Design and analyses of a transdermal drug delivery device (TD3 )

In this paper, we introduce a novel type of transdermal drug delivery device (TD3 ) with a micro-electro-mechanical system (MEMS) design using computer-aided design (CAD) techniques as well as computational fluid dynamics (CFD) simulations regarding the fluid interaction inside the device during the actuation process. For the actuation principles of the chamber and microvalve, both thermopneumatic and piezoelectric principles are employed respectively, originating that the design perfectly integrates those principles through two different components, such as a micropump with integrated microvalves and a microneedle array. The TD3 has shown to be capable of delivering a volumetric flow of 2.92 × 10−5 cm3 /s with a 6.6 Hz membrane stroke frequency. The device only needs 116 Pa to complete the suction process and 2560 Pa to complete the discharge process. A 38-microneedle array with 450 µm in length fulfills the function of permeating skin, allowing that the fluid reaches the desired destination and avoiding any possible pain during the insertion

• Autores: Fonthal Rico, Faruk; García Cruz, Jennifer; Ríos Afanador, Ismael Alberto
• Tipo de recurso: Article of journal
• Fecha de publicación: 2019
• Institución: Universidad Autónoma de Occidente
• Repositorio: RED: Repositorio Educativo Digital UAO
• Idioma: eng
• OAI Identifier: oai:red.uao.edu.co:10614/13434
• Acceso en línea: https://hdl.handle.net/10614/13434
• Palabra clave: Sistemas microelectromecánicos; Dispositivos electromecánicos; Sistemas microelectromecánicos; Microelectromechanical systems; Electromechanical devices; Transdermal drug delivery; Micro-electro-mechanical systems (MEMS); Finite element analysi; Microstructures; Computational fluid dynamic
• Rights: openAccess
• License: Derechos reservados - MDPI, 2019