In vitro genotoxicity of para-phenylenediamine and its N-monoacetyl or N,N′-diacetyl metabolites,” Mutat. Res. Toxicol. Environ. Mutagen., vol. 608, no. 1, pp. 58–71, Sep. 2006, doi: 10.1016/j.mrgentox.2006.05.001.M. Qin et al., “Application of the in vivo Pig-a gene mutation assay to test the potential genotoxicity of p-phenylenediamine,” Food Chem. Toxicol., vol. 123, pp. 424–430, Jan. 2019, doi: 10.1016/j.fct.2018.10.061.M. Gube, K. Heinrich, P. Dewes, P. Brand, T. Kraus, and T. Schettgen, “Internal exposure of hairdressers to permanent hair dyes: a biomonitoring study using urinary aromatic diamines as biomarkers of exposure,” Int. Arch. Occup. Environ. Health, vol. 84, no. 3, pp. 287–292, Mar. 2011, doi: 10.1007/s00420-010-0539-x.L. He, F. Michailidou, H. L. Gahlon, and W. Zeng, “Hair Dye Ingredients and Potential Health Risks from Exposure to Hair Dyeing,” Chem. Res. Toxicol., vol. 35, no. 6, pp. 901–915, Jun. 2022, doi: 10.1021/acs.chemrestox.1c00427.R. L. Bronaugh and H. I. Maibach, Eds., Topical Absorption of Dermatological Products, 0 ed. CRC Press, 2002. doi: 10.3109/9780203904015.V. Santamaría and D. Araceli, “Flora cutánea como protección y barrera de la piel normal.,” Rev Cent Dermatol Pascua, vol. 11, no. 1, pp. 18–21, 2002.Centre international de recherche sur le cancer, Ed., Occupational exposures of hairdressers and barbers and personal use of hair colourants: some hair dyes, cosmetic colourants, industrial dyestuffs and aromatic amines. in IARC monographs on the evaluation of carcinogenic risks to humans, no. 57. Lyon: IARC, 1993.“Occupational Dermal Exposure to Permanent Hair Dyes Among Hairdressers,” Ann. Occup. Hyg., Aug. 2005, doi: 10.1093/annhyg/mei030.A. Ramirez-Martinez, P. Granda-Torres, N. Wesolek, A. S. Ficheux, and A. C. Roudot, “Exposure of hairdressers to the main cosmetics used in hairdressing salons in France: A preliminary study,” Arch. Environ. Occup. Health, vol. 71, no. 5, pp. 247–258, Sep. 2016, doi: 10.1080/19338244.2015.1024390.E. Ronda, B. E. Hollund, and B. E. Moen, “Airborne exposure to chemical substances in hairdresser salons,” Environ. Monit. Assess., vol. 153, no. 1–4, pp. 83–93, Jun. 2009, doi: 10.1007/s10661-008-0338-y.M. C. Kheirabadi, E. Hesari, M. Shariat, and M. Gharagozlou, “Respiratory Health Risks in Hairdressing: A Cross-sectional Study of Occupational Subgroups,” Iran. J. Allergy Asthma Immunol., Sep. 2025, doi: 10.18502/ijaai.v24i5.19744.A. Bernard et al., “Consumption of hair dye products by the French women population: Usage pattern and exposure assessment,” Food Chem. Toxicol., vol. 88, pp. 123–132, Feb. 2016, doi: 10.1016/j.fct.2016.01.002.L. J. Wolfram and H. I. Maibach, “Percutaneous penetration of hair dyes,” Arch. Dermatol. Res., vol. 277, no. 3, pp. 235–241, Feb. 1985, doi: 10.1007/BF00404323.G. J. Nohynek et al., “Human systemic exposure to [14C]-paraphenylenediamine-containing oxidative hair dyes: Absorption, kinetics, metabolism, excretion and safety assessment,” Food Chem. Toxicol., vol. 81, pp. 71–80, Jul. 2015, doi: 10.1016/j.fct.2015.04.003.T. B. Zanoni et al., “The oxidation of p-phenylenediamine, an ingredient