Computational MEMS design and analyses of a transdermal drug delivery device (TD3)

In this paper we introduce a novel type of transdermal drug delivery de-vice (TD3) MEMS (Microelectrome-chanical Systems) design using CAD techniques as well as CFD (Compu-tational Fluid Dynamics) simulations regarding the fluid interaction inside the device during the actuation pro-cess. Both thermopneumatic and piezoelectric principles are employed as actuation chamber and microvalve actuation principles respectively, originating that the design integrates perfectly those principles through two different components such as a micro-pump with integrated microvalves and a microneedles array. The TD3 have shown to be capable of delivering a volumetric flow of 2.92x10-5 cm3/s with a 3.11 Hz membrane stroke fre-quency. The device only needs 116 Pa to complete the suction process and 2560 Pa to complete the discharge process. A 38 microneedle array with 450 µm in length fulfill the function of per-meate skin allowing that the fluid reaches the desired destination and avoiding any possible pain during the insertion.

• Autores: García Cruz, Jennifer; Ríos Afanador, Ismael Alberto; Fonthal Rico, Faruk; Laín Beatove, Santiago
• Tipo de recurso: Article of journal
• Fecha de publicación: 2012
• Institución: Universidad Autónoma de Occidente
• Repositorio: RED: Repositorio Educativo Digital UAO
• Idioma: spa
• OAI Identifier: oai:red.uao.edu.co:10614/10933
• Acceso en línea: http://hdl.handle.net/10614/10933
• Palabra clave: Sistemas microelectromecánicos; Microelectromechanical systems; Administración transdérmica de medicamentos; Simulación
• Rights: openAccess
• License: Derechos Reservados - Universidad Autónoma de Occidente