An Entropy-Based Graph Construction Method for Representing and Clustering Biological Data

Unsupervised learning methods are commonly used to perform the non-trivial task of uncovering structure in biological data. However, conventional approaches rely on methods that make assumptions about data distribution and reduce the dimensionality of the input data. Here we propose the incorporatio...

Full description

Autores:
Ariza-Jiménez L.
Pinel N.
Villa L.F.
Quintero O.L.
Tipo de recurso:
Fecha de publicación:
2019
Institución:
Universidad EAFIT
Repositorio:
Repositorio EAFIT
Idioma:
eng
OAI Identifier:
oai:repository.eafit.edu.co:10784/26750
Acceso en línea:
https://eafit.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=9841
http://hdl.handle.net/10784/26750
Palabra clave:
Biomedical
engineering
Biophysics
Entropy
Graphic
methods
Machine
learning
Unsupervised
learning
Biological
data
Clustering
Graph
Metagenomic
binning
Spike-sorting
Sorting
Rights
License
https://v2.sherpa.ac.uk/id/publication/issn/1680-0737
Description
Summary:Unsupervised learning methods are commonly used to perform the non-trivial task of uncovering structure in biological data. However, conventional approaches rely on methods that make assumptions about data distribution and reduce the dimensionality of the input data. Here we propose the incorporation of entropy related measures into the process of constructing graph-based representations for biological datasets in order to uncover their inner structure. Experimental results demonstrated the potential of the proposed entropy-based graph data representation to cope with biological applications related to unsupervised learning problems, such as metagenomic binning and neuronal spike sorting, in which it is necessary to organize data into unknown and meaningful groups. © 2020, Springer Nature Switzerland AG.