A rich and complex dynamics emerges between the subthalamic nucleus and the globus pallidus externa in the basal ganglia
The oscillatory nature of basal ganglia activity is highly tied with some movement disorders. We study, through bifurcation analysis and computer simulations, the appearance of abnormal oscillations in an already proposed reduced neural circuit model of the subthalamic nucleus and globus pallidus lo...
- Autores:
-
Hurtado López, Julián
Amador-Rodríguez, Andrés Felipe
Ramírez Moreno, David Fernando
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2023
- Institución:
- Universidad Autónoma de Occidente
- Repositorio:
- RED: Repositorio Educativo Digital UAO
- Idioma:
- eng
- OAI Identifier:
- oai:red.uao.edu.co:10614/15542
- Acceso en línea:
- https://hdl.handle.net/10614/15542
https://red.uao.edu.co/
- Palabra clave:
- Rights
- openAccess
- License
- Derechos reservados - Unión Matemática Argentina, 2023
| Summary: | The oscillatory nature of basal ganglia activity is highly tied with some movement disorders. We study, through bifurcation analysis and computer simulations, the appearance of abnormal oscillations in an already proposed reduced neural circuit model of the subthalamic nucleus and globus pallidus loop. The results show that the model exhibits stable steady states associated to normal activity and oscillatory activity corresponding to the often termed “tremor frequency” oscillations due to their coherence with parkinsonian tremor observed in patients with Parkinson’s disease |
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