Pllans−II: Unveiling the action mechanism of a promising chemotherapeutic agent targeting cervical cancer cell adhesion and survival pathways
Despite advances in chemotherapeutic drugs used against cervical cancer, available chemotherapy treatments adversely affect the patient’s quality of life. For this reason, new molecules from natural sources with antitumor potential and few side effects are required. In previous research, Pllans-II,...
- Autores:
-
Montoya-Gómez, Alejandro
Tonello, Fiorella
Spolaore, Barbara
Massimino, Maria Lina
Montealegre-Sánchez, Leonel
Castillo, Andrés
Rivera Franco, Nelson
Sevilla-Sánchez, María José
Solano-Redondo, Luis Manuel
Mosquera-Escudero, Mildrey
Jiménez-Charris, Eliécer
Montealegre Sánchez, Leonel Ives
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2023
- Institución:
- Universidad Autónoma de Occidente
- Repositorio:
- RED: Repositorio Educativo Digital UAO
- Idioma:
- eng
- OAI Identifier:
- oai:red.uao.edu.co:10614/15905
- Acceso en línea:
- https://hdl.handle.net/10614/15905
https://doi.org/10.3390/cells12232715
https://red.uao.edu.co/
- Palabra clave:
- Snake venom
Phospholipase A2
Bioprospecting
Antitumor potential
Transcriptomic analysis
Membrane receptor target
- Rights
- openAccess
- License
- Derechos reservados - MDPI, 2023
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| dc.title.eng.fl_str_mv |
Pllans−II: Unveiling the action mechanism of a promising chemotherapeutic agent targeting cervical cancer cell adhesion and survival pathways |
| title |
Pllans−II: Unveiling the action mechanism of a promising chemotherapeutic agent targeting cervical cancer cell adhesion and survival pathways |
| spellingShingle |
Pllans−II: Unveiling the action mechanism of a promising chemotherapeutic agent targeting cervical cancer cell adhesion and survival pathways Snake venom Phospholipase A2 Bioprospecting Antitumor potential Transcriptomic analysis Membrane receptor target |
| title_short |
Pllans−II: Unveiling the action mechanism of a promising chemotherapeutic agent targeting cervical cancer cell adhesion and survival pathways |
| title_full |
Pllans−II: Unveiling the action mechanism of a promising chemotherapeutic agent targeting cervical cancer cell adhesion and survival pathways |
| title_fullStr |
Pllans−II: Unveiling the action mechanism of a promising chemotherapeutic agent targeting cervical cancer cell adhesion and survival pathways |
| title_full_unstemmed |
Pllans−II: Unveiling the action mechanism of a promising chemotherapeutic agent targeting cervical cancer cell adhesion and survival pathways |
| title_sort |
Pllans−II: Unveiling the action mechanism of a promising chemotherapeutic agent targeting cervical cancer cell adhesion and survival pathways |
| dc.creator.fl_str_mv |
Montoya-Gómez, Alejandro Tonello, Fiorella Spolaore, Barbara Massimino, Maria Lina Montealegre-Sánchez, Leonel Castillo, Andrés Rivera Franco, Nelson Sevilla-Sánchez, María José Solano-Redondo, Luis Manuel Mosquera-Escudero, Mildrey Jiménez-Charris, Eliécer Montealegre Sánchez, Leonel Ives |
| dc.contributor.author.none.fl_str_mv |
Montoya-Gómez, Alejandro Tonello, Fiorella Spolaore, Barbara Massimino, Maria Lina Montealegre-Sánchez, Leonel Castillo, Andrés Rivera Franco, Nelson Sevilla-Sánchez, María José Solano-Redondo, Luis Manuel Mosquera-Escudero, Mildrey Jiménez-Charris, Eliécer Montealegre Sánchez, Leonel Ives |
| dc.subject.proposal.eng.fl_str_mv |
Snake venom Phospholipase A2 Bioprospecting Antitumor potential Transcriptomic analysis Membrane receptor target |
| topic |
Snake venom Phospholipase A2 Bioprospecting Antitumor potential Transcriptomic analysis Membrane receptor target |
| description |
Despite advances in chemotherapeutic drugs used against cervical cancer, available chemotherapy treatments adversely affect the patient’s quality of life. For this reason, new molecules from natural sources with antitumor potential and few side effects are required. In previous research, Pllans-II, a phospholipase A2 type-Asp49 from Porthidium lansbergii lansbergii snake venom, has shown selective attack against the HeLa and Ca Ski cervical cancer cell lines. This work suggests that the cytotoxic effect generated by Pllans-II on HeLa cells is triggered without affecting the integrity of the cytoplasmic membrane or depolarizing the mitochondrial membranes. The results allow us to establish that cell death in HeLa is related to the junction blockage between a5B1 integrins and fibronectin of the extracellular matrix. Pllans-II reduces the cells’ ability of adhesion and affects survival and proliferation pathways mediated by intracellular communication with the external environment. Our findings confirmed Pllans-II as a potential prototype for developing a selective chemotherapeutic drug against cervical cancer |
| publishDate |
