In Silico Study of Gaseous Air Pollutants Effects on Human Atrial Tissue
Exposure to gaseous air pollutants such as carbon monoxide (CO), nitric oxide (NO) and sulfur dioxide (SO2) promotes the occurrence of cardiac diseases. Investigations have shown that CO and SO2 block the calcium channel (ICaL) of myocytes. The SO2 also increases the sodium channel (INa), the transi...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2019
- Institución:
- Universidad de Medellín
- Repositorio:
- Repositorio UDEM
- Idioma:
- eng
- OAI Identifier:
- oai:repository.udem.edu.co:11407/5818
- Acceso en línea:
- http://hdl.handle.net/11407/5818
- Palabra clave:
- Calcium compounds
Carbon monoxide
Cardiology
Fog
Nitric oxide
Sodium compounds
Sulfur dioxide
Tissue
Action potential durations
Action potentials
Calcium channels
Concentration-dependent
Gaseous pollutants
Inward-rectifying
Pollutant concentration
Potassium currents
Air pollution
- Rights
- License
- http://purl.org/coar/access_right/c_16ec
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In Silico Study of Gaseous Air Pollutants Effects on Human Atrial Tissue |
| title |
In Silico Study of Gaseous Air Pollutants Effects on Human Atrial Tissue |
| spellingShingle |
In Silico Study of Gaseous Air Pollutants Effects on Human Atrial Tissue Calcium compounds Carbon monoxide Cardiology Fog Nitric oxide Sodium compounds Sulfur dioxide Tissue Action potential durations Action potentials Calcium channels Concentration-dependent Gaseous pollutants Inward-rectifying Pollutant concentration Potassium currents Air pollution |
| title_short |
In Silico Study of Gaseous Air Pollutants Effects on Human Atrial Tissue |
| title_full |
In Silico Study of Gaseous Air Pollutants Effects on Human Atrial Tissue |
| title_fullStr |
In Silico Study of Gaseous Air Pollutants Effects on Human Atrial Tissue |
| title_full_unstemmed |
In Silico Study of Gaseous Air Pollutants Effects on Human Atrial Tissue |
| title_sort |
In Silico Study of Gaseous Air Pollutants Effects on Human Atrial Tissue |
| dc.subject.none.fl_str_mv |
Calcium compounds Carbon monoxide Cardiology Fog Nitric oxide Sodium compounds Sulfur dioxide Tissue Action potential durations Action potentials Calcium channels Concentration-dependent Gaseous pollutants Inward-rectifying Pollutant concentration Potassium currents Air pollution |
| topic |
Calcium compounds Carbon monoxide Cardiology Fog Nitric oxide Sodium compounds Sulfur dioxide Tissue Action potential durations Action potentials Calcium channels Concentration-dependent Gaseous pollutants Inward-rectifying Pollutant concentration Potassium currents Air pollution |
| description |
Exposure to gaseous air pollutants such as carbon monoxide (CO), nitric oxide (NO) and sulfur dioxide (SO2) promotes the occurrence of cardiac diseases. Investigations have shown that CO and SO2 block the calcium channel (ICaL) of myocytes. The SO2 also increases the sodium channel (INa), the transient outward (Ito) and inward rectifying (IK1) potassium currents. The NO blocks INa and increases ICaL. We developed concentration dependent equations to simulate the gaseous pollutants effects on the ionic currents. They were incorporated in the Courtemanche model of human atrial cell and in a 2D tissue model. A train of 10 stimuli was applied. The action potential duration (APD) was measured. S1-S2 cross-field protocol was applied to initiate a rotor. The CO and SO2 concentrations from 0 to 1000 uM and NO concentration from 0 to 500 nM were implemented. Six concentration combinations were simulated (cases 1 to 6). The gaseous air pollutants caused an APD shortening and loss of plateau phase of the action potential in a fraction that increases as the pollutant concentration increases. When the highest concentration was applied, the APD decreased by 81%. In the 2D model, from case 4 conditions it was possible to generate rotor, propagating with high stability. These results show pro-arrhythmic effects of gaseous air pollutants. © 2019 Creative Commons. |
