Factores relacionados con la prescripción inadecuada de antibioticoterapia en adultos con infecciones de piel en consulta ambulatoria

Introducción: Las infecciones de piel y tejidos blandos (IPTB) son frecuente motivo de consulta ambulatoria. El estudio de los factores relacionados con no adecuación antibiótica en IPTB constituye el punto inicial para enfrentar a la resistencia bacteriana. Objetivo: Relacionar los factores de las...

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Fecha de publicación:
2023
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Universidad de Caldas
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Repositorio Institucional U. Caldas
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spa
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oai:repositorio.ucaldas.edu.co:ucaldas/23810
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https://repositorio.ucaldas.edu.co/handle/ucaldas/23810
https://doi.org/10.17151/biosa.2019.18.2.1
Palabra clave:
infecciones de los tejidos blandos
prescripción inadecuada
antibacterianos
automedicación
atención ambulatoria
guía de práctica clínica
soft tissue infections
inappropriate prescription
antibacterials
self-medication
outpatient care
clinical practice guideline
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openAccess
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oai_identifier_str oai:repositorio.ucaldas.edu.co:ucaldas/23810
network_acronym_str REPOUCALDA
network_name_str Repositorio Institucional U. Caldas
repository_id_str
dc.title.none.fl_str_mv Factores relacionados con la prescripción inadecuada de antibioticoterapia en adultos con infecciones de piel en consulta ambulatoria
Factors related to the inappropriate prescription of antibiotic therapy in adults with skin infections in outpatient clinics
title Factores relacionados con la prescripción inadecuada de antibioticoterapia en adultos con infecciones de piel en consulta ambulatoria
spellingShingle Factores relacionados con la prescripción inadecuada de antibioticoterapia en adultos con infecciones de piel en consulta ambulatoria
infecciones de los tejidos blandos
prescripción inadecuada
antibacterianos
automedicación
atención ambulatoria
guía de práctica clínica
soft tissue infections
inappropriate prescription
antibacterials
self-medication
outpatient care
clinical practice guideline
title_short Factores relacionados con la prescripción inadecuada de antibioticoterapia en adultos con infecciones de piel en consulta ambulatoria
title_full Factores relacionados con la prescripción inadecuada de antibioticoterapia en adultos con infecciones de piel en consulta ambulatoria
title_fullStr Factores relacionados con la prescripción inadecuada de antibioticoterapia en adultos con infecciones de piel en consulta ambulatoria
title_full_unstemmed Factores relacionados con la prescripción inadecuada de antibioticoterapia en adultos con infecciones de piel en consulta ambulatoria
title_sort Factores relacionados con la prescripción inadecuada de antibioticoterapia en adultos con infecciones de piel en consulta ambulatoria
dc.subject.none.fl_str_mv infecciones de los tejidos blandos
prescripción inadecuada
antibacterianos
automedicación
atención ambulatoria
guía de práctica clínica
soft tissue infections
inappropriate prescription
antibacterials
self-medication
outpatient care
clinical practice guideline
topic infecciones de los tejidos blandos
prescripción inadecuada
antibacterianos
automedicación
atención ambulatoria
guía de práctica clínica
soft tissue infections
inappropriate prescription
antibacterials
self-medication
outpatient care
clinical practice guideline
description Introducción: Las infecciones de piel y tejidos blandos (IPTB) son frecuente motivo de consulta ambulatoria. El estudio de los factores relacionados con no adecuación antibiótica en IPTB constituye el punto inicial para enfrentar a la resistencia bacteriana. Objetivo: Relacionar los factores de las IPTB no purulentas en pacientes adultos ambulatorios con prescripción inadecuada de antibioticoterapia en una IPS de Palmira en el año 2019. Métodos: Estudio transversal analítico retrospectivo. Se usó muestreo aleatorio simple. Se recolectó información de historias clínicas. El tratamiento antibiótico se consideró adecuado si fue acorde a guías. Se realizó estadística descriptiva de todas las variables, posteriormente se realizaron comparaciones de grupos según sí la terapia antibiótica fue adecuada o no; finalmente, se realizó análisis multivariado para control de confusión. Resultados: Para una muestra de 213 historias clínicas el antibiótico más prescrito fue cefalexina (37,1 %); se encuentra una automedicación antibiótica (13,1 %) y 76,1 % de las prescripciones fueron adecuadas. En el análisis multivariante, la automedicación antibiótica (OR 17,523, IC 95 % 1,127-272,5) y la vía intramuscular (OR 44,358, IC 95 % 1,161-1695,461) se relacionaron con prescripción antibiótica no adecuada. Conclusión: Se recomienda la implementación de guías locales en servicios médicos ambulatorios con afianzamiento en sus directrices y la educación a comunidad respecto a la automedicación antibiótica desde la atención primaria para disminuir la no adecuación de la terapia antibiótica.