2023 |
| dc.date.issued.none.fl_str_mv |
2023 |
| dc.date.accessioned.none.fl_str_mv |
2024-11-15T20:24:47Z |
| dc.date.available.none.fl_str_mv |
2024-11-15T20:24:47Z |
| dc.type.spa.fl_str_mv |
Artículo de revista |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.coar.eng.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
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Text |
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info:eu-repo/semantics/article |
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http://purl.org/redcol/resource_type/ART |
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info:eu-repo/semantics/publishedVersion |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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Montoya-Gómez, A., et. al. (2023). Pllans−II: Unveiling the action mechanism of a promising chemotherapeutic agent targeting cervical cancer cell adhesion and survival pathways. Cells. 12(23). 18 p. https://doi.org/10.3390/cells12232715 |
| dc.identifier.issn.spa.fl_str_mv |
20734409 |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/10614/15905 |
| dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.3390/cells12232715 |
| dc.identifier.instname.spa.fl_str_mv |
Universidad Autónoma de Occidente |
| dc.identifier.reponame.spa.fl_str_mv |
Respositorio Educativo Digital UAO |
| dc.identifier.repourl.none.fl_str_mv |
https://red.uao.edu.co/ |
| identifier_str_mv |
Montoya-Gómez, A., et. al. (2023). Pllans−II: Unveiling the action mechanism of a promising chemotherapeutic agent targeting cervical cancer cell adhesion and survival pathways. Cells. 12(23). 18 p. https://doi.org/10.3390/cells12232715 20734409 Universidad Autónoma de Occidente Respositorio Educativo Digital UAO |
| url |
https://hdl.handle.net/10614/15905 https://doi.org/10.3390/cells12232715 https://red.uao.edu.co/ |
| dc.language.iso.eng.fl_str_mv |
eng |
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eng |
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18 |
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23 |
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1 |
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12 |
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Cells |
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Montoya-Gómez, AlejandroTonello, FiorellaSpolaore, BarbaraMassimino, Maria LinaMontealegre-Sánchez, LeonelCastillo, AndrésRivera Franco, NelsonSevilla-Sánchez, María JoséSolano-Redondo, Luis ManuelMosquera-Escudero, MildreyJiménez-Charris, EliécerMontealegre Sánchez, Leonel Ivesvirtual::5776-12024-11-15T20:24:47Z2024-11-15T20:24:47Z2023Montoya-Gómez, A., et. al. (2023). Pllans−II: Unveiling the action mechanism of a promising chemotherapeutic agent targeting cervical cancer cell adhesion and survival pathways. Cells. 12(23). 18 p. https://doi.org/10.3390/cells1223271520734409https://hdl.handle.net/10614/15905https://doi.org/10.3390/cells12232715Universidad Autónoma de OccidenteRespositorio Educativo Digital UAOhttps://red.uao.edu.co/Despite advances in chemotherapeutic drugs used against cervical cancer, available chemotherapy treatments adversely affect the patient’s quality of life. For this reason, new molecules from natural sources with antitumor potential and few side effects are required. In previous research, Pllans-II, a phospholipase A2 type-Asp49 from Porthidium lansbergii lansbergii snake venom, has shown selective attack against the HeLa and Ca Ski cervical cancer cell lines. This work suggests that the cytotoxic effect generated by Pllans-II on HeLa cells is triggered without affecting the integrity of the cytoplasmic membrane or depolarizing the mitochondrial membranes. The results allow us to establish that cell death in HeLa is related to the junction blockage between a5B1 integrins and fibronectin of the extracellular matrix. Pllans-II reduces the cells’ ability of adhesion and affects survival and proliferation pathways mediated by intracellular communication with the external environment. Our findings confirmed Pllans-II as a potential prototype for developing a selective chemotherapeutic drug against cervical cancer18 páginasapplication/pdfengMDPIBasel, SwitzerlandDerechos reservados - MDPI, 2023https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)http://purl.org/coar/access_right/c_abf2Pllans−II: Unveiling the action mechanism of a promising chemotherapeutic agent targeting cervical cancer cell adhesion and survival pathwaysArtículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a851823112Cells1. Arbyn, M.;Weiderpass, E.; Bruni, L.; de Sanjosé, S.; Saraiya, M.; Ferlay, J.; Bray, F. Estimates of Incidence and Mortality of Cervical Cancer in 2018: A Worldwide Analysis. Lancet Glob. Health 2020, 8, e191–e203. 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