Computational MEMS design and analyses of a transdermal drug delivery device (TD3)
In this paper we introduce a novel type of transdermal drug delivery de-vice (TD3) MEMS (Microelectrome-chanical Systems) design using CAD techniques as well as CFD (Compu-tational Fluid Dynamics) simulations regarding the fluid interaction inside the device during the actuation pro-cess. Both therm...
- Autores:
-
García Cruz, Jennifer
Ríos Afanador, Ismael Alberto
Fonthal Rico, Faruk
Laín Beatove, Santiago
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2012
- Institución:
- Universidad Autónoma de Occidente
- Repositorio:
- RED: Repositorio Educativo Digital UAO
- Idioma:
- spa
- OAI Identifier:
- oai:red.uao.edu.co:10614/10933
- Acceso en línea:
- http://hdl.handle.net/10614/10933
- Palabra clave:
- Sistemas microelectromecánicos
Microelectromechanical systems
Administración transdérmica de medicamentos
Simulación
- Rights
- openAccess
- License
- Derechos Reservados - Universidad Autónoma de Occidente
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Computational MEMS design and analyses of a transdermal drug delivery device (TD3) |
| title |
Computational MEMS design and analyses of a transdermal drug delivery device (TD3) |
| spellingShingle |
Computational MEMS design and analyses of a transdermal drug delivery device (TD3) Sistemas microelectromecánicos Microelectromechanical systems Administración transdérmica de medicamentos Simulación |
| title_short |
Computational MEMS design and analyses of a transdermal drug delivery device (TD3) |
| title_full |
Computational MEMS design and analyses of a transdermal drug delivery device (TD3) |
| title_fullStr |
Computational MEMS design and analyses of a transdermal drug delivery device (TD3) |
| title_full_unstemmed |
Computational MEMS design and analyses of a transdermal drug delivery device (TD3) |
| title_sort |
Computational MEMS design and analyses of a transdermal drug delivery device (TD3) |
| dc.creator.fl_str_mv |
García Cruz, Jennifer Ríos Afanador, Ismael Alberto Fonthal Rico, Faruk Laín Beatove, Santiago |
| dc.contributor.author.none.fl_str_mv |
García Cruz, Jennifer Ríos Afanador, Ismael Alberto Fonthal Rico, Faruk Laín Beatove, Santiago |
| dc.subject.armarc.spa.fl_str_mv |
Sistemas microelectromecánicos |
| topic |
Sistemas microelectromecánicos Microelectromechanical systems Administración transdérmica de medicamentos Simulación |
| dc.subject.armarc.eng.fl_str_mv |
Microelectromechanical systems |
| dc.subject.proposal.spa.fl_str_mv |
Administración transdérmica de medicamentos Simulación |
| description |
In this paper we introduce a novel type of transdermal drug delivery de-vice (TD3) MEMS (Microelectrome-chanical Systems) design using CAD techniques as well as CFD (Compu-tational Fluid Dynamics) simulations regarding the fluid interaction inside the device during the actuation pro-cess. Both thermopneumatic and piezoelectric principles are employed as actuation chamber and microvalve actuation principles respectively, originating that the design integrates perfectly those principles through two different components such as a micro-pump with integrated microvalves and a microneedles array. The TD3 have shown to be capable of delivering a volumetric flow of 2.92x10-5 cm3/s with a 3.11 Hz membrane stroke fre-quency. The device only needs 116 Pa to complete the suction process and 2560 Pa to complete the discharge process. A 38 microneedle array with 450 µm in length fulfill the function of per-meate skin allowing that the fluid reaches the desired destination and avoiding any possible pain during the insertion. |
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2012 |
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2012-04 |
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2019-06-01T19:55:34Z |
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2019-06-01T19:55:34Z |
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Artículo de revista |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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01210777 |
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http://hdl.handle.net/10614/10933 |
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spa |
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spa |
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El Hombre y la Máquina. Número 38 (enero-abril, 2012); páginas 75-80 |
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80 |
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38 |
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75 |
