Fractional Diffusion Modulates Distribution of Action Potential Duration in Fibrotic Atrial Strands

Background: Fibroblast proliferation, as a component of the fibrotic process, plays a role in structural remodeling, but also can alter the electrophysiology of the cardiomyocytes. Aim: To study the action potential duration dispersion (dAPD) in fibrotic atrial strands, where fibroblasts exerts both, structural and electrical influence on the propagation, using a fractional diffusion model. Methods: The Courtemanche model of human atrial cell is implemented under chronic atrial fibrillation (AF) remodeling conditions. The atrial strands are designed as 1D domains, having a fibrotic portion localized in the middle. Fibrosis is modeled taking into account an electrical component, implemented by coupling a number of fibroblasts to a single cardiomyocyte, and a structural component, implemented through a q-order fractional derivative. Results: The variations of q define two dAPD dispersion regimes. For q < 1.4, the fibrosis density and the number of fibroblast per cardiomyocyte do not alter the dAPD. For q ? 1.4, the dAPD depends on the fibrosis spatial characteristics. Conclusion: This study shows that the structural component of fibrosis, modeled using fractional diffusion, modulates the spatial dAPD in a domain including electrical coupling of cardiomyocytes and fibroblasts, under chronic AF conditions. © 2018 Creative Commons Attribution.

• Fecha de publicación: 2018
• Institución: Universidad de Medellín
• Repositorio: Repositorio UDEM
• Idioma: eng
• OAI Identifier: oai:repository.udem.edu.co:11407/5721
• Acceso en línea: http://hdl.handle.net/11407/5721
• Palabra clave: Cardiology; Cell culture; Diffusion; Dispersion (waves); Electrophysiology; Action potential durations; Electrical components; Fibroblast proliferation; Fractional derivatives; Fractional diffusion; Spatial characteristics; Structural component; Structural remodeling; Fibroblasts
• License: http://purl.org/coar/access_right/c_16ec