used for permanent hair dyeing purposes, leads to the formation of hydroxyl radicals: Oxidative stress and DNA damage in human immortalized keratinocytes,” Toxicol. Lett., vol. 239, no. 3, pp. 194–204, Dec. 2015, doi: 10.1016/j.toxlet.2015.09.026.C. A. Juan, J. M. Pérez De La Lastra, F. J. Plou, and E. Pérez-Lebeña, “The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies,” Int. J. Mol. Sci., vol. 22, no. 9, p. 4642, Apr. 2021, doi: 10.3390/ijms22094642.J. Wang and J. Yi, “Cancer cell killing via ROS: To increase or decrease, that is the question,” Cancer Biol. Ther., vol. 7, no. 12, pp. 1875–1884, Dec. 2008, doi: 10.4161/cbt.7.12.7067.C. Chatgilialoglu, C. Ferreri, M. G. Krokidis, A. Masi, and M. A. Terzidis, “On the relevance of hydroxyl radical to purine DNA damage,” Free Radic. Res., vol. 55, no. 4, pp. 384–404, Apr. 2021, doi: 10.1080/10715762.2021.1876855.M. Cao and X. Zhang, “DNA Adductomics: A Narrative Review of Its Development, Applications, and Future,” Biomolecules, vol. 14, no. 9, p. 1173, Sep. 2024, doi: 10.3390/biom14091173.B. Hwa Yun, J. Guo, M. Bellamri, and R. J. Turesky, “DNA adducts: Formation, biological effects, and new biospecimens for mass spectrometric measurements in humans,” Mass Spectrom. Rev., vol. 39, no. 1–2, pp. 55–82, Mar. 2020, doi: 10.1002/mas.21570.S. M. Chye et al., “Apoptosis induced by para-phenylenediamineinvolves formation of ROS and activation of p38 and JNK in chang liver cells,” Environ. Toxicol., vol. 29, no. 9, pp. 981–990, Sep. 2014, doi: 10.1002/tox.21828.K. Reena, K. Y. Ng, R. Y. Koh, P. Gnanajothy, and S. M. Chye, “para ‐Phenylenediamine induces apoptosis through activation of reactive oxygen species‐mediated mitochondrial pathway, and inhibition of the NF‐ΚB , m TOR , and W nt pathways in human urothelial cells,” Environ. Toxicol., vol. 32, no. 1, pp. 265–277, Jan. 2017, doi: 10.1002/tox.22233.Y. Sun, Y. Yin, J. Zhang, H. Yu, and X. Wang, “Bioaccumulation and ROS generation in liver of freshwater fish, goldfish Carassius auratus under HC Orange No. 1 exposure,” Environ. Toxicol., vol. 22, no. 3, pp. 256–263, Jun. 2007, doi: 10.1002/tox.20262.C. B. Ambrosone, S. M. Abrams, K. Gorlewska-Roberts, and F. F. Kadlubar, “Hair dye use, meat intake, and tobacco exposure and presence of carcinogen-DNA adducts in exfoliated breast ductal epithelial cells,” Arch. Biochem. Biophys., vol. 464, no. 2, pp. 169–175, Aug. 2007, doi: 10.1016/j.abb.2007.05.018.S. Khan et al., “4-Chloro-orthophenylenediamine alters DNA integrity and affects cell survival: inferences from a computational, biophysical/biochemical, microscopic and cell-based study,” J. Biomol. Struct. Dyn., vol. 40, no. 24, pp. 14176–14187, Dec. 2022, doi: 10.1080/07391102.2021.2001376.D. Sharma, S. Mishra, G. Jha, B. Tomar, and S. K. Rath, “Bacterial Reverse Mutation Test: Ames Test,” in Genotoxicity Assessment, vol. 2986, A. Dhawan and M. Bajpayee, Eds., in Methods in Molecular Biology, vol. 2986. , New York, NY: Springer US, 2025, pp. 3–15. doi: 10.1007/978-1-0716-4976-3_1.C. Ladeira et al., “The Comet Assay as a Tool in Human Biomonitoring Studies of Environmental and Occupational