publishDate 2023
dc.date.none.fl_str_mv 2023-12-14T11:57:37Z
2023-12-14T11:57:37Z
2023-12-14
2025-10-08T21:17:10Z
2025-10-08T21:17:10Z
dc.type.none.fl_str_mv Artículo de revista
http://purl.org/coar/resource_type/c_6501
http://purl.org/coar/resource_type/c_2df8fbb1
Text
info:eu-repo/semantics/article
Journal article
http://purl.org/redcol/resource_type/ART
info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.none.fl_str_mv 1657-9550
https://repositorio.ucaldas.edu.co/handle/ucaldas/23810
10.17151/biosa.2019.18.2.1
2462-960X
https://doi.org/10.17151/biosa.2019.18.2.1
identifier_str_mv 1657-9550
10.17151/biosa.2019.18.2.1
2462-960X
url https://repositorio.ucaldas.edu.co/handle/ucaldas/23810
https://doi.org/10.17151/biosa.2019.18.2.1
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv 18
2
7
18
Biosalud
Valderrama-Beltrán S, Cortés J, Caro M, Cely-Andrade L, Osorio-Pinzón J, Gualtero S, et al. Clinical Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections in Colombia. Infectio [Internet]. 2019; 23(4):318-46. Available from: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0123-93922019000400318
Yunquera-Romero L, Márquez-Gómez I, Henares-López A, Morales-Lara M, Gallego Fernández C, Asensi-Díez R. Appropriateness of antimicrobial prescriptions in the emergency department of a tertiary hospital. Rev Española Quimioter [Internet]. 2018; 31(3):209-16. Available from: http://www.ncbi.nlm.nih.gov/pubmed/29771104
Yadav K, Nath A, Suh K, Sikora L, Eagles D. Treatment failure definitions for non-purulent skin and soft tissue infections: a systematic review. Infection [Internet]. 2020; 48(1):75-83. Available from: https://doi.org/10.1007/s15010-019-01347-w
Fritz S, Shapiro D, Hersh A. National Trends in Incidence of Purulent Skin and Soft Tissue Infections in Patients Presenting to Ambulatory and Emergency Department Settings, 2000-2015. Clin Infect Dis [Internet]. 2019; 0(0):pii: ciz977. Available from: https://academic.oup.com/cid/advance-articleabstract/doi/10.1093/cid/ciz977/5586461?redirectedFrom=fulltext
Castrillón-Spitia J, Ocampo-Palacio A, Rivera-Echeverry C, Londoño-Montes J, Martínez-Betancur S, Machado-Alba J. Prescription of antibiotics in infections of the skin and soft tissues. Ces Med [Internet]. 2018; 32(1):3-13. Available from: http://revistas.ces.edu.co/index.php/medicina/article/view/4015
Broek A, Hest R, Lettinga K, Jimmink A, Lauw F, Visser C, et al. The appropriateness of antimicrobial use in the outpatient clinics of three hospitals in the Netherlands. Antimicrob Resist Infect Control [Internet]. 2020; 9(1):40. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036246/
Fleming-Dutra KE, Hersh AL, Shapiro DJ, Bartoces M, Enns EA, File TM, et al. Prevalence of inappropriate antibiotic prescriptions among us ambulatory care visits, 2010-2011. JAMA - J Am Med Assoc [Internet]. 2016; 315(17):1864-73. Available from: https://jamanetwork.com/journals/jama/fullarticle/2518263