| dc.relation.cites.spa.fl_str_mv |
García Cruz, J., Ríos Afanador, I. A., Fonthal Rico, F., Lain Beatove, S. (enero-abril, 2012). Computational MEMS design and analyses of a transdermal drug delivery device (TD3). Hombre y la Máquina. (38), 75-80. http://hdl.handle.net/10614/10933 |
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El hombre y la máquina |
| dc.relation.references.none.fl_str_mv |
Hood, R.R.; Kendall, E.L.; DeVoe, D.L.; Quezado, Z.; Junqueira, M.J.; Finkel, C.; Vreeland, W.N. Microfluidicformation of nanoscale liposomes for passive transdermal drug delivery. In Proceedings of the Microsystemsfor Measurement and Instrumentation (MAMNA), Gaithersburg, MD, USA, 14 May 2013; pp. 12–15 Dol˙zan, T.; Vrtaˇcnik, D.; Resnik, D.; Aljanˇciˇc, U.; Mo˙zek, M.; Peˇcar, B.; Amon, S. Design of transdermal drugdelivery system with PZT actuated micropump. In Proceedings of the 37th International Convention onInformation and Communication Technology, Electronics and Microelectronics (MIPRO), Opatija, Croatia,26–30 May 2014; pp. 96–99 Lee, H.; Song, C.; Baik, S.; Kim, D.; Hyeon, T.; Kim, D.H. Device-assisted transdermal drug delivery. Adv. DrugDeliv. Rev. 2018,127, 35–45 Mousoulis, C.; Ochoa, M.; Papageorgiou, D.; Ziaie, B. A Skin-Contact-Actuated Micropump for Transdermal Drug Delivery. IEEE Trans. Biomed. Eng. 2011,58, 1492–1498 Wang, W.; Soper, S.A. Bio-MEMS Technologies and Applications, 1st ed.; CRC Press: Boca Raton, NY, USA,2006; pp. 7–237. ISBN 9780849335327 Jurcicek, P.; Zou, H.; Zhang, S.; Liu, C. Design and fabrication of hollow out-of-plane silicon microneedles.IET Micro Nano Lett. 2013,8, 78–81 Shoji, E. Fabrication of a diaphragm micropump system utilizing the ionomer-based polymer actuator.Sens. Actuators B Chem. 2016,237, 660–665. Kawun, P.; Leahy, S.; Lai, Y. A thin PDMS nozzle/diffuser micropump for biomedical applications. Sens.Actuators B Chem. 2016,249, 149–154 Singh, S.; Kumar, N.; George, D.; Sen, A.K. Analytical modeling, simulations and experimental studies of aPZT actuated planar valveless PDMS micropump. Sens. Actuators B Chem. 2015,225, 81–94 Nguyen, N.T.; Mousavi, S.A.; Kashaninejad, N.; Phan, D.T. Design, fabrication and characterization of drugdelivery systems based on lab-on-a-chip technology. Adv. Drug Deliv. Rev.2013,65, 1403–1419 Davis, S.P.; Martanto, W.; Allen, M.G.; Prausnitz, M.R. Hollow metal microneedles for insulin delivery todiabetic rats. IEEE Trans. Biomed. Eng. 2005,52, 909–915. Roxhed, N.T.; Gasser, C.; Griss, P.; Holzapfel, G.A.; Stemme, G. Penetration-enhanced ultrasharp microneedlesand prediction on skin interaction for efficient transdermal drug delivery. J. Microelectromech. Syst.2007,16,1429–1440 |
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Derechos Reservados - Universidad Autónoma de Occidente |
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Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) |
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García Cruz, Jennifer678452ac098b2be6b666ccb001c2c900Ríos Afanador, Ismael Albertobc2895a32977193084abd941e0483a7eFonthal Rico, Farukvirtual::1749-1Laín Beatove, Santiagovirtual::2545-1Universidad Autónoma de Occidente. Calle 25 115-85. Km 2 vía Cali-Jamundí2019-06-01T19:55:34Z2019-06-01T19:55:34Z2012-0401210777http://hdl.handle.net/10614/10933In this paper we introduce a novel type of transdermal drug delivery de-vice (TD3) MEMS (Microelectrome-chanical Systems) design using CAD techniques as well as CFD (Compu-tational Fluid Dynamics) simulations regarding the fluid interaction inside the device during the actuation pro-cess. Both thermopneumatic and piezoelectric principles are employed as actuation chamber and microvalve actuation principles respectively, originating that the design integrates perfectly those principles through two different components such as a micro-pump with integrated microvalves and a microneedles array. The TD3 have shown to be capable of delivering a volumetric flow of 2.92x10-5 cm3/s with a 3.11 Hz membrane stroke fre-quency. The device only needs 116 Pa to complete the suction process and 2560 Pa to complete the discharge process. A 38 microneedle array with 450 µm in length fulfill the function of per-meate skin allowing that the fluid reaches the desired destination and avoiding any possible pain during the insertion.application/pdf6 páginasspaUniversidad Autónoma de OccidenteEl Hombre y la Máquina. Número 38 (enero-abril, 2012); páginas 75-80803875García Cruz, J., Ríos Afanador, I. A., Fonthal Rico, F., Lain Beatove, S. (enero-abril, 2012). Computational MEMS design and analyses of a transdermal drug delivery