Optimal release programs for dengue prevention using aedes aegypti mosquitoes transinfected with wmel or wmelpop wolbachia strains

In this paper, we propose a dengue transmission model of SIR(S)-SI type that accounts for two sex-structured mosquito populations: the wild mosquitoes (males and females that are Wol- bachia-free), and those deliberately infected with either wMel or wMelPop strain of Wolbachia. This epidemiological model has four possible outcomes: with or without Wolbachia and with or without dengue. To reach the desired outcome, with Wolbachia and without dengue, we employ the dynamic optimization approach and then design optimal programs for releasing Wolbachia-carrying male and female mosquitoes. Our discussion is focused on advantages and drawbacks of two Wolbachia strains, wMelPop and wMel, that are recommended for dengue prevention and control. On the one hand, the wMel strain guarantees a faster population replacement, ensures durable Wolbachia persistence in the wild mosquito population, and requiters fewer releases. On the other hand, the wMelPop strain displays better results for averting dengue infections in the human population

• Autores: Cardona Salgado, Daiver; Campo Duarte, Doris Elena; Sepúlveda Salcedo, Lilian Sofía; Vasilieva, Olga; Svinin, Mikhail
• Tipo de recurso: Article of journal
• Fecha de publicación: 2021
• Institución: Universidad Autónoma de Occidente
• Repositorio: RED: Repositorio Educativo Digital UAO
• Idioma: eng
• OAI Identifier: oai:red.uao.edu.co:10614/13901
• Acceso en línea: https://hdl.handle.net/10614/13901; https://red.uao.edu.co/
• Palabra clave: Virus del dengue; Modelos matemáticos; Dengue viruses; Mathematical models; Aedes aegypti mosquitoes; Sex-structured model; Dengue transmission model; Wolbachia-based biocontrol; wMelPop and wMel strains; Optimal control; Optimal release program
• Rights: openAccess
• License: Derechos reservados - AIMS Press, 2021