Shively NR, Buehrle DJ, Clancy CJ, Decker BK. Prevalence of inappropriate antibiotic prescribing in primary care clinics within a veterans affairs health care system. Antimicrob Agents Chemother [Internet]. 2018; 62(8):1-7. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105840/pdf/e00337-18.pdf
Jeong D, Nguyen H, Tyndall M, Schreiber Y. Antibiotic use among twelve Canadian First Nations communities: A retrospective chart review of skin and soft tissue infections. BMC Infect Dis [Internet]. 2020; 20(1):118. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011559/
O’Keefe C, Thompson A, McKenzie D, Lee K. Concordance with antibiotic guidelines in Australian primary care: A retrospective study of prior-to-hospital therapy. Int J Clin Pract [Internet]. 2019; 00:e13427. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1111/ijcp.13427
Pulia M, Kern M, Schwei R, Shah M, Sampene E, Crnich C. Comparing appropriateness of antibiotics for nursing home residents by setting of prescription initiation: A cross-sectional analysis. Antimicrob Resist Infect Control [Internet]. 2018; 7(74):1-8. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000953/
Hansen M, Arpi M, Hedin K, Melander E, Hertz F, Thorsted A, et al. Antibiotic-prescribing and antibiotic-resistance patterns among elderly citizens residing in two Nordic regions. Infect Dis (Auckl) [Internet]. 2020; 52(4):257-65. Available from: https://doi.org/10.1080/23744235.2019.1711159
Higuita-Gutiérrez L, Molina-Garcia V, Acevedo Guiral J, Gómez Cadena L, Roncancio G, Jiménez J. Knowledge regarding antibiotic use among students of three medical schools in Medellin, Colombia: A cross-sectional study. BMC Med Educ. 2020; 20(1):22.
Fernández-Urrusuno R, Flores-Dorado M, Vilches-Arenas A, Serrano-Martino C, Corral-Baena S, Montero-Balosa MC. Adecuación de la prescripción de antibióticos en un área de atención primaria: estudio descriptivo transversal. Enferm Infecc Microbiol Clin[Internet]. 2014; 32(5):285-92. Available from: http://dx.doi.org/10.1016/j.eimc.2013.05.004
Shehab N, Patel PR, Srinivasan A, Budnitz DS. Emergency department visits for antibiotic-associated adverse events. Clin Infect Dis. 2008; 47(6):735–43.
Macía-Rodríguez C, Alende-Castro V, Vazquez-Ledo L, Novo-Veleiro I, González-Quintela A. Skin and soft-tissue infections: Factors associated with mortality and re-admissions. Enferm Infecc Microbiol Clin (English ed) [Internet]. 2017; 35(2):76-81. Available from: http://dx.doi.org/10.1016/j.eimce.2017.01.028
Valderrama-Beltrán S, Gualtero S, Álvarez-Moreno C, Gil F, Ruiz AJ, Rodríguez JY, et al. Risk factors associated with methicillin-resistant Staphylococcus aureus skin and soft tissue infections in hospitalized patients in Colombia. Int J Infect Dis [Internet]. 2019; 87:60-6. Available from: https://www.ijidonline.com/article/S1201-9712(19)30292-9/fulltext
Barlam TF, Cosgrove SE, Abbo LM, Macdougall C, Schuetz AN, Septimus EJ, et al. Implementing an antibiotic stewardship program: Guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America. Clin Infect Dis. 2016; 62(10):e51-77.