| publishDate |
2019 |
| dc.date.accessioned.none.fl_str_mv |
2020-04-29T14:54:09Z |
| dc.date.available.none.fl_str_mv |
2020-04-29T14:54:09Z |
| dc.date.none.fl_str_mv |
2019 |
| dc.type.eng.fl_str_mv |
Conference Paper |
| dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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info:eu-repo/semantics/article |
| dc.identifier.isbn.none.fl_str_mv |
9781728169361 |
| dc.identifier.issn.none.fl_str_mv |
23258861 |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/11407/5818 |
| dc.identifier.doi.none.fl_str_mv |
10.23919/CinC49843.2019.9005892 |
| identifier_str_mv |
9781728169361 23258861 10.23919/CinC49843.2019.9005892 |
| url |
http://hdl.handle.net/11407/5818 |
| dc.language.iso.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.isversionof.none.fl_str_mv |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081137801&doi=10.23919%2fCinC49843.2019.9005892&partnerID=40&md5=f33b533b998d7d7b0a8bfe555f8c0771 |
| dc.relation.citationvolume.none.fl_str_mv |
2019-September |
| dc.relation.references.none.fl_str_mv |
(2014) Air Pollution: World's Worst Environmental Health Risk, , United Nations Environment Programme, UNEP Year Book 2014: Emerging Issues in Our Global Environment Abramochkin, D.V., Haertdinov, N.N., Porokhnya, M.V., Zefirov, A.L., Sitdikova, G.F., Carbon monoxide affects electrical and contractile activity of rat myocardium (2011) J. Biomed. Sci., 18 (1), p. 40 Zhang, R.-Y., Sulfur dioxide derivatives depress Ltype calcium channel in rat cardiomyocytes (2011) Clin. Exp. Pharmacol. Physiol., 38 (7), pp. 416-422 Nie, A., Meng, Z., Modulation of L-type calcium current in rat cardiac myocytes by sulfur dioxide derivatives (2006) Food Chem. Toxicol., 44 (3), pp. 355-363 Nie, A., Meng, Z., Study of the interaction of sulfur dioxide derivative with cardiac sodium channel (2005) Biochim Biophys Acta, 1718, pp. 67-73 Nie, A., Meng, Z., Sulfur dioxide derivative modulation of potassium channels in rat ventricular myocytes (2005) Arch. Biochem. Biophys., 442 (2), pp. 187-195 Kirstein, M., Rivet-Bastide, M., Hatem, S., Benardeau, A., Mercadirer, J., Fischmeister, R., Nitric oxide regulates the calcium current in isolated human atrial myocytes (1995) J. Clin. Invest., 95 (2), pp. 794-802 Ahmmed, G., Xu, Y., Hong Dong, P., Zhao, Z., Eiserich, J., Chiamvimonvat, N., Nitric oxide modulates cardiac Na+ channel via protein kinase A and protein kinase G (2001) Circ. Res., 89, pp. 1005-1013 Courtemanche, M., Ramirez, R.J., Nattel, S., Ionic mechanisms underlying human atrial action potential properties: Insights from a mathematical model (1998) Am. J. Physiol., 275, pp. H301-H321 Nie, A., Meng, Z., Modulation of L-type calcium current in rat cardiac myocytes by sulfur dioxide derivatives (2006) Food Chem. Toxicol., 44 (3), pp. 355-363 Ugarte, J., Tobon, C., Orozco-Duque, A., Entropy mapping approach for functional reentry detection in atrial fibrillation: An in-silico study (2019) Entropy, 21 (2), p. 194 Bray, M.A., Lin, S.F., Aliev, R.R., Roth, B.J., Wikswo, J.P., Experimental and theoretical analysis of phase singularity dynamics in cardiac tissue (2001) J. Cardiovasc. Electrophysiol., 12 (6), pp. 716-722 Miller, K.A., Long-term exposure to air pollution and incidence of cardiovascular events in women (2007) N. Engl. J. Med., 356 (5), pp. 447-458 Peters, A., Dockery, D.W., Muller, J.E., Mittleman, M.A., Increased particulate air pollution and the triggering of myocardial infarction (2001) Circulation, 103 (23), pp. 2810-2815 Glantz, S.A., Air pollution as a cause of heart disease. Time for action (2002) J. Am. Coll. Cardiol., 39 (6), pp. 943-945 Thurston, G.D., Ambient particulate matter air pollution exposure and mortality in the NIH-AARP diet and health cohort (2016) Environ. Health Perspect., 124 (4), pp. 484-490 Atkinson, D., Sim, T., Grant, J., Sodium metabisulfite and SO2 release: An under-recognized hazard among shrimp fishermen (1993) Ann. Allergy, 71 (6), pp. 563-566 Henry, C.R., Satran, D., Lindgren, B., Adkinson, C., Nicholson, C.I., Henry, T.D., Myocardial injury and longterm mortality following moderate to severe carbon monoxide poisoning (2006) Am. Med. Assoc., 295 (4), pp. 398-402 Trenor, B., Cardona, K., Saiz, J., Rajamani, S., Belardinelli, L., Giles, W.R., Carbon monoxide effects on human ventricle action potential assessed by mathematical simulations (2013) Front. Physiol., 4, p. 282 |
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http://purl.org/coar/access_right/c_16ec |
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http://purl.org/coar/access_right/c_16ec |
| dc.publisher.none.fl_str_mv |
IEEE Computer Society |
| dc.publisher.program.none.fl_str_mv |
Facultad de Ciencias Básicas |
| dc.publisher.faculty.none.fl_str_mv |
Facultad de Ciencias Básicas |
| publisher.none.fl_str_mv |
IEEE Computer Society |
| dc.source.none.fl_str_mv |
Computing in Cardiology |
| institution |
Universidad de Medellín |
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Repositorio Institucional Universidad de Medellin |
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repositorio@udem.edu.co |
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1814159136717275136 |
| spelling |
20192020-04-29T14:54:09Z2020-04-29T14:54:09Z978172816936123258861http://hdl.handle.net/11407/581810.23919/CinC49843.2019.9005892Exposure to gaseous air pollutants such as carbon monoxide (CO), nitric oxide (NO) and sulfur dioxide (SO2) promotes the occurrence of cardiac diseases. Investigations have shown that CO and SO2 block the calcium channel (ICaL) of myocytes. The SO2 also increases the sodium channel (INa), the transient outward (Ito) and inward rectifying (IK1) potassium currents. The NO blocks INa and increases ICaL. We developed concentration dependent equations to simulate the gaseous pollutants effects on the ionic currents. They were incorporated in the Courtemanche model of human atrial cell and in a 2D tissue model. A train of 10 stimuli was applied. The action potential duration (APD) was measured. S1-S2 cross-field protocol was applied to initiate a rotor. The CO and SO2 concentrations from 0 to 1000 uM and NO concentration from 0 to 500 nM were implemented. Six concentration combinations were simulated (cases 1 to 6). The gaseous air pollutants caused an APD shortening and loss of plateau phase of the action potential in a fraction that increases as the pollutant concentration increases. When the highest concentration was applied, the APD decreased by 81%. In the 2D model, from case 4 conditions it was possible to generate rotor, propagating with high stability. These results show pro-arrhythmic effects of gaseous air pollutants. © 2019 Creative Commons.engIEEE Computer SocietyFacultad de Ciencias BásicasFacultad de Ciencias Básicashttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85081137801&doi=10.23919%2fCinC49843.2019.9005892&partnerID=40&md5=f33b533b998d7d7b0a8bfe555f8c07712019-September(2014) Air Pollution: World's Worst Environmental Health Risk, , United Nations Environment Programme, UNEP Year Book 2014: Emerging Issues in Our Global EnvironmentAbramochkin, D.V., Haertdinov, N.N., Porokhnya, M.V., Zefirov, A.L., Sitdikova, G.F., Carbon monoxide affects electrical and contractile activity of rat myocardium (2011) J. Biomed. Sci., 18 (1), p. 40Zhang, R.