Exposure to Chemicals—A Systematic Scoping Review,” Toxics, vol. 12, no. 4, p. 270, Apr. 2024, doi: 10.3390/toxics12040270.H. Norppa, “Cytogenetic biomarkers,” IARC Sci. Publ., no. 157, pp. 179–205, 2004.U. Vijay, S. Gupta, P. Mathur, P. Suravajhala, and P. Bhatnagar, “Microbial Mutagenicity Assay: Ames Test,” BIO-Protoc., vol. 8, no. 6, 2018, doi: 10.21769/BioProtoc.2763. [40] T. Watanabe, T. Hirayama, and S. Fukui, “Mutagenicity of commercial hair dyes and detection of 2,7-diaminophenazine,” Mutat. Res. Lett., vol. 244, no. 4, pp. 303–308, Aug. 1990, doi: 10.1016/0165-7992(90)90077-W.S. Zhou et al., “Analysis of mutagenic components of oxidative hair dyes with the Ames test,” Hum. Exp. Toxicol., vol. 40, no. 11, pp. 1921–1937, Nov. 2021, doi: 10.1177/09603271211013433.N. P. Singh, M. T. McCoy, R. R. Tice, and E. L. Schneider, “A simple technique for quantitation of low levels of DNA damage in individual cells,” Exp. Cell Res., vol. 175, no. 1, pp. 184–191, Mar. 1988, doi: 10.1016/0014-4827(88)90265-0.S. Kumar, V. Vishwakarma, B. Yadav, R. Gupta, N. Aggarwal, and A. Yadav, “Antigenotoxic Effects of Epigallocatechin Gallate against Hair Dye Induced Genotoxicity in Cultured Human Peripheral Blood Lymphocytes,” J. Biol. Act. Prod. Nat., vol. 10, no. 2, pp. 141–152, Mar. 2020, doi: 10.1080/22311866.2020.1764866.J. Cho, E. Oh, E. Lee, and D. Sul, “Effects of Hair Dyeing on DNA Damage in Human Lymphocytes,” J. Occup. Health, vol. 45, no. 6, pp. 376–381, Nov. 2003, doi: 10.1539/joh.45.376.Y.-C. Huang, W.-C. Hung, W.-Y. Kang, W.-T. Chen, and C.-Y. Chai, “p-Phenylenediamine induced DNA damage in SV-40 immortalized human uroepithelial cells and expression of mutant p53 and COX-2 proteins,” Toxicol. Lett., vol. 170, no. 2, pp. 116–123, Apr. 2007, doi: 10.1016/j.toxlet.2007.02.011.S. M. Chye, Y. C. Hseu, S.-H. Liang, C.-H. Chen, and S. C. Chen, “Single Strand DNA Breaks in Human Lymphocytes Exposed to para-Phenylenediamine and its Derivatives,” Bull. Environ. Contam. Toxicol., vol. 80, no. 1, pp. 58–62, Jan. 2008, doi: 10.1007/s00128-007-9316-2.S. C. Chen, C. H. Chen, Y. L. Tioh, P. Y. Zhong, Y. S. Lin, and S. M. Chye, “Para-phenylenediamine induced DNA damage and apoptosis through oxidative stress and enhanced caspase-8 and -9 activities in Mardin–Darby canine kidney cells,” Toxicol. In Vitro, vol. 24, no. 4, pp. 1197–1202, Jun. 2010, doi: 10.1016/j.tiv.2010.02.011.A. Zeller and S. Pfuhler, “N-acetylation of three aromatic amine hair dye precursor molecules eliminates their genotoxic potential,” Mutagenesis, vol. 29, no. 1, pp. 37–48, Jan. 2014, doi: 10.1093/mutage/get053.Y. Tafurt-Cardona, P. Suares-Rocha, T. C. C. Fernandes, and M. A. Marin-Morales, “Cytotoxic and genotoxic effects of two hair dyes used in the formulation of black color,” Food Chem. Toxicol., vol. 86, pp. 9–15, Dec. 2015, doi: 10.1016/j.fct.2015.09.010.H. Kamiya and M. Kurokawa, “Mutagenic Bypass of 8-Oxo-7,8-dihydroguanine (8-Hydroxyguanine) by DNA Polymerase κ in Human Cells,” Chem. Res. Toxicol., vol. 25, no. 8, pp. 1771–1776, Aug. 2012, doi: 10.1021/tx300259x.M. Murata, R. Thanan, N. Ma, and S. Kawanishi, “Role of