Haran J, Wu G, Bucci V, Fischer A, Boyer E, Hibberd P. Treatment of bacterial skin infections in ED observation units: Factors influencing prescribing practice. Am J Emerg Med [Internet]. 2015; 33(12):1780-5. Available from: http://dx.doi.org/10.1016/j.ajem.2015.08.035
Rath E, Skrede S, Oppegaard O, Bruun T. Non-purulent skin and soft tissue infections: predictive power of a severity score and the appropriateness of treatment in a prospective cohort. Infect Dis (Auckl) [Internet]. 2020; 0(0):1-11. Available from: https://doi.org/10.1080/23744235.2020.1726447
Lipsky B, Napolitano L, Moran G, Vo L, Nicholson S, Kim M. Inappropriate initial antibiotic treatment for complicated skin and soft tissue infections in hospitalized patients: Incidence and associated factors. Diagn Microbiol Infect Dis [Internet]. 2014; 79(2):273-9. Available from: https://www.sciencedirect.com/science/article/abs/pii/S0732889314000741?via %3Dihub
Haran J, Goulding M, Campion M, Scully G, Chandra A, Goldberg R, et al. Reduction of Inappropriate Antibiotic Use and Improved Outcomes by Implementation of an Algorithm-Based Clinical Guideline for Nonpurulent Skin and Soft Tissue Infections. Ann Emerg Med [Internet]. 2020; 0(0):1-11. Available from: https://doi.org/10.1016/j.annemergmed.2019.12.012
Goss F, Bookman K, Barron M, Bickley D, Landgren B, Kroehl M, et al. Improved antibiotic prescribing using indication based clinical decision support in the emergency department. J Am Coll Emerg Physicians Open [Internet]. 2020; 1(3):214-21. Available from: https://onlinelibrary.wiley.com/doi/full/10.1002/emp2.12029
Stevens D, Bisno A, Chambers H, Dellinger E, Goldstein E, Gorbach S, et al. Executive summary: Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the infectious diseases society of America. Clin Infect Dis [Internet]. 2014; 59(2):147-59. Available from: https://academic.oup.com/cid/article/59/2/e10/2895845
Kwak Y, Choi S, Kim T, Park S, Seo S, Kim M, et al. Clinical guidelines for the antibiotic treatment for community-acquired skin and soft tissue infection. Infect Chemother [Internet]. 2017; 49(4):301-25. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754343/
Walsh T, Chan L, Konopka C, Burkitt M, Moffa M, Bremmer D, et al. Appropriateness of antibiotic management of uncomplicated skin and soft tissue infections in hospitalized adult patients. BMC Infect Dis [Internet]. 2016; 16(1):1-8. Available from: http://dx.doi.org/10.1186/s12879-016-2067-0
Haran J, Wilsterman E, Zeoli T, Goulding M, McLendon E, Clark M. Deviating from IDSA treatment guidelines for non-purulent skin infections increases the risk of treatment failure in emergency department patients. Epidemiol Infect [Internet]. 2019; 5:-7. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518578/
Sutton J, Carico R, Burk M, Jones M, Wei X, Neuhauser M, et al. Inpatient Management of Uncomplicated Skin and Soft Tissue Infections in 34 Veterans Affairs Medical Centers: A Medication Use Evaluation. Open Forum Infect Dis [Internet]. 2020; 7(1):ofz554. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984672/
Sandoe J, Saeed K, Guleri A, Hand K, Dillon R, Allen M, et al. Opportunities for antimicrobial stewardship in patients with acute bacterial skin and skin structure infections who are unsuitable for beta-lactam antibiotics: a multicenter prospective observational study. Ther Adv Infect Dis [Internet]. 2019; 6:204993611882365. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365991/
Hurley H, Knepper B, Price C, Mehler P, Burman W, Jenkins T. Avoidable antibiotic exposure for uncomplicated skin and soft tissue infections in the ambulatory care setting. Am J Med [Internet]. 2013; 126(12):1099-106. Available from: http://dx.doi.org/10.1016/j.amjmed.2013.08.016
Nickerson E, West T, Day N, Peacock S. Staphylococcus aureus disease and drug resistance in resource-limited countries in south and east Asia. Lancet Infect Dis [Internet]. 2009; 9(2):130-5. Available from: http://dx.doi.org/10.1016/S1473-3099(09)70022-2
Núm. 2 , Año 2019 : Julio - Diciembre
https://revistasojs.ucaldas.edu.co/index.php/biosalud/article/download/8516/6983
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dc.publisher.none.fl_str_mv Universidad de Caldas
publisher.none.fl_str_mv Universidad de Caldas