-Y., Sulfur dioxide derivatives depress Ltype calcium channel in rat cardiomyocytes (2011) Clin. Exp. Pharmacol. Physiol., 38 (7), pp. 416-422Nie, A., Meng, Z., Modulation of L-type calcium current in rat cardiac myocytes by sulfur dioxide derivatives (2006) Food Chem. Toxicol., 44 (3), pp. 355-363Nie, A., Meng, Z., Study of the interaction of sulfur dioxide derivative with cardiac sodium channel (2005) Biochim Biophys Acta, 1718, pp. 67-73Nie, A., Meng, Z., Sulfur dioxide derivative modulation of potassium channels in rat ventricular myocytes (2005) Arch. Biochem. Biophys., 442 (2), pp. 187-195Kirstein, M., Rivet-Bastide, M., Hatem, S., Benardeau, A., Mercadirer, J., Fischmeister, R., Nitric oxide regulates the calcium current in isolated human atrial myocytes (1995) J. Clin. Invest., 95 (2), pp. 794-802Ahmmed, G., Xu, Y., Hong Dong, P., Zhao, Z., Eiserich, J., Chiamvimonvat, N., Nitric oxide modulates cardiac Na+ channel via protein kinase A and protein kinase G (2001) Circ. Res., 89, pp. 1005-1013Courtemanche, M., Ramirez, R.J., Nattel, S., Ionic mechanisms underlying human atrial action potential properties: Insights from a mathematical model (1998) Am. J. Physiol., 275, pp. H301-H321Nie, A., Meng, Z., Modulation of L-type calcium current in rat cardiac myocytes by sulfur dioxide derivatives (2006) Food Chem. Toxicol., 44 (3), pp. 355-363Ugarte, J., Tobon, C., Orozco-Duque, A., Entropy mapping approach for functional reentry detection in atrial fibrillation: An in-silico study (2019) Entropy, 21 (2), p. 194Bray, M.A., Lin, S.F., Aliev, R.R., Roth, B.J., Wikswo, J.P., Experimental and theoretical analysis of phase singularity dynamics in cardiac tissue (2001) J. Cardiovasc. Electrophysiol., 12 (6), pp. 716-722Miller, K.A., Long-term exposure to air pollution and incidence of cardiovascular events in women (2007) N. Engl. J. Med., 356 (5), pp. 447-458Peters, A., Dockery, D.W., Muller, J.E., Mittleman, M.A., Increased particulate air pollution and the triggering of myocardial infarction (2001) Circulation, 103 (23), pp. 2810-2815Glantz, S.A., Air pollution as a cause of heart disease. Time for action (2002) J. Am. Coll. Cardiol., 39 (6), pp. 943-945Thurston, G.D., Ambient particulate matter air pollution exposure and mortality in the NIH-AARP diet and health cohort (2016) Environ. Health Perspect., 124 (4), pp. 484-490Atkinson, D., Sim, T., Grant, J., Sodium metabisulfite and SO2 release: An under-recognized hazard among shrimp fishermen (1993) Ann. Allergy, 71 (6), pp. 563-566Henry, C.R., Satran, D., Lindgren, B., Adkinson, C., Nicholson, C.I., Henry, T.D., Myocardial injury and longterm mortality following moderate to severe carbon monoxide poisoning (2006) Am. Med. Assoc., 295 (4), pp. 398-402Trenor, B., Cardona, K., Saiz, J., Rajamani, S., Belardinelli, L., Giles, W.R., Carbon monoxide effects on human ventricle action potential assessed by mathematical simulations (2013) Front. Physiol., 4, p. 282Computing in CardiologyCalcium compoundsCarbon monoxideCardiologyFogNitric oxideSodium compoundsSulfur dioxideTissueAction potential durationsAction potentialsCalcium channelsConcentration-dependentGaseous pollutantsInward-rectifyingPollutant concentrationPotassium currentsAir pollutionIn Silico Study of Gaseous Air Pollutants Effects on Human Atrial TissueConference Paperinfo:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1Tobón, C., Universidad de Medellín, MATBIOM, Cra. 87 #30-65, Medellín, Colombia; Pachajoa, D.C., Instituto Tecnológico Metropolitano, GI2B, Medellín, Colombia; Ugarte, J.P., Universidad de San Buenaventura, GIMSC, Medellín, Colombia; Saiz, J., Universitat Politècnica de València, CI2B, Valencia, Spainhttp://purl.org/coar/access_right/c_16ecTobón C.Pachajoa D.C.Ugarte J.P.Saiz J.11407/5818oai:repository.udem.edu.co:11407/58182020-05-27 16:23:30.099Repositorio Institucional Universidad de Medellinrepositorio@udem.edu.co |