Nitrative and Oxidative DNA Damage in Inflammation-Related Carcinogenesis,” J. Biomed. Biotechnol., vol. 2012, pp. 1–11, 2012, doi: 10.1155/2012/623019.M. Murata, T. Nishimura, F. Chen, and S. Kawanishi, “Oxidative DNA damage induced by hair dye components ortho-phenylenediamines and the enhancement by superoxide dismutase,” Mutat. Res. Toxicol. Environ. Mutagen., vol. 607, no. 2, pp. 184–191, Sep. 2006, doi: 10.1016/j.mrgentox.2006.04.014.S. Khan et al., “Hepatocellular carcinoma antibodies preferably identify nitro-oxidative-DNA lesions induced by 4-Chloro-orthophenylenediamine and DEANO,” Sci. Rep., vol. 14, no. 1, p. 27620, Nov. 2024, doi: 10.1038/s41598-024-75649-x.M. S. Warsi et al., “4-Chloro-1,2-phenylenediamine induced structural perturbation and genotoxic aggregation in human serum albumin,” Front. Chem., vol. 10, p. 1016354, Sep. 2022, doi: 10.3389/fchem.2022.1016354.D. Vlastos and A. Ntinopoulos, “Induction of micronuclei on Greek hairdressers occupationally exposed to chemical mixtures,” Environ. Toxicol., vol. 26, no. 5, pp. 506–514, Oct. 2011, doi: 10.1002/tox.20579.A. A. Sukuroglu and S. Burgaz, “Micronuclei and other nuclear anomalies in exfoliated urothelial cells and urinary 8-hydroxy-deoxyguanosine levels among Turkish hairdressers,” Mutat. Res. - Genet. Toxicol. Environ. Mutagen., vol. 896, p. 503754, May 2024, doi: 10.1016/j.mrgentox.2024.503754.S. Farhadi, M. Jolehar, and F. Safapour, “Micronucleus Assay of Buccal Mucosal Cells in Hairdressers: The Importance of Occupational Exposure,” Asian Pac. J. Cancer Prev., vol. 19, no. 8, Aug. 2018, doi: 10.22034/APJCP.2018.19.8.2131.M. Soto, I. García-Santisteban, L. Krenning, R. H. Medema, and J. A. Raaijmakers, “Chromosomes trapped in micronuclei are liable to segregation errors,” J. Cell Sci., vol. 131, no. 13, p. jcs214742, Jul. 2018, doi: 10.1242/jcs.214742.F. Espinoza et al., “Micronuclei assessment in the urothelial cells of women using hair dyes and its modulation by genetic polymorphisms,” Cancer Lett., vol. 263, no. 2, pp. 259–266, May 2008, doi: 10.1016/j.canlet.2008.01.010.Ö. S. Aslantürk and T. Aşkin Çelik, “Genotoxic risk assessment in professionals working hairdressers area using buccal micronucleus assay, in Aydın City, Turkey,” Environ. Sci. Pollut. Res., vol. 24, no. 17, pp. 14700–14705, Jun. 2017, doi: 10.1007/s11356-017-9075-5.B. He, N. Gnawali, A. W. Hinman, A. J. Mattingly, A. Osimani, and D. Cimini, “Chromosomes missegregated into micronuclei contribute to chromosomal instability by missegregating at the next division,” Oncotarget, vol. 10, no. 28, pp. 2660–2674, Apr. 2019, doi: 10.18632/oncotarget.26853.Y.-F. Lin et al., “Mitotic clustering of pulverized chromosomes from micronuclei,” Nature, vol. 618, no. 7967, pp. 1041–1048, Jun. 2023, doi: 10.1038/s41586-023-05974-0.P. Mosesso and S. Cinelli, “In Vitro Cytogenetic Assays: Chromosomal Aberrations and Micronucleus Tests,” in Genotoxicity Assessment, vol. 2986, A. Dhawan and M. Bajpayee, Eds., in Methods in Molecular Biology, vol. 2986. , New York, NY: Springer US, 2026, pp. 109–137. doi: 10.1007/978-1-0716-4976-3_6.S. Sunada, J. S. Haskins, and