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spelling Factores relacionados con la prescripción inadecuada de antibioticoterapia en adultos con infecciones de piel en consulta ambulatoriaFactors related to the inappropriate prescription of antibiotic therapy in adults with skin infections in outpatient clinicsinfecciones de los tejidos blandosprescripción inadecuadaantibacterianosautomedicaciónatención ambulatoriaguía de práctica clínicasoft tissue infectionsinappropriate prescriptionantibacterialsself-medicationoutpatient careclinical practice guidelineIntroducción: Las infecciones de piel y tejidos blandos (IPTB) son frecuente motivo de consulta ambulatoria. El estudio de los factores relacionados con no adecuación antibiótica en IPTB constituye el punto inicial para enfrentar a la resistencia bacteriana. Objetivo: Relacionar los factores de las IPTB no purulentas en pacientes adultos ambulatorios con prescripción inadecuada de antibioticoterapia en una IPS de Palmira en el año 2019. Métodos: Estudio transversal analítico retrospectivo. Se usó muestreo aleatorio simple. Se recolectó información de historias clínicas. El tratamiento antibiótico se consideró adecuado si fue acorde a guías. Se realizó estadística descriptiva de todas las variables, posteriormente se realizaron comparaciones de grupos según sí la terapia antibiótica fue adecuada o no; finalmente, se realizó análisis multivariado para control de confusión. Resultados: Para una muestra de 213 historias clínicas el antibiótico más prescrito fue cefalexina (37,1 %); se encuentra una automedicación antibiótica (13,1 %) y 76,1 % de las prescripciones fueron adecuadas. En el análisis multivariante, la automedicación antibiótica (OR 17,523, IC 95 % 1,127-272,5) y la vía intramuscular (OR 44,358, IC 95 % 1,161-1695,461) se relacionaron con prescripción antibiótica no adecuada. Conclusión: Se recomienda la implementación de guías locales en servicios médicos ambulatorios con afianzamiento en sus directrices y la educación a comunidad respecto a la automedicación antibiótica desde la atención primaria para disminuir la no adecuación de la terapia antibiótica.Introduction: Skin and soft tissue infections (SSTIs) are a frequent reason for outpatient consultation. The study of the factors related to antibiotic inadequacy in SSTI constitutes the starting point to face bacterial resistance. Objective: Relate the factors of non-purulent STI in adult outpatients with inadequate prescription of antibiotic therapy in an IPS in Palmira in 2019. Methods: Retrospective analytical cross-sectional study. Simple random sampling was used. Information was collected from medical records. Antibiotic treatment was considered adequate if it was in accordance with the guidelines. Descriptive statistics of all the variables were performed, then group comparisons were made according to whether the antibiotic therapy was adequate or not; Finally, multivariate analysis was performed to control for confusion. Results: For a sample of 213 medical records, the most prescribed antibiotic was cephalexin (37.1 %); antibiotic self-medication is found (13.1 %) and 76.1 % of the prescriptions were adequate. In the multivariate analysis, antibiotic self-medication (OR 17.523, 95 % CI 1.127-272.5) and the intramuscular route (OR 44.358, 95 % CI 1.161-1695.461) were related to inappropriate antibiotic prescription. Conclusion: The implementation of local guidelines in outpatient medical services is recommended, strengthening their guidelines and educating the community regarding antibiotic self-medication from primary care to reduce the inappropriateness of antibiotic therapy.Universidad de Caldas2023-12-14T11:57:37Z2025-10-08T21:17:10Z2023-12-14T11:57:37Z2025-10-08T21:17:10Z2023-12-14Artículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articleJournal articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85application/pdf1657-9550https://repositorio.ucaldas.edu.co/handle/ucaldas/2381010.17151/biosa.2019.18.2.12462-960Xhttps://doi.org/10.17151/biosa.2019.18.2.1https://revistasojs.ucaldas.edu.co/index.php/biosalud/article/view/8516spa182718BiosaludValderrama-Beltrán S, Cortés J, Caro M, Cely-Andrade L, Osorio-Pinzón J, Gualtero S, et al. Clinical Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections in Colombia. Infectio [Internet]. 2019; 23(4):318-46. Available from: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0123-93922019000400318Yunquera-Romero L, Márquez-Gómez I, Henares-López A, Morales-Lara M, Gallego Fernández C, Asensi-Díez R. Appropriateness of antimicrobial prescriptions in the emergency department of a tertiary hospital. Rev Española Quimioter [Internet]. 