device (TD3). Hombre y la Máquina. (38), 75-80. http://hdl.handle.net/10614/10933El hombre y la máquinaHood, R.R.; Kendall, E.L.; DeVoe, D.L.; Quezado, Z.; Junqueira, M.J.; Finkel, C.; Vreeland, W.N. Microfluidicformation of nanoscale liposomes for passive transdermal drug delivery. In Proceedings of the Microsystemsfor Measurement and Instrumentation (MAMNA), Gaithersburg, MD, USA, 14 May 2013; pp. 12–15Dol˙zan, T.; Vrtaˇcnik, D.; Resnik, D.; Aljanˇciˇc, U.; Mo˙zek, M.; Peˇcar, B.; Amon, S. Design of transdermal drugdelivery system with PZT actuated micropump. In Proceedings of the 37th International Convention onInformation and Communication Technology, Electronics and Microelectronics (MIPRO), Opatija, Croatia,26–30 May 2014; pp. 96–99Lee, H.; Song, C.; Baik, S.; Kim, D.; Hyeon, T.; Kim, D.H. Device-assisted transdermal drug delivery. Adv. DrugDeliv. Rev. 2018,127, 35–45Mousoulis, C.; Ochoa, M.; Papageorgiou, D.; Ziaie, B. A Skin-Contact-Actuated Micropump for Transdermal Drug Delivery. IEEE Trans. Biomed. Eng. 2011,58, 1492–1498Wang, W.; Soper, S.A. Bio-MEMS Technologies and Applications, 1st ed.; CRC Press: Boca Raton, NY, USA,2006; pp. 7–237. ISBN 9780849335327Jurcicek, P.; Zou, H.; Zhang, S.; Liu, C. Design and fabrication of hollow out-of-plane silicon microneedles.IET Micro Nano Lett. 2013,8, 78–81Shoji, E. Fabrication of a diaphragm micropump system utilizing the ionomer-based polymer actuator.Sens. Actuators B Chem. 2016,237, 660–665.Kawun, P.; Leahy, S.; Lai, Y. A thin PDMS nozzle/diffuser micropump for biomedical applications. Sens.Actuators B Chem. 2016,249, 149–154Singh, S.; Kumar, N.; George, D.; Sen, A.K. Analytical modeling, simulations and experimental studies of aPZT actuated planar valveless PDMS micropump. Sens. Actuators B Chem. 2015,225, 81–94Nguyen, N.T.; Mousavi, S.A.; Kashaninejad, N.; Phan, D.T. Design, fabrication and characterization of drugdelivery systems based on lab-on-a-chip technology. Adv. Drug Deliv. Rev.2013,65, 1403–1419Davis, S.P.; Martanto, W.; Allen, M.G.; Prausnitz, M.R. Hollow metal microneedles for insulin delivery todiabetic rats. IEEE Trans. Biomed. Eng. 2005,52, 909–915.Roxhed, N.T.; Gasser, C.; Griss, P.; Holzapfel, G.A.; Stemme, G. Penetration-enhanced ultrasharp microneedlesand prediction on skin interaction for efficient transdermal drug delivery. J. Microelectromech. Syst.2007,16,1429–1440Derechos Reservados - Universidad Autónoma de Occidentehttps://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)http://purl.org/coar/access_right/c_abf2Computational MEMS design and analyses of a transdermal drug delivery device (TD3)Artículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTREFinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Sistemas microelectromecánicosMicroelectromechanical systemsAdministración transdérmica de medicamentosSimulaciónPublication2bf30a66-1e41-42a5-8415-189ea7ccdfa8virtual::1749-1082b0926-3385-4188-9c6a-bbbed7484a95virtual::2545-12bf30a66-1e41-42a5-8415-189ea7ccdfa8virtual::1749-1082b0926-3385-4188-9c6a-bbbed7484a95virtual::2545-1https://scholar.google.com/citations?user=zxVYtU0AAAAJ&hl=envirtual::1749-1https://scholar.google.com/citations?user=g-iBdUkAAAAJ&hl=esvirtual::2545-10000-0002-9331-0491virtual::1749-10000-0002-0269-2608virtual::2545-1https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000895857virtual::1749-1https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000262129virtual::2545-1TEXTA0132_Computational MEMS design and analyses of a transdermal drug delivery device (TD3).pdf.txtA0132_Computational MEMS design and analyses of a transdermal drug delivery device (TD3).pdf.txtExtracted texttext/plain16246https://red.uao.edu.co/bitstreams/3711f4e8-0c25-4312-9326-f2c65ae99e58/download0ad30920d94e87742b37c098f1fbd613MD56THUMBNAILA0132_Computational MEMS design and analyses of a transdermal drug delivery device (TD3).pdf.jpgA0132_Computational MEMS design and analyses of a transdermal drug delivery device (TD3).pdf.jpgGenerated Thumbnailimage/jpeg11934https://red.uao.edu.co/bitstreams/f2dd7d38-03e9-45d5-b353-d7b362e5093d/downloadc3e5359deb374ed4816ecb11ade79bf8MD57ORIGINALA0132_Computational MEMS design and analyses of a transdermal drug delivery device (TD3).pdfA0132_Computational MEMS design and analyses of a transdermal drug delivery device (TD3).pdfTexto archivo completo del artículo de revista, PDFapplication/pdf2312757https://red.uao.edu.co/bitstreams/75bd9937-c681-4d71-88d4-47718e2723c1/download875238be1e356fe15b33a3b35c67a37fMD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; 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