T. A. Kato, “Sister Chromatid Exchange as a Genotoxic Stress Marker,” in Radiation Cytogenetics, vol. 1984, T. A. Kato and P. F. Wilson, Eds., in Methods in Molecular Biology, vol. 1984. , New York, NY: Springer New York, 2019, pp. 61–68. doi: 10.1007/978-1-4939-9432-8_7.H. Hofer, N. Bornatowicz, and E. Reindl, “Analysis of human chromosomes after repeated hair dyeing,” Food Chem. Toxicol., vol. 21, no. 6, pp. 785–789, Dec. 1983, doi: 10.1016/0278-6915(83)90213-2.J. Xie, Y. Liu, L. Li, and Y. Wu, “[A clinical analysis of fetal chromosomal aberration induced by paint and hair dye],” Nan Fang Yi Ke Da Xue Xue Bao, vol. 30, no. 7, pp. 1651–1653, Jul. 2010.K. Turanitz, R. Kovac, H. Tuschl, and E. Pavlicek, “Investigations on the effect of repeated hair dyeing on sister chromatid exchanges,” Food Chem. Toxicol., vol. 21, no. 6, pp. 791–793, Dec. 1983, doi: 10.1016/0278-6915(83)90214-4.D. J. Kirkland, S. D. Lawler, and S. Venitt, “Chromosomal Damage and Hair Dyes,” The Lancet, vol. 312, no. 8081, pp. 124–128, Jul. 1978, doi: 10.1016/S0140-6736(78)91508-8.B. Takkouche, C. Regueira-Mendez, and A. Montes-Martinez, “Risk of cancer among hairdressers and related workers: a meta-analysis,” Int. J. Epidemiol., vol. 38, no. 6, pp. 1512–1531, Dec. 2009, doi: 10.1093/ije/dyp283.Y. Zhang et al., “Personal use of permanent hair dyes and cancer risk and mortality in US women: prospective cohort study,” BMJ, p. m2942, Sep. 2020, doi: 10.1136/bmj.m2942.C. E. Eberle, D. P. Sandler, K. W. Taylor, and A. J. White, “Hair dye and chemical straightener use and breast cancer risk in a large US population of black and white women,” Int. J. Cancer, vol. 147, no. 2, pp. 383–391, Jul. 2020, doi: 10.1002/ijc.32738.E. E. McCall, A. F. Olshan, and J. L. Daniels, “Maternal hair dye use and risk of neuroblastoma in offspring*,” Cancer Causes Control, vol. 16, no. 6, pp. 743–748, Aug. 2005, doi: 10.1007/s10552-005-1229-y.H. M. Bolt and K. Golka, “The Debate on Carcinogenicity of Permanent Hair Dyes: New Insights,” Crit. Rev. Toxicol., vol. 37, no. 6, pp. 521–536, Jan. 2007, doi: 10.1080/10408440701385671.European Commission. Directorate General for Health and Food Safety., Opinion on resorcinol. LU: Publications Office, 2022. doi: 10.2875/527921.European Commission. Directorate General for Health and Consumers., Opinion on p-Phenylenediamine: COLIPA n° A7. Revision of 18 September 2012. LU: Publications Office, 2012. doi: 10.2772/8451.3E16Ciencia en DesarrolloNúm. 3E , Año 2025 : Vol. 16 Núm. 3E (2025): VIII Encuentro Internacional de la Facultad de Ciencias (IMFaS 2025)PublicationOREORE.xmltext/xml2117https://repositorio.uptc.edu.co/bitstreams/d4f69c53-2e7a-4990-a8fd-6447b42efa6f/download9990d4568cc5e03c924ea1bec4a4a197MD51falseAnonymousREAD001/23140oai:repositorio.uptc.edu.co:001/231402026-10-22 01:15:16.118https://creativecommons.org/licenses/by-nc-sa/4.0/metadata.onlyhttps://repositorio.uptc.edu.coRepositorio Institucional UPTCbdigital@metabiblioteca.com

Tintes capilares permanentes y genotoxicidad: un desafío emergente para la evaluación de la seguridad química

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