2018; 31(3):209-16. Available from: http://www.ncbi.nlm.nih.gov/pubmed/29771104Yadav K, Nath A, Suh K, Sikora L, Eagles D. Treatment failure definitions for non-purulent skin and soft tissue infections: a systematic review. Infection [Internet]. 2020; 48(1):75-83. Available from: https://doi.org/10.1007/s15010-019-01347-wFritz S, Shapiro D, Hersh A. National Trends in Incidence of Purulent Skin and Soft Tissue Infections in Patients Presenting to Ambulatory and Emergency Department Settings, 2000-2015. Clin Infect Dis [Internet]. 2019; 0(0):pii: ciz977. Available from: https://academic.oup.com/cid/advance-articleabstract/doi/10.1093/cid/ciz977/5586461?redirectedFrom=fulltextCastrillón-Spitia J, Ocampo-Palacio A, Rivera-Echeverry C, Londoño-Montes J, Martínez-Betancur S, Machado-Alba J. Prescription of antibiotics in infections of the skin and soft tissues. Ces Med [Internet]. 2018; 32(1):3-13. Available from: http://revistas.ces.edu.co/index.php/medicina/article/view/4015Broek A, Hest R, Lettinga K, Jimmink A, Lauw F, Visser C, et al. The appropriateness of antimicrobial use in the outpatient clinics of three hospitals in the Netherlands. Antimicrob Resist Infect Control [Internet]. 2020; 9(1):40. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036246/Fleming-Dutra KE, Hersh AL, Shapiro DJ, Bartoces M, Enns EA, File TM, et al. Prevalence of inappropriate antibiotic prescriptions among us ambulatory care visits, 2010-2011. JAMA - J Am Med Assoc [Internet]. 2016; 315(17):1864-73. Available from: https://jamanetwork.com/journals/jama/fullarticle/2518263Shively NR, Buehrle DJ, Clancy CJ, Decker BK. Prevalence of inappropriate antibiotic prescribing in primary care clinics within a veterans affairs health care system. Antimicrob Agents Chemother [Internet]. 2018; 62(8):1-7. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105840/pdf/e00337-18.pdfJeong D, Nguyen H, Tyndall M, Schreiber Y. Antibiotic use among twelve Canadian First Nations communities: A retrospective chart review of skin and soft tissue infections. BMC Infect Dis [Internet]. 2020; 20(1):118. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011559/O’Keefe C, Thompson A, McKenzie D, Lee K. Concordance with antibiotic guidelines in Australian primary care: A retrospective study of prior-to-hospital therapy. Int J Clin Pract [Internet]. 2019; 00:e13427. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1111/ijcp.13427Pulia M, Kern M, Schwei R, Shah M, Sampene E, Crnich C. Comparing appropriateness of antibiotics for nursing home residents by setting of prescription initiation: A cross-sectional analysis. Antimicrob Resist Infect Control [Internet]. 2018; 7(74):1-8. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000953/Hansen M, Arpi M, Hedin K, Melander E, Hertz F, Thorsted A, et al. Antibiotic-prescribing and antibiotic-resistance patterns among elderly citizens residing in two Nordic regions. Infect Dis (Auckl) [Internet]. 2020; 52(4):257-65. Available from: https://doi.org/10.1080/23744235.2019.1711159Higuita-Gutiérrez L, Molina-Garcia V, Acevedo Guiral J, Gómez Cadena L, Roncancio G, Jiménez J. Knowledge regarding antibiotic use among students of three medical schools in Medellin, Colombia: A cross-sectional study. BMC Med Educ. 2020; 20(1):22.Fernández-Urrusuno R, Flores-Dorado M, Vilches-Arenas A, Serrano-Martino C, Corral-Baena S, Montero-Balosa MC. Adecuación de la prescripción de antibióticos en un área de atención primaria: estudio descriptivo transversal. Enferm Infecc Microbiol Clin[Internet]. 2014; 32(5):285-92. Available from: http://dx.doi.org/10.1016/j.eimc.2013.05.004Shehab N, Patel PR, Srinivasan A, Budnitz DS. Emergency department visits for antibiotic-associated adverse events. Clin Infect Dis. 2008; 47(6):735–43.Macía-Rodríguez C, Alende-Castro V, Vazquez-Ledo L, Novo-Veleiro I, González-Quintela A. Skin and soft-tissue infections: Factors associated with mortality and re-admissions. Enferm Infecc Microbiol Clin (English ed) [Internet]. 2017; 35(2):76-81. Available from: http://dx.doi.org/10.1016/j.eimce.2017.01.028Valderrama-Beltrán S, Gualtero S, Álvarez-Moreno C, Gil F, Ruiz AJ, Rodríguez JY, et al. 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Available from: http://dx.doi.org/10.1016/S1473-3099(09)70022-2Núm. 2 , Año 2019 : Julio - Diciembrehttps://revistasojs.ucaldas.edu.co/index.php/biosalud/article/download/8516/6983https://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Risueño Blanco, José Aliriooai:repositorio.ucaldas.edu.co:ucaldas/238102025-10-08T21:17:10Z