Design and analyses of a transdermal drug delivery device (TD3)†
In this paper, we introduce a novel type of transdermal drug delivery device (TD3) with a micro-electro-mechanical system (MEMS) design using computer-aided design (CAD) techniques as well as computational fluid dynamics (CFD) simulations regarding the fluid interaction inside the device during the...
- Autores:
-
García, Jennifer
Ríos, Ismael
Fonthal Rico, Faruk
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2019
- Institución:
- Universidad Autónoma de Occidente
- Repositorio:
- RED: Repositorio Educativo Digital UAO
- Idioma:
- spa
- OAI Identifier:
- oai:red.uao.edu.co:10614/15899
- Acceso en línea:
- https://hdl.handle.net/10614/15899
https://doi.org/10.3390/s19235090
https://red.uao.edu.co/
- Palabra clave:
- Transdermal drug delivery
Micro-electro-mechanical systems (MEMS)
Finite element analysis
Microstructures
Computational fluid dynamic
- Rights
- openAccess
- License
- Derechos reservados - MDPI, 2019
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Design and analyses of a transdermal drug delivery device (TD3)† |
| title |
Design and analyses of a transdermal drug delivery device (TD3)† |
| spellingShingle |
Design and analyses of a transdermal drug delivery device (TD3)† Transdermal drug delivery Micro-electro-mechanical systems (MEMS) Finite element analysis Microstructures Computational fluid dynamic |
| title_short |
Design and analyses of a transdermal drug delivery device (TD3)† |
| title_full |
Design and analyses of a transdermal drug delivery device (TD3)† |
| title_fullStr |
Design and analyses of a transdermal drug delivery device (TD3)† |
| title_full_unstemmed |
Design and analyses of a transdermal drug delivery device (TD3)† |
| title_sort |
Design and analyses of a transdermal drug delivery device (TD3)† |
| dc.creator.fl_str_mv |
García, Jennifer Ríos, Ismael Fonthal Rico, Faruk |
| dc.contributor.author.none.fl_str_mv |
García, Jennifer Ríos, Ismael Fonthal Rico, Faruk |
| dc.subject.proposal.eng.fl_str_mv |
Transdermal drug delivery Micro-electro-mechanical systems (MEMS) Finite element analysis Microstructures Computational fluid dynamic |
| topic |
Transdermal drug delivery Micro-electro-mechanical systems (MEMS) Finite element analysis Microstructures Computational fluid dynamic |
| description |
In this paper, we introduce a novel type of transdermal drug delivery device (TD3) with a micro-electro-mechanical system (MEMS) design using computer-aided design (CAD) techniques as well as computational fluid dynamics (CFD) simulations regarding the fluid interaction inside the device during the actuation process. For the actuation principles of the chamber and microvalve, both thermopneumatic and piezoelectric principles are employed respectively, originating that the design perfectly integrates those principles through two different components, such as a micropump with integrated microvalves and a microneedle array. The TD3 has shown to be capable of delivering a volumetric flow of 2.92 × 10−5 cm3/s with a 6.6 Hz membrane stroke frequency. The device only needs 116 Pa to complete the suction process and 2560 Pa to complete the discharge process. A 38-microneedle array with 450 µm in length fulfills the function of permeating skin, allowing that the fluid reaches the desired destination and avoiding any possible pain during the insertion |
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2024-11-14T19:34:48Z |
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García, J.; Ríos, I. y k Fonthal Rico, F. (2019). Design and analyses of a transdermal drug device (TD3)†. Sensors 19(23). 11 p. https://doi.org/10.3390/s19235090 |
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14248220 |
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Universidad Autónoma de Occidente |
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Respositorio Educativo Digital UAO |
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https://red.uao.edu.co/ |
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García, J.; Ríos, I. y k Fonthal Rico, F. (2019). Design and analyses of a transdermal drug device (TD3)†. Sensors 19(23). 11 p. https://doi.org/10.3390/s19235090 14248220 Universidad Autónoma de Occidente Respositorio Educativo Digital UAO |
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1. Hood, R.R.; Kendall, E.L.; DeVoe, D.L.; Quezado, Z.; Junqueira, M.J.; Finkel, C.; Vreeland, W.N. Microfluidic formation of nanoscale liposomes for passive transdermal drug delivery. In Proceedings of the Microsystems for Measurement and Instrumentation (MAMNA), Gaithersburg, MD, USA, 14 May 2013; pp. 12–15. 2. Dol ˙zan, T.; Vrtaˇcnik, D.; Resnik, D.; Aljanˇciˇc, U.; Mo ˙zek, M.; Peˇcar, B.; Amon, S. Design of transdermal drug delivery system with PZT actuated micropump. In Proceedings of the 37th International Convention on Information and Communication Technology, Electronics and Microelectronics (MIPRO), Opatija, Croatia, 26–30 May 2014; pp. 96–99. 3. Lee, H.; Song, C.; Baik, S.; Kim, D.; Hyeon, T.; Kim, D.H. Device-assisted transdermal drug delivery. Adv. Drug Deliv. Rev. 2018, 127, 35–45. [CrossRef] [PubMed] 4. Mousoulis, C.; Ochoa, M.; Papageorgiou, D.; Ziaie, B. A Skin-Contact-Actuated Micropump for Transdermal Drug Delivery. IEEE Trans. Biomed. Eng. 2011, 58, 1492–1498. [CrossRef] [PubMed] 5. Camovi´c, M.; Bišˇcevi´c, A.; Brˇci´c, I.; Borˇcak, K.; Bušatli´c, S.; Cenanovi´c, N.; Mulali´c, A.; Osmanli´c, M.; ´ Sirbubalo, M.; Tucak, A.; et al. Coated 3d printed PLA microneedles as transdermal drug delivery systems. IFMBE Proc. 2020, 73, 735–742. [CrossRef] 6. Wang, W.; Soper, S.A. Bio-MEMS Technologies and Applications, 1st ed.; CRC Press: Boca Raton, NY, USA, 2006; pp. 7–237. ISBN 9780849335327. 7. Ashraf, M.W.; Tayyaba, S.; Afzulpurkr, N. Tapered tip hollow silicon microneedles for transdermal drug delivery. In Proceedings of the 2nd International Conference on Mechanical and Electronics Engineering (ICMEE), Kyoto, Japan, 1–3 August 2010. 8. Jurcicek, P.; Zou, H.; Zhang, S.; Liu, C. Design and fabrication of hollow out-of-plane silicon microneedles. IET Micro Nano Lett. 2013, 8, 78–81. [CrossRef] 9. Varadan, V.K.; Vinoy, K.J.; Gopalakrishnan, S. Smart Material Systems and MEMS: Design and Development Methodologies, 1st ed.; John Wiley & Sons: Chichester, UK, 2006; ISBN 9780470093610. 10. Cong, W.; Jin-seong, K.; Jungyul, P. Micro check valve integrated magnetically actuated micropump for implantable drug delivery. In Proceedings of the 19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), Kaohsiung, Taiwan, 18–22 June 2017; pp. 1711–1713. 11. Shoji, E. Fabrication of a diaphragm micropump system utilizing the ionomer-based polymer actuator. Sens. Actuators B Chem. 2016, 237, 660–665. [CrossRef] 12. Garcia, J.; Rios, I.; Fonthal, F. Structural and microfluidic analysis of microneedle array for drug delivery. In Proceedings of the 31st Symposium on Microelectronics Technology and Devices IEEE SBMicro 2016, Belo Horizonte, Brazil, 29 August–3 September 2016; pp. 1–4. 13. Kawun, P.; Leahy, S.; Lai, Y. A thin PDMS nozzle/diffuser micropump for biomedical applications. Sens. Actuators B Chem. 2016, 249, 149–154. [CrossRef] 14. Singh, S.; Kumar, N.; George, D.; Sen, A.K. Analytical modeling, simulations and experimental studies of a PZT actuated planar valveless PDMS micropump. Sens. Actuators B Chem. 2015, 225, 81–94. [CrossRef] 15. Nguyen, N.T.; Mousavi, S.A.; Kashaninejad, N.; Phan, D.T. Design, fabrication and characterization of drug delivery systems based on lab-on-a-chip technology. Adv. Drug Deliv. Rev. 2013, 65, 1403–1419. [CrossRef] [PubMed] 16. Davis, S.P.; Martanto, W.; Allen, M.G.; Prausnitz, M.R. Hollow metal microneedles for insulin delivery to diabetic rats. IEEE Trans. Biomed. Eng. 2005, 52, 909–915. [CrossRef] [PubMed] 17. Roxhed, N.T.; Gasser, C.; Griss, P.; Holzapfel, G.A.; Stemme, G. Penetration-enhanced ultrasharp microneedles and prediction on skin interaction for efficient transdermal drug delivery. J. Microelectromech. Syst. 2007, 16, 1429–1440. [CrossRef] 18. Sanjay, S.T.; Zhou, W.; Dou, M.; Tavakoli, H.; Ma, L.; Xu, F.; Li, X. Recent advances of controlled drug delivery using microfluidic platforms. Adv. Drug Deliv. Rev. 2018, 128, 3–28. [CrossRef] [PubMed] 19. Bao, S.J.; Xie, D.L.; Zhang, J.P.; Chang, W.R.; Liang, D.C. Crystal structure of desheptapeptide (B24–B30) insulin at 1.6 Å resolution: Implications for receptor binding. Proc. Natl. Acad. Sci. USA 1997, 94, 2975–2980. [CrossRef] [PubMed] |
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García, JenniferRíos, IsmaelFonthal Rico, Farukvirtual::5768-12024-11-14T19:34:48Z2024-11-14T19:34:48Z2019García, J.; Ríos, I. y k Fonthal Rico, F. (2019). Design and analyses of a transdermal drug device (TD3)†. Sensors 19(23). 11 p. https://doi.org/10.3390/s19235090https://hdl.handle.net/10614/15899https://doi.org/10.3390/s1923509014248220Universidad Autónoma de OccidenteRespositorio Educativo Digital UAOhttps://red.uao.edu.co/In this paper, we introduce a novel type of transdermal drug delivery device (TD3) with a micro-electro-mechanical system (MEMS) design using computer-aided design (CAD) techniques as well as computational fluid dynamics (CFD) simulations regarding the fluid interaction inside the device during the actuation process. For the actuation principles of the chamber and microvalve, both thermopneumatic and piezoelectric principles are employed respectively, originating that the design perfectly integrates those principles through two different components, such as a micropump with integrated microvalves and a microneedle array. The TD3 has shown to be capable of delivering a volumetric flow of 2.92 × 10−5 cm3/s with a 6.6 Hz membrane stroke frequency. The device only needs 116 Pa to complete the suction process and 2560 Pa to complete the discharge process. A 38-microneedle array with 450 µm in length fulfills the function of permeating skin, allowing that the fluid reaches the desired destination and avoiding any possible pain during the insertion11 páginasapplication/pdfspaMDPIBasel, SwitzerlandDerechos reservados - MDPI, 2019https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)http://purl.org/coar/access_right/c_abf2Design and analyses of a transdermal drug delivery device (TD3)†Artículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a851123119Sensors1. Hood, R.R.; Kendall, E.L.; DeVoe, D.L.; Quezado, Z.; Junqueira, M.J.; Finkel, C.; Vreeland, W.N. Microfluidic formation of nanoscale liposomes for passive transdermal drug delivery. In Proceedings of the Microsystems for Measurement and Instrumentation (MAMNA), Gaithersburg, MD, USA, 14 May 2013; pp. 12–15. 2. Dol ˙zan, T.; Vrtaˇcnik, D.; Resnik, D.; Aljanˇciˇc, U.; Mo ˙zek, M.; Peˇcar, B.; Amon, S. Design of transdermal drug delivery system with PZT actuated micropump. In Proceedings of the 37th International Convention on Information and Communication Technology, Electronics and Microelectronics (MIPRO), Opatija, Croatia, 26–30 May 2014; pp. 96–99. 3. Lee, H.; Song, C.; Baik, S.; Kim, D.; Hyeon, T.; Kim, D.H. Device-assisted transdermal drug delivery. Adv. Drug Deliv. Rev. 2018, 127, 35–45. [CrossRef] [PubMed] 4. Mousoulis, C.; Ochoa, M.; Papageorgiou, D.; Ziaie, B. A Skin-Contact-Actuated Micropump for Transdermal Drug Delivery. IEEE Trans. Biomed. Eng. 2011, 58, 1492–1498. [CrossRef] [PubMed] 5. Camovi´c, M.; Bišˇcevi´c, A.; Brˇci´c, I.; Borˇcak, K.; Bušatli´c, S.; Cenanovi´c, N.; Mulali´c, A.; Osmanli´c, M.; ´ Sirbubalo, M.; Tucak, A.; et al. Coated 3d printed PLA microneedles as transdermal drug delivery systems. IFMBE Proc. 2020, 73, 735–742. [CrossRef] 6. Wang, W.; Soper, S.A. Bio-MEMS Technologies and Applications, 1st ed.; CRC Press: Boca Raton, NY, USA, 2006; pp. 7–237. ISBN 9780849335327. 7. Ashraf, M.W.; Tayyaba, S.; Afzulpurkr, N. Tapered tip hollow silicon microneedles for transdermal drug delivery. In Proceedings of the 2nd International Conference on Mechanical and Electronics Engineering (ICMEE), Kyoto, Japan, 1–3 August 2010. 8. Jurcicek, P.; Zou, H.; Zhang, S.; Liu, C. Design and fabrication of hollow out-of-plane silicon microneedles. IET Micro Nano Lett. 2013, 8, 78–81. [CrossRef] 9. Varadan, V.K.; Vinoy, K.J.; Gopalakrishnan, S. Smart Material Systems and MEMS: Design and Development Methodologies, 1st ed.; John Wiley & Sons: Chichester, UK, 2006; ISBN 9780470093610. 10. Cong, W.; Jin-seong, K.; Jungyul, P. Micro check valve integrated magnetically actuated micropump for implantable drug delivery. In Proceedings of the 19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), Kaohsiung, Taiwan, 18–22 June 2017; pp. 1711–1713. 11. Shoji, E. Fabrication of a diaphragm micropump system utilizing the ionomer-based polymer actuator. Sens. Actuators B Chem. 2016, 237, 660–665. [CrossRef] 12. Garcia, J.; Rios, I.; Fonthal, F. Structural and microfluidic analysis of microneedle array for drug delivery. In Proceedings of the 31st Symposium on Microelectronics Technology and Devices IEEE SBMicro 2016, Belo Horizonte, Brazil, 29 August–3 September 2016; pp. 1–4. 13. Kawun, P.; Leahy, S.; Lai, Y. A thin PDMS nozzle/diffuser micropump for biomedical applications. Sens. Actuators B Chem. 2016, 249, 149–154. [CrossRef] 14. Singh, S.; Kumar, N.; George, D.; Sen, A.K. Analytical modeling, simulations and experimental studies of a PZT actuated planar valveless PDMS micropump. Sens. Actuators B Chem. 2015, 225, 81–94. [CrossRef] 15. Nguyen, N.T.; Mousavi, S.A.; Kashaninejad, N.; Phan, D.T. Design, fabrication and characterization of drug delivery systems based on lab-on-a-chip technology. Adv. Drug Deliv. Rev. 2013, 65, 1403–1419. [CrossRef] [PubMed] 16. Davis, S.P.; Martanto, W.; Allen, M.G.; Prausnitz, M.R. Hollow metal microneedles for insulin delivery to diabetic rats. IEEE Trans. Biomed. Eng. 2005, 52, 909–915. [CrossRef] [PubMed] 17. Roxhed, N.T.; Gasser, C.; Griss, P.; Holzapfel, G.A.; Stemme, G. Penetration-enhanced ultrasharp microneedles and prediction on skin interaction for efficient transdermal drug delivery. J. Microelectromech. Syst. 2007, 16, 1429–1440. [CrossRef] 18. Sanjay, S.T.; Zhou, W.; Dou, M.; Tavakoli, H.; Ma, L.; Xu, F.; Li, X. Recent advances of controlled drug delivery using microfluidic platforms. Adv. Drug Deliv. Rev. 2018, 128, 3–28. [CrossRef] [PubMed] 19. Bao, S.J.; Xie, D.L.; Zhang, J.P.; Chang, W.R.; Liang, D.C. Crystal structure of desheptapeptide (B24–B30) insulin at 1.6 Å resolution: Implications for receptor binding. Proc. Natl. Acad. Sci. USA 1997, 94, 2975–2980. [CrossRef] [PubMed]Transdermal drug deliveryMicro-electro-mechanical systems (MEMS)Finite element analysisMicrostructuresComputational fluid dynamicComunidad generalPublication2bf30a66-1e41-42a5-8415-189ea7ccdfa8virtual::5768-12bf30a66-1e41-42a5-8415-189ea7ccdfa8virtual::5768-1https://scholar.google.com/citations?user=zxVYtU0AAAAJ&hl=envirtual::5768-10000-0002-9331-0491virtual::5768-1https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000895857virtual::5768-1ORIGINALDesign_and_analyses_of_a_transdermal_drug_delivery_device_(TD3).pdfDesign_and_analyses_of_a_transdermal_drug_delivery_device_(TD3).pdfArchivo texto completo del artículo de revista, PDFapplication/pdf5208751https://red.uao.edu.co/bitstreams/e0607123-cdd8-4f1a-b8b9-8720bfae4ca0/download3141ec24b4a6bfd6abfc140851520b24MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81672https://red.uao.edu.co/bitstreams/2828a503-1786-4c55-922e-6b20d1f02789/download6987b791264a2b5525252450f99b10d1MD52TEXTDesign_and_analyses_of_a_transdermal_drug_delivery_device_(TD3).pdf.txtDesign_and_analyses_of_a_transdermal_drug_delivery_device_(TD3).pdf.txtExtracted texttext/plain38293https://red.uao.edu.co/bitstreams/a154ebd9-67a3-4fb3-a314-0d5076974ddd/downloade0ec9065505ba7d1f3764d3d51f92a7bMD53THUMBNAILDesign_and_analyses_of_a_transdermal_drug_delivery_device_(TD3).pdf.jpgDesign_and_analyses_of_a_transdermal_drug_delivery_device_(TD3).pdf.jpgGenerated Thumbnailimage/jpeg14682https://red.uao.edu.co/bitstreams/9dcad206-030a-4b4b-8998-187380f12eed/downloadd39bf9c006ddf9bf20063fda7f60e4eeMD5410614/15899oai:red.uao.edu.co:10614/158992024-11-16 03:00:26.513https://creativecommons.org/licenses/by-nc-nd/4.0/Derechos reservados - MDPI, 2019open.accesshttps://red.uao.edu.coRepositorio Digital Universidad Autonoma de Occidenterepositorio